C. Kang

发表

Solution NMR study of the transmembrane domain of single-span membrane proteins: opportunities and strategies.

S. Gayen, Qingxin Li, C. Kang, 2012, Current protein & peptide science.

FKBP Family Proteins: Immunophilins with Versatile Biological Functions

H. Yoon, C. Kang, S. Dhe-Paganon, 2008, Neurosignals.

Zika Virus Protease: An Antiviral Drug Target.

T. Keller, C. Kang, D. Luo, 2017, Trends in microbiology.

Mechanisms of Action for Small Molecules Revealed by Structural Biology in Drug Discovery

Qingxin Li, C. Kang, 2020, International journal of molecular sciences.

Insights into Structures and Dynamics of Flavivirus Proteases from NMR Studies

Qingxin Li, Qingxin Li, C. Kang, 2020, International journal of molecular sciences.

Title Structure of the NS 2 BNS 3 protease from Zika virus afterself-cleavage

J. Lescar, C. Kang, D. Luo, 2019 .

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

J. Lescar, C. Kang, D. Luo, 2016, Nature Communications.

Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins

Qingxin Li, C. Kang, 2022, Membranes.

Structural characterization of the linked NS2B‐NS3 protease of Zika virus

T. Keller, C. Kang, D. Luo, 2017, FEBS letters.

Selection of suitable detergents for obtaining an active dengue protease in its natural form from E. coli.

Qingxin Li, C. Kang, Michelle Yueqi Lee, 2016, Protein expression and purification.

Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy.

Yan Li, Qingxin Li, Qingxin Li, 2015, Biochimica et biophysica acta.

Lyso-myristoyl phosphatidylcholine micelles sustain the activity of Dengue non-structural (NS) protein 3 protease domain fused with the full-length NS2B.

J. Lescar, Jeffrey Hill, Qingxin Li, 2013, Protein expression and purification.

Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease.

C. Kang, D. Luo, A. Hung, 2020, Antiviral research.

Characterization of Dengue Virus NS4A and NS4B Protein Interaction

Hongping Dong, Xuping Xie, Pei-Yong Shi, 2015, Journal of Virology.

A Practical Perspective on the Roles of Solution NMR Spectroscopy in Drug Discovery

Qingxin Li, C. Kang, 2020, Molecules.

The Natively Disordered Loop of Bcl-2 Undergoes Phosphorylation-Dependent Conformational Change and Interacts with Pin1

N. Bharatham, H. Yoon, C. Kang, 2012, PloS one.

The flexible loop of Bcl‐2 is required for molecular interaction with immunosuppressant FK‐506 binding protein 38 (FKBP38)

H. Yoon, C. Kang, Joel Chia, 2005, FEBS letters.

Solid-Phase Synthesis and NMR Structural Studies of the Marine Antibacterial Cyclic Tetrapeptide: Cyclo[GSPE]

C. Kang, H. A. Lim, C. Chia, 2010, International Journal of Peptide Research and Therapeutics.

Functional role of the flexible N-terminal extension of FKBP38 in catalysis

B. Simon, M. Sattler, Bo-Hwa Choi, 2013, Scientific Reports.

Probing Biological Mechanisms with Chemical Tools.

T. Keller, C. Kang, 2020, Pharmacological research.

Structural basis for KCNE3 modulation of potassium recycling in epithelia

Nicholas J. Sisco, C. Sanders, J. Meiler, 2016, Science Advances.

The NS5A Domain II of HCV: Conservation of Intrinsic Disorder in Several Genotypes

J. Wieruszeski, G. Lippens, H. Yoon, 2011 .

Waste water produced from an oilfield and continuous treatment with an oil-degrading bacterium

Qingxin Li, C. Kang, Changkai Zhang, 2005 .

Structure–activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase

H. Ford, Jeffrey Hill, T. Keller, 2021, Protein science : a publication of the Protein Society.

Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells

H. Ford, D. Ghosh, J. Marugan, 2019, Molecular Cancer Therapeutics.

Determinants of Dengue Virus NS4A Protein Oligomerization

Xuping Xie, P. Shi, C. Kang, 2015, Journal of Virology.

Application of Fragment-Based Drug Discovery against DNA Gyrase B.

A. Poulsen, Qiu Ying Lau, F. Ng, 2015, ChemPlusChem.

Discovery of Dengue Virus NS4B Inhibitors

Paul W Smith, P. Shi, J. Lescar, 2015, Journal of Virology.

Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD)

B. Simon, M. Sattler, H. Yoon, 2006, Journal of biomolecular NMR.

Applications of In-Cell NMR in Structural Biology and Drug Discovery

C. Kang, 2019, International journal of molecular sciences.

Dengue virus NS4B protein as a target for developing antivirals

Qingxin Li, C. Kang, 2022, Frontiers in Cellular and Infection Microbiology.

The impact of window functions on NMR-based paramagnetic relaxation enhancement measurements in membrane proteins.

C. Sanders, Wade D. Van Horn, C. Kang, 2010, Biochimica et biophysica acta.

Structure of the NS2B-NS3 Protease from Zika Virus Caught after Self-Cleavage

J. Lescar, C. Kang, D. Luo, 2016 .

Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase

J. Lescar, P. Dedon, Jeffrey Hill, 2018, Biomolecular NMR assignments.

The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity.

S. Vasudevan, J. Lescar, C. Kang, 2018, Advances in experimental medicine and biology.

Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket

Stéphanie M. Guéret, Hacer Karatas, H. Waldmann, 2020, Journal of medicinal chemistry.

NMR structural study of the intracellular loop 3 of the serotonin 5-HT(1A) receptor and its interaction with calmodulin.

M. Raida, S. Gayen, C. Kang, 2011, Biochimica et biophysica acta.

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor

Jeffrey Hill, T. Keller, C. Kang, 2017, Biomolecular NMR Assignments.

Dengue NS2A Protein Orchestrates Virus Assembly.

Xinwen Chen, Xuping Xie, P. Shi, 2019, Cell host & microbe.

19F-NMR in target-based drug discovery.

C. Kang, 2019, Current medicinal chemistry.

Molecular characterization of the recombinant A-chain of a type II ribosome-inactivating protein (RIP) from Viscum album coloratum and structural basis on its ribosome-inactivating activity and the sugar-binding properties of the B-chain.

R. Nanga, H. Yoon, C. Kang, 2006, Journal of biochemistry and molecular biology.

Progress in Developing Inhibitors of SARS-CoV-2 3C-Like Protease

Qingxin Li, C. Kang, 2020, Microorganisms.

Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2.

Lin Feng, H. Yoon, C. Kang, 2005, Biochemical and biophysical research communications.

Membrane Topology and Function of Dengue Virus NS2A Protein

Xuping Xie, P. Shi, S. Gayen, 2013, Journal of Virology.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

G. Rastelli, P. Fossa, A. Mangoni, 2020, Molecules.

Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe

H. Ford, Qiulian Wu, J. Rich, 2021, The Journal of experimental medicine.

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.

Xiao Han, A. Pobbati, W. Hong, 2015, Structure.

Structural insight into the transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles.

Qingxin Li, C. Kang, Y. Wong, 2014, Biophysical journal.

Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs

Hongjian Xu, Glen F. Tibbits, C. Sanders, 2010, The Journal of general physiology.

Mechanistic basis for LQT 1 caused by S 3 mutations in the KCNQ 1 subunit of IKs

C. Sanders, Hongjian Xu, M. Loewen, 2010 .

Erythropoietin Receptor Structural Domains.

Qingxin Li, C. Kang, 2017, Vitamins and hormones.

Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles

Qingxin Li, C. Kang, Yan Li, 2015, Scientific Reports.

Identification of covalent active site inhibitors of dengue virus protease

S. Vasudevan, S. Gayen, A. Poulsen, 2015, Drug design, development and therapy.

The N-terminal domain of tumor suppressor p53 is involved in the molecular interaction with the anti-apoptotic protein Bcl-Xl.

H. Yoon, C. Kang, H. Ye, 2006, Biochemical and biophysical research communications.

Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel.

Jens Meiler, Carlos G Vanoye, Charles R Sanders, 2008, Biochemistry.

Application of microbial enhanced oil recovery technique to Daqing Oilfield

Changkai Zhang, Chunde Liu, Qingxin Li, 2002 .

NMR Solution Structure of Human Vaccinia-related Kinase 1 (VRK1) Reveals the C-terminal Tail Essential for Its Structural Stability and Autocatalytic Activity*

T. Kigawa, Kyong-Tai Kim, Joon Shin, 2011, The Journal of Biological Chemistry.

Structural and ligand-binding analysis of the YAP-binding domain of transcription factor TEAD4.

