M. Gopalakrishnan

发表

Distinct Profiles of α7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes

Murali Gopalakrishnan, John Malysz, Clark A. Briggs, 2007, Molecular Pharmacology.

Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.

G. Gintant, M. Gopalakrishnan, Ruth L. Martin, 2006, Biochemical pharmacology.

High content screen microscopy analysis of Aβ1–42-induced neurite outgrowth reduction in rat primary cortical neurons: Neuroprotective effects of α7 neuronal nicotinic acetylcholine receptor ligands

Murali Gopalakrishnan, Mark E. Schurdak, Min Hu, 2007, Brain Research.

Distribution and functional characterization of human Nav1.3 splice variants

M Gopalakrishnan, T. Neelands, M. Gopalakrishnan, 2005, The European journal of neuroscience.

Characterization of human cannabinoid CB2 receptor coupled to chimeric Galpha(qi5) and Galpha(qo5) proteins.

M. Gopalakrishnan, J. Malysz, K. Kage, 2009, European journal of pharmacology.

Functional characterization of adenosine receptors and coupling to ATP-sensitive K+ channels in Guinea pig urinary bladder smooth muscle.

U. Warrior, D. Burns, D. Groebe, 2002, Journal of Pharmacology and Experimental Therapeutics.

Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K+ channel Kir6.2 combination expressed in HEK‐293 cells

J. Sullivan, J. Brioni, C. Shieh, 2000, British journal of pharmacology.

Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes.

M. Gopalakrishnan, V. Scott, R. Davis-Taber, 2001, Journal of pharmacological and toxicological methods.

Selective α7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3β and decreases tau phosphorylation in vivo

S. Otte, M. Gopalakrishnan, R. Bitner, 2009, Brain Research.

Effects of the Novel α7 Nicotinic Acetylcholine Receptor Agonist ABT-107 on Sensory Gating in DBA/2 Mice: Pharmacodynamic Characterization

M. Gopalakrishnan, R. Bitner, K. Stevens, 2012, Journal of Pharmacology and Experimental Therapeutics.

Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats.

D. Donnelly-roberts, M. Gopalakrishnan, S. McGaraughty, 2018, Journal of pharmacological and toxicological methods.

An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo

C. Briggs, E. Nielsen, M. Gopalakrishnan, 2007, Journal of Pharmacology and Experimental Therapeutics.

In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of α7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile

C. Briggs, M. Håkerud, H. Ween, 2009, Journal of Pharmacology and Experimental Therapeutics.

Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.

C. Briggs, H. Ween, M. Gopalakrishnan, 2009, Journal of medicinal chemistry.

In Vivo Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107: Preclinical Considerations in Alzheimer's Disease

K. Browman, J. Buccafusco, M. Decker, 2010, Journal of Pharmacology and Experimental Therapeutics.

Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors

C. Briggs, H. Ween, K. Thorin-Hagene, 2009, British journal of pharmacology.

RESEARCH PAPER Role of channel activation in cognitive enhancement mediated by a7 nicotinic acetylcholine receptors

C. Briggs, H. Ween, K. Thorin-Hagene, 2009 .

Recent Developments in the Biology and Medicinal Chemistry of Potassium Channel Modulators: Update from a Decade of Progress

M. Gopalakrishnan, M. Coghlan, W. Carroll, 2001 .

Functional implication of spare ATP-sensitive K(+) channels in bladder smooth muscle cells.

J. Sullivan, J. Brioni, C. Shieh, 2001, The Journal of pharmacology and experimental therapeutics.

Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation.

C. Shieh, M. Gopalakrishnan, M. Coghlan, 2003, European journal of pharmacology.

Losartan improves renal function and pathology in obese ZSF-1 rats

D. Donnelly-roberts, M. Gopalakrishnan, S. McGaraughty, 2018, Journal of basic and clinical physiology and pharmacology.

Cloning and transient expression of genes encoding the human α4 and β2 neuronal nicotinic acetylcholine receptor (nAChR) subunits

S. Arneric, J. Sullivan, T. Giordano, 1995 .

Cloning and transient expression of genes encoding the human alpha 4 and beta 2 neuronal nicotinic acetylcholine receptor (nAChR) subunits.

