G. Thakur

V. Torchilin, Jiayi Pan, M. Yao, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward

J. Crystal, A. Hohmann, Sumanta Garai, 2020, Frontiers in Molecular Neuroscience.

Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokine levels

Leisha M. Armijo, Ellen C. Dengler, A. Makriyannis, 2012, PAIN®.

Scalable, One-Pot, Microwave-Accelerated Tandem Synthesis of Unsymmetrical Urea Derivatives.

Sumanta Garai, G. Thakur, Abhijit R. Kulkarni, 2017, The Journal of organic chemistry.

Identification of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure-Activity Relationship Studies.

Sumanta Garai, G. Thakur, D. Hurst, 2019, ACS medicinal chemistry letters.

Identi ﬁ cation of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure − Activity Relationship Studies

Sumanta Garai, G. Thakur, D. Hurst, 2019 .

Cannabinoid Discrimination and Antagonism by CB1 Neutral and Inverse Agonist Antagonists

A. Makriyannis, G. Thakur, J. Bergman, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Design and Synthesis of Novel Allosteric Modulators of α7 Nicotinic Acetylcholine Receptor

G. Thakur, K. S. Raja, 2017 .

Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands.

A. Makriyannis, G. Thakur, H. Teng, 2011, Bioorganic & medicinal chemistry letters.

Enantiomeric resolution of a novel chiral cannabinoid receptor ligand.

M. Tius, G. Thakur, A. Makriyannis, 2002, Journal of biochemical and biophysical methods.

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Sumanta Garai, G. Thakur, R. Pertwee, 2022, Frontiers in Pharmacology.

Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

J. Howland, Sumanta Garai, G. Thakur, 2021, Neuropharmacology.

Effects of the cannabinoid receptor 1 positive allosteric modulator GAT211 and acute MK-801 on visual attention and impulsivity in rats assessed using the five-choice serial reaction time task

Timothy J. Onofrychuk, J. Howland, Sumanta Garai, 2020, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Cannabinergic ligands.

G. Thakur, A. Makriyannis, S. Palmer, 2002, Chemistry and physics of lipids.

Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors

A. Makriyannis, M. Storr, G. Thakur, 2014, PloS one.

Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation

G. Thakur, D. Thapa, A. Szcześniak, 2020, Molecules.

Diuretic Effects of Cannabinoids

S. Nikas, A. Makriyannis, G. Thakur, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Cannabinoid mediated diuresis in mice

Rishi Sharma, A. Makriyannis, G. Thakur, 2011 .

Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

K. Mackie, A. Hohmann, G. Thakur, 2017, Biological Psychiatry.

Positive allosteric modulation of CB1 suppresses pathological pain without producing tolerance or dependence

A. Hohmann, G. Thakur, R. Pertwee, 2018 .

Natural cannabinoids: templates for drug discovery.

A. Makriyannis, R. Duclos, G. Thakur, 2005, Life sciences.

Inhibition of PSD95‐nNOS protein–protein interactions decreases morphine reward and relapse vulnerability in rats

Kendra D Bunner, G. Rebec, J. Crystal, 2022, Addiction biology.

Tolerance to the Diuretic Effects of Cannabinoids and Cross-Tolerance to a κ-Opioid Agonist in THC-Treated Mice

A. Makriyannis, G. Thakur, S. Gatley, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Small molecule inhibitors of PSD95–nNOS protein–protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats

A. Hohmann, G. Thakur, Lawrence M. Carey, 2017, Neuroscience.

Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

F. Guarnieri, D. Logothetis, G. Thakur, 2022, International journal of molecular sciences.

A high efficacy cannabinergic ligand (AM4054) used as a discriminative stimulus: Generalization to other adamantyl analogs and Δ9-THC in rats

A. Makriyannis, G. Thakur, T. Järbe, 2016, Pharmacology Biochemistry and Behavior.

Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats

A. Hohmann, A. Makriyannis, G. Thakur, 2008, Journal of Pharmacology and Experimental Therapeutics.

Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties

A. Makriyannis, G. Thakur, J. Bergman, 2008, Physiology & Behavior.

Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity.

