N. Miyata

发表

Microtubule acetylation through HDAC6 inhibition results in increased transfection efficiency.

Aaron M. Miller, Takayoshi Suzuki, D. Dean, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Non-hydroxamate histone deacetylase inhibitors.

Takayoshi Suzuki, N. Miyata, 2005, Current medicinal chemistry.

Mutagenicity of the fullerene C60-generated singlet oxygen dependent formation of lipid peroxides.

N. Miyata, N. Sera, H. Tokiwa, 1996, Carcinogenesis.

Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo

T. Tsuchiya, N. Miyata, Ikuko Oguri, 1996, FEBS letters.

[Reactive species responsible for biological actions of photoexcited fullerenes].

N. Miyata, Y. Yamakoshi, I. Nakanishi, 2000, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2006, Bioorganic & medicinal chemistry letters.

Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation

Takafumi Hara, G. Tsujimoto, Takayoshi Suzuki, 2010, Molecular Pharmacology.

Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors.

Takayoshi Suzuki, Takayoshi Suzuki, N. Miyata, 2010, Bioorganic & medicinal chemistry letters.

DIRECT TOXIC EFFECTS OF ETHYLENE-1, 2-DIMETHANESULFONATE (EDS) ON THE RAT EPIDIDYMIS

K. Mitsumori, K. Toyoda, N. Miyata, 1996 .

A novel promoting action of fullerene C60 on the chondrogenesis in rat embryonic limb bud cell culture system.

T. Tsuchiya, N. Miyata, Y. Yamakoshi, 1995, Biochemical and biophysical research communications.

Photomanipulation of vasodilation with a blue-light-controllable nitric oxide releaser.

N. Miyata, H. Nakagawa, Naoya Ieda, 2014, Journal of the American Chemical Society.

Synthesis and biological evaluation of all A-ring stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D3 and their 20-epimers: possible binding modes of potent A-ring analogues to vitamin D receptor

N. Miyata, K. Nakagawa, T. Okano, 2001 .

Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors.

Yukihiro Itoh, Takayoshi Suzuki, Minoru Yoshida, 2007, Journal of medicinal chemistry.

The 4'-hydroxy group is responsible for the in vitro cytogenetic activity of resveratrol.

N. Miyata, A. Furuta, K. Takeshita, 2002, Mutation research.

Scavenging mechanisms of (-)-epigallocatechin gallate and (-)-epicatechin gallate on peroxyl radicals and formation of superoxide during the inhibitory action.

N. Miyata, M. Kurihara, K. Kondo, 1999, Free radical biology & medicine.

Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.

M. Makishima, Takayoshi Suzuki, N. Miyata, 2007, Bioorganic & medicinal chemistry letters.

Acridine Adduct of [60]Fullerene with Enhanced DNA-Cleaving Activity.

T. Yagami, N. Miyata, Y. Yamakoshi, 1996, The Journal of organic chemistry.

Nitration of specific tyrosine residues of cytochrome C is associated with caspase-cascade inactivation.

N. Miyata, T. Toda, H. Nakagawa, 2007, Biological & pharmaceutical bulletin.

Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors.

Yukihiro Itoh, Takayoshi Suzuki, N. Miyata, 2007, Bioorganic & medicinal chemistry letters.

Mutagenicity of nitro-azabenzo[a]pyrene and its related compounds.

N. Miyata, N. Sera, K. Horikawa, 1992, Mutation research.

Reduction properties of nitrated naphthalenes: relationship between electrochemical reduction potential and the enzymatic reduction by microsomes or cytosol from rat liver.

N. Miyata, N. Iwata, K. Suzuki, 1992, Chemico-biological interactions.

Profiling and relative quantification of multiply nitrated and oxidized fatty acids

J. Galano, T. Durand, N. Miyata, 2015, Analytical and Bioanalytical Chemistry.

Photocontrollable peroxynitrite generator based on N-methyl-N-nitrosoaminophenol for cellular application.

Takayoshi Suzuki, Dan Yang, N. Miyata, 2012, Journal of the American Chemical Society.

Identification of novel PPARα ligands by the structural modification of a PPARγ ligand

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2006 .

Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2.

Takayoshi Suzuki, N. Miyata, M. Imagawa, 2005, Bioorganic & medicinal chemistry letters.

•OH and O2•- Generation in Aqueous C60 and C70 Solutions by Photoirradiation: An EPR Study

N. Miyata, Y. Yamakoshi, M. Kohno, 1998 .

Clastogenicity of 1-nitropyrene, dinitropyrenes, fluorene and mononitrofluorenes in cultured Chinese hamster cells.