Rong Li, A. Pobbati, W. Hong, 2018, The Biochemical journal.

Functional delivery of a membrane protein into oocyte membranes using bicelles.

C. Sanders, Wade D. Van Horn, C. Kang, 2010, Biochemistry.

Reconstitution of KCNE1 into lipid bilayers: comparing the structural, dynamic, and activity differences in micelle and vesicle environments.

Indra D Sahu, C. Sanders, C. Kang, 2011, Biochemistry.

Mapping the Interactions between the NS4B and NS3 Proteins of Dengue Virus

Xuping Xie, P. Shi, J. Lescar, 2015, Journal of Virology.

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function

G. Petsko, K. Lim, H. Park, 2020, Nature Chemical Biology.

Solution NMR Spectroscopy in Target-Based Drug Discovery

C. Kang, Yan Li, 2017, Molecules.

1 H, 15 N and 13 C resonance assignments of the Q61H mutant of human KRAS bound to GDP

Qingxin Li, C. Kang, Elizabeth Yihui Ng, 2021, Biomolecular NMR Assignments.

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.

Anders Poulsen, Yan Li, Alex Matter, 2019, ACS infectious diseases.

Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport

G. Grüber, Q. T. Nguyen, H. Yoon, 2015, Scientific Reports.

Crystal structure of unlinked NS2B-NS3 protease from Zika virus

C. Kang, D. Luo, A. Hung, 2016, Science.

Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2.

C. Verma, Qiu Ying Lau, F. Ng, 2018, Biochimica et biophysica acta. Biomembranes.

Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy*

J. Cherian, F. Ng, Jeffrey Hill, 2016, The Journal of Biological Chemistry.

Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit

C. Kang, Yan Li, Michelle Yueqi Lee, 2016, Biomolecular NMR assignments.

Characterization of the interaction between Escherichia coli topoisomerase IV E subunit and an ATP competitive inhibitor.

J. Cherian, F. Ng, Jeffrey Hill, 2015, Biochemical and biophysical research communications.

Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor.

J. Cherian, Jeffrey Hill, T. Keller, 2015, Biophysical journal.

Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit

C. Kang, Yan Li, Michelle Yueqi Lee, 2015, Biomolecular NMR Assignments.

NMR structural characterization of the N‐terminal active domain of the gyrase B subunit fromPseudomonas aeruginosa and its complex with an inhibitor

J. Cherian, Jeffrey Hill, T. Keller, 2015, FEBS letters.

Structural insight into the transmembrane segments 3 and 4 of the hERG potassium channel

S. Gayen, Qingxin Li, C. Kang, 2014, Journal of peptide science : an official publication of the European Peptide Society.

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

J. Lescar, C. Kang, D. Luo, 2021, bioRxiv.

Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome.

C. Sanders, A. George, C. Tian, 2007, Biochemistry.

Secondary structure and membrane topology of dengue virus NS4A protein in micelles.

C. Kang, Yan Li, Michelle Yueqi Lee, 2018, Biochimica et biophysica acta. Biomembranes.

Solution structure of the transmembrane domain of the insulin receptor in detergent micelles.

Qingxin Li, C. Kang, Y. Wong, 2014, Biochimica et biophysica acta.

Molecular and structural characterization of the domain 2 of hepatitis C virus non-structural protein 5A.

H. Yoon, C. Kang, Yu Liang, 2006, Molecules and cells.

Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.

Rong Li, Jeffrey Hill, T. Keller, 2018, Structure.

Expression, purification, and molecular characterization of Plasmodium falciparum FK506-binding protein 35 (PfFKBP35).

H. Yoon, C. Kang, Joel Chia, 2007, Protein expression and purification.

Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded.

H. Yoon, C. Kang, Yu Liang, 2007, Biochemistry.

Drug design for flavivirus proteases: what are we missing?

A. Poulsen, T. Keller, C. Kang, 2014, Current pharmaceutical design.

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors.

T. Keller, C. Kang, D. Luo, 2017, Structure.

NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex*

Rong Li, P. Shi, S. Gayen, 2013, The Journal of Biological Chemistry.

Structure and Dynamics of Zika Virus Protease and Its Insights into Inhibitor Design

Qingxin Li, C. Kang, 2021, Biomedicines.

