I. Denisov

发表

Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment.

S. Sligar, S. Kynde, L. Arleth, 2015, Acta crystallographica. Section D, Biological crystallography.

Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment.

S. Sligar, I. Denisov, B. Baas, 2004, Archives of biochemistry and biophysics.

Molecular dynamics simulations of discoidal bilayers assembled from truncated human lipoproteins.

Klaus Schulten, James C. Phillips, James C Phillips, 2005, Biophysical journal.

Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs.

S. Sligar, I. Denisov, T. H. Bayburt, 2009, Methods in enzymology.

Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomer.

Emad Tajkhorshid, Javier L Baylon, E. Tajkhorshid, 2015, Biochemistry.

Cryoradiolysis as a Method for Mechanistic Studies in Inorganic Biochemistry

I. Denisov, 2010 .

Oxidase uncoupling in heme monooxygenases: human cytochrome P450 CYP3A4 in Nanodiscs.

S. Sligar, I. Denisov, Y. Grinkova, 2013, Biochemical and biophysical research communications.

Dark, Ultra-Dark and Ultra-Bright Nanodiscs for membrane protein investigations.

S. Sligar, I. Denisov, Y. Grinkova, 2020, Analytical biochemistry.

Nanodiscs: A toolkit for membrane protein science

S. Sligar, I. Denisov, 2020, Protein science : a publication of the Protein Society.

Investigations of heme ligation and ligand switching in cytochromes p450 and p420.

Yuhan Sun, S. Sligar, Jing Du, 2013, Biochemistry.

Nanoscale Membrane Mimetics for Biophysical Studies of Membrane Proteins

S. Sligar, I. Denisov, Catherine J Baker, 2014 .

Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes.

Michael C. Gregory, S. Sligar, I. Denisov, 2013, Methods in molecular biology.

Temperature derivative spectroscopy to monitor the autoxidation decay of cytochromes P450.

S. Sligar, I. Denisov, A. Luthra, 2011, Analytical chemistry.

Spectroscopic features of cytochrome P450 reaction intermediates.

S. Sligar, I. Denisov, A. Luthra, 2011, Archives of biochemistry and biophysics.

The ferrous-oxy complex of human aromatase.

M. Waterman, N. Kagawa, S. Sligar, 2008, Biochemical and biophysical research communications.

Active site proton delivery and the lyase activity of human CYP17A1.

Michael C. Gregory, S. Sligar, I. Denisov, 2014, Biochemical and Biophysical Research Communications - BBRC.

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by CYP3A4

S. Sligar, I. Denisov, Y. Grinkova, 2022, Biomolecules.

Cryoradiolysis and cryospectroscopy for studies of heme-oxygen intermediates in cytochromes p450.

S. Sligar, I. Denisov, Y. Grinkova, 2012, Methods in molecular biology.

Cytochrome P450 Monooxygenases, Chemistry of

I. Denisov, 2008 .

Low-frequency dynamics of Caldariomyces fumago chloroperoxidase probed by femtosecond coherence spectroscopy.

T. Poulos, A. Das, S. Sligar, 2008, Biochemistry.

Cryoradiolytic reduction of heme proteins: Maximizing dose dependent yield.

S. Sligar, I. Denisov, Doreen C Victoria, 2007, Radiation physics and chemistry.

Thirty years of microbial P450 monooxygenase research: peroxo-heme intermediates--the central bus station in heme oxygenase catalysis.

S. Sligar, I. Denisov, T. Makris, 2005, Biochemical and biophysical research communications.

Cryoradiolysis for the study of P450 reaction intermediates.

S. Sligar, I. Denisov, T. Makris, 2002, Methods in enzymology.

MECHANISTIC ENZYMOLOGY OF OXYGEN ACTIVATION BY THE CYTOCHROMES P450

S. Sligar, B. Hoffman, I. Denisov, 2002, Drug metabolism reviews.

Cryogenic absorption spectra of hydroperoxo‐ferric heme oxygenase, the active intermediate of enzymatic heme oxygenation

S. Sligar, M. Ikeda-Saito, I. Denisov, 2002, FEBS letters.

Cryotrapped Reaction Intermediates of Cytochrome P450 Studied by Radiolytic Reduction with Phosphorus-32*

S. Sligar, I. Denisov, T. Makris, 2001, The Journal of Biological Chemistry.

Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4.

E. Tajkhorshid, S. Sligar, I. Denisov, 2017, Biochemistry.

Structural differences between soluble and membrane bound cytochrome P450s.

S. Sligar, I. Denisov, A. Shih, 2012, Journal of inorganic biochemistry.

Haem-oxygen reactive intermediates: catalysis by the two-step.

