H. Kobayashi

发表

Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

H Akita, H Hatakeyama, H Harashima, 2007, Gene Therapy.

L-lysine effectively blocks renal uptake of 125I- or 99mTc-labeled anti-Tac disulfide-stabilized Fv fragment.

I. Pastan, J. Carrasquillo, H. Kobayashi, 1996, Cancer research.

Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier.

Y. Sai, I. Tamai, A. Tsuji, 1997, The Journal of pharmacology and experimental therapeutics.

Chemical modification to reduce renal uptake of disulfide-bonded variable region fragment of anti-Tac monoclonal antibody labeled with 99mTc.

I. Pastan, J. Carrasquillo, H. Kobayashi, 1999, Bioconjugate chemistry.

Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin.

I. Pastan, M. Brechbiel, J. Carrasquillo, 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies.

I. Pastan, M. Brechbiel, J. Carrasquillo, 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA.

I. Pastan, M. Brechbiel, J. Carrasquillo, 1997, Bioorganic & medicinal chemistry.

Favorable effects of glycolate conjugation on the biodistribution of humanized antiTac Fab fragment.

T. Waldmann, D. Paik, J. Carrasquillo, 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

I. Pastan, J. Carrasquillo, E. Han, 1998, Nuclear medicine and biology.

Effects of insulinlike growth factor binding proteins on insulinlike growth factor-I biodistribution in tumor-bearing nude mice.

J. Carrasquillo, H. Kobayashi, C. Paik, 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Application of boron-entrapped stealth liposomes to inhibition of growth of tumour cells in the in vivo boron neutron-capture therapy model.

K. Ono, Y. Sakurai, R. Ilić, 2006, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Pharmacokinetics and clearance properties of nano-sized particles and molecules as multi-modality imaging agents: Considerations and caveats

H. Kobayashi, 2011 .

Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2.

T. Waldmann, I. Pastan, J. Carrasquillo, 1999, Cytokine.

Differences of biodistribution, pharmacokinetics, and tumor targeting between interleukins 2 and 15.

T. Waldmann, J. Carrasquillo, H. Kobayashi, 2000, Cancer research.

Improved biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment by blocking its binding to the alpha subunit of the interleukin 2 receptor in the circulation with preinjected humanized anti-Tac IgG.

T. Waldmann, I. Pastan, J. Carrasquillo, 1997, Cancer research.

Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolism.

J. Carrasquillo, H. Kobayashi, C. Paik, 1997, Cancer research.

S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters

Tadaki Suzuki, Y. Orba, H. Sawa, 2022, Science Translational Medicine.

Inhibition of growth of human breast cancer cells in culture by neutron capture using liposomes containing 10B.

M. Eriguchi, H. Kobayashi, H. Yasuhara, 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Inhibition of human pancreatic cancer growth in nude mice by boron neutron capture therapy.

H. Yanagie, M. Eriguchi, H. Kobayashi, 1997, British Journal of Cancer.

Evaluation of 99mTc-mercaptoacetyltriglycine-biocytin as a new hepatobiliary imaging agent in mice coinjected with bilirubin.

J. Seidel, M. Green, J. Carrasquillo, 1999, Nuclear medicine and biology.

Metabolic fate of 1-hexylcarbamoyl-5-fluorouracil in rats.

H. Kobayashi, S. Watanabe, I. Shirakawa, 1978, Xenobiotica; the fate of foreign compounds in biological systems.

Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.

H. Nariuchi, H. Yanagie, H. Kobayashi, 1991, British Journal of Cancer.

Design of poly(α-malic acid) -5fu-saccharide conjugate exhibiting antitumor activity

Y. Ohya, T. Ouchi, H. Kobayashi, 1991 .

Design of poly(α‐malic acid)‐5FU conjugate exhibiting antitumor activity

T. Ouchi, H. Kobayashi, T. Banba, 1990 .

Release Behavior of 5-Fluorouracil from Chitosan-Gel Nanospheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell Specific Cytotoxicity

Yuichi Ohya, Y. Ohya, T. Ouchi, 1994 .

Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition.

T. Takei, Y. Ohya, T. Ouchi, 1993, Journal of microencapsulation.

Design of Poly(α-malic acid)—Antitumor Drug—Saccharide Conjugate Exhibiting Cell-Specific Antitumor Activity

Y. Ohya, T. Ouchi, H. Kobayashi, 1993 .

Pharmacokinetics and absolute bioavailability of sitafloxacin, a new fluoroquinolone antibiotic, in healthy male and female Caucasian subjects

H. Kobayashi, J. O'grady, D. Milatović, 2001, Xenobiotica; the fate of foreign compounds in biological systems.

Use of 99mTc-mercaptoacetyltriglycine (MAG3)-biocytin hepatobiliary scintigraphy to study the protective effect of a synthetic enzyme inhibitor on acute hepatotoxicity in mice.

J. Seidel, M. Green, J. Carrasquillo, 1998, Nuclear medicine and biology.

Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes.

S. Yamamoto, F. Gonzalez, H. Kobayashi, 2000, Chemico-biological interactions.

Purification and some properties of a novel racemase, which racemizes 2-oxothiazolidine-4-carboxylic acid and 5-oxoproline, from Flectobacillus sp. strain B-1.

H. Kobayashi, K. Hosono, K. Mochizuki, 1994, Biochimica et biophysica acta.

The pharmacokinetic characteristics of glycolated humanized anti-Tac Fabs are determined by their isoelectric points.

T. Waldmann, D. Paik, J. Carrasquillo, 1999, Cancer research.

Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody.

M. Brechbiel, Hisataka Kobayashi, J. Carrasquillo, 1999, Bioconjugate chemistry.

Oral administration of S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and accelerates recovery from clinical aspects of COVID-19

Tadaki Suzuki, Y. Orba, W. Hall, 2022, bioRxiv.

Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: preinjection of intact antibody versus clearance of antigen with adivin-biotin system.

T. Waldmann, I. Pastan, J. Carrasquillo, 1999, Journal of Nuclear Medicine.