Expression, purification of Zika virus membrane protein-NS2B in detergent micelles for NMR studies.

Qingxin Li, C. Kang, Yan Li, 2019, Protein expression and purification.

Solution NMR study of integral membrane proteins.

Qingxin Li, C. Kang, 2011, Current opinion in chemical biology.

Biomimetic membrane platform containing hERG potassium channel and its application to drug screening.

E. Sinner, C. Kang, Ahu Arslan Yildiz, 2013, The Analyst.

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor

Jeffrey Hill, T. Keller, C. Kang, 2017, Biomolecular NMR Assignments.

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids.

Xuping Xie, P. Shi, J. Lescar, 2015, Biochimica et biophysica acta.

1H, 13C and 15N resonance assignments of the first BIR domain of cellular inhibitor of apoptosis protein 1

Qingxin Li, C. Kang, H. Q. Ng, 2022, Biomolecular NMR Assignments.

Purification and structural characterization of the voltage-sensor domain of the hERG potassium channel.

Ahu Arslan Yildiz, S. Gayen, H. Yoon, 2012, Protein expression and purification.

Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1

Qingxin Li, C. Kang, Yan Li, 2021, Journal of peptide science : an official publication of the European Peptide Society.

Targeting RNA‐binding proteins with small molecules: Perspectives, pitfalls and bifunctional molecules

Qingxin Li, C. Kang, 2023, FEBS letters.

Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome

Qingxin Li, C. Kang, Yan Li, 2016, Scientific Reports.

Structure of the C-terminal Region of the Frizzled Receptor 1 in Detergent Micelles

S. Gayen, Qingxin Li, C. Kang, 2013, Molecules.

Structure of the transmembrane domain of human nicastrin-a component of γ-secretase

Qingxin Li, C. Kang, Yan Li, 2016, Scientific Reports.

West Nile virus protease activity in detergent solutions and application for affinity tag removal.

Qingxin Li, C. Kang, Qiwei Huang, 2013, Analytical biochemistry.

Expression and purification of the p75 neurotrophin receptor transmembrane domain using a ketosteroid isomerase tag

S. Gayen, Qingxin Li, C. Kang, 2012, Microbial Cell Factories.

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles.

P. Shi, J. Lescar, Qing-yin Wang, 2016, Angewandte Chemie.

Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex.

S. Gayen, C. Kang, 2011, Biochemical and biophysical research communications.

Perspectives on Fragment-based Drug Discovery: A Strategy Applicable to Diverse Targets.

Qingxin Li, C. Kang, 2021, Current topics in medicinal chemistry.

Dimerization of Flavivirus NS4B Protein

Ramyavardhanee Chandrasekaran, Xuping Xie, P. Shi, 2014, Journal of Virology.

Dimerization of Flavivirus NS 4 B Protein

Ramyavardhanee Chandrasekaran, Xuping Xie, J. Lescar, 2014 .

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.

Xiao Han, A. Pobbati, W. Hong, 2015, Structure.

Determinants of Dengue Virus NS4A Protein Oligomerization

Xuping Xie, P. Shi, C. Kang, 2015, Journal of Virology.

Molecular and structural characterization of the domain 2 of hepatitis C virus non-structural protein 5A.

H. Yoon, C. Kang, Yu Liang, 2006, Molecules and cells.

NMR solution structure of the N-terminal domain of hERG and its interaction with the S4-S5 linker.

M. Raida, S. Gayen, Qingxin Li, 2010, Biochemical and biophysical research communications.

Characterization of Dengue Virus NS4A and NS4B Protein Interaction

Xuping Xie, P. Shi, Qing-yin Wang, 2015, Journal of Virology.

Insight into the molecular interaction between the cyclic nucleotide‐binding homology domain and the eag domain of the hERG channel

H. Yoon, Qingxin Li, C. Kang, 2014, FEBS letters.

Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel.

H. Yoon, Qingxin Li, C. Kang, 2014, Journal of structural biology.

1H, 13C and 15N chemical shift assignments for the cyclic-nucleotide binding homology domain of a KCNH channel

Qingxin Li, C. Kang, H. Ng, 2014, Biomolecular NMR Assignments.

1H, 13C and 15N chemical shift assignments for the N-terminal PAS domain of the KCNH channel from Zebrafish

H. Yoon, Qingxin Li, C. Kang, 2013, Biomolecular NMR Assignments.