T. Sofuni, M. Ishidate, N. Miyata, 1991, Mutation research.

An unexpected example of protein-templated click chemistry.

Takayoshi Suzuki, M. G. Finn, N. Miyata, 2010, Angewandte Chemie.

Determination of N-acetyl-S-carbethoxycysteine in rat and mouse urine by liquid chromatography with fluorescence detection

T. Toyo’oka, N. Miyata, M. Kurihara, 1989 .

Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species.

K. Imaida, C. Uneyama, N. Miyata, 1992, Cancer research.

Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2007, Bioorganic & medicinal chemistry letters.

Development of a DNA-binding TEMPO derivative for evaluation of nuclear oxidative stress and its application in living cells.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2010, Free radical biology & medicine.

A reductant-resistant and metal-free fluorescent probe for nitroxyl applicable to living cells.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2013, Journal of the American Chemical Society.

Visible light-induced nitric oxide release from a novel nitrobenzene derivative cross-conjugated with a coumarin fluorophore.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2014, Bioorganic & medicinal chemistry letters.

Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor.

Yukihiro Itoh, Takayoshi Suzuki, N. Miyata, 2007, Bioorganic & medicinal chemistry letters.

Detection of nitro-azabenzo[a]pyrene derivatives in the semivolatile phase originating from airborne particulate matter, diesel and gasoline vehicles.

N. Miyata, N. Sera, H. Tokiwa, 1994, Mutagenesis.

FFA1‐selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models

Takafumi Hara, G. Tsujimoto, Takayoshi Suzuki, 2013, British journal of pharmacology.

Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.

M. Makishima, G. Tsujimoto, Yukihiro Itoh, 2008, Journal of medicinal chemistry.

Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8‐Selective Inhibitors

K. Shirahige, Yukihiro Itoh, Takayoshi Suzuki, 2014, ChemMedChem.

Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2005, Bioorganic & medicinal chemistry.

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.

Yukihiro Itoh, Takayoshi Suzuki, R. Janknecht, 2009, Bioorganic & medicinal chemistry letters.

Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2005, Bioorganic & medicinal chemistry letters.

Thiol-based SAHA analogues as potent histone deacetylase inhibitors.

A. Kohara, Takayoshi Suzuki, N. Miyata, 2004, Bioorganic & medicinal chemistry letters.

Initiating activity of quinones in the two-stage transformation of BALB/3T3 cells.

N. Miyata, A. Sakai, A. Takahashi, 1995, Carcinogenesis.

Piloty's acid derivative with improved nitroxyl-releasing characteristics.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2013, Bioorganic & medicinal chemistry letters.

Alternative photoinduced release of HNO or NO from an acyl nitroso compound, depending on environmental polarity.

Takayoshi Suzuki, Y. Adachi, N. Miyata, 2010, Chemical communications.

Photoactivatable HNO-releasing compounds using the retro-Diels-Alder reaction.

Takayoshi Suzuki, Y. Adachi, N. Miyata, 2008, Chemical communications.

Fullerene: a photosensitizer effectively generates oxyl radicals to cause DNA cleavage

N. Miyata, Y. Yamakoshi, 1999 .

Synthesis of C60 derivatives for photoaffinity labeling

T. Tsuchiya, N. Miyata, H. Inoue, 2004 .

Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2010, Bioorganic & Medicinal Chemistry Letters.

Effects of magnesium ion on kinetic stability and spin distribution of phenoxyl radical derived from a vitamin E analogue: mechanistic insight into antioxidative hydrogen-transfer reaction of vitamin E

K. Ohkubo, S. Fukuzumi, N. Miyata, 2002 .

Design and synthesis of cyclic urea compounds: a pharmacological study for retinoidal activity.

H. Kagechika, N. Miyata, A. S. Rouf, 2004, Bioorganic & medicinal chemistry letters.

Peroxynitrite generation from a NO-releasing nitrobenzene derivative in response to photoirradiation.

Takayoshi Suzuki, Dan Yang, N. Miyata, 2011, Chemical communications.

Direct detection of superoxide anion generated in C60-photosensitized oxidation of NADH and an analogue by molecular oxygen

K. Ohkubo, S. Fukuzumi, O. Ito, 2002 .

Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative bearing a lysine moiety.

K. Ohkubo, S. Fukuzumi, N. Miyata, 2009, Chemical communications.

Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1

Yukihiro Itoh, Miki Suzuki, Takayoshi Suzuki, 2015 .

Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism.

Yukihiro Itoh, Takayoshi Suzuki, T. Mizukami, 2013, Angewandte Chemie.

Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II).

K. Ohkubo, S. Fukuzumi, N. Miyata, 2006, Bioorganic & medicinal chemistry.

Efficient and versatile synthesis of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors

N. Miyata, K. Yamaguchi, M. Kurihara, 2001 .

Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2010, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation, and conformational analysis of A-ring diastereomers of 2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: unique activity profiles depending on the stereochemistry of the A-ring and at C-20.

H. DeLuca, S. Maki, N. Miyata, 2000, Journal of medicinal chemistry.

The Effects of Fullernes on the Initiation and Promotion Stages of Balb/3t3 Cell Transformation

N. Miyata, Y. Yamakoshi, A. Sakai, 1995 .

Visible Light-Controlled Nitric Oxide Release from Hindered Nitrobenzene Derivatives for Specific Modulation of Mitochondrial Dynamics.

N. Miyata, H. Nakagawa, Mitsuyasu Kawaguchi, 2016, ACS chemical biology.

Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue.

K. Ohkubo, S. Fukuzumi, S. Hecht, 2005, Organic & biomolecular chemistry.

Search for a novel SIRT1 activator: structural modification of SRT1720 and biological evaluation.

Yukihiro Itoh, Takayoshi Suzuki, H. Sawada, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.

Takayoshi Suzuki, S. Iida, R. Ueda, 2009, Bioorganic & medicinal chemistry.

ASSOCIATIONS BETWEEN CHEMICAL PROPERTIES AND OXIDATIVE DAMAGE DUE TO NITROPHENANTHRENES AND THEIR RELATED COMPOUNDS IN PRIMARY RAT HEPATOCYTES

H. Utsumi, S. Sasaki, N. Miyata, 2004 .

Structural activity relationship between Salmonella-mutagenicity and nitro-orientation of nitroazaphenanthrenes.

H. Utsumi, S. Sasaki, N. Miyata, 2003, Chemico-biological interactions.

Oxidative DNA damage by a metabolite of carcinogenic 1-nitropyrene.

N. Miyata, S. Ohnishi, S. Kawanishi, 2001, Biochemical and biophysical research communications.

Effect of [60] Fullerene on the Chondrogenesis in Mouse Embryonic Limb Bud Cell Culture System

T. Tsuchiya, N. Miyata, Y. Yamakoshi, 1996 .

(7-Diethylaminocoumarin-4-yl)methyl ester of suberoylanilide hydroxamic acid as a caged inhibitor for photocontrol of histone deacetylase activity.

N. Miyata, H. Nakagawa, Sota Yamada, 2016, Bioorganic & medicinal chemistry.

Distinguishing the 5,5-dimethyl-1-pyrroline N-oxide (DMPO)-OH radical quenching effect from the hydroxyl radical scavenging effect in the ESR spin-trapping method

N. Miyata, K. Imai, T. Mashino, 2004 .

2‐Anilinobenzamides as SIRT Inhibitors

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2006, ChemMedChem.

Histone Deacetylase Inhibitor Valproic Acid Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells

Takayoshi Suzuki, N. Miyata, Katsunori Nakamura, 2014, PloS one.

DMPO-OH Radical Formation from 5,5-Dimethyl-1-pyrroline N-Oxide (DMPO) in Hot Water

N. Miyata, T. Mashino, M. Mochizuki, 2007, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.

Takayoshi Suzuki, N. Miyata, Mineko Kurotaki, 2005, Journal of medicinal chemistry.

Identification of novel SIRT2-selective inhibitors using a click chemistry approach.

Peng Zhan, Yukihiro Itoh, Takayoshi Suzuki, 2014, Bioorganic & medicinal chemistry letters.

Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages.

Takayoshi Suzuki, K. Hanaoka, T. Nagano, 2014, Chemical communications.

Photoinduced nitric oxide release from nitrobenzene derivatives.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2005, Journal of the American Chemical Society.

Development of photo-controllable hydrogen sulfide donor applicable in live cells.

K. Hanaoka, T. Nagano, N. Miyata, 2015, Bioorganic & medicinal chemistry letters.

Facile Procedure for Acetalization Using Diols, Alkoxysilane and a Catalytic Amount of Trimethylsilyl Trifluoromethanesulfonate

N. Miyata, M. Kurihara, 1995 .

Novel ninhydrin adduct of catechin with potent antioxidative activity

N. Miyata, I. Nakanishi, H. Okuda, 2009 .

New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.

Takayoshi Suzuki, K. Doh-ura, S. Ohta, 2007, Journal of medicinal chemistry.

