C. Hilty

发表

Lipid–protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy

Kurt Wüthrich, Christian Hilty, Gerhard Wider, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Determination of protein–ligand binding modes using fast multi-dimensional NMR with hyperpolarization† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0sc00266f

Yunyi Wang, C. Hilty, Jihyun Kim, 2020, Chemical science.

NMR analysis on microfluidic devices by remote detection.

Christian Hilty, Alexander Pines, A. Pines, 2005, Analytical chemistry.

Sequentially acquired two-dimensional NMR spectra from hyperpolarized sample.

C. Hilty, Sean Bowen, Haifeng Zeng, 2009, Journal of magnetic resonance.

Characterization of protein–ligand interactions by SABRE

C. Hilty, Ratnamala Mandal, Pierce Pham, 2021, Chemical science.

Tunable iridium catalyst designs with bidentate N-heterocyclic carbene ligands for SABRE hyperpolarization of sterically hindered substrates.

C. Hilty, Pierce Pham, 2020, Chemical communications.

Nuclear Spin Hyperpolarization of NH2 and CH3-substituted Pyridine and Pyrimidine Moieties by SABRE.

C. Hilty, Ratnamala Mandal, Pierce Pham, 2020, Chemphyschem : a European journal of chemical physics and physical chemistry.

Controlling membrane permeability with bacterial porins: application to encapsulated enzymes.

W. Meier, S. Bezrukov, M. Winterhalter, 2001, Talanta.

Application of blind source separation to real-time dissolution dynamic nuclear polarization.

C. Hilty, Mukundan Ragavan, 2015, Analytical chemistry.

Spontaneous emission of NMR signals in hyperpolarized proton spin systems.

C. Hilty, Sean Bowen, Youngbok Lee, 2011, Journal of magnetic resonance.

Application of Relaxation Dispersion of Hyperpolarized 13C Spins to Protein-Ligand Binding.

Yunyi Wang, C. Hilty, Chang Qi, 2021, Angewandte Chemie.

Application of Relaxation Dispersion of Hyperpolarized 13 C Spins to Protein–Ligand Binding

Yunyi Wang, C. Hilty, Chang Qi, 2021, Angewandte Chemie.

Calculations of neon nuclear-spin optical rotation, Verdet and hyperfine constants with configuration-interaction many-body perturbation theory

I. Savukov, C. Hilty, R. Castro, 2019, The European Physical Journal D.

Modeling of Polarization Transfer Kinetics in Protein Hydration Using Hyperpolarized Water.

C. Hilty, Jihyun Kim, Mengxiao Liu, 2017, The journal of physical chemistry. B.

Rapid determination of biosynthetic pathways using fractional isotope enrichment and high‐resolution dynamic nuclear polarization enhanced NMR

C. Hilty, Sean Bowen, G. Sekar, 2011, NMR in biomedicine.

Determination of Intermolecular Interactions Using Polarization Compensated Heteronuclear Overhauser Effect of Hyperpolarized Spins.

C. Hilty, Jihyun Kim, Mengxiao Liu, 2015, Analytical chemistry.

Applications of dynamic nuclear polarization to the study of reactions and reagents in organic and biomolecular chemistry.

C. Hilty, Sean Bowen, 2010, Organic & biomolecular chemistry.

Broadening the Application Range of NMR and MRI by Remote Detection

J. Granwehr, C. Hilty, Songi Han, 2006 .

Dynamic Nuclear Polarization Using 3D Aromatic Boron Cluster Radicals.

Alexander M. Spokoyny, C. Hilty, Julia M. Stauber, 2020, The journal of physical chemistry letters.

Multinuclear Detection of Nuclear Spin Optical Rotation at Low Field.

I. Savukov, C. Hilty, Yue Zhu, 2018, The journal of physical chemistry letters.

Quantitative rate determination by dynamic nuclear polarization enhanced NMR of a Diels-Alder reaction.