C. George, R. Duclos, G. Thakur, 2007, Journal of medicinal chemistry.

Adamantyl cannabinoids: a novel class of cannabinergic ligands.

J. Deschamps, C. George, G. Thakur, 2005, Journal of medicinal chemistry.

Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.

Alexandros Makriyannis, Patricia H Reggio, David R Janero, 2008, Chemistry & biology.

CB1 cannabinoid receptor ligands.

S. Nikas, G. Thakur, A. Makriyannis, 2005, Mini reviews in medicinal chemistry.

The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats

J. Salamone, A. Makriyannis, G. Thakur, 2005, Behavioural pharmacology.

Negative allosteric modulation of CB1 cannabinoid receptor signaling suppresses opioid-mediated reward.

G. Rebec, K. Mackie, J. Crystal, 2022, Pharmacological research.

The interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α represents a new antinociceptive signaling pathway in mice

R. Papke, A. Lichtman, G. Donvito, 2017, Experimental Neurology.

The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome

A. Makriyannis, J. Fichna, M. Storr, 2018, European journal of pharmacology.

Regiospecifically deuterated (−)-Δ9-tetrahydrocannabivarins

S. Nikas, G. Thakur, A. Makriyannis, 2002 .

Synthesis of side chain specifically deuterated (-)-Δ9-tetrahydrocannabinols

S. Nikas, G. Thakur, A. Makriyannis, 2002 .

Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies

J. Howland, Sumanta Garai, G. Thakur, 2021, Psychopharmacology.

Progress in the Synthesis of Oxindole‐Naphthoquinone Molecular Hybrid Scaffolds: A Concise Review

G. Thakur, V. Patil, Rupashri K. Kadu, 2020 .

A Novel Example of Metal-Mediated Aromatic Thiolation in a Ruthenium Complex. Crystal Structure of RuII(SC6H4NNC6H4N)2†

A. Pramanik, G. Thakur, B. Santra, 1996 .

Cu ‐Assisted Cyanation Reactions

Sumanta Garai, G. Thakur, 2020 .

Raman spectroscopic study of phase transformation in single crystals of cadmium fluorosilicate hexahydrate

G. Thakur, A. Verma, 1989 .

Laser Raman study of phase transformation in single crystals of cadmium fluorotitanate hexahydrate

G. Thakur, A. Verma, 1986 .

Microwave-accelerated Conjugate Addition of 2-Arylindoles to Substituted β-Nitrostyrenes in the Presence of Ammonium Trifluoroacetate: An Efficient Approach for the Synthesis of a Novel Class of CB1 Cannabinoid Receptor Allosteric Modulators

Sumanta Garai, G. Thakur, P. Kulkarni, 2017 .

B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation.

R. Papke, J. Deschamps, Sumanta Garai, 2018, ACS medicinal chemistry letters.

Heteroadamantyl cannabinoids.

Anna L. Bowman, M. Tius, J. Wood, 2010, Journal of medicinal chemistry.

Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein–protein interaction inhibitors

J. Crystal, A. Hohmann, G. Thakur, 2016, Behavioural Brain Research.

Synthesis, spectral, thermal and antibacterial investigations of mixed ligand complexes of thorium(IV) derived from 8-hydroxyquinoline and some amino acids.

G. Thakur, S. S. Patil, M. Shaikh, 2012, Acta poloniae pharmaceutica.

Synthesis, Characterization, and Antibacterial Studies of Mixed Ligand Dioxouranium Complexes with 8-Hydroxyquinoline and Some Amino Acids

G. Thakur, S. S. Patil, M. Shaikh, 2011, ISRN pharmaceutics.

Laser Raman study of single crystals of deuterated cadmium fluorosilicate

G. Thakur, A. Verma, 1989 .

The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

G. Thakur, Abhijit R. Kulkarni, C. Ashby, 2021, Antioxidants.

Diuretic effects of cannabinoid agonists in mice.

