M. Aceto

发表

Pharmacological properties of JDTic: a novel κ-opioid receptor antagonist

James L. Howard, Louis S. Harris, J. L. Howard, 2004 .

Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.

S. Breeden, M. Aceto, C. Neilan, 2004, European journal of pharmacology.

Anandamide, an endogenous cannabinoid, has a very low physical dependence potential.

M. Aceto, R. Razdan, B. Martin, 1998, The Journal of pharmacology and experimental therapeutics.

Cocaine, ecgonine methyl ester, and benzoylecgonine plasma profiles in rhesus monkeys.

M. Aceto, J. Saady, E. Bowman, 1995, Journal of analytical toxicology.

Cocaine-induced rausch: overt behaviour and plasma concentrations in rhesus monkeys

M. Aceto, J. Saady, E. Bowman, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Functional and dispositional tolerance develops during continuous cocaine exposure

M. Aceto, B. Martin, E. Johansson, 1992, European Journal of Drug Metabolism and Pharmacokinetics.

Central actions of nicotine

M. Aceto, B. Martin, Mario D. Aceto, 1982, Medicinal research reviews.

In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.

J. Lowe, M. Aceto, D. R. Compton, 1996, The Journal of pharmacology and experimental therapeutics.

Metals in wine.

V. Preedy, R. Watson, M. Aceto, 2003 .

BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism.

S. Breeden, M. Aceto, C. Neilan, 2005, European journal of pharmacology.

Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan.

S. Srivastava, M. Aceto, S. Husbands, 2004, Journal of medicinal chemistry.

Assessment of the abuse potential of acetorphan, an enkephalinase inhibitor.

J. Knisely, M. Aceto, L. Harris, 1989, Drug and alcohol dependence.

CENTRAL ACTIVITY OF AQUEOUS EXTRACTS OF PIPER METHYSTICUM (KAVA).

M. Aceto, J. Buckley, W. Kinnard, 1965, Journal of pharmaceutical sciences.

Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys.

M. Aceto, L. Harris, E. Bowman, 2004, Experimental and clinical psychopharmacology.

Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.

J. Lowe, M. Aceto, B. Martin, 1995, European journal of pharmacology.

Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model.

M. Aceto, L. Harris, F. Carroll, 2005, European journal of pharmacology.

Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist.

J. L. Howard, I. Carroll, James B. Thomas, 2004, European journal of pharmacology.

Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity

Mark P Thomas, M. Aceto, S. Husbands, 2013, Journal of medicinal chemistry.

Varenicline does not alter brain stimulation reward thresholds and reverses nicotine‐facilitated thresholds in rats

M. Aceto, L. Harris, R. Vann, 2011 .

Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible μ Opioid Receptor Antagonist Effects

Mark P Thomas, M. Aceto, L. Harris, 2012, Journal of medicinal chemistry.

Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships.

M. Aceto, L. Harris, A. Coop, 2003, Journal of medicinal chemistry.

14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties: Extending the Scope of Common Structure-Activity Relationships

Received December, M. Aceto, L. Harris, 2003 .

Antinociceptive studies of the optical isomers of N-allylnormetazocine (SKF 10,047).

M. Aceto, E. May, 1983, European journal of pharmacology.

The effects of delta9-tetrahydrocannabinol physical dependence on brain cannabinoid receptors.

C. Breivogel, M. Aceto, B. Martin, 2003, European journal of pharmacology.

Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55212-2.

B. Martin, M. Aceto, S. Scates, 2001, European journal of pharmacology.

Compounds affecting the central nervous system. 4. 3 Beta-phenyltropane-2-carboxylic esters and analogs.

R. L. Clarke, M. Aceto, A. Gambino, 1973, Journal of medicinal chemistry.

Etorphines: mu-opioid receptor-selective antinociception and low physical dependence capacity.