C. Hilty, Haifeng Zeng, Youngbok Lee, 2010, Analytical chemistry.

Membrane protein dynamics in different environments: simulation study of the outer membrane protein X in a lipid bilayer and in a micelle

K. Wüthrich, W. V. Gunsteren, A. Glättli, 2010, European Biophysics Journal.

Hyperpolarized water as universal sensitivity booster in biomolecular NMR

L. Frydman, C. Hilty, D. Kurzbach, 2022, Nature Protocols.

Detection of living anionic species in polymerization reactions using hyperpolarized NMR.

K. Wooley, C. Hilty, G. S. Heo, 2013, Journal of the American Chemical Society.

Measurement of Kinetics and Active Site Distances in Metalloenzymes Using Paramagnetic NMR with 13C Hyperpolarization.

Guannan Zhang, C. Hilty, N. Mahanta, 2018, The journal of physical chemistry letters.

2D NMR spectroscopy of refolding RNase Sa using polarization transfer from hyperpolarized water.

C. Hilty, Jihyun Kim, Ratnamala Mandal, 2021, Journal of magnetic resonance.

Polyolefin catalysis of propene, 1-butene and isobutene monitored using hyperpolarized NMR†

C. Hilty, Yaewon Kim, H. Samouei, 2021, Chemical science.

Screening of Protein-Ligand Binding Using a SABRE Hyperpolarized Reporter.

C. Hilty, Ratnamala Mandal, Pierce Pham, 2022, Analytical chemistry.

Detection of Protein-Ligand Interactions by 19F Nuclear Magnetic Resonance Using Hyperpolarized Water.

C. Hilty, Jihyun Kim, Jiandu Hu, 2022, The journal of physical chemistry letters.

Dynamic Nuclear Polarization Using 3D Aromatic Boron Cluster Radicals.

Alexander M. Spokoyny, C. Hilty, Julia M. Stauber, 2020, The journal of physical chemistry letters.

Indirect detection of intermediate in decarboxylation reaction of phenylglyoxylic acid by hyperpolarized 13C NMR.

C. Hilty, Jihyun Kim, Yaewon Kim, 2020, Chemical communications.

Amplification of Nuclear Overhauser Effect by Hyperpolarization for Screening of Ligand Binding to Immobilized Target Proteins.

Yunyi Wang, C. Hilty, 2020, Analytical chemistry.

Observation of Fast 2D NMR Spectra During Protein Folding Using Polarization Transfer from Hyperpolarized Water.

C. Hilty, Jihyun Kim, Ratnamala Mandal, 2019, The journal of physical chemistry letters.

Direct observation of Ru-alkylidene forming into ethylene in ring-closing metathesis from hyperpolarized 1H NMR.

C. Hilty, Chia-Hsiu Chen, Yaewon Kim, 2018, Chemical communications.

Real-time Analysis of Folding Upon Binding of a Disordered Protein using Dissolution DNP NMR

R. Kriwacki, Luigi I. Iconaru, C. Hilty, 2017 .

Implementation and characterization of flow injection in dissolution dynamic nuclear polarization NMR spectroscopy.

C. Hilty, Hsueh-Ying Chen, 2015, Chemphyschem : a European journal of chemical physics and physical chemistry.

In Situ Determination of Tacticity, Deactivation, and Kinetics in [rac-(C2H4(1-Indenyl)2)ZrMe][B(C6F5)4] and [Cp2ZrMe][B(C6F5)4]-Catalyzed Polymerization of 1-Hexene Using (13)C Hyperpolarized NMR.

C. Hilty, Chia-Hsiu Chen, Wei-Chun Shih, 2015, Journal of the American Chemical Society.

Protein folding studied by dissolution dynamic nuclear polarization.

C. Hilty, Mukundan Ragavan, Hsueh-Ying Chen, 2013, Angewandte Chemie.

Hyperpolarized Hadamard spectroscopy using flow NMR.

C. Hilty, Hsueh-Ying Chen, 2013, Analytical chemistry.

Solution NMR of polypeptides hyperpolarized by dynamic nuclear polarization.

