T. Wiedmer

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Isolation of an Erythrocyte Membrane Protein that Mediates Ca2+-dependent Transbilayer Movement of Phospholipid*

P. Sims, F. Basse, J. Stout, 1996, The Journal of Biological Chemistry.

Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids.

P. Sims, T. Wiedmer, J. Zhao, 1998, Biochemistry.

Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding site.

P. Sims, J. Stout, T. Wiedmer, 1998, Biochemistry.

Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids.

P. Sims, T. Wiedmer, Q. Zhou, 1998, Biochemistry.

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.

P. Sims, T. Wiedmer, Jun Sun, 2002, Biochemistry.

Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane.

P. Sims, T. Wiedmer, M. Nanjundan, 2003, Biochemistry.

Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA.

L. Gerace, P. Sims, T. Wiedmer, 2004, Biochemistry.

Cyanine dye fluorescence used to measure membrane potential changes due to the assembly of complement proteins C5b-9

P. Sims, T. Wiedmer, 2005, The Journal of Membrane Biology.

Level of Expression of Phospholipid Scramblase Regulates Induced Movement of Phosphatidylserine to the Cell Surface*

P. Sims, T. Wiedmer, J. Zhao, 1998, The Journal of Biological Chemistry.

Molecular Cloning of Human Plasma Membrane Phospholipid Scramblase

P. Sims, J. Stout, T. Wiedmer, 1997, The Journal of Biological Chemistry.

Scott syndrome erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane phospholipids.

P. Sims, F. Basse, J. Stout, 1997, The Journal of clinical investigation.

Production and characterization of a mutant cell line defective in aminophospholipid translocase.

P. Sims, T. Wiedmer, J. Zhao, 1997, Biochimica et biophysica acta.

Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome

P. Sims, T. Wiedmer, H. Weiss, 1992 .

Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome.

S. Israels, P. Sims, T. Wiedmer, 1991, Blood.

Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

P. Sims, T. Wiedmer, E. Faioni, 1988, The Journal of biological chemistry.

Caspase-Independent Exposure of Aminophospholipids and Tyrosine Phosphorylation in Bicarbonate Responsive Human Sperm Cells1

P. Sims, T. Wiedmer, B. Gadella, 2003, Biology of reproduction.

Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.

K. Feingold, C. Grunfeld, A. Moser, 2007, Biochimica et biophysica acta.

The response of human platelets to activated components of the complement system.

P. Sims, T. Wiedmer, Peter J. Sims, 1991, Immunology today.

Platelet-derived microparticles express high affinity receptors for factor VIII.

B. Furie, P. Sims, T. Wiedmer, 1991, The Journal of biological chemistry.

Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane vesicles.

P. Sims, T. Wiedmer, 1991, Blood.

On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity.

C. Esmon, P. Sims, T. Wiedmer, 1986, The Journal of biological chemistry.

Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica.

P. Sims, T. Wiedmer, S. Eacker, 1992, The Journal of clinical investigation.

Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome.

S. Israels, P. Sims, T. Wiedmer, 1991, Blood.

Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles.

B. Dahlbäck, P. Sims, T. Wiedmer, 1992, Biochemistry.

Sphingomyelin Hydrolysis to Ceramide during the Execution Phase of Apoptosis Results from Phospholipid Scrambling and Alters Cell-Surface Morphology

W. V. van Blitterswijk, J. Borst, P. Sims, 2000, The Journal of cell biology.

Protein kinase C (cid:1) mediates retinoic acid and phorbol myristate acetate–induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation

P. Sims, T. Wiedmer, Ji Zhao, 2004 .

Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor.

P. Sims, T. Wiedmer, S. Shattil, 1990, Biochemistry.

Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potential.

P. Sims, T. Wiedmer, 1985, The Journal of biological chemistry.

Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase.

C. Esmon, P. Sims, T. Wiedmer, 1986, Blood.

Regulation of the Tyrosine Phosphorylation of Phospholipid Scramblase 1 in Mast Cells That Are Stimulated through the High-Affinity IgE Receptor

J. Rivera, P. Sims, T. Wiedmer, 2014, PloS one.

Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa.