Rishi Sharma, A. Makriyannis, G. Thakur, 2013, European journal of pharmacology.

Design and Synthesis of Cannabinoid 1 Receptor (CB1R) Allosteric Modulators: Drug Discovery Applications.

Sumanta Garai, G. Thakur, Abhijit R. Kulkarni, 2017, Methods in enzymology.

Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target

G. Thakur, D. Janero, 2016, Expert opinion on drug discovery.

Mass spectrometry-based proteomics of human cannabinoid receptor 2: covalent cysteine 6.47(257)-ligand interaction affording megagonist receptor activation.

A. Makriyannis, Sangwon Cha, B. Karger, 2011, Journal of proteome research.

Novel adamantyl cannabinoids as CB1 receptor probes.

Anna L. Bowman, M. Caron, J. Deschamps, 2013, Journal of medicinal chemistry.

Behavioral effects of the novel cannabinoid full agonist AM 411

J. Salamone, G. Thakur, A. Makriyannis, 2005, Pharmacology Biochemistry and Behavior.

Controlled-deactivation cannabinergic ligands.

S. Nikas, A. Makriyannis, J. Wood, 2013, Journal of medicinal chemistry.

Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model

V. Torchilin, W. Hartner, G. Thakur, 2016, Pharmaceutical Research.

Some Reactions of Microgel in Polyacrylamide Solutions

G. Thakur, E. Burcik, 1974 .

GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating macrophage mitochondrial oxidative stress via reducing MnSOD-S-glutathionylation

G. Thakur, Abhijit R. Kulkarni, L. Mantell, 2023, Redox biology.

Stable desensitization of α7 nicotinic acetylcholine receptors by NS6740 requires interaction with S36 in the orthosteric agonist binding site.

R. Papke, C. Stokes, G. Thakur, 2021, European journal of pharmacology.

PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD

Melissa M. Haulcomb, A. Shekhar, G. Thakur, 2018, Translational Psychiatry.

Allosteric Agonism of α7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site

R. Papke, C. Stokes, M. Quadri, 2019, Molecular Pharmacology.

The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor

R. Papke, G. Thakur, Abhijit R. Kulkarni, 2015, Neuropharmacology.

Differential Activation and Desensitization States Promoted by Noncanonical α7 Nicotinic Acetylcholine Receptor Agonists

R. Papke, Xiaoxuan Wu, C. Stokes, 2022, The Journal of Pharmacology and Experimental Therapeutics.

Allosterically Potentiated α7 Nicotinic Acetylcholine Receptors: Reduced Calcium Permeability and Current-Independent Control of Intracellular Calcium

R. Papke, C. Stokes, Sumanta Garai, 2020, Molecular Pharmacology.

The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal

R. Papke, J. Bigbee, D. Gewirtz, 2019, Experimental Neurology.

Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107

R. Papke, C. Stokes, M. Quadri, 2018, Molecular Pharmacology.

Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant β Subunits Acquire Sensitivity to α7-Selective Positive Allosteric Modulators

R. Papke, K. Abboud, C. Stokes, 2019, The Journal of Pharmacology and Experimental Therapeutics.

In vitro and non‐invasive in vivo effects of the cannabinoid‐1 receptor agonist AM841 on gastrointestinal motor function in the rat

A. Makriyannis, G. Thakur, A. Makriyannis, 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner

K. Mackie, G. Thakur, M. Bashashati, 2015, British journal of pharmacology.

The Novel Cannabinoid CB1 Receptor Neutral Antagonist AM4113 Suppresses Food Intake and Food-Reinforced Behavior but Does not Induce Signs of Nausea in Rats

J. Salamone, J. Wood, G. Thakur, 2008, Neuropsychopharmacology.

Potentiation of (α4)2(β2)3, but not (α4)3(β2)2, nicotinic acetylcholine receptors reduces nicotine self-administration and withdrawal symptoms

C. D. Fowler, Sumanta Garai, G. Thakur, 2021, Neuropharmacology.

Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia

Ellen C. Dengler, A. Makriyannis, G. Thakur, 2012, Brain and behavior.

Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: Antinociception without central nervous system side-effects

A. Hohmann, A. Makriyannis, J. Wood, 2011, Pharmacology Biochemistry and Behavior.

Latest advances in cannabinoid receptor agonists

Alexandros Makriyannis, A. Makriyannis, G. Thakur, 2009, Expert opinion on therapeutic patents.

Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington's disease in the R6/2 mouse model

G. Thakur, R. Laprairie, A. Zrein, 2019, Neuropharmacology.

Mutation Studies of Ser7.39 and Ser2.60 in the Human CB1 Cannabinoid Receptor: Evidence for a Serine-Induced Bend in CB1 Transmembrane Helix 7

Daniel Fleischer, Mary E Abood, Alexandros Makriyannis, 2007, Molecular Pharmacology.

Enantiomer‐specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons

K. Mackie, G. Thakur, R. Ross, 2017, Pharmacological research.

C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor.

Anna L. Bowman, M. Tius, Han Zhou, 2012, Bioorganic & medicinal chemistry letters.

Mapping the Structural Requirements in the CB1 Cannabinoid Receptor Transmembrane Helix II for Signal Transduction

A. Makriyannis, G. Thakur, M. Abood, 2008, Journal of Pharmacology and Experimental Therapeutics.

Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats

J. Salamone, E. Nunes, A. Makriyannis, 2009, Psychopharmacology.

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

A. Lichtman, G. Thakur, R. Pertwee, 2014, Behavioural pharmacology.

Differing Activity Profiles of the Stereoisomers of 2,3,5,6TMP-TQS, a Putative Silent Allosteric Modulator of α7 nAChR

R. Papke, K. Abboud, C. Stokes, 2020, Molecular Pharmacology.

Analysis of Tolerance and Behavioral/Physical Dependence during Chronic CB1 Agonist Treatment: Effects of CB1 Agonists, Antagonists, and Noncannabinoid Drugs

A. Makriyannis, G. Thakur, J. Bergman, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy.

J. Deschamps, S. Schulz, Sumanta Garai, 2021, Journal of medicinal chemistry.

Peripherally administered cannabinoid receptor 2 (CB2R) agonists lose anti-allodynic effects in TRPV1 knockout mice, while intrathecal administration leads to anti-allodynia and reduced GFAP, CCL2 and TRPV1 expression in the dorsal spinal cord and DRG

G. Thakur, J. Wilkerson, E. Milligan, 2021, Brain Research.

Cannabinoid receptors as therapeutic targets.

S. Nikas, G. Thakur, A. Makriyannis, 2006, Current pharmaceutical design.

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

J. Howland, Sumanta Garai, G. Thakur, 2022, IBRO neuroscience reports.

The In Vivo Effects of the CB1-Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice.

G. Thakur, R. Pertwee, W. Baldridge, 2017, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation.

M. Treinin, G. Thakur, Abhijit R. Kulkarni, 2020, International immunopharmacology.

Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain

C. Ledent, A. Makriyannis, G. Thakur, 2020, Brain and behavior.

A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels

Hao Tan, D. Logothetis, G. Thakur, 2021, The Journal of biological chemistry.

The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy

A. Hohmann, A. Makriyannis, G. Thakur, 2012, Molecular pain.

Behavioral effects of the novel potent cannabinoid CB1 agonist AM 4054

J. Salamone, J. Wood, G. Thakur, 2013, Pharmacology Biochemistry and Behavior.

Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ8-Tetrahydrocannabinols

Rishi Sharma, S. Nikas, A. Makriyannis, 2014, Journal of medicinal chemistry.