D. Wilton

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Mapping the interfacial binding surface of human secretory group IIa phospholipase A2.

M. Gelb, Y. Snitko, R. Koduri, 1997, Biochemistry.

Action of human group IIa secreted phospholipase A2 on cell membranes. Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme.

M. Gelb, Y. Snitko, R. Koduri, 1998, The Journal of biological chemistry.

Conversion of citrate synthase into citryl-CoA lyase as a result of mutation of the active-site aspartic acid residue to glutamic acid.

D. Wilton, C. O'Connor, W. J. Man, 1991, The Biochemical journal.

Probing phospholipid dynamics by electrospray ionisation mass spectrometry.

A. Postle, D. Wilton, G. Attard, 2007, Progress in lipid research.

Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan.

M. Gelb, D. Wilton, W. Cho, 1999, Current opinion in structural biology.

The effect of replacing the conserved active-site residues His-264, Asp-312 and Arg-314 on the binding and catalytic properties of Escherichia coli citrate synthase.

D. Wilton, C. O'Connor, W. J. Man, 1994, The Biochemical journal.

The binding of propionyl-CoA and carboxymethyl-CoA to Escherichia coli citrate synthase.

D. Wilton, C. O'Connor, W. J. Man, 1995, Biochimica et biophysica acta.

Microsomal fatty acyl-CoA transacylation and hydrolysis: fatty acyl-CoA species dependent modulation by liver fatty acyl-CoA binding proteins.

D. Wilton, F. Schroeder, C. Jolly, 2000, Biochimica et biophysica acta.

Mutations of recombinant rat liver fatty acid-binding protein at residues 102 and 122 alter its structural integrity and affinity for physiological ligands.

D. Wilton, A. Thumser, J. Voysey, 1996, The Biochemical journal.

Roles of Trp31 in High Membrane Binding and Proinflammatory Activity of Human Group V Phospholipase A2 *

M. Gelb, R. Koduri, D. Wilton, 1999, The Journal of Biological Chemistry.

Tryptophan-containing mutant of human (group IIa) secreted phospholipase A2 has a dramatically increased ability to hydrolyze phosphatidylcholine vesicles and cell membranes.

R. Othman, S. Baker, D. Wilton, 1998, Biochemistry.

The antibacterial properties of secreted phospholipases A(2).

D. Wilton, A. Buckland, A. G. Buckland, 2000, Biochimica et biophysica acta.

The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin.

D. Wilton, A. Thumser, J. Voysey, 1994, The Biochemical journal.

A Catalytically Independent Physiological Function for Human Acute Phase Protein Group IIA Phospholipase A2

D. Wilton, C. Barton, Charles N. Birts, 2008, Journal of Biological Chemistry.

A comparison of the molecular species compositions of mammalian lung surfactant phospholipids.

A. Postle, D. Wilton, E. Heeley, 2001, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

Phospholipases A2: structure and function

D. Wilton, 2005 .

Annexins and phospholipases

D. Wilton, A. Buckland, A. G. Buckland, 2003 .

The Antibacterial Properties of Secreted Phospholipases A2

M. Gelb, R. Koduri, D. Wilton, 2002, The Journal of Biological Chemistry.

Bacterial cell membrane hydrolysis by secreted phospholipases A(2): a major physiological role of human group IIa sPLA(2) involving both bacterial cell wall penetration and interfacial catalysis.

D. Wilton, E. Heeley, A. Buckland, 2000, Biochimica et biophysica acta.

1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIA phospholipase A: X-ray structure of the complex and interfacial selection of inhibitors from a structural library.

B. Stoddard, M. Gelb, R. Koduri, 1999, Bioorganic & medicinal chemistry letters.

Catalytic and non-catalytic functions of human IIA phospholipase A2.

D. Wilton, C. Barton, Charles N. Birts, 2010, Trends in biochemical sciences.

Comparison of the catalytic properties of phospholipase A2 from pancreas and venom using a continuous fluorescence displacement assay.

D. Wilton, A. Kinkaid, David C. Wilton, 1991, The Biochemical journal.

Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates.

S. Baker, D. Wilton, M. Jain, 1997, Biochemistry.

Phospholipase D and phosphatidic acid enhance the hydrolysis of phospholipids in vesicles and in cell membranes by human secreted phospholipase A2.

R. Othman, D. Wilton, J. Voysey, 1998, Biochimica et biophysica acta.

Enhanced hydrolysis of phosphatidylcholine by human group II non-pancreatic secreted phospholipase A2 as a result of interfacial activation by specific anions. Potential role of cholesterol sulphate.

D. Wilton, A. Kinkaid, 1995, The Biochemical journal.

Cholesterol-3-sulfate enhances phospholipase A2 activity by promoting interfacial binding.

D. Wilton, J. Voysey, A. Kinkaid, 1997, Biochemical Society transactions.

Human non-pancreatic (group II) secreted phospholipase A2 expressed from a synthetic gene in Escherichia coli: characterisation of N-terminal mutants.

R. Othman, S. Baker, D. Wilton, 1996, Biochimica et biophysica acta.

Studies on fatty acid-binding proteins. The detection and quantification of the protein from rat liver by using a fluorescent fatty acid analogue.

D. Wilton, T. C. Wilkinson, 1986, The Biochemical journal.

Effect on ligand binding of arginine mutations in recombinant rat liver fatty acid-binding protein.

D. Wilton, A. Thumser, C. Evans, 1994, The Biochemical journal.

Mammalian secreted and cytosolic phospholipase A2 show different specificities for phospholipid molecular species.

A. Postle, D. Wilton, G. Burdge, 1995, The international journal of biochemistry & cell biology.

Inhibition of secreted phospholipases A2 by annexin V. Competition for anionic phospholipid interfaces allows an assessment of the relative interfacial affinities of secreted phospholipases A2.

D. Wilton, A. Buckland, A. G. Buckland, 1998, Biochimica et biophysica acta.

Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2.

D. Wilton, A. Buckland, A. Kinkaid, 1998, Biochimica et biophysica acta.

The binding of natural and fluorescent lysophospholipids to wild-type and mutant rat liver fatty acid-binding protein and albumin.

D. Wilton, A. Thumser, 1995, The Biochemical journal.

Inhibition of human cytosolic phospholipase A2 by human annexin V.

D. Wilton, A. Buckland, A. G. Buckland, 1998, The Biochemical journal.

Chapter 11 Phospholipases

D. Wilton, M. Waite, 2002 .

Combined effects of sphingomyelin and cholesterol on the hydrolysis of emulsion particle triolein by lipoprotein lipase.

D. Wilton, L. I. Lobo, 1997, Biochimica et biophysica acta.

The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.

S. Skinner, D. Wilton, K. A. Munday, 1968, The Biochemical journal.

The conversion of 7-dehydrocholesterol into cholesterol.

D. Wilton, K. A. Munday, M. Akhtar, 1966, The Biochemical journal.

Action of Human Group IIa Secreted Phospholipase A2on Cell Membranes

M. Gelb, Y. Snitko, R. Koduri, 1998, The Journal of Biological