S. Runyon

发表

Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity.

F Ivy Carroll, S Wayne Mascarella, J. L. Howard, 2010, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profile

James B. Thomas, S. Runyon, L. Brieaddy, 2014, Journal of medicinal chemistry.

Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.

J. L. Howard, M. Kuhar, G. T. Pollard, 2004, Journal of medicinal chemistry.

Dopamine transporter ligands: recent developments and therapeutic potential.

S. Runyon, F. Carroll, 2006, Current topics in medicinal chemistry.

Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery.

S. Runyon, R. Maitra, S. Narayanan, 2015, Journal of medicinal chemistry.

Identifying structural determinants of potency for analogs of apelin-13: integration of C-terminal truncation with structure-activity.

R. Snyder, S. Runyon, Yanyan Zhang, 2014, Bioorganic & medicinal chemistry.

Effect of the 3- and 4-Methyl Groups on the Opioid Receptor Properties of N-Substituted trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines

James B. Thomas, S. Runyon, L. Brieaddy, 2014, Journal of medicinal chemistry.

Indenopyride derivative RTI-4587-073(l): a candidate for male contraception in stallions.

S. Runyon, J. Roser, B. Thomas, 2013, Theriogenology.

Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product.

J. Deschamps, J. Flippen-Anderson, M. Kuhar, 2005, Bioorganic & medicinal chemistry.

Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.

B. Roth, R. Glennon, S. Runyon, 2008, Journal of medicinal chemistry.

Identification of neuropeptide S antagonists: structure-activity relationship studies, X-ray crystallography, and in vivo evaluation.

J. Deschamps, T. Fennell, R. Snyder, 2014, ACS chemical neuroscience.

Discovery of a novel small molecule agonist scaffold for the APJ receptor.

K. Bortoff, James B. Thomas, S. Runyon, 2016, Bioorganic & medicinal chemistry.

Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor.

R. Snyder, S. Runyon, R. Wiethe, 2018, Journal of medicinal chemistry.

17β-Nitro-5α-androstan-3α-ol and its 3β-methyl derivative: Neurosteroid analogs with potent anticonvulsant and anxiolytic activities

M. Rogawski, R. Kaminski, S. Runyon, 2017 .

Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic).

T. Fennell, R. Snyder, James B. Thomas, 2018, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists.

J. Deschamps, S. Runyon, S. Mascarella, 2016, The Journal of organic chemistry.

Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists.

I. Carroll, James B. Thomas, S. Runyon, 2013, Journal of medicinal chemistry.

The frequency of early-activated hapten-specific B cell subsets predicts the efficacy of vaccines for nicotine dependence.

S. Runyon, F. Carroll, M. Pravetoni, 2015, Vaccine.

Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins.

A. Birnbaum, S. Runyon, M. Pravetoni, 2018, Molecular pharmaceutics.

The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.

S. Runyon, B. Thomas, B. Gilmour, 2015, Bioorganic & medicinal chemistry.

Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor.

S. Runyon, B. Thomas, B. Gilmour, 2015, ACS chemical neuroscience.

Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.

S. Runyon, B. Thomas, B. Gilmour, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents.

James B. Thomas, S. Runyon, S. Mascarella, 2015, Bioorganic & medicinal chemistry.

Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic).

T. Fennell, R. Snyder, James B. Thomas, 2018, Journal of medicinal chemistry.

Identification of the first biased NPS receptor agonist that retains anxiolytic and memory promoting effects with reduced levels of locomotor stimulation

R. Reinscheid, S. Runyon, S. Gertz, 2017, Neuropharmacology.

9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist.

B. Roth, R. Glennon, J. Savage, 1999, European journal of pharmacology.

A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats

S. Runyon, S. Dhungana, N. Goeders, 2015, Behavioural Brain Research.

Effects of inhibitory GABA-active neurosteroids on cocaine seeking and cocaine taking in rats

S. Runyon, N. Goeders, Christopher D. Schmoutz, 2014, Psychopharmacology.

Formulation and Characterization of Conjugate Vaccines to Reduce Opioid Use Disorders Suitable for Pharmaceutical Manufacturing and Clinical Evaluation.

A. Birnbaum, S. Runyon, F. Carroll, 2019, Molecular pharmaceutics.

Identification of potent pyrazole based APELIN receptor (APJ) agonists.

S. Runyon, S. Rajagopal, R. Maitra, 2019, Bioorganic & medicinal chemistry.

Identification of N-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

L. Gendron, James B. Thomas, S. Runyon, 2014, Journal of medicinal chemistry.

1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists.

James B. Thomas, S. Runyon, S. Mascarella, 2010, ACS medicinal chemistry letters.

Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies.

S. Runyon, L. Brieaddy, S. Mascarella, 2012, Bioorganic & medicinal chemistry letters.

Anti-Müllerian hormone as a biomarker for acute testicular degeneration caused by toxic insults to stallion testes.

