L. Pike

发表

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.

P. Sims, T. Wiedmer, Jun Sun, 2002, Biochemistry.

Lipid rafts Published, JLR Papers in Press, February 1, 2003. DOI 10.1194/jlr.R200021-JLR200

L. Pike, 2003, Journal of Lipid Research.

Rafts defined: a report on the Keystone symposium on lipid rafts and cell function Published, JLR Papers in Press, April 27, 2006.

L. Pike, 2006, Journal of Lipid Research.

Oligomerization of the EGF receptor investigated by live cell fluorescence intensity distribution analysis.

E. Elson, S. Saffarian, L. Pike, 2007, Biophysical journal.

Lipid rafts: heterogeneity on the high seas.

L. Pike, 2004, The Biochemical journal.

Cholesterol Depletion Results in Site-specific Increases in Epidermal Growth Factor Receptor Phosphorylation due to Membrane Level Effects

Rhoderick E. Brown, L. Pike, D. Covey, 2003, Journal of Biological Chemistry.

Targeting the Dimerization of Epidermal Growth Factor Receptors with Small‐Molecule Inhibitors

G. Marshall, L. Pike, Katherine S Yang, 2010, Chemical biology & drug design.

Allosteric regulation of epidermal growth factor (EGF) receptor ligand binding by tyrosine kinase inhibitors

L. Pike, Jennifer L. Macdonald-Obermann, 2018, The Journal of Biological Chemistry.

Lipid rafts Published, JLR Papers in Press, February 1, 2003. DOI 10.1194/jlr.R200021-JLR200

L. Pike, 2003, Journal of Lipid Research.

The membrane proximal disulfides of the EGF receptor extracellular domain are required for high affinity binding and signal transduction but do not play a role in the localization of the receptor to lipid rafts.

L. Pike, Zhengzhe Li, Jennifer L. Macdonald, 2006, Biochimica et biophysica acta.

Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking.

L. Pike, L. Casey, 2002, Biochemistry.

Functional Characterization of an Epidermal Growth Factor Receptor/RET Chimera*

L. Pike, T. O'hare, H. Donis-Keller, 1997, The Journal of Biological Chemistry.

Epidermal Growth Factor Receptors Are Localized to Lipid Rafts That Contain a Balance of Inner and Outer Leaflet Lipids

Xianlin Han, R. Gross, L. Pike, 2005, Journal of Biological Chemistry.

A simplified method for the preparation of detergent-free lipid rafts Published, JLR Papers in Press, February 16, 2005. DOI 10.1194/jlr.D400041-JLR200

L. Pike, Jennifer L. Macdonald, Jennifer L. Macdonald, 2005, Journal of Lipid Research.

Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.

L. Pike, A. T. Eakes, 1987, The Journal of biological chemistry.

Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.

E. Krebs, R. Ross, L. Pike, 1983, The Journal of biological chemistry.

Protein Tyrosine Kinase Activity of Hormone and Growth Factor Receptors

E. Krebs, L. Pike, 1986 .

Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line.

E. Krebs, J. Casnellie, L. Pike, 1982, Proceedings of the National Academy of Sciences of the United States of America.

A comparison of the insulin- and epidermal growth factor-stimulated protein kinases from human placenta.

E. Krebs, J. Casnellie, L. Pike, 1984, Journal of Biological Chemistry.

Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes.

E. Krebs, J. Casnellie, P. Bornstein, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes

E. Krebs, J. Olefsky, L. Pike, 1986, Nature.

Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta adrenergic receptors.

R. Lefkowitz, L. Pike, 1978, Molecular pharmacology.

Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner.

E. Krebs, J. Casnellie, P. Bornstein, 1982, Journal of Biological Chemistry.

Assay of growth factor-stimulated tyrosine kinases using synthetic peptide substrates.

L. Pike, 1987, Methods in enzymology.

Substrate specificity and kinetic mechanism of human placental insulin receptor/kinase.

D. H. Walker, L. Pike, D. Kuppuswamy, 1987, Biochemistry.

Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function.

E. Krebs, L. Pike, A. T. Eakes, 1986, The Journal of biological chemistry.

β-Adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants

R. Lefkowitz, L. Pike, L. Limbird, 1979, Nature.

Dynamic Sensitivity of ATP-sensitive K+Channels to ATP*

F. Ashcroft, C. Nichols, E. Makhina, 2001, The Journal of Biological Chemistry.

Mutation of proline-1003 to glycine in the epidermal growth factor (EGF) receptor enhances responsiveness to EGF.