C. Hilty, Mukundan Ragavan, Hsueh-Ying Chen, 2011, Analytical chemistry.

Molecular Imaging Using a Targeted Magnetic Resonance Hyperpolarized Biosensor

Christian Hilty, Leif Schröder, Alexander Pines, 2006, Science.

Temporal chemical shift correlations in reactions studied by hyperpolarized nuclear magnetic resonance.

C. Hilty, Sean Bowen, 2009, Analytical chemistry.

Chemical shift correlations from hyperpolarized NMR by off-resonance decoupling.

C. Hilty, Sean Bowen, Haifeng Zeng, 2008, Analytical chemistry.

Site specific polarization transfer from a hyperpolarized ligand of dihydrofolate reductase

Yunyi Wang, C. Hilty, Mukundan Ragavan, 2016, Journal of Biomolecular NMR.

NMR-Solution Structures in Methanol of an α-Heptapeptide, of a β3/β2-Nonapeptide, and of an all-β3-Icosapeptide Carrying the 20 Proteinogenic Side Chains

B. Jaun, D. Seebach, C. Hilty, 2005 .

Nmr-structural investigations of a β3-dodecapeptide with proteinogenic side chains in methanol and in aqueous solutions

K. Wüthrich, D. Seebach, C. Hilty, 2002 .

Reversal of the hofmeister series: specific ion effects on peptides.

J. Heyda, P. Cremer, P. Jungwirth, 2013, The journal of physical chemistry. B.

para-Hydrogen-induced polarization in heterogeneous hydrogenation reactions.

A. Pines, C. Hilty, Song-I Han, 2007, Journal of the American Chemical Society.

Spectrally resolved magnetic resonance imaging of a xenon biosensor.

A. Pines, D. Wemmer, C. Hilty, 2005, Angewandte Chemie.

Folding of a tryptophan zipper peptide investigated on the basis of the nuclear Overhauser effect and thermal denaturation.

C. Hilty, Soyoun Hwang, 2011, The journal of physical chemistry. B.

Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet† †Electronic supplementary information (ESI) available: Experimental details and numerical results pertaining to the D–T2 maps. See DOI: 10.1039/c8sc01329b

Guannan Zhang, C. Hilty, Ville-Veikko Telkki, 2018, Chemical science.

Characterization of Chemical Exchange Using Relaxation Dispersion of Hyperpolarized Nuclear Spins.

C. Hilty, Yaewon Kim, Mengxiao Liu, 2017, Analytical chemistry.

Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy.

Harald Schwalbe, Lucio Frydman, Christian Griesinger, 2015, Angewandte Chemie.

Molecular mechanisms of ion-specific effects on proteins.

J. Heyda, P. Cremer, P. Jungwirth, 2012, Journal of the American Chemical Society.

Affinity screening using competitive binding with fluorine-19 hyperpolarized ligands.

C. Hilty, Yaewon Kim, 2015, Angewandte Chemie.

Membrane Protein–Lipid Interactions in Mixed Micelles Studied by NMR Spectroscopy with the Use of Paramagnetic Reagents

G. Wider, K. Wüthrich, C. Fernández, 2004, Chembiochem : a European journal of chemical biology.

Genetic incorporation of twelve meta-substituted phenylalanine derivatives using a single pyrrolysyl-tRNA synthetase mutant.

C. Hilty, Yane-Shih Wang, W. Liu, 2013, ACS chemical biology.

Methanol strengthens hydrogen bonds and weakens hydrophobic interactions in proteins--a combined molecular dynamics and NMR study.

Qiang Shao, Y. Gao, C. Hilty, 2011, The journal of physical chemistry. B.

NMR-derived dynamic aspects of N-type inactivation of a Kv channel suggest a transient interaction with the T1 domain.

G. Wider, K. Wüthrich, S. Choe, 2006, Biochemistry.

Effective rotational correlation times of proteins from NMR relaxation interference.