Facile Procedure for Acetalization Using Diols, Alkoxysilane and a Catalytic Amount of Trimethylsilyl Trifluoromethanesulfonate.

N. Miyata, M. Kurihara, 1995 .

Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2.

Yukihiro Goda, Tetsuo Nagano, T. Nagano, 2003, Journal of the American Chemical Society.

Planar catechin analogues with alkyl side chains: a potent antioxidant and an alpha-glucosidase inhibitor.

Toshihiko Ozawa, Yuriko Nakamura, Haruhiro Okuda, 2006, Journal of the American Chemical Society.

Enhanced radical-scavenging activity of a planar catechin analogue.

N. Miyata, I. Nakanishi, K. Yamaguchi, 2002, Journal of the American Chemical Society.

Thiol-based SAHA analogues as potent histone deacetylase inhibitors.

A. Kohara, Takayoshi Suzuki, N. Miyata, 2004, Bioorganic & medicinal chemistry letters.

Stereoselective epoxidation with dioxiranes generated from ketones

S. Ito, N. Miyata, M. Kurihara, 1994 .

Activation of the human Ah receptor by aza-polycyclic aromatic hydrocarbons and their halogenated derivatives.

N. Miyata, T. Matsuda, Katsuya Yamada, 2003, Biological & pharmaceutical bulletin.

Product analyses of ozone mediated nitration of benzimidazole derivatives with nitrogen dioxide: formation of 1-nitrobenzimidazoles and conversion to benzotriazoles.

N. Miyata, K. Kohda, T. Kaiya, 2004, Chemical & pharmaceutical bulletin.

Effect of methyl substitution on the antioxidative property and genotoxicity of resveratrol.

N. Miyata, I. Nakanishi, S. Saito, 2008, Chemical research in toxicology.

A planar catechin analogue as a promising antioxidant with reduced prooxidant activity.

K. Ohkubo, S. Fukuzumi, K. Miyazaki, 2003, Chemical research in toxicology.

Enantioselective Radical Cross-Coupling Reactions of Silyl Enol Ethers Using Chiral Oxovanadium

N. Miyata, M. Kurihara, T. Hayashi, 2001 .

DEOXYGENATION OF TERTIARY AMINE N-OXIDES AND ARENE OXIDES BY IRON (II) PORPHYRIN AS A MODEL OF CYTOCHROME P-450 DEPENDENT REDUCTION

N. Miyata, T. Santa, M. Hirobe, 1984 .

Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates.

A. Kohara, Takayoshi Suzuki, N. Miyata, 2003, Bioorganic & medicinal chemistry letters.

Lysine demethylases inhibitors.

Takayoshi Suzuki, N. Miyata, 2011, Journal of medicinal chemistry.

Solubilization of fullerenes into water with polyvinylpyrrolidone applicable to biological tests

T. Yagami, N. Miyata, Y. Yamakoshi, 1994 .

Conversion of procyanidin B-type (catechin dimer) to A-type: evidence for abstraction of C-2 hydrogen in catechin during radical oxidation

N. Miyata, Takashi Tanaka, M. Kurihara, 2000 .

An HPLC assay of hydroxyl radicals by the hydroxylation reaction of terephthalic acid.

N. Miyata, K. Imai, T. Mashino, 2004, Biomedical chromatography : BMC.

Studies on the tumor-promoting activity of additives in biomaterials: inhibition of metabolic cooperation by phenolic antioxidants involved in rubber materials.

N. Miyata, Y. Ikarashi, K. Fukuhara, 1995, Journal of biomedical materials research.

Oxidative DNA damage induced by carcinogenic dinitropyrenes in the presence of P450 reductase.

N. Miyata, S. Ohnishi, S. Kawanishi, 2004, Chemical Research in Toxicology.

Promoting activity of 3-tert-butyl-4-hydroxyanisole (BHA) in BALB/3T3 cell transformation.

N. Miyata, A. Sakai, A. Takahashi, 1997, Cancer letters.

Stereoselective synthesis of an erythro N-protected α-amino epoxide derivative

N. Miyata, M. Kurihara, Yoko Kasahara, 1999 .

Preparation of deuterated methyl and dimethyl substituted nicotinoylating agents for derivatization of the N-terminal of protein.

R. Taguchi, N. Miyata, H. Tsumoto, 2003, Chemical & pharmaceutical bulletin.

Electron transfer from quinone and nitroarene anion radicals to molecular oxygen studied by the potential-step chronocoulometry method

N. Miyata, K. Fukuhara, Y. Hara, 1994 .

Stereoselective Epoxidation of Acyclic Allylic Ethers Using Ketone-Oxone^ System

N. Miyata, M. Kurihara, A. Pathak, 1997 .

Stereoselective Epoxidation of Acyclic Allylic Ethers Using Ketone—Oxone® System.