M. Aceto, L. Harris, E. Bowman, 1997, European journal of pharmacology.

The spinal cord as a major site for the antinociceptive action of nicotine in the rat

T. Fu, M. Aceto, B. Martin, 1986, Neuropharmacology.

Dihydroetorphine: physical dependence and stereotypy after continuous infusion in the rat.

M. Aceto, L. Harris, S. Scates, 2000, European journal of pharmacology.

Opiate vs non-opiate footshock-induced analgesia (FSIA): The body region shocked is a critical factor

L. Watkins, P. Faris, M. Aceto, 1982, Brain Research.

Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.

J. Lowe, M. Aceto, B. Martin, 1996, The Journal of pharmacology and experimental therapeutics.

The Effects of Isosorbide Dinitrate On Coronary Vascular Resistance

M. Aceto, J. Buckley, W. Kinnard, 1961 .

Effects of reserpine and chlorpromazine on rats subjected to experimental stress

J. Estevez, M. Aceto, H. Kato, 1964, Psychopharmacologia.

Nicotine-induced antinociception in rats and mice: correlation with nicotine brain levels.

M. Aceto, B. Martin, H. Tripathi, 1982, The Journal of pharmacology and experimental therapeutics.

EFFECT OF VARIOUS AGENTS ON RESERPINE-INDUCED BLEPHAROPTOSIS.

M. Aceto, L. Harris, 1965, Toxicology and applied pharmacology.

Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.

M. Aceto, L. Harris, A. Coop, 2003, Journal of medicinal chemistry.

14-Phenylpropoxymetopon : An Extremely Powerful Analgesic

M. Aceto, L. Harris, A. Coop, 2022 .

N-Substituted 14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties : Extending the Scope of Common Structure-Activity Relationships

M. Aceto, L. Harris, A. Coop, 2022 .

Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a µ-agonist δ-antagonist and δ-inverse agonists

K. Rice, M. Aceto, L. Harris, 2007 .

Rat Bioassay of Combinations of Diuretics

M. Aceto, C. T. Ichniowski, 1960 .

2,5-Dimethyl-2′-hydroxy-9α- and 9β-(3-Methylbutyl)-6,7-benzomorphans and N-Substituted Compounds in the 9α-(3-Methylbutyl) Series: Chemistry, Pharmacology, and Biochemistry

T. Burke, K. Rice, M. Aceto, 1987 .

Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.

J. Deschamps, K. Rice, M. Aceto, 2007, Journal of medicinal chemistry.

Synthesis and Structure-Activity Relationships of a Potent μ-Agonist δ-Antagonist and an Exceedingly Potent Antinociceptive in the Enantiomeric C 9-Substituted 5-( 3-Hydroxyphenyl )-N-phenylethylmorphan Series

J. Deschamps, K. Rice, M. Aceto, 2022 .

Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice

M. Aceto, A. Coop, P. Beardsley, 2002, Psychopharmacology.

Pharmacological effects of 1,2,3,5,6,10b-hexahydropyrido[2,3g]indolizine, a bridged-nicotine analog.

M. Aceto, B. Martin, J. Egle, 1986, Life sciences.

Synthesis of 4,4-ditritio-(+)-nicotine: comparative binding and distribution studies with natural enantiomer.

M. Aceto, L. Harris, B. Martin, 1981, Journal of pharmaceutical sciences.

Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist.

M. Aceto, M. Damaj, B. Martin, 1999, The Journal of pharmacology and experimental therapeutics.

Stereoselective μ- and δ-opioid receptor-related antinociception and binding with (+)-thebaine

K. Rice, M. Aceto, L. Harris, 1999 .

Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates.

E. Atkinson, M. Aceto, L. Harris, 1977, Journal of medicinal chemistry.

9a- and 9-hydroxyphenylmorphans

M. Aceto, A. E. Jacobson, E. May, 1984 .

4'-Arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity.

S. Srivastava, M. Aceto, S. Husbands, 2002, Journal of medicinal chemistry.

Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082).

M. Aceto, L. Harris, E. Bowman, 2007, European journal of pharmacology.

N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole.