L. Pike, E. Newberry, M. Dalton, 1994, Molecular biology of the cell.

Rapid increases in the transglutaminase activity of A431 cells following treatment with epidermal growth factor.

L. Pike, C. Dadabay, 1987, Biochemistry.

Tumor promoter enhances mitogenesis by PDGF with little effect on PDGF binding

E. Krebs, R. Ross, L. Pike, 1986, Journal of cellular physiology.

Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes.

R. Lefkowitz, L. Pike, 1980, The Journal of biological chemistry.

The Membrane-proximal Intracellular Domain of the Epidermal Growth Factor Receptor Underlies Negative Cooperativity in Ligand Binding*

L. Pike, Jennifer L. Macdonald-Obermann, Katherine S. Yang, 2011, The Journal of Biological Chemistry.

Purification and characterization of a phosphatidylinositol kinase from A431 cells.

D. H. Walker, L. Pike, N. Dougherty, 1988, Biochemistry.

Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling.

R. Lefkowitz, L. Pike, L. Limbird, 1979, Biochimica et biophysica acta.

Localization and Turnover of Phosphatidylinositol 4,5-Bisphosphate in Caveolin-enriched Membrane Domains*

L. Pike, L. Casey, 1996, The Journal of Biological Chemistry.

Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A 431 cell membranes

E. Krebs, J. Casnellie, L. Pike, 2022 .

Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis.

Xianlin Han, R. Gross, L. Pike, 2002, Biochemistry.

Treatment of A431 cells with epidermal growth factor (EGF) induces desensitization of EGF-stimulated phosphatidylinositol turnover.

L. Pike, D. Kuppuswamy, T. W. Cunningham, 1989, The Journal of biological chemistry.

Ligand-induced desensitization of 125I-epidermal growth factor internalization.

L. Pike, D. Kuppuswamy, 1989, The Journal of biological chemistry.

Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor.

D. H. Walker, L. Pike, Linda J. Pike, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Stimulation of purified phosphatidylinositol 4-kinase by cobra venom cardiotoxin.

D. H. Walker, L. Pike, 1990, Biochimica et biophysica acta.

Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin.

Y. Liu, L. Pike, L. Casey, 1998, Biochemical and biophysical research communications.

Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains.

L. Pike, H. Hope, Heidi Rath Hope, 1996, Molecular biology of the cell.

The challenge of lipid rafts This work was supported by National Institutes of Health grants RO1 GM064491 and R01 GM082824 to LJP. Published, JLR Papers in Press, October 27, 2008.

L. Pike, 2009, Journal of Lipid Research.

Lack of correlation between changes in polyphosphoinositide levels and actin/gelsolin complexes in A431 cells treated with epidermal growth factor

Jonathan A. Cooper, L. Pike, C. Dadabay, 1991, The Journal of cell biology.

Desensitization of the EGF receptor alters its ability to undergo EGF-induced dimerization.

L. Pike, D. Kuppuswamy, 1991, Cellular signalling.

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

Anton Arkhipov, Martyn D Winn, Alireza Lajevardipour, 2016, Nature Communications.

Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase.

C. Nichols, S. Shyng, C. Cukras, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Lack of Correlation between Changes in Polyphosphoinositide Levels and Actin / Gelsolin Complexes in A 431 Cells Treated with Epidermal Growth Factor

L. Pike, J. Cooper, H. Hughes, 2002 .

Epidermal growth factor receptors containing a single tyrosine in their C-terminal tail bind different effector molecules and are signaling-competent

L. Pike, Jennifer L. Macdonald-Obermann, Kamaldeep Gill, 2017, The Journal of Biological Chemistry.

Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins* ♦

Tom Ronan, Kristen M. Naegle, L. Pike, 2016, The Journal of Biological Chemistry.

Growth factor receptors, lipid rafts and caveolae: an evolving story.

L. Pike, 2005, Biochimica et biophysica acta.

Purification and characterization of a cytosolic transglutaminase from a cultured human tumour-cell line.

L. Pike, C. Dadabay, 1989, The Biochemical journal.

Different Epidermal Growth Factor (EGF) Receptor Ligands Show Distinct Kinetics and Biased or Partial Agonism for Homodimer and Heterodimer Formation*

L. Pike, Jennifer L. Macdonald-Obermann, Linda J. Pike, 2014, The Journal of Biological Chemistry.

Quantitation of the Effect of ErbB2 on Epidermal Growth Factor Receptor Binding and Dimerization*

Linda J Pike, David Piwnica-Worms, D. Piwnica-Worms, 2012, The Journal of Biological Chemistry.