S. Sligar, I. Denisov, T. Makris, 2003, Biochemical Society transactions.

Resonance Raman detection of the hydroperoxo intermediate in the cytochrome P450 enzymatic cycle.

S. Sligar, I. Denisov, J. Kincaid, 2007, Journal of the American Chemical Society.

The kinetics of the reaction between NO and O2 as studied by a novel approach.

M. Perrella, I. Denisov, S. Caccia, 1999, Biophysical chemistry.

Thermal stability of proteins in intermolecular complexes.

I. Denisov, 1992, Biophysical chemistry.

Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5.

S. Sligar, I. Denisov, J. Kincaid, 2021, Journal of the American Chemical Society.

Resonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450.

S. Sligar, I. Denisov, J. Kincaid, 2008, The journal of physical chemistry. A.

26 Cytochrome P450 Enzymes

S. Sligar, I. Denisov, 2010 .

Functional heterogeneity of the alpha and beta subunits in the association reaction between hemoglobin and carbon monoxide.

M. Perrella, I. Denisov, L. Benazzi, 1996, Biophysical chemistry.

Structure and chemistry of cytochrome P450.

Ilme Schlichting, I. Schlichting, S. Sligar, 2005, Chemical reviews.

Activation of Molecular Oxygen in Cytochromes P450

S. Sligar, I. Denisov, 2015 .

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Elizabeth A Ambrose, E. Petricoin, Dafydd G. Thomas, 2017, Cell chemical biology.

P450 CYP17A1 variant with a disordered proton shuttle assembly retains peroxo-mediated lyase efficiency.

S. Sligar, I. Denisov, Y. Grinkova, 2020, Chemistry.

Unveiling the crucial intermediates in androgen production

Michael C. Gregory, S. Sligar, I. Denisov, 2015, Proceedings of the National Academy of Sciences.

Study of the structure of streptokinase conjugates with a hydrophilic vinylpyrrolidone copolymer.

I. Denisov, L. Volkova, S. I. Klenin, 1990, Biophysical chemistry.

Nanodiscs for structural and functional studies of membrane proteins

S. Sligar, I. Denisov, Stephen G Sligar, 2016, Nature Structural &Molecular Biology.

Nanodiscs in Membrane Biochemistry and Biophysics.

S. Sligar, I. Denisov, Stephen G Sligar, 2017, Chemical reviews.

Confirmation of a unique intra‐dimer cooperativity in the human hemoglobin α1β1half‐oxygenated intermediate supports the symmetry rule model of allosteric regulation

Alexandra L. Klinger, G. K. Ackers, I. Denisov, 2000 .

Nanodiscs as a new tool to examine lipid-protein interactions.

S. Sligar, M. Schuler, I. Denisov, 2013, Methods in molecular biology.

Engineering extended membrane scaffold proteins for self-assembly of soluble nanoscale lipid bilayers.

S. Sligar, I. Denisov, Y. Grinkova, 2010, Protein engineering, design & selection : PEDS.

Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size.

S. Sligar, I. Denisov, Y. Grinkova, 2004, Journal of the American Chemical Society.

Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy‐complex in the lyase step

S. Sligar, I. Denisov, Ruchia Duggal, 2018, FEBS letters.

Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.

Michael C. Gregory, S. Sligar, I. Denisov, 2018, Journal of the American Chemical Society.

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis.

Michael C. Gregory, S. Sligar, I. Denisov, 2016, Biochemical and biophysical research communications.

Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.

S. Sligar, I. Denisov, Y. Grinkova, 2013, Journal of the American Chemical Society.

Functional reconstitution of monomeric CYP3A4 with multiple cytochrome P450 reductase molecules in Nanodiscs.

S. Sligar, I. Denisov, Y. Grinkova, 2010, Biochemical and biophysical research communications.

The Ferrous-Dioxygen Intermediate in Human Cytochrome P450 3A4

S. Sligar, I. Denisov, Y. Grinkova, 2006, Journal of Biological Chemistry.

Cryoradiolysis of oxygenated cytochrome P450 17A1 with lyase substrates generates expected products

S. Sligar, I. Denisov, J. Kincaid, 2021 .

Spectroscopic studies of the cytochrome P450 reaction mechanisms.

I. Denisov, P. Mak, 2018, Biochimica et biophysica acta. Proteins and proteomics.

Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1.

Michael C. Gregory, S. Sligar, I. Denisov, 2022, Biochemistry.

Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1.

Michael C. Gregory, S. Sligar, I. Denisov, 2021, Biochemistry.

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.

S. Sligar, G. Bérubé, I. Denisov, 2016, Journal of inorganic biochemistry.

Formation and Decay of Hydroperoxo-Ferric Heme Complex in Horseradish Peroxidase Studied by Cryoradiolysis*

S. Sligar, I. Denisov, T. Makris, 2002, The Journal of Biological Chemistry.

Low-temperature electrophoresis methods.