N. Miyata, M. Kurihara, A. Pathak, 1998 .

Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.

Hiroki Tsumoto, Katsuhiko Shirahige, Yukihiro Itoh, 2012, Journal of medicinal chemistry.

Small-molecular modulators of cancer-associated epigenetic mechanisms.

Yukihiro Itoh, Takayoshi Suzuki, N. Miyata, 2013, Molecular bioSystems.

Resveratrol as a new type of DNA-cleaving agent.

N. Miyata, K. Fukuhara, 1998, Bioorganic & medicinal chemistry letters.

Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-β C-terminal peptides.

M. Shibanuma, N. Miyata, H. Nakagawa, 2016, Bioorganic & medicinal chemistry letters.

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.

P. Zhan, Yukihiro Itoh, Miki Suzuki, 2016, Journal of medicinal chemistry.

An Overview of Phenylcyclopropylamine Derivatives: Biochemical and Biological Significance and Recent Developments

Takayoshi Suzuki, N. Miyata, M. N. A. Khan, 2013, Medicinal research reviews.

Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2)

H. Narita, Takayoshi Suzuki, T. Mizukami, 2014, Bioscience, biotechnology, and biochemistry.

Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer

A. Sood, Takayoshi Suzuki, R. Vadlamudi, 2012, Breast Cancer Research.

Identification of cell-active lysine specific demethylase 1-selective inhibitors.

Makoto Hasegawa, Takayoshi Suzuki, Hiroki Tsumoto, 2009, Journal of the American Chemical Society.

NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect

Takayoshi Suzuki, K. Tozawa, A. Naiki‐Ito, 2014, Oncotarget.

Trans-4-hydroxy-2-nonenal, an aldehydic lipid peroxidation product, lacks genotoxicity in lacI transgenic mice.

A. Nishikawa, F. Furukawa, M. Hirose, 2000, Cancer letters.

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

Makoto Hasegawa, Hiroki Tsumoto, Yukihiro Itoh, 2010, Journal of medicinal chemistry.

Fine spatiotemporal control of nitric oxide release by infrared pulse-laser irradiation of a photolabile donor.

Takayoshi Suzuki, J. Nabekura, N. Miyata, 2013, ACS chemical biology.

Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

P. Zhan, Yukihiro Itoh, Takayoshi Suzuki, 2013, Journal of medicinal chemistry.

Effects of 3-tert-Butyl-4-hydroxyanisole and its hydroquinone and quinone metabolites on rat and human embryonic cells in culture.

A. Ishida, T. Tsuchiya, N. Miyata, 1988, Toxicology in vitro : an international journal published in association with BIBRA.

Photoaffinity labeling of opioid receptor with morphine-7,8-oxide (morphine epoxide).

N. Miyata, M. Hirobe, I. Takayanagi, 1982, Journal of pharmacological methods.

Effects of epoxides of heroin, morphine and codeine on the electrically stimulated guinea pig ileum.

N. Miyata, I. Takayanagi, Hirobe Masaaki, 1981 .

Synthesis and analgesic activity of morphine-7,8-oxide and heroin-7,8-oxide.

N. Miyata, M. Hirobe, K. Watanabe, 1980, Chemical & pharmaceutical bulletin.

Erratum to: Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer

A. Sood, Takayoshi Suzuki, R. Vadlamudi, 2012, Breast Cancer Research.

ADVANTAGES OF SIMPLIFIED QUANTITATIVE MORPHOMETRY USING STAGE GROUPING ANALYSIS OF SPERMATOGENIC CYCLE FOR EVALUATION OF THE TESTICULAR TOXICITY OF ETHYLENE-1, 2-DIMETHANESULFONATE IN RATS

K. Mitsumori, K. Toyoda, N. Miyata, 1996 .

Determination of 4-hydroxy-2-nonenal in primary rat hepatocyte cultures by liquid chromatography with laser induced fluorescence detection.

T. Toyo’oka, H. Jinno, N. Miyata, 1999, Biomedical chromatography : BMC.

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

Takayoshi Suzuki, Yoshifumi Watanabe, N. Miyata, 2011, Neuron.

Resveratrol, a naturally occurring polyphenol, induces sister chromatid exchanges in a Chinese hamster lung (CHL) cell line.