K. Rice, M. Aceto, L. Harris, 2000, Bioorganic & medicinal chemistry letters.

Antipodal alpha-N-(methyl through decyl)-N-normetazocines (5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphans): in vitro and in vivo properties.

M. Aceto, L. Harris, B. Martin, 1994, Journal of medicinal chemistry.

Dynorphin-(1-13): effects in nontolerant and morphine-dependent rhesus monkeys.

M. Aceto, N. Lee, W. Dewey, 1982, European journal of pharmacology.

Characterization of prototypical opioid antagonists, agonist-antagonists, and agonists in the morphine-dependent rhesus monkey

M. Aceto, 1984, Neuropeptides.

Annual report: dependence studies of new compounds in the rhesus monkey (1980).

M. Aceto, L. Harris, W. Dewey, 1981, NIDA research monograph.

Pharmacologic studies with 7-benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid.

G. Y. Lesher, M. Aceto, L. Harris, 1967, The Journal of pharmacology and experimental therapeutics.

Optically pure (+)-nicotine from (+/-)-nicotine and biological comparisons with (-)-nicotine.

M. Aceto, L. Harris, B. Martin, 1979, Journal of medicinal chemistry.

Relationship of the biodisposition of the stereoisomers of nicotine in the central nervous system to their pharmacological actions.

M. Aceto, B. Martin, H. Tripathi, 1983, The Journal of pharmacology and experimental therapeutics.

Rapid and brief tolerance to (+)- and (-)-nicotine in unanesthetized rats.

M. Aceto, S. Tucker, G. S. Ferguson, 1986, European journal of pharmacology.

Discriminative stimulus properties of the optical isomers of nicotine

M. Aceto, L. Harris, J. Rosecrans, 2004, Psychopharmacology.

Nicotine binding sites and their localization in the central nervous system

M. Aceto, B. Martin, 1981, Neuroscience & Biobehavioral Reviews.

Synthesis and preliminary binding studies of 4,4-ditritio-(-)-nicotine of high specific activity.

M. Aceto, B. Martin, E. Bowman, 1980, Journal of medicinal chemistry.

OPTICALLY PURE (+)-NICOTINE FROM (.+-.)-NICOTINE AND BIOLOGICAL COMPARISONS WITH (-)-NICOTINE

M. Aceto, L. Harris, W. Dewey, 1979 .

Plasma concentrations of nicotine in rats during tolerance and chronic exposure studies

M. Aceto, B. Thomas, E. Bowman, 1988, European Journal of Drug Metabolism and Pharmacokinetics.

Nicotine's opioid and anti-opioid interactions: proposed role in smoking behavior.

M. Aceto, S. Scates, E. Bowman, 1993, European journal of pharmacology.

M. Aceto, L. Harris, J. Pearl, 1966 .

Effects of certain compounds on experimental muscular dystrophy.

M. Aceto, J. Buckley, W. Kinnard, 1962, Journal of pharmaceutical sciences.

Pharmacological actions of the racemic and the enantiomeric 1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benz azo nines (C-homobenzomorphans).

M. Aceto, L. Harris, J. Woods, 1985, Japanese journal of pharmacology.

R. Glennon, M. Aceto, R. Young, 1984, Pharmacology, Biochemistry and Behavior.

Pharmacologic properties and mechanism of action of amfonelic acid.

M. Aceto, M. Levitt, P. Speight, 1970, European journal of pharmacology.

Racemic and optically active 2,9-dimethyl-5-(m-hydroxyphenyl)morphans and pharmacological comparison with the 9-demethyl homologues.

M. Aceto, L. Harris, M. Rogers, 1984, Journal of medicinal chemistry.

The effects of naloxone and nalorphine during the development of morphine dependence in rhesus monkeys.

M. Aceto, L. Harris, R. Flora, 1977, Pharmacology.

Dependence studies of new compounds in the rhesus monkey and mouse (1991).

