S. Quimby

发表

Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer.

D. McKinzie, S. D. Kahl, M. Statnick, 2011, Journal of medicinal chemistry.

Na+-dependent high affinity binding of [3H]LY515300, a 3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid receptor inverse agonist.

P. Emmerson, T. Suter, M. Statnick, 2003, European journal of pharmacology.

Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.

J. F. Soriano, P. Ornstein, M. Blanco, 2016, Bioorganic & medicinal chemistry letters.

Effect of 4-(4-methoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydropyridine, an analog of MPTP, on mouse heart norepinephrine and brain catecholamines

R. Fuller, C. Mitch, S. Quimby, 1993, Neurochemistry International.

Novel alkoxy-oxazolyl-tetrahydropyridine muscarinic cholinergic receptor antagonists

F. Bymaster, C. Mitch, S. Quimby, 2005, Psychopharmacology.

Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.

F. Bymaster, P. Suzdak, Michael D B Swedberg, 1997, Journal of medicinal chemistry.

Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.

Shobha N. Bhattachar, J. Luz, M. J. Fisher, 2016, Bioorganic & medicinal chemistry letters.

Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: Comparison with the distribution of mu, delta and kappa binding sites

J. Pintar, T. Suter, M. Statnick, 2005, Neuropeptides.

Muscarinic antagonist activity of 3-(5-alkoxy-oxazol-2-yl)-1,2,5,6-tetrahydropyridines.

D. Wong, F. Bymaster, D. Schoepp, 1994 .

Muscarinic Antagonist Activity of 3‐(5‐Alkoxy‐oxazol‐2‐yl)‐1,2,5,6‐ tetrahydropyridines.

D. Wong, F. Bymaster, D. Schoepp, 1995 .

Metabotropic Glutamate Receptor

J. F. Soriano, P. Ornstein, S. Atwell, 2016 .

LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders

D. McKinzie, Xia Li, J. Witkin, 2014, Neuropharmacology.

Synthesis and Evaluation of 11C-LY2795050 as a κ-Opioid Receptor Antagonist Radiotracer for PET Imaging

Richard E. Carson, Nabeel Nabulsi, Evan D. Morris, 2013, The Journal of Nuclear Medicine.

SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIPS OF ALKYL SUBSTITUTED ANALOGUES OF THE FUNCTIONAL M1 SELECTIVE MUSCARINIC RECEPTOR AGONIST XANOMELINE

F. Bymaster, P. Suzdak, C. Mitch, 1994 .

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

J. F. Soriano, P. Ornstein, S. Atwell, 2016, Journal of medicinal chemistry.

Steric and electronic requirements for muscarinic receptor-stimulated phosphoinositide turnover in the CNS in a series of arecoline bioisosteres.

W. Hoss, C. Mitch, S. Quimby, 1992, Biochemical and biophysical research communications.

SAR and biological evaluation of novel trans-3,4-dimethyl-4-arylpiperidine derivatives as opioid antagonists.

M. Siegel, P. Emmerson, P. Surface, 2005, Bioorganic & medicinal chemistry letters.

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.

Shobha N. Bhattachar, J. Luz, M. J. Fisher, 2017, Bioorganic & medicinal chemistry letters.

LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders

D. McKinzie, Xia Li, J. Witkin, 2014, Neuropharmacology.

Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2.

M. Siegel, P. Emmerson, P. Surface, 2007, Bioorganic & medicinal chemistry letters.