I. Denisov, M. Perrella, 1995, Methods in enzymology.

Thermodynamic stability of the asymmetric doubly-ligated hemoglobin tetramer (alpha+CNbeta+CN)(alphabeta): methodological and mechanistic issues.

G. K. Ackers, M. Perrella, I. Denisov, 1997, Biochemistry.

The ferric-hydroperoxo complex of chloroperoxidase.

S. Sligar, J. Dawson, I. Denisov, 2007, Biochemical and biophysical research communications.

Understanding Cooperativity in Human P450 Mediated Drug-Drug Interactions

S. Sligar, I. Denisov, 2007, Drug metabolism reviews.

Thermotropic phase transition in soluble nanoscale lipid bilayers.

S. Sligar, I. Denisov, Y. Grinkova, 2005, The journal of physical chemistry. B.

Biotransformation of the Mycotoxin Enniatin B1 by CYP P450 3A4 and Potential for Drug-Drug Interactions

S. Sligar, C. Fæste, I. Denisov, 2019, Metabolites.

Cooperativity in Cytochrome P450 3A4

S. Sligar, I. Denisov, Y. Grinkova, 2007, Journal of Biological Chemistry.

Nanodiscs as a New Tool to Examine Lipid-Protein Interactions.

S. Sligar, M. Schuler, I. Denisov, 2019, Methods in molecular biology.

Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213.

E. Tajkhorshid, S. Sligar, Prithviraj Nandigrami, 2019, Biochemistry.

Synthesis of liquid-crystal copolymers containing alicyclic fragments in the main chain

S. S. Skorokhodov, I. Denisov, V. Zuyev, 1989 .

Cooperative properties of cytochromes P450.

S. Sligar, I. Denisov, Daniel J. Frank, 2009, Pharmacology & therapeutics.

Resonance Raman spectroscopic studies of hydroperoxo-myoglobin at cryogenic temperatures.

Mohammed Salah Ibrahim, S. Sligar, I. Denisov, 2003, Journal of the American Chemical Society.

The One-electron Autoxidation of Human Cytochrome P450 3A4*

S. Sligar, I. Denisov, Y. Grinkova, 2007, Journal of Biological Chemistry.

Cytochromes P450 in nanodiscs.

S. Sligar, I. Denisov, 2011, Biochimica et biophysica acta.

Characterization of the oxygenated intermediate of the thermophilic cytochrome P450 CYP119.

S. Sligar, P. Champion, I. Denisov, 2001, Journal of inorganic biochemistry.

Midazolam as a Probe for Drug-Drug Interactions Mediated by CYP3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation.

S. Sligar, I. Denisov, Y. Grinkova, 2021, Biochemistry.

The critical iron-oxygen intermediate in human aromatase.

S. Sligar, I. Denisov, Y. Grinkova, 2009, Biochemical and biophysical research communications.

A novel type of allosteric regulation: functional cooperativity in monomeric proteins.

S. Sligar, I. Denisov, 2012, Archives of biochemistry and biophysics.

Investigation of the low frequency dynamics of heme proteins: native and mutant cytochrome P450(cam) and redox partner complexes.

S. Sligar, P. Champion, I. Denisov, 2011, The journal of physical chemistry. B.

Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450.

Stephen G. Sligar, S. Sligar, I. Denisov, 2011, Journal of the American Chemical Society.

Solvent isotope effects in the catalytic cycle of P450 CYP17A1: Computational modeling of the hydroxylation and lyase reactions.

S. Sligar, I. Denisov, 2023, Journal of inorganic biochemistry.

Cooperativity in P450 CYP3A4: Linkages in Substrate Binding, Spin State, Uncoupling and Product Formation *

S. Sligar, I. Denisov, Y. Grinkova, 2007 .

Engineering extended membrane scaffold proteins for self-assembly of soluble nanoscale lipid bilayers.

S. Sligar, I. Denisov, Y. Grinkova, 2010, Protein engineering, design & selection : PEDS.

Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.

Michael C. Gregory, S. Sligar, I. Denisov, 2013, Journal of the American Chemical Society.

Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4.

S. Sligar, I. Denisov, Daniel J. Frank, 2009, Archives of biochemistry and biophysics.

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.

S. Sligar, G. Bérubé, I. Denisov, 2016, Journal of inorganic biochemistry.

Analysis of Heterotropic Cooperativity in Cytochrome P450 3A4 Using α-Naphthoflavone and Testosterone*

S. Sligar, I. Denisov, Daniel J. Frank, 2010, The Journal of Biological Chemistry.