N. Miyata, A. Furuta, K. Fukuhara, 2001, Mutation research.

KDM1 is a novel therapeutic target for the treatment of gliomas

A. Brenner, Takayoshi Suzuki, B. Nair, 2012, Oncotarget.

Novel histone deacetylase inhibitor NCH‐51 activates latent HIV‐1 gene expression

Takayoshi Suzuki, T. Okamoto, K. Ochiai, 2011, FEBS letters.

HDAC8 regulates neural differentiation through embryoid body formation in P19 cells.

Takayoshi Suzuki, N. Miyata, T. Inazu, 2018, Biochemical and biophysical research communications.

Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2009, Journal of the American Chemical Society.

[Nitric oxide donors activated by two-photon excitation].

N. Miyata, H. Nakagawa, Kazuhiro Hishikawa, 2011, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Effects of C60, a Fullerene, on the Activities of Glutathione S-Transferase and Glutathione-Related Enzymes in Rodent and Human Livers

Nobuhisa Iwata, N. Miyata, N. Iwata, 1998 .

Steady-state and nanosecond spectroscopic studies of triplet sensitized reaction of K-region arene oxides

K. Shudo, N. Miyata, M. Itoh, 1979 .

Studies on the oxidation of N-substituted-dibenz[b,f]azepines. II: Syntheses and reactions of 5H-dibenz[b,f]azepine 10,11-oxides

N. Miyata, M. Hirobe, T. Ohta, 1984 .

Studies on the Oxidation of N-Substituted-dibenz [b, f] azepines I. Oxidation with m-Chloroperbenzoic Acid

N. Miyata, M. Hirobe, T. Ohta, 1981 .

Epigenetic control using natural products and synthetic molecules.

Takayoshi Suzuki, N. Miyata, 2006, Current medicinal chemistry.

The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma

Takayoshi Suzuki, K. Pajtler, R. Büttner, 2013, Acta neuropathologica communications.

Loss of Deacetylation Activity of Hdac6 Affects Emotional Behavior in Mice

Yoshiharu Kawaguchi, Atsuo Nakayama, Takayoshi Suzuki, 2012, PloS one.

Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor.

Takayoshi Suzuki, T. Mizukami, K. Koseki, 2011, Bioorganic & medicinal chemistry.

Syntheses and Identification of Benzo[C]Chrysene Metabolites

D. Jerina, S. Amin, D. Desai, 2000 .

Micronucleus induction and chromosomal aberration of 1- and 3-nitroazabenzo[a]pyrene and their N-oxides.

N. Miyata, N. Sera, H. Tokiwa, 2001, Mutagenesis.

Reactions of K-region oxides of carcinogenic and noncarcinogenic aromatic hydrocarbons. Comparative studies on reactions with nucleophiles and acid-catalyzed reactions.

K. Shudo, N. Miyata, T. Okamoto, 1978, Chemical & pharmaceutical bulletin.

Quantitative Cancer Risk Analysis of BHA Based on Integration of Pathological and Biological/Biochemical Information

N. Miyata, Hidetaka Sato, Y. Hayashi, 1993, Toxicology and industrial health.

DNA damage in forestomach epithelium from male F344 rats following oral administration of tert-butylquinone, one of the forestomach metabolites of 3-BHA.

N. Miyata, K. Tsuji, K. Morimoto, 1991, Carcinogenesis.

Involvement of Electron Transfer in the Radical-scavenging Reaction of Resveratrol

K. Ohkubo, S. Fukuzumi, N. Miyata, 2007 .

Target-guided Synthesis: Medicinal Chemistry Strategy to Allow Target Enzymes Themselves to Synthesize their Own Inhibitors

Yukihiro Itoh, Takayoshi Suzuki, N. Miyata, 2014 .

1-amino-4-phenyl-1,2,3,6-tetrahydropyridine and 1-amino-4-phenylpyridinium salt, the 1-amino analogues of neurotoxins, MPTP and MPP+, induce apoptosis in PC12 cells: detection of apoptotic cells by Comet assay and flow cytometric analysis.

N. Miyata, Y. Noda, K. Kohda, 2004, In vivo.

An irreversible inhibitor of peptidyl-prolyl cis/trans isomerase Pin1 and evaluation of cytotoxicity.

Y. Inoue, Kaoru Itoh, N. Miyata, 2019, Bioorganic & medicinal chemistry letters.

Peptidyl prolyl isomerase Pin1-inhibitory activity of D-glutamic and D-aspartic acid derivatives bearing a cyclic aliphatic amine moiety.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2015, Bioorganic & medicinal chemistry letters.

Photoinduced nitric oxide release from a hindered nitrobenzene derivative by two-photon excitation.