S. Runyon, J. Roser, A. Conley, 2018, Theriogenology.

17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities.

M. Rogawski, R. Kaminski, S. Runyon, 2009, European journal of pharmacology.

Therapeutic and Prophylactic Vaccines to Counteract Fentanyl Use Disorders and Toxicity.

S. Runyon, S. Comer, M. Lesage, 2020, Journal of medicinal chemistry.

Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats

A. Birnbaum, S. Runyon, F. Carroll, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse

F I Carroll, S. Runyon, H. Navarro, 2017, PloS one.

Acute and chronic effects of a contraceptive compound RTI-4587-073(l) on testicular histology and endocrine function in miniature horse stallions.

S. Runyon, D. Dymock, J. Roser, 2014, Reproduction in domestic animals = Zuchthygiene.

Epigenetic Changes in Foxp 3 in Treg of Identical Twins Discordant for Asthma NATURAL SCIENCES

K. Nadeau, S. Runyon, Leslie M Cachola, 2011 .

Enhanced bioactivity of silybin B methylation products.

R. Agarwal, S. Polyak, N. Oberlies, 2013, Bioorganic & medicinal chemistry.

Decreased Maternal Plasma Apelin Concentrations in Preeclampsia

K. Bortoff, S. Runyon, C. Qiu, 2012, Hypertension in pregnancy.

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.

James B. Thomas, S. Runyon, R. Wiethe, 2015, Bioorganic & medicinal chemistry letters.

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.

James B. Thomas, S. Runyon, R. Wiethe, 2015, Bioorganic & medicinal chemistry letters.

Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

L. Gendron, James B. Thomas, S. Runyon, 2014, Journal of medicinal chemistry.

Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.

R. Snyder, S. Runyon, R. Wiethe, 2019, Journal of medicinal chemistry.

Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

R. Snyder, S. Runyon, R. Uprety, 2021, Pharmaceuticals.

Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats

S. Runyon, N. Goeders, Christopher D. Schmoutz, 2012, Pharmacology Biochemistry and Behavior.

Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activity.

S. Runyon, H. Navarro, B. Gilmour, 2008, Bioorganic & medicinal chemistry letters.

Doppler indices of vascular impedance as indicators of testicular dysfunction in stallions

S. Runyon, J. Roser, M. Pozor, 2014 .

Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities.

M. Murtaugh, S. Runyon, F. Carroll, 2012, Biochemical pharmacology.

Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists.

Thuy-Ai T Nguyen, S. Runyon, D. Harris, 2017, ACS chemical neuroscience.

Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene.

B. Roth, R. Glennon, J. Savage, 2002, Journal of medicinal chemistry.

Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats

S. Runyon, M. Pravetoni, C. Baehr, 2022, ACS omega.

Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.

B. Roth, R. Glennon, J. Savage, 2001, Bioorganic & medicinal chemistry letters.

The effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the Orexin-1 receptor

S. Runyon, B. Thomas, B. Gilmour, 2015 .

Development of a functional HTS assay for the APJ receptor

K. Bortoff, James B. Thomas, S. Runyon, 2010 .

Simple Tetrahydroisoquinolines Are Potent and Selective Kappa Opioid Receptor Antagonists.

James B. Thomas, S. Runyon, S. Mascarella, 2017, ACS medicinal chemistry letters.

Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats.

S. Runyon, S. Comer, M. Pravetoni, 2022, ACS pharmacology & translational science.

Effects of the neuropeptide S receptor antagonist RTI-118 on abuse-related facilitation of intracranial self-stimulation produced by cocaine and methylenedioxypyrovalerone (MDPV) in rats.

R. Glennon, S. Runyon, S. Stevens Negus, 2014, European journal of pharmacology.

Aplnr knockout mice display sex-specific changes in conditioned fear

Lucas T. Laudermilk, Bin Zhou, B. Koller, 2020, Behavioural Brain Research.

Chapter 6: Tropane-based Dopamine Transporter–Uptake Inhibitors

S. Runyon, F. Carroll, 2008 .

Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization.

R. Snyder, S. Runyon, R. Wiethe, 2019, Bioorganic & medicinal chemistry.

Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists.

R. Snyder, S. Runyon, R. Wiethe, 2018, Bioorganic & medicinal chemistry.

Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor.

R. Snyder, S. Runyon, R. Wiethe, 2018, Journal of medicinal chemistry.

B. Roth, R. Glennon, S. Runyon, 2008, Journal of medicinal chemistry.

The frequency of early-activated hapten-specific B cell subsets predicts the efficacy of vaccines for nicotine dependence.

S. Runyon, F. Carroll, M. Laudenbach, 2015, Vaccine.

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres.

James B. Thomas, S. Runyon, C. Kormos, 2016, Bioorganic & medicinal chemistry.