Kurt Wüthrich, Christian Hilty, Gerhard Wider, 2006, Journal of magnetic resonance.

NMR structure of the integral membrane protein OmpX.

G. Wider, K. Wüthrich, P. Güntert, 2004, Journal of molecular biology.

Facilitated substrate transport through membrane proteins.

M. Winterhalter, C. Hilty, 2001, Physical review letters.

Parallelized Ligand Screening Using Dissolution Dynamic Nuclear Polarization.

C. Hilty, Yaewon Kim, Mengxiao Liu, 2016, Analytical chemistry.

Site specific polarization transfer from a hyperpolarized ligand of dihydrofolate reductase

Yunyi Wang, C. Hilty, Mukundan Ragavan, 2016, Journal of Biomolecular NMR.

Applications of Dissolution-DNP for NMR Screening.

C. Hilty, Yaewon Kim, 2019, Methods in enzymology.

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

Guannan Zhang, C. Hilty, 2018, Magnetic resonance in chemistry : MRC.

In-Vitro Dissolution Dynamic Nuclear Polarization for Sensitivity Enhancement of NMR with Biological Molecules.

Yunyi Wang, C. Hilty, Yaewon Kim, 2018, Methods in molecular biology.

Polarization Transfer from Ligands Hyperpolarized by Dissolution Dynamic Nuclear Polarization for Screening in Drug Discovery

C. Hilty, Hlaing Min, Giridhar Sekar, 2015, ChemMedChem.

Nuclear magnetic resonance of hyperpolarized fluorine for characterization of protein-ligand interactions.

C. Hilty, Haifeng Zeng, S. Ruedisser, 2012, Journal of the American Chemical Society.

Time-resolved dynamic nuclear polarization enhanced NMR spectroscopy.

C. Hilty, Sean Bowen, 2008, Angewandte Chemie.

Nonrandom structure in the urea-unfolded Escherichia coli outer membrane protein X (OmpX).

K. Wüthrich, Hakim Tafer, C. Fernández, 2004, Biochemistry.

Hyperpolarized binding pocket nuclear Overhauser effect for determination of competitive ligand binding.

A. Mazur, S. Becker, C. Griesinger, 2012, Angewandte Chemie.

Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis

Guannan Zhang, Hsueh-Ying Chen, Christian Hilty, 2015, Nature Communications.

Identification of Intracellular and Extracellular Metabolites in Cancer Cells Using 13C Hyperpolarized Ultrafast Laplace NMR

Guannan Zhang, C. Hilty, S. Ahola, 2018, Analytical chemistry.

Metabolic Measurements of Nonpermeating Compounds in Live Cells Using Hyperpolarized NMR.

C. Hilty, Mengxiao Liu, 2018, Analytical chemistry.

Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor

D. Budker, D. Budker, A. Pines, 2007, Proceedings of the National Academy of Sciences.

Dispersion measurements using time-of-flight remote detection MRI.

A. Pines, P. Sen, E. Harel, 2007, Magnetic resonance imaging.

Spin coherence transfer in chemical transformations monitored by remote detection NMR.

A. Pines, C. Hilty, L. Bouchard, 2007, Analytical chemistry.

Time-of-flight flow imaging of two-component flow inside a microfluidic chip.

Katherine A. Koen, A. Pines, E. Harel, 2007, Physical review letters.

Bilayer in small bicelles revealed by lipid-protein interactions using NMR spectroscopy.

Korvin F. A. Walter, S. Becker, C. Griesinger, 2008, Journal of the American Chemical Society.

Characterization of Membrane Protein‐Lipid Interactions in Unfolded OmpX with Enhanced Time Resolution by Hyperpolarized NMR

C. Hilty, Jihyun Kim, Ratnamala Mandal, 2020, Chembiochem : a European journal of chemical biology.

Real-Time Analysis of Folding upon Binding of a Disordered Protein by Using Dissolution DNP NMR Spectroscopy.

R. Kriwacki, Luigi I. Iconaru, C. Hilty, 2017, Angewandte Chemie.

An NH moiety is not required for anion binding to amides in aqueous solution.

