D. Lietha

发表

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions

Paula Tapial Martínez, Pilar López Navajas, D. Lietha, 2020, Biomolecules.

Spatial and Temporal Regulation of Focal Adhesion Kinase Activity in Living Cells

Ken Jacobson, Xinming Cai, Michael J. Eck, 2007, Molecular and Cellular Biology.

Structural Basis for the Autoinhibition of Focal Adhesion Kinase

Xinming Cai, Michael J. Eck, M. Eck, 2007, Cell.

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

Francesco Luigi Gervasio, Marta Camacho-Artacho, Agnieszka Bronowska, 2014, Proceedings of the National Academy of Sciences.

Allosteric regulation of focal adhesion kinase by PIP₂ and ATP.

F. Gräter, D. Lietha, Jing Zhou, 2015, Biophysical journal.

The FERM domain: organizing the structure and function of FAK

M. Eck, M. Frame, D. Lietha, 2010, Nature Reviews Molecular Cell Biology.

Crystal structures of NK1–heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor

T L Blundell, T. Blundell, E. Gherardi, 2001, The EMBO journal.

Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2

D. Lietha, Johanne Le Coq, Luis Heredia Gallego, 2016, The Protein Journal.

Structural and mechanistic insights into mechanoactivation of focal adhesion kinase

Lukas F. Milles, H. Gaub, Davide Mercadante, 2019, Proceedings of the National Academy of Sciences.

Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies

T. Pons, M. Hidalgo, C. Blanco-Aparicio, 2018, Clinical Cancer Research.

ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange

E. Ikonen, V. Olkkonen, D. Lietha, 2021, The EMBO journal.

Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses*

D. Lietha, J. Pastor, R. Campos-Olivas, 2015, The Journal of Biological Chemistry.

Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma.

X. Coumoul, D. Lietha, Yongliang Li, 2020, Journal of medicinal chemistry.

A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical–Genetic High-Content Phenotypic Screen

John C. Dawson, N. Carragher, A. von Kriegsheim, 2019, Molecular Cancer Therapeutics.

Spatial and Temporal Regulation of Focal Adhesion Kinase Activity in Living Cells (cid:1)

K. Hahn, K. Jacobson, A. Karginov, 2007 .

New insights into FAK structure and function in focal adhesions.

Pilar López Navajas, D. Lietha, J. Le Coq, 2022, Journal of cell science.

Tyrosine Phosphorylation of Rac1: A Role in Regulation of Cell Spreading

M. Eck, L. Romer, F. Chang, 2011, PloS one.

Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities.

J. Herbeuval, D. Lietha, C. Garbay, 2014, Cancer letters.

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

John C. Dawson, N. Carragher, M. Arends, 2021, Cancer Research.

Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.

X. Coumoul, J. Herbeuval, D. Lietha, 2015, Journal of medicinal chemistry.

Roles of Membrane Domains in Integrin-Mediated Cell Adhesion

T. Izard, D. Lietha, 2020, International journal of molecular sciences.

Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.

John C. Dawson, X. Coumoul, M. Frame, 2018, ACS chemical biology.

Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity.

D. Lietha, C. Garbay, M. Ethève-Quelquejeu, 2017, Bioorganic & medicinal chemistry letters.

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

M. Eck, D. Lietha, 2008, PloS one.

Whole-exome sequencing of plasma cell-free DNA portrays the somatic mutation landscape of refractory metastatic colorectal cancer and enables the discovery of mutated KDR/VEGFR2 receptors as modulators of anti-angiogenic therapies

T. Pons, M. Hidalgo, C. Blanco-Aparicio, 2017, bioRxiv.

Phosphoinositides – The Seven Species: Conversion and Cellular Roles

D. Lietha, 2011 .

Structural basis of Focal Adhesion Kinase activation on lipid membranes

H. Stahlberg, F. Gräter, N. Biyani, 2020, The EMBO journal.

A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions

H. Gaub, E. Procko, J. Lipfert, 2021, bioRxiv.

Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity.

D. Lietha, C. Garbay, Y. Lepelletier, 2013, Bioorganic & medicinal chemistry letters.

TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.

S. Knapp, Ana Martínez, A. Chaikuad, 2022, Journal of medicinal chemistry.

A new layer of phosphoinositide‐mediated allosteric regulation uncovered for SHIP2

C. Alfonso, Pilar López Navajas, D. Lietha, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping.

T. Blundell, E. Gherardi, D. Chirgadze, 2002, Journal of molecular biology.

Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor

T. Blundell, E. Gherardi, D. Chirgadze, 2002 .

Structural basis for interdomain communication in SHIP2 providing high phosphatase activity

D. Lietha, M. Camacho-Artacho, N. Dölker, 2017, eLife.

Adhesion Kinase Activity in Living Cells Spatial and Temporal Regulation of Focal

K. Hahn, K. Jacobson, M. Eck, 2013 .

The Interactions of Hepatocyte Growth Factor/Scatter Factor and Its NK1 and NK2 Variants with Glycosaminoglycans Using a Modified Gel Mobility Shift Assay

E. Gherardi, M. Lyon, D. Lietha, 2004, Journal of Biological Chemistry.

Forcing FAK into Transcriptional Activity.

D. Lietha, 2016, Structure.

Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity.

D. Lietha, C. Garbay, M. Ethève-Quelquejeu, 2017, Bioorganic & medicinal chemistry letters.