M. Aceto, L. Harris, E. Bowman, 1992, NIDA research monograph.

Cynomolgus monkeys and morphine tolerance and dependence.

M. Aceto, L. Harris, 1985, Drug and alcohol dependence.

Dependence studies of new compounds in the rhesus monkey, rat, and mouse (1983).

M. Aceto, L. Harris, E. May, 1984, NIDA research monograph.

Caffeine elicited withdrawal signs in morphine-dependent rhesus monkeys.

R. Carchman, M. Aceto, L. Harris, 1978, European journal of pharmacology.

l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice

L. Wise, A. Lichtman, M. Aceto, 2012, Pharmacology Biochemistry and Behavior.

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

M. Aceto, L. Harris, P. Portoghese, 2012, International journal of medicinal chemistry.

N-(trifluoromethyl)benzyl substituted N-normetazocines and N-norketobemidones.

M. Aceto, L. Harris, A. Coop, 2003, Bioorganic & medicinal chemistry.

Cocaine-morphine interactions in morphine-dependent rhesus monkeys☆

M. Aceto, E. Bowman, 1990 .

Dependence studies of new compounds in the rhesus monkey and mouse (1990).

M. Aceto, L. Harris, E. Bowman, 1990, NIDA research monograph.

Effects of β-funaltrexamine (β-FNA) on morphine dependence in rats and monkeys

M. Aceto, P. Portoghese, A. Takemori, 1986 .

Dependence studies of new compounds in the rhesus monkey, rat, and mouse (1981).

M. Aceto, L. Harris, E. May, 1982, NIDA research monograph.

The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans.

M. Aceto, L. Harris, A. Coop, 2008, Bioorganic & medicinal chemistry.

Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues.

M. Aceto, L. Harris, J. Woods, 2000, Journal of medicinal chemistry.

Agonist-antagonist actions and stereoselectivity of optical pairs of some N-substituted alpha-N-normetazocines.

M. Aceto, L. Harris, A. E. Jacobson, 1984, Journal of pharmaceutical sciences.

Synthesis, in vitro, and in vivo activity of N-p-substituted-benzyl- (- )- and (+)-N-normetazocines, (-)- and (+)-N-normorphinans, N- norketobemidones, and (-)-N-nor-4,5-epoxymorphinans

M. Aceto, L. Harris, A. Coop, 1998 .

Zomepirac: preclinical narcotic abuse liability evaluation.

M. Aceto, L. Harris, J. Woods, 1983, Arzneimittel-Forschung.

Antinociceptive action of nicotine and its methiodide derivatives in mice and rats

M. Aceto, B. Martin, E. May, 1983, British journal of pharmacology.

NIH 11082 produces anti-depressant-like activity in the mouse tail-suspension test through a delta-opioid receptor mechanism of action.

A. Lichtman, M. Aceto, L. Harris, 2007, European journal of pharmacology.

A simple and economical apparatus for measuring general activity of animals.

M. Aceto, H. C. Bentley, 1966, Archives internationales de pharmacodynamie et de therapie.

The effects of certain psychopharmacologic drugs on conditioning in the rat. I. Avoidance-escape conditioning.

M. Aceto, V. Lynch, R. Thoms, 1960, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

Effects of beta-funaltrexamine (beta-FNA) on morphine dependence in rats and monkeys.

M. Aceto, P. Portoghese, A. Takemori, 1986, European Journal of Pharmacology.

Cinnamoyl Derivatives of 7α-Aminomethyl-6,14-endoethanotetrahydrothebaine and 7α-Aminomethyl-6,14-endoethanotetrahydrooripavine and Related Opioid Ligands

A. Neal, M. Aceto, S. Husbands, 2007 .

Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.

A. Neal, M. Aceto, S. Husbands, 2007, Journal of Medicinal Chemistry.

Dependence studies on new compounds in the rhesus monkey, rat and mouse (1989).

M. Aceto, L. Harris, E. Bowman, 1989, NIDA research monograph.

Dependence studies of new compounds in the rhesus monkey, rat, and mouse, 1987.