P. Cremer, C. Hilty, H. Okur, 2015, Langmuir : the ACS journal of surfaces and colloids.

Effects of End Group Termination on Salting-Out Constants for Triglycine.

J. Heyda, P. Cremer, P. Jungwirth, 2013, The journal of physical chemistry letters.

Interfacing Liquid State Hyperpolarization Methods with NMR Instrumentation

C. Hilty, Ratnamala Mandal, Pierce Pham, 2022, Journal of magnetic resonance open.

Determination of Ligand Binding Epitope Structures Using Polarization Transfer from Hyperpolarized Ligands.

Yunyi Wang, C. Hilty, 2019, Journal of medicinal chemistry.

Intermolecular interactions determined by NOE build-up in macromolecules from hyperpolarized small molecules.

Yunyi Wang, C. Hilty, Chia-Hsiu Chen, 2018, Methods.

Reaction monitoring using hyperpolarized NMR with scaling of heteronuclear couplings by optimal tracking.

S. Glaser, Guannan Zhang, F. Schilling, 2016, Journal of magnetic resonance.

Rapid sample injection for hyperpolarized NMR spectroscopy.

C. Hilty, Sean Bowen, 2010, Physical chemistry chemical physics : PCCP.

Milli-tesla NMR and spectrophotometry of liquids hyperpolarized by dissolution dynamic nuclear polarization.

I. Savukov, C. Hilty, Chia-Hsiu Chen, 2016, Journal of magnetic resonance.

Folding determinants of disulfide bond forming protein B explored by solution nuclear magnetic resonance spectroscopy

C. Hilty, Soyoun Hwang, 2011, Proteins.

Stereospecific assignments of the isopropyl methyl groups of the membrane protein OmpX in DHPC micelles

G. Wider, K. Wüthrich, C. Fernández, 2003, Journal of biomolecular NMR.

Side chain NMR assignments in the membrane protein OmpX reconstituted in DHPC micelles

G. Wider, K. Wüthrich, C. Fernández, 2002, Journal of biomolecular NMR.

Quantifying the diffusion of a fluid through membranes by double phase encoded remote detection magnetic resonance imaging.

A. Pines, E. Harel, C. Hilty, 2007, The journal of physical chemistry. B.

Microfluidic gas-flow profiling using remote-detection NMR.

Christian Hilty, Josef Granwehr, Alexander Pines, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Method for accurate measurements of nuclear-spin optical rotation for applications in correlated optical-NMR spectroscopy.

I. Savukov, C. Hilty, T. Karaulanov, 2013, Journal of magnetic resonance.

Bilayer in small bicelles revealed by lipid-protein interactions using NMR spectroscopy.

Korvin F. A. Walter, S. Becker, C. Griesinger, 2008, Journal of the American Chemical Society.

Genetic incorporation of twelve meta-substituted phenylalanine derivatives using a single pyrrolysyl-tRNA synthetase mutant.

C. Hilty, Yane-Shih Wang, W. Liu, 2013, ACS chemical biology.

Chemical shift correlations from hyperpolarized NMR using a single SHOT.

S. Glaser, Guannan Zhang, F. Schilling, 2013, Analytical chemistry.

An ultra-low cost NMR device with arbitrary pulse programming.

Hsueh-Ying Chen, Yaewon Kim, Pulak Nath, 2015, Journal of magnetic resonance.

Protein folding studied by dissolution dynamic nuclear polarization.

C. Hilty, Mukundan Ragavan, Hsueh-Ying Chen, 2013, Angewandte Chemie.

Hyperpolarized binding pocket nuclear Overhauser effect for determination of competitive ligand binding.

A. Mazur, S. Becker, C. Griesinger, 2012, Angewandte Chemie.

Solution NMR studies of the integral membrane proteins OmpX and OmpA from Escherichia coli

K. Wüthrich, C. Fernández, C. Hilty, 2001, FEBS letters.