S. Arneric, J. Sullivan, T. Giordano, 1995, Gene.

Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle

M. Gopalakrishnan, J. Malysz, S. Buckner, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators

M. Gopalakrishnan, S. Buckner, A. Daza, 2002, British journal of pharmacology.

Characterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells.

J. Sullivan, J. Brioni, C. Shieh, 1999, The Journal of pharmacology and experimental therapeutics.

Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.

M. Gopalakrishnan, M. Brune, S. Buckner, 2006, European journal of pharmacology.

In vitro and in vivo characterization of a novel naphthylamide ATP‐sensitive K+ channel opener, A‐151892

J. Sullivan, C. Shieh, M. Gopalakrishnan, 2004, British journal of pharmacology.

(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a Novel ATP-Sensitive Potassium Channel Opener: Hemodynamic Comparison to ZD-6169, WAY-133537, and Nifedipine in the Anesthetized Canine

R. Fryer, Yanhui Hu, M. Gopalakrishnan, 2004, Journal of cardiovascular pharmacology.

AhR activation underlies the CYP1A autoinduction by A-998679 in rats

J. Waring, E. Blomme, Hong Liu, 2012, Front. Gene..

Characterization of human ASIC2a homomeric channels stably expressed in murine Ltk- cells.

M. Gopalakrishnan, J. Malysz, C. Faltynek, 2008, Life Science.

Pharmacological and molecular characterization of ATP-sensitive K+ channels in the TE671 human medulloblastoma cell line.

J. Brioni, M. Gopalakrishnan, L. Monteggia, 1999, European journal of pharmacology.

Characterization of binding of the ATP-sensitive potassium channel ligand, [3H]glyburide, to neuronal and muscle preparations.

D. Triggle, M. Gopalakrishnan, D. Johnson, 1991, The Journal of pharmacology and experimental therapeutics.

In vivo evaluation of the potency and bladder‐vascular selectivity of the ATP‐sensitive potassium channel openers (–)‐cromakalim, ZD6169 and WAY‐133537 in rats

J. Brioni, M. Gopalakrishnan, J. J. Lynch, 2003, BJU international.

[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.

G. Gintant, C. Shieh, M. Gopalakrishnan, 2003, Molecular pharmacology.

(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. II. In Vivo Characterization

J. Sullivan, M. Williams, J. Brioni, 2002, Journal of Pharmacology and Experimental Therapeutics.

Characterization and modulation of [125I]iberiotoxin-D19Y/Y36F binding in the guinea-pig urinary bladder.

J. Brioni, M. Gopalakrishnan, J. Sullivan, 2000, European journal of pharmacology.

The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles.

J. Sullivan, C. Shieh, M. Gopalakrishnan, 2003, Bioorganic & medicinal chemistry letters.

Targeting Anti-TGF-β Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach.

M. Gopalakrishnan, S. McGaraughty, Todd B. Cole, 2017, Journal of the American Society of Nephrology : JASN.

Advances in the discovery of novel positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor.

M. Gopalakrishnan, G. Gfesser, R. Faghih, 2007, Recent patents on CNS drug discovery.

Sperm ion channels: molecular targets for the next generation of contraceptive medicines?

M. Gopalakrishnan, Di Zhang, 2005, Journal of andrology.

Regulation of Human α4β2 Neuronal Nicotinic Acetylcholine Receptors by Cholinergic Channel Ligands and Second Messenger Pathways

J. Sullivan, M. Gopalakrishnan, E. Molinari, 1997 .

Structure-activity relationships of α-amino acid ligands for the α2δ subunit of voltage-gated calcium channels

S. Baker, Chih-Hung Lee, M. Gopalakrishnan, 2006 .

Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination.