M. Aceto, E. Bowman, E. May, 1988, NIDA research monograph.

Dependence studies of new compounds in the rhesus monkey, rat and mouse (1992).

M. Aceto, L. Harris, E. Bowman, 1993, NIDA research monograph.

Blockade of dynorphin A(1–13) overt psychomotor effects by naloxone

M. Aceto, E. Bowman, 1992, Peptides.

Very long-acting narcotic antagonists: the 14 beta-p-substituted cinnamoylaminomorphinones and their partial mu agonist codeinone relatives.

M. Aceto, L. Harris, J. Woods, 1989, Arzneimittel-Forschung.

3-Alkyl ethers of clocinnamox : Delayed long-term μ-antagonists with variable μ efficacy

M. Aceto, L. Harris, S. Husbands, 1998 .

Effects of ganglion blocking agents on nicotine extensor convulsions and lethality in mice

M. Aceto, H. C. Bentley, J. R. DEMBINSKI, 1969, British journal of pharmacology.

Effects of opiates and opiate antagonists on the Straub tail reaction in mice

M. Aceto, J. Pearl, D. B. McKean, 1969, British journal of pharmacology.

Differences in antiwrithing activity of morphine and nalorphine over time and in slopes of the dose-response lines

M. Aceto, J. Fitzgerald, J. Pearl, 2004, Psychopharmacologia.

Antinociceptive mechanism and acute and chronic behavioral effects of clonidine.

M. Aceto, L. Harris, 1981, Progress in clinical and biological research.

Stimulant drugs and temporary increases in avoidance responding.

M. Aceto, J. Fitzgerald, J. Pearl, 1968, Journal of comparative and physiological psychology.

Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology.

K. Rice, M. Aceto, L. Harris, 1986, Journal of medicinal chemistry.

Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor

M. Aceto, L. Harris, A. Coop, 2014, Molecular pain.

Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.

K. Rice, M. Aceto, L. Harris, 1999, European journal of pharmacology.

Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist

M. Aceto, M. Damaj, S. Welch, 1995, Psychopharmacology.

3-Aminotetrahydrocarbazoles as a new series of central nervous system agents.

A. Mooradian, M. Aceto, J. Pearl, 1977, Journal of medicinal chemistry.

3-AMINOTETRAHYDROCARBAZOLES AS A NEW SERIES OF CENTRAL NERVOUS SYSTEM AGENTS

A. Mooradian, M. Aceto, J. Pearl, 1977 .

Potential long acting opiate antagonists: preparation, pharmacological activity, and opiate-receptor binding of N-substituted 2'-hydroxy-5-methyl-9 alpha-propyl-6,7-benzomorphans.

K. Rice, M. Aceto, W. Klee, 1977, Journal of pharmaceutical sciences.

EFFECT OF COMPOUNDS ON BLOOD PRESSURE AND BEHAVIORAL RESPONSES OF RATS CHRONICALLY SUBJECTED TO AN AVOIDANCE-ESCAPE SITUATION.

M. Aceto, J. Buckley, W. Kinnard, 1963, Archives internationales de pharmacodynamie et de therapie.

Effect of a 6-cyano substituent in 14-oxygenated N-methylmorphinans on opioid receptor binding and antinociceptive potency.

M. Aceto, L. Harris, A. Coop, 2005, Journal of medicinal chemistry.

Synthesis and biological evaluation of 14-alkoxymorphinans. 21. Novel 4-alkoxy and 14-phenylpropoxy derivatives of the mu opioid receptor antagonist cyprodime.

M. Aceto, L. Harris, A. Coop, 2004, Journal of medicinal chemistry.

The effects of certain psychotropic agents on the conditioned emotional response behavior pattern of the albino rat

M. Aceto, J. Buckley, W. Kinnard, 2004, Psychopharmacologia.

Drugs and avoidance performance

M. Aceto, J. Fitzgerald, J. Pearl, 1966 .