Takayoshi Suzuki, N. Miyata, T. Furuta, 2009, Journal of the American Chemical Society.

Photoinduced nitric oxide release from a nitrobenzene derivative in mitochondria.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2011, Chemistry.

A novel mitochondria-localizing nitrobenzene derivative as a donor for photo-uncaging of nitric oxide.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2011, Bioorganic & medicinal chemistry letters.

Mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites in short-term tests in vitro.

T. Sofuni, M. Ishidate, N. Miyata, 1990, Mutation research.

Codeine-7,8-oxide (4,5 alpha-epoxy-7 beta, 8 beta-epoxy-3-methoxy-17-methyl-morphinan-6 alpha -ol: identification as a metabolite of codeine.

N. Miyata, M. Hirobe, K. Uba, 1980, Chemical & pharmaceutical bulletin.

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.

Yukihiro Itoh, Takayoshi Suzuki, H. Sawada, 2012, Journal of medicinal chemistry.

Mechanistic studies of catechins as antioxidants against radical oxidation.

N. Miyata, M. Kurihara, K. Kondo, 1999, Archives of biochemistry and biophysics.

A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section.

Takayoshi Suzuki, J. Nabekura, N. Miyata, 2015, Bioorganic & Medicinal Chemistry Letters.

Photochemical generation of nitric oxide from 6-nitrobenzo[a]pyrene.

N. Miyata, M. Kurihara, K. Fukuhara, 2001, Journal of the American Chemical Society.

Mutagenicity of nitrophenanthrene derivatives for Salmonella typhimurium: effects of nitroreductase and acetyltransferase.

N. Miyata, N. Sera, H. Tokiwa, 1996, Mutation research.

Multiple bond-conjugated photoinduced nitric oxide releaser working with two-photon excitation.

Takayoshi Suzuki, N. Miyata, T. Furuta, 2010, Bioorganic & medicinal chemistry letters.

Novel bisbenzimide-nitroxides for nuclear redox imaging in living cells.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2012, Bioorganic & medicinal chemistry letters.

Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2007, Bioorganic & medicinal chemistry letters.

Visible light irradiation of [60]fullerene causes killing and initiation of transformation in BALB/3T3 cells

N. Miyata, Y. Yamakoshi, Ayako Sakai, 1999 .

DNA Cleavage via Superoxide Anion Formed in Photoinduced Electron Transfer from NADH to γ-Cyclodextrin-Bicapped C60 in an Oxygen-Saturated Aqueous Solution

K. Ohkubo, S. Fukuzumi, O. Ito, 2002 .

Synthesis and radical-scavenging activity of a dimethyl catechin analogue.

N. Miyata, I. Nakanishi, Ken-ichiro Matsumoto, 2014, Bioorganic & medicinal chemistry letters.

Synergistic effect of naphthoquinones on the mutagenicity of nitroarene.

N. Miyata, K. Ohmori, M. Kishi, 1999, Biological & pharmaceutical bulletin.

[60]Fullerene as a Novel Photoinduced Antibiotic

Atsuko Miyajima, N. Miyata, Y. Yamakoshi, 2003 .

Nitric oxide generation from aromatic N-nitrosoureas at ambient temperature

N. Miyata, S. Sueyoshi, M. Tanno, 1996 .

Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2009, Bioorganic & medicinal chemistry letters.

9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy.

N. Miyata, S. Oikawa, Y. Hiraku, 2007, Bioorganic & medicinal chemistry.

Degradation of 1,3-diaryl-1-nitrosoureas in aqueous solutions and in organic solvents.

N. Miyata, M. Hirobe, M. Miyahara, 1987 .

Carcinogenicity and toxicity study of m-phenylenediamine administered in the drinking-water to (C57BL/6 x C3H/He)F1 mice.

M. Matsuyama, M. Kawai, N. Miyata, 1988, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[Biological activity of photoexcited fullerene].

N. Miyata, Y. Yamakoshi, S. Sueyoshi, 1999, Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences.

Efficient identification and quantification of proteins using isotope-coded 1-(6-methylnicotinoyloxy)succinimides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

R. Taguchi, N. Miyata, H. Tsumoto, 2007, Rapid communications in mass spectrometry : RCM.

Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly

Takashi Okamoto, Peng Zhan, Takayoshi Suzuki, 2013, PloS one.

Mutagenicity of K-region epoxides of polycyclic aromatic compounds: structure-activity relationship.

K. Shudo, N. Miyata, T. Okamoto, 1976, Mutation research.

Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.

Yukihiro Itoh, Takayoshi Suzuki, Minoru Yoshida, 2006, Journal of medicinal chemistry.

Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.

T. Nakano, Takayoshi Suzuki, T. Yamori, 2009, Journal of medicinal chemistry.

Rational design of non-hydroxamate histone deacetylase inhibitors.

Takayoshi Suzuki, Takayoshi Suzuki, N. Miyata, 2006, Mini reviews in medicinal chemistry.

A new source of pluripotent-like stem cells DPPSC

A. Brenner, Takayoshi Suzuki, B. Nair, 2013 .

Synthesis and biological evaluation of all A-ring stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: possible binding modes of potent A-ring analogues to vitamin D receptor.

N. Miyata, K. Nakagawa, T. Okano, 2001, Chemistry and Biology.

Design and Efficient Synthesis of 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity

M. Ohmori, N. Miyata, Nozomi Saito, 2004 .

Pharmacological properties of codeine-7,8-oxide (codeine epoxide), a new metabolite of codeine.

N. Miyata, M. Hirobe, I. Takayanagi, 1982, Japanese journal of pharmacology.

Some pharmacological properties of morphine-7,8-oxide (morphine epoxide).

N. Miyata, M. Hirobe, I. Takayanagi, 1982, Journal of Pharmacobio-Dynamics.

Stereospecific synthesis of codeine 7,8-oxide and codeinone 7,8-oxide.

N. Miyata, M. Hirobe, K. Uba, 1979 .

CHEMICAL STUDIES ON DRUG METABOLISM. PART 1. STEREOSPECIFIC SYNTHESIS OF CODEINE 7,8-OXIDE AND CODEINONE 7,8-OXIDE

N. Miyata, M. Hirobe, K. Uba, 1980 .

Oxidation of tertiary amines and sulfides by an iron(III)porphyrin-O2-Na2S2O4 system as a model of cytochrome P-450.

N. Miyata, T. Santa, M. Hirobe, 1984 .

CHEMICAL STUDIES ON DRUG METABOLISM. 7. OXIDATION OF TERTIARY AMINES AND SULFIDES BY AN IRON(III)PORPHYRIN-OXYGEN-SODIUM DITHIONITE SYSTEM AS A MODEL OF CYTOCHROME P-450

N. Miyata, T. Santa, M. Hirobe, 1984 .

Different N-Terminal Motifs Determine Plasma Membrane Targeting of the Human Concentrative Nucleoside Transporter 3 in Polarized and Nonpolarized Cells

S. Hammond, Takafumi Hara, G. Tsujimoto, 2010, Molecular Pharmacology.

Isoform-selective histone deacetylase inhibitors.

Yukihiro Itoh, Takayoshi Suzuki, N. Miyata, 2008, Current pharmaceutical design.

Synthesis of 6-azabenzo[a]pyrene

N. Miyata, K. Fukuhara, S. Kamiya, 1990 .

2,2,6,6-tetramethylpiperidin-1-oxyl probes for evaluating oxidative stress on the cell membrane and mitochondria.

N. Miyata, H. Nakagawa, 2008, Methods in molecular biology.

Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease.

M. Shibanuma, S. Ishida, N. Miyata, 2016, Bioorganic & medicinal chemistry.

Search for a novel SIRT1 activator: structural modification of SRT1720 and biological evaluation.

Yukihiro Itoh, Takayoshi Suzuki, H. Sawada, 2013, Bioorganic & medicinal chemistry letters.

Alternative photoinduced release of HNO or NO from an acyl nitroso compound, depending on environmental polarity.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2010, Chemical communications.

Signal Enhancement in ESR Spin-trapping for Hydroxyl Radicals

N. Miyata, T. Mashino, M. Mochizuki, 2003, Analytical Sciences.

Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2009, Journal of the American Chemical Society.

Microtubule acetylation through HDAC6 inhibition results in increased transfection efficiency.

Takayoshi Suzuki, R. C. Geiger, N. Miyata, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

An unexpected example of protein-templated click chemistry.

M. G. Finn, N. Miyata, Y. Kawamura, 2010, Angewandte Chemie.

Synthesis and evaluation of 2-Nonylaminopyridine derivatives as PPAR ligands.

M. Makishima, Takayoshi Suzuki, N. Miyata, 2007, Chemical & pharmaceutical bulletin.

Iron-chelating agents never suppress Fenton reaction but participate in quenching spin-trapped radicals.

Masataka Mochizuki, Miho Tanaka, Linxiang Li, 2007, Analytica chimica acta.

Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.

Takayoshi Suzuki, N. Miyata, H. Nakagawa, 2009, Bioorganic & medicinal chemistry letters.