P. Sims, T. Wiedmer, K. Hamilton, 1988, The Journal of biological chemistry.

Induction of cellular procoagulant activity by the membrane attack complex of complement.

P. Sims, T. Wiedmer, 1995, Seminars in cell biology.

Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome.

J. Zhao, P. Sims, T. Wiedmer, 1994, The Journal of clinical investigation.

The complex of phosphatidylinositol 4,5-bisphosphate and calcium ions is not responsible for Ca2+-induced loss of phospholipid asymmetry in the human erythrocyte: a study in Scott syndrome, a disorder of calcium-induced phospholipid scrambling.

P. Williamson, R. Schlegel, A. Schroit, 1995, Blood.

Effects of amphiphiles on structure and activity of human erythrocyte membrane acetylcholinesterase.

T. Wiedmer, U. Brodbeck, C. D. Di Francesco, 1979, European journal of biochemistry.

Characterization of the complement sensitivity of paroxysmal nocturnal hemoglobinuria erythrocytes.

P. Sims, T. Wiedmer, C. Parker, 1985, The Journal of clinical investigation.

Regulatory control of complement on blood platelets. Modulation of platelet procoagulant responses by a membrane inhibitor of the C5b-9 complex.

P. Sims, T. Wiedmer, S. Rollins, 1989, The Journal of biological chemistry.

The secretory release reaction initiated by complement proteins C5b-9 occurs without platelet aggregation through glycoprotein IIb-IIIa.

P. Sims, T. Wiedmer, B. Ando, 1989, Blood.

Single-channel analysis of the conductance fluctuations induced in lipid bilayer membranes by complement proteins C5b-9

R. Benz, P. Sims, T. Wiedmer, 2005, The Journal of Membrane Biology.

Protein Kinase Cδ Mediates Retinoic Acid and Phorbol Myristate Acetate-induced Phospholipid Scramblase 1 Gene Expression: Its Role in Leukemic Cell Differentiation Short tilte: PKCδ regulates PLSCR1 expression

P. Sims, T. Wiedmer, Ji Zhao, 2004 .

Resistance and Sensitivity of Chloroplast Ribosomes to Streptomycin in Mutants of Chlamydomonas reinhardi

A. Boschetti, V. Niggli, T. Wiedmer, 1974 .

Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity.

C. Esmon, P. Sims, T. Wiedmer, 1989, The Journal of biological chemistry.

Binding of acetylcholinesterases to concanavalin A

T. Wiedmer, U. Brodbeck, R. Gentinetta, 1974, FEBS letters.

Properties of the M antigen solubilized from genetically high potassium sheep red cells.

T. Wiedmer, P. Lauf, 1981, Membrane biochemistry.

Interactions of acetylcholine receptor and acetylcholinesterase with lipid monolayers.

T. Wiedmer, P. Zahler, U. Brodbeck, 1978, Biochimica et biophysica acta.

Electron spin resonance and steady-state fluorescence polarization studies of lipid bilayers containing integral proteins.

D. Pink, T. Wiedmer, D. Chapman, 1984, Biochemistry.

Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1.

R. Silverman, F. Al-Zoghaibi, D. Kushner, 2002, Cancer research.

Unraveling the Mysteries of Phospholipid Scrambling

P. Sims, T. Wiedmer, P. J. Sims, 2001, Thrombosis and Haemostasis.

Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome.

P. Sims, T. Wiedmer, H. Weiss, 1992, Blood.

Kinetics of polymerization of a fluoresceinated derivative of complement protein C9 by the membrane-bound complex of complement proteins C5b-8.

T. Wiedmer, P. J. Sims, 1984, Biochemistry.

Inhibition of the complement membrane attack complex by the galactose-specific adhesin of Entamoeba histolytica.

P. Sims, T. Wiedmer, C. Pham, 1992, Archives of medical research.

Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine.

P. Sims, T. Wiedmer, J. Zhao, 1993, The Journal of biological chemistry.

Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice

W. R. Wikoff, G. Siuzdak, Grace O'Maille, 2007, Genome Biology.

Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model.