The Multiple Endocrine Neoplasia Type 2B Point Mutation Alters Long-term Regulation and Enhances the Transforming Capacity of the Epidermal Growth Factor Receptor (*)

T. Iwamoto, J. Tomich, L. Pike, 1996, The Journal of Biological Chemistry.

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system

Linda J Pike, L. Pike, Jennifer L Macdonald, 2008, Proceedings of the National Academy of Sciences.

Phosphatidylinositol 4-kinases and the role of polyphosphoinositides in cellular regulation.

L. Pike, Linda J. Pike, 1992, Endocrine reviews.

Role of Lipid Domains in EGF Receptor Signaling

L. Pike, 2010 .

CHAPTER 58 – Role of Lipid Domains in EGF Receptor Signaling

L. Pike, 2003 .

Cholesterol Depletion Delocalizes Phosphatidylinositol Bisphosphate and Inhibits Hormone-stimulated Phosphatidylinositol Turnover*

L. Pike, Joanne M. Miller, 1998, The Journal of Biological Chemistry.

Dynamic Analysis of the Epidermal Growth Factor (EGF) Receptor-ErbB2-ErbB3 Protein Network by Luciferase Fragment Complementation Imaging*

R. Landgraf, D. Piwnica-Worms, L. Pike, 2013, The Journal of Biological Chemistry.

Receptor Binding Studies of Beta-Adrenergic Receptors: New Insights into Activation and Desensitization of Adenylate Cyclase

R. Lefkowitz, L. Williams, M. Wessels, 1979 .

The Intracellular Juxtamembrane Domain of the Epidermal Growth Factor (EGF) Receptor Is Responsible for the Allosteric Regulation of EGF Binding*♦

L. Pike, Jennifer L. Macdonald-Obermann, Linda J. Pike, 2009, Journal of Biological Chemistry.

Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes.

R. Lefkowitz, L. Pike, 1981, The Journal of biological chemistry.

Correlating EGFR Expression with Receptor-Binding Properties and Internalization of 64Cu-DOTA-Cetuximab in 5 Cervical Cancer Cell Lines

M. Watson, P. Fracasso, L. Pike, 2008, Journal of Nuclear Medicine.

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

M. Caron, R. Lefkowitz, J. Benovic, 1985, The Journal of biological chemistry.

The Tethering Arm of the EGF Receptor Is Required for Negative Cooperativity and Signal Transduction*

L. Pike, Sangeeta Adak, Linda J. Pike, 2010, The Journal of Biological Chemistry.

Palmitoylation of the EGF receptor impairs signal transduction and abolishes high-affinity ligand binding.

L. Pike, Jennifer L. Macdonald-Obermann, 2009, Biochemistry.

Activation of a ribosomal protein S6 protein kinase in Xenopus oocytes by insulin and insulin‐receptor kinase.

J. Maller, L. Pike, D. Stefanović, 1986, The EMBO journal.

Luciferase Fragment Complementation Imaging of Conformational Changes in the Epidermal Growth Factor Receptor*

D. Piwnica-Worms, L. Pike, M. Ilagan, 2009, Journal of Biological Chemistry.

Interaction of epidermal growth factor-dependent protein kinase with endogenous membrane proteins and soluble peptide substrate.

E. Krebs, G. A. Grant, L. Glaser, 1983, Journal of Biological Chemistry.

Growth factors promote inositol uptake in BC3H1 cells.

G. Spizz, L. Pike, 1992, Biochemical and biophysical research communications.

Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging

Linda J Pike, David Piwnica-Worms, D. Piwnica-Worms, 2011, Proceedings of the National Academy of Sciences.

Serine 1002 is a site of in vivo and in vitro phosphorylation of the epidermal growth factor receptor.

L. Pike, D. Kuppuswamy, M. Dalton, 1993, The Journal of biological chemistry.

Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes.

R. Lefkowitz, L. Pike, 1980, Biochimica et biophysica acta.

Purification and characterization of a polyphosphoinositide phosphatase from rat brain.

L. Pike, H. Hope, 1994, The Journal of biological chemistry.

Negative co-operativity in the EGF receptor.

L. Pike, 2012, Biochemical Society transactions.

Negative Cooperativity in the EGF Receptor

L. Pike, 2009 .