D. Rotstein

发表

A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

D. Swinney, Jun Zhang, P. Beavis, 2014, British journal of pharmacology.

Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors

B. Graves, A. Kuglstatter, M. Stahl, 2011, Journal of medicinal chemistry.

Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase.

D. Rotstein, C. Ramesha, M. Browner, 2006, Journal of medicinal chemistry.

Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.

D. Swinney, D. Rotstein, P. Berry, 1993, Journal of medicinal chemistry.

Stereoisomers of ketoconazole: preparation and biological activity.

D. Swinney, D. Rotstein, K. A. Walker, 1992, Journal of medicinal chemistry.

Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.

A. Kuglstatter, Brian R. Wong, J. D. Dal Porto, 2013, Bioorganic & medicinal chemistry letters.

Spiropiperidine CCR5 antagonists.

C. Brotherton-Pleiss, L. Setti, D. Rotstein, 2009, Bioorganic & medicinal chemistry letters.

The selective reduction of .alpha.,.beta.-unsaturated esters, nitriles and nitro compounds with sodium cyanoborohydride

D. Rotstein, D. Dimmel, R. O. Hutchins, 1976 .

Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles.

Jutta Wanner, L. Setti, D. Rotstein, 2010, Bioorganic & medicinal chemistry letters.

NUCLEOPHILIC BOROHYDRIDE- SELECTIVE REDUCTIVE DISPLACEMENT OF HALIDES, SULFONATE ESTERS, TERTIARY AMINES, AND N,N-DISULFONIMIDES WITH BOROHYDRIDE REAGENTS IN POLAR APROTIC SOLVENTS

D. Rotstein, F. Dux, C. Maryanoff, 1978 .

Nucleophilic borohydride: selective reductive displacement of halides, sulfonate esters, tertiary amines, and N,N-disulfonimides with borohydride reagents in polar aprotic solvents

D. Rotstein, C. Maryanoff, W. Burgoyne, 1978 .

The synthesis and antifungal activity of the enantiomers of butoconazole nitrate

D. Rotstein, K. A. Walker, 1993 .

The Synthesis and Antifungal Activity of the Enantiomers of Butoconazole Nitrate.

D. Rotstein, K. A. Walker, 1993 .

C-5-Substituted nucleoside analogs

D. Bergstrom, D. Rotstein, J. Ruth, 1992 .

A new synthesis of novel 2-substituted derivatives of the anhydro-3-hydroxythiazolo[3,2-a]pyridinium hydroxide inner salt ring system

D. Rotstein, J. O. Gardner, C. Beard, 1982 .

Practical and divergent synthesis of 1- and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones

D. Rotstein, Hanbiao Yang, F. Padilla, 2008 .

Novel CCR5 antagonists for the treatment of HIV infection: a review of compounds patented in 2006 – 2008

D. Rotstein, Hanbiao Yang, 2010, Expert opinion on therapeutic patents.

Exploration of a new series of CCR5 antagonists: multi-dimensional optimization of a sub-series containing N-substituted pyrazoles.

L. Setti, D. Rotstein, Ann C. Petersen, 2010, Bioorganic & medicinal chemistry letters.

Synthesis, SAR and evaluation of [1,4']-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists.

D. Rotstein, M. Dioszegi, S. Sankuratri, 2010, Bioorganic & medicinal chemistry letters.

Molecular Interactions of CCR5 with Major Classes of Small-Molecule Anti-HIV CCR5 Antagonists

Jun Zhang, Jun Zhang, D. Rotstein, 2008, Molecular Pharmacology.

Molecular Interactions of CCR5 with Major Classes of Small-Molecule Anti-HIV CCR5 Antagonists

Jun Zhang, Jun Zhang, D. Rotstein, 2008, Molecular Pharmacology.

Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.

A. Kuglstatter, Brian R. Wong, J. D. Dal Porto, 2013, Bioorganic & medicinal chemistry letters.