P. Liu, R. Karni, Jiaxi Zhou, 2012, Blood.

c-Abl Tyrosine Kinase Binds and Phosphorylates Phospholipid Scramblase 1*

M. Schwartz, Jean Y. J. Wang, P. Sims, 2001, The Journal of Biological Chemistry.

Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression.

S. Orrenius, B. Fadeel, Afshin Samali, 1999, Biochemical and biophysical research communications.

Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).

A. Hevener, J. Olefsky, P. Sims, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9.

L. Brass, P. Sims, T. Wiedmer, 1992, The Journal of biological chemistry.

Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria.

T. Ortel, P. Sims, T. Wiedmer, 1993, Blood.

Expression of proteins controlling transbilayer movement of plasma membrane phospholipids in the B lymphocytes from a patient with Scott syndrome.

P. Sims, T. Wiedmer, Q. Zhou, 1998, Blood.

Phospholipid Scramblase 1 Potentiates the Antiviral Activity of Interferon

R. N. Harty, B. Williams, R. Silverman, 2004, Journal of Virology.

Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1.

P. Sims, T. Wiedmer, Ji Zhao, 2002, Blood.

Transcriptional control of the human plasma membranephospholipid scramblase 1 gene is mediated by interferon-α

R. Silverman, F. Al-Zoghaibi, P. Sims, 2000 .

Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha.

R. Silverman, F. Al-Zoghaibi, P. Sims, 2000, Blood.

Complement-Induced Vesiculation and Exposure of Membrane Prothrombinase Sites in Platelets of Paroxysmal Nocturnal Hemoglobinuria

T. Ortel, P. Sims, T. Wiedmer, 1993 .

Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G‐CSF‐induced granulopoiesis

M. Sowden, P. Sims, T. Wiedmer, 2011, Journal of leukocyte biology.

Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59.

P. Sims, T. Wiedmer, J. Zhao, 1994, The Journal of biological chemistry.

Phospholipid Scramblase 1 Binds to the Promoter Region of the Inositol 1,4,5-Triphosphate Receptor Type 1 Gene to Enhance Its Expression*

P. Sims, T. Wiedmer, I. Ben-Efraim, 2005, Journal of Biological Chemistry.

Plasma Membrane Phospholipid Scramblase 1 Promotes EGF-dependent Activation of c-Src through the Epidermal Growth Factor Receptor*

P. Sims, T. Wiedmer, Jun Sun, 2003, Journal of Biological Chemistry.

Identification of three new members of the phospholipid scramblase gene family.

P. Sims, T. Wiedmer, Q. Zhou, 2000, Biochimica et biophysica acta.

Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores.

P. Sims, T. Wiedmer, 1986, Blood.

Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores

P. Sims, T. Wiedmer, 1986 .

Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases.

P. Sims, T. Wiedmer, B. Ando, 1987, The Journal of biological chemistry.

Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors

Robert D. Finn, Alex Bateman, Johannes Söding, 2008, Bioinform..

The influence of electrochemical gradients of Na+ and K+ upon the membrane binding and pore forming activity of the terminal complement proteins

P. Sims, T. Wiedmer, 2005, The Journal of Membrane Biology.

Sphingomyelin Hydrolysis to Ceramide during the Execution Phase of Apoptosis Results from Phospholipid Scrambling and Alters Cell-Surface Morphology

W. V. van Blitterswijk, J. Borst, P. Sims, 2000, The Journal of cell biology.

Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice

W. R. Wikoff, G. Siuzdak, Grace O'Maille, 2007, Genome Biology.

Protein kinase C (cid:1) mediates retinoic acid and phorbol myristate acetate–induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation

P. Sims, T. Wiedmer, Ji Zhao, 2022 .

Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells

Y. Huang, P. Sims, T. Wiedmer, 2006, Oncogene.

Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G‐CSF‐induced granulopoiesis

M. Sowden, P. Sims, T. Wiedmer, 2011, Journal of leukocyte biology.

EngagedScholarship@CSU EngagedScholarship@CSU

T. Wiedmer, Peter J. Sims, Quansheng Amiya Banerjee Dong, 2022 .