C. Briggs, M. Håkerud, M. Gopalakrishnan, 2009, Biochemical pharmacology.

Allosteric modulators of the alpha7 nicotinic acetylcholine receptor.

C. Briggs, M. Gopalakrishnan, R. Faghih, 2008, Journal of medicinal chemistry.

Chapter 2. Potassium channel modulators for the treatment of CNS disorders

M. Gopalakrishnan, M. Coghlan, W. Carroll, 2001 .

Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an α7 nAChR selective agonist

J. Waring, Jinhe Li, E. Blomme, 2008, Neuroscience Research.

Role of GSK‐3β activation and α7 nAChRs in Aβ1–42‐induced tau phosphorylation in PC12 cells

J. Waring, Jinhe Li, M. Gopalakrishnan, 2008, Journal of neurochemistry.

A Festschrift in honor of David J. Triggle.

C. Triggle, M. Gopalakrishnan, D. Rampe, 2015, Biochemical pharmacology.

Voltage-Gated Ion Channels as Drug Targets: TRIGGLE: VOLTAGE-GATED ION CHANNELS AS DRUG TARGETS O-BK

D. Triggle, M. Gopalakrishnan, D. Rampe, 2006 .

Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.

M. Gopalakrishnan, M. Coghlan, W. Carroll, 2001, Journal of medicinal chemistry.

Characterization of human urinary bladder KATP channels containing SUR2B splice variants expressed in L-cells.

M. Gopalakrishnan, P. Kroeger, V. Scott, 2004, European journal of pharmacology.

Effects of ATP‐sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction

J. Sullivan, J. Brioni, M. Gopalakrishnan, 2003, Neurourology and urodynamics.

The Regulation of Neuronal Calcium Channels

D. Triggle, M. Gopalakrishnan, M. Hawthorn, 1993 .

Regulation of ATP-sensitive K+ channels by chronic glyburide and pinacidil administration.

D. Triggle, M. Gopalakrishnan, 1992, Biochemical pharmacology.

Glutamate substitution in repeat IV alters divalent and monovalent cation permeation in the heart Ca2+ channel.

M. Gopalakrishnan, L. Parent, Leslie J. Parent, 1995, Biophysical journal.

Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.

M. Gopalakrishnan, M. Coghlan, W. Carroll, 2001, Journal of medicinal chemistry.

Interactions of analogs of the 1,4-dihydropyridine tiamdipine in cardiac and smooth muscle.

F. Galletti, D. Triggle, M. Gopalakrishnan, 1991, European journal of pharmacology.

Regulation of K+ and Ca2+ channels in experimental cardiac failure.

D. Triggle, M. Gopalakrishnan, J. Bauer, 1991, The American journal of physiology.

Pharmacology of α7 nicotinic acetylcholine receptor mediated extracellular signal‐regulated kinase signalling in PC12 cells

M. Gopalakrishnan, R. E. Kouhen, M. Hu, 2009, British journal of pharmacology.

RESEARCH PAPER Pharmacology of a7 nicotinic acetylcholine receptor mediated extracellular signal-regulated kinase signalling in PC12 cells

M. Gopalakrishnan, M. Hu, R. E. Kouhen, 2009 .

Regulation of human alpha4beta2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways.

J. Sullivan, M. Gopalakrishnan, E. Molinari, 1997, Molecular pharmacology.

ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders.

D. Donnelly-roberts, G. Gintant, J. Sullivan, 2006, CNS drug reviews.

Characterization of a novel ATP‐sensitive K+ channel opener, A‐251179, on urinary bladder relaxation and cystometric parameters

J. Brioni, C. Shieh, Y. Kurachi, 2007, British journal of pharmacology.

(l)-Phenylglycine, but not necessarily other α2δ subunit voltage-gated calcium channel ligands, attenuates neuropathic pain in rats

Chih-Hung Lee, M. Gopalakrishnan, P. Honore, 2006, Pain.

(L)-Phenylglycine, but not necessarily other alpha2delta subunit voltage-gated calcium channel ligands, attenuates neuropathic pain in rats.

Chih-Hung Lee, M. Gopalakrishnan, P. Honore, 2006, Pain.

α4β2 Nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gating

M. Decker, M. Gopalakrishnan, R. Bitner, 2006, Psychopharmacology.

ATP‐sensitive K+ channels: Pharmacologic properties, regulation, and therapeutic potential

David J. Triggle, M. Gopalakrishnan, Ronald A. Janis, 1993 .

Potassium channels: molecular defects, diseases, and therapeutic opportunities.

J. Sullivan, C. Shieh, M. Gopalakrishnan, 2000, Pharmacological reviews.

Human α4β2 Neuronal Nicotinic Acetylcholine Receptor in HEK 293 Cells: A Patch-Clamp Study

D. Bertrand, S. Arneric, J. Sullivan, 1996, The Journal of Neuroscience.

IR and NMR spectral studies of 4-bromo-1-naphthyl chalcones-assessment of substituent effects.

M. Gopalakrishnan, G. Vanangamudi, G. Thirunarayanan, 2007, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

Microwave‐Assisted Beckmann Rearrangement: Convenient Synthesis of 1,3‐Diaza‐bicyclo[3.2.2]nonane

M. Gopalakrishnan, T. Pagano, R. Faghih, 2006 .

Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.

R. Henry, M. Gopalakrishnan, M. Kort, 2006, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro.

J. Sullivan, R. Henry, M. Gopalakrishnan, 2004, Journal of medicinal chemistry.

Structure–activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers

R. Henry, M. Gopalakrishnan, J. Darbyshire, 2004 .

Structure-Activity studies for a novel series of tricyclic dihydropyrimidines as K(ATP) channel openers (KCOs).

J. Sullivan, M. Gopalakrishnan, Henry Q. Zhang, 2002, Bioorganic & medicinal chemistry letters.

Pharmacological characterization of a 1,4‐dihydropyridine analogue, 9‐(3,4‐dichlorophenyl)‐3,3,6,6‐tetramethyl‐3,4,6,7,9,10‐hexahydro‐1,8(2H,5H)‐acridinedione (A‐184209) as a novel KATP channel inhibitor

J. Sullivan, M. Gopalakrishnan, S. Buckner, 2003, British journal of pharmacology.

Synthesis and Structure−Activity Relationships of a Novel Series of 2,3,5,6,7,9-Hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide KATP Channel Openers: Discovery of (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637), a Potent KATP Open

J. Sullivan, R. Henry, J. Brioni, 2004 .

Ion Channels – Ligand Gated

C. Briggs, M. Gopalakrishnan, 2007 .

Preclinical Pharmacology of ABT‐418: A Prototypical Cholinergic Channel Activator for the Potential Treatment of Alzheimer's Disease

A. D. Rodrigues, D. Donnelly-roberts, S. Arneric, 1995 .

α7 nAChR-mediated activation of MAP kinase pathways in PC12 cells

Jinhe Li, M. Gopalakrishnan, E. Gubbins, 2010, Brain Research.

Potassium channel subtypes as molecular targets for overactive bladder and other urological disorders

C. Shieh, M. Gopalakrishnan, 2004, Expert opinion on therapeutic targets.

Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent α4β2 nicotinic acetylcholine receptor ligands.

Chih-Hung Lee, K. Thorin-Hagene, M. Gopalakrishnan, 2011, Journal of medicinal chemistry.

α4β2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of α4β2 nAChR agonists in pain.

Chih-Hung Lee, Murali Gopalakrishnan, John Malysz, 2011, Biochemical pharmacology.

A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: In Vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand

D. Donnelly-roberts, D. Mckenna, S. Arneric, 1996, Neuropharmacology.

ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties.

D. Donnelly-roberts, D. Mckenna, S. Arneric, 1997, The Journal of pharmacology and experimental therapeutics.

The potential of neuronal nicotinic acetylcholine receptor agonists for treating CNS conditions

M. Decker, M. Gopalakrishnan, M. Meyer, 2008, Expert opinion on drug discovery.

Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys.

J. Buccafusco, M. Decker, M. Gopalakrishnan, 2007, Biochemical pharmacology.

Pharmacological Characterization of the Novel Dihydropyridine Potassium Channel Opener, (9R)-9-(3-Iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione (A-325100), and the Regulation of Cardiovascular Function in Conscious and Anesthetized Beagle Dogs

C. Shieh, R. Fryer, M. Gopalakrishnan, 2005, Journal of cardiovascular pharmacology.

Stable expression and pharmacological properties of the human alpha 7 nicotinic acetylcholine receptor.

D. Bertrand, D. Donnelly-roberts, S. Arneric, 1995, European journal of pharmacology.

J. Sullivan, R. Chess-Williams, M. Williams, 2002, Journal of Pharmacology and Experimental Therapeutics.

Interaction of azimilide with neurohumoral and channel receptors.

D J Triggle, R R Brooks, S F Pong, 2001, Biochemical pharmacology.

Interaction of a novel dihydropyridine K+ channel opener, A‐312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075

M. Gopalakrishnan, U. Quast, W. Carroll, 2004, British journal of pharmacology.

Molecular characterization of human SUR2-containing K(ATP) channels.

Murali Gopalakrishnan, Paul E. Kroeger, R. Simmer, 2000, Gene.

Activation of the recombinant human alpha 7 nicotinic acetylcholine receptor significantly raises intracellular free calcium.

J. Sullivan, M. Messi, O. Delbono, 1997, The Journal of pharmacology and experimental therapeutics.

The regulation of receptors, ion channels, and G proteins in congestive heart failure

David J. Triggle, M. Gopalakrishnan, D. Triggle, 1990 .

Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.

D. Donnelly-roberts, S. Arneric, J. Sullivan, 1996, The Journal of pharmacology and experimental therapeutics.

Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station.

C. Briggs, M. Håkerud, H. Ween, 2009, Assay and drug development technologies.

Importance of M2-M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera.

C. Briggs, Jinhe Li, H. Ween, 2010, European journal of pharmacology.

Utility of Large-Scale Transiently Transfected Cells for Cell-Based High-Throughput Screens to Identify Transient Receptor Potential Channel A1 (TRPA1) Antagonists

Jing Xu, Murali Gopalakrishnan, Wende Niforatos, 2007, Journal of biomolecular screening.

Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis

M. Gopalakrishnan, L. Rueter, R. Bitner, 2012, Psychopharmacology.

Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain.

Murali Gopalakrishnan, C. Briggs, M. Marks, 2009, Biochemical pharmacology.

In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

C. Briggs, E. Nielsen, Jinhe Li, 2010, Journal of Pharmacology and Experimental Therapeutics.

Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties

J. Waring, S. Otte, K. Browman, 2008, CNS neuroscience & therapeutics.

Broad-Spectrum Efficacy across Cognitive Domains by α7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways

J. Sullivan, C. Briggs, J. Buccafusco, 2007, The Journal of Neuroscience.

[3H]A-585539 [(1S,4S)-2,2-Dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a Novel High-Affinity α7 Neuronal Nicotinic Receptor Agonist: Radioligand Binding Characterization to Rat and Human Brain

D. Bertrand, E. Tribollet, M. Gopalakrishnan, 2008, Journal of Pharmacology and Experimental Therapeutics.

Novel High-Affinity 7 Neuronal Nicotinic Receptor Agonist : Radioligand Binding Characterization to Rat and Human Brain

D. Bertrand, E. Tribollet, M. Gopalakrishnan, 2007 .

[H]A-585539 [(1S,4S)-2,2-Dimethyl-5-(6-phenylpyridazin-3-yl)- 5-aza-2-azoniabicyclo[2.2.1]heptane], a Novel High-Affinity 7 Neuronal Nicotinic Receptor Agonist: Radioligand Binding Characterization to Rat and Human Brain

D. Bertrand, E. Tribollet, M. Gopalakrishnan, 2007 .

Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study.

M Gopalakrishnan, D Bertrand, D. Bertrand, 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.

C. Briggs, M. Gopalakrishnan, C. Surowy, 2012, Bioorganic & medicinal chemistry letters.

α3* and α7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells

Chih-Hung Lee, H. Ween, K. Thorin-Hagene, 2010, Neurochemistry International.

Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists

J. Waring, S. Mathieu, Jinhe Li, 2009, Journal of Neuroimmunology.

Variants in Apaf-1 segregating with major depression promote apoptosome function

Jean M. Severin, T. Holzman, V. Abkevich, 2006, Molecular Psychiatry.

Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats.

M. Decker, G. Fox, Chih-Liang Chin, 2011, Biochemical pharmacology.

Functional Characterization of the Novel Neuronal Nicotinic Acetylcholine Receptor Ligand GTS-21 In Vitro and In Vivo

W. J. Jackson, D. Donnelly-roberts, S. Arneric, 1997, Pharmacology Biochemistry and Behavior.

Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment

D. Bertrand, Jinhe Li, S. Bertrand, 2008, Molecular Pharmacology.

Allosteric modulation of nicotinic acetylcholine receptors.

D. Bertrand, M. Gopalakrishnan, 2007, Biochemical Pharmacology.

On Becoming a Pharmacologist: Channeling David Triggle.

M. Gopalakrishnan, D. Rampe, 2015, Biochemical pharmacology.

Association of Catsper1 or -2 with Cav3.3 Leads to Suppression of T-type Calcium Channel Activity*

J. Sullivan, J. Brioni, A. Saraf, 2006, Journal of Biological Chemistry.

Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands.

S. Arneric, J. Sullivan, M. Messi, 1998, European journal of pharmacology.

Continuous Versus Intermittent Nitroglycerin Administration in Experimental Heart Failure: Vascular Relaxation and Radioligand Binding to Adrenoceptors and Ion Channels

Yong Wha Kwon, D. Triggle, M. Gopalakrishnan, 1993, Journal of cardiovascular pharmacology.

A novel potassium channel encoded by Ectocarpus siliculosus virus.

M. Gopalakrishnan, Jun Chen, S. Cassar, 2005, Biochemical and biophysical research communications.

Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry.

U. Warrior, C. Shieh, D. Groebe, 2003, Assay and drug development technologies.

Irreversible modification of the voltage-sensitive calcium channel by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ).

D. Triggle, M. Gopalakrishnan, 1990, Biochemical pharmacology.

Modulation of action potential firing by iberiotoxin and NS1619 in rat dorsal root ganglion neurons

C. Shieh, M. Gopalakrishnan, X.-F. Zhang, 2003, Neuroscience.

Gene Expression Changes Related to Synaptic Deficits in the Tg2576 Mouse Model of Alzheimer's Disease

J. Waring, C. Briggs, Jinhe Li, 2012 .

P1-053: Gene expression changes related to synaptic deficits in the Tg2576 mouse model of Alzheimer's disease

J. Waring, C. Briggs, Jinhe Li, 2008, Alzheimer's & Dementia.

Antisense knockdown of the rat α7 nicotinic acetylcholine receptor produces spatial memory impairment

M. Decker, G. Fox, M. Gopalakrishnan, 2006, Neuroscience Letters.

Gain of function mutation of the α7 nicotinic receptor: distinct pharmacology of the human α7V274T variant

D. Mckenna, S. Arneric, J. Sullivan, 1999 .

Selectivity of ABT-089 for α 4 β 2* and α 6 β 2* nicotinic acetylcholine receptors in brain

C. Briggs, M. Marks, S. Grady, 2009 .

Molecular characterization of human SUR2-containing K(ATP) channels.

M Gopalakrishnan, R. Simmer, J. Sullivan, 2000, Gene.

Cell‐Based Assays Using the Fluorometric Imaging Plate Reader (FLIPR)

J. Sullivan, M. Gopalakrishnan, Kristi L. Whiteaker, 2000, Current protocols in pharmacology.

Regulation and function of the tonic component of cortical acetylcholine release.

M. Sarter, M. Gopalakrishnan, G. Paolone, 2010 .

A‐272651, a nonpeptidic blocker of large‐conductance Ca2+‐activated K+ channels, modulates bladder smooth muscle contractility and neuronal action potentials

C. Shieh, M. Gopalakrishnan, Xufeng Zhang, 2007, British journal of pharmacology.

A-306989, an inhibitor of adenosine kinase, is renoprotective in rodent models of podocyte, basement membrane, and obstructive injury.

Chih-Hung Lee, M. Gopalakrishnan, S. McGaraughty, 2016, European journal of pharmacology.

Synthetic Organic Ligands active at Voltage‐Gated Calcium Channels a

D J Triggle, A Rutledge, W Zheng, 1991, Annals of the New York Academy of Sciences.

Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant.

D. Mckenna, S. Arneric, J. Sullivan, 1999, European journal of pharmacology.

Electrophysiological analysis of ATP-sensitive potassium channels in mammalian cells and Xenopus oocytes.

C. Shieh, M. Gopalakrishnan, 2003, Current protocols in pharmacology.

Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.

J. Sullivan, M. Gopalakrishnan, M. Kort, 2004, Bioorganic & Medicinal Chemistry Letters.

Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gating.

M. Decker, M. Gopalakrishnan, R. Bitner, 2006, Psychopharmacology.

α7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues

C. Briggs, Jinhe Li, M. Håkerud, 2008 .

A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.

D. Mckenna, S. Arneric, J. Sullivan, 1996, Neuropharmacology.

Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury

Murali Gopalakrishnan, Prisca Honore, Char-Chang Shieh, 2004, Brain Research.

Targeting Anti-TGF-β Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach.

M. Gopalakrishnan, S. McGaraughty, Todd B. Cole, 2017, Journal of the American Society of Nephrology.

Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis

M. Gopalakrishnan, L. Rueter, R. Bitner, 2011, Psychopharmacology.

Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands.

M. Håkerud, M. Gopalakrishnan, J. Malysz, 2010, Bioorganic & medicinal chemistry letters.

Functional characterization and high-throughput screening of positive allosteric modulators of α7 nicotinic acetylcholine receptors in IMR-32 neuroblastoma cells.

U. Warrior, D. Burns, M. Gopalakrishnan, 2011, Assay and drug development technologies.

Allosteric modulators of the alpha7 nicotinic acetylcholine receptor.

C. Briggs, M. Gopalakrishnan, R. Faghih, 2008, Journal of medicinal chemistry.

KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels

M. Gopalakrishnan, C. Surowy, P. Honore, 2011, Journal of Neuroscience Methods.

Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: A novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia

J. Waring, Jinhe Li, Chih-Hung Lee, 2013, Alzheimer's & Dementia.

α7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues

C. Briggs, Jinhe Li, M. Håkerud, 2008, British journal of pharmacology.

Automated Parallel Oocyte Electrophysiology Test station (POETs): a screening platform for identification of ligand-gated ion channel modulators.

D. Mckenna, C. Shieh, M. Gopalakrishnan, 2003, Assay and drug development technologies.

Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands.

M. Håkerud, M. Gopalakrishnan, J. Malysz, 2010, Bioorganic & medicinal chemistry letters.

Voltage‐dependent inactivation in a cardiac‐skeletal chimeric calcium channel

M. Gopalakrishnan, L. Parent, Xiangyang Wei, 1995, FEBS letters.

Tissue specific expression of alternative splice forms of human cyclic nucleotide gated channel subunit CNGA3.

M. Gopalakrishnan, Jun Chen, S. Cassar, 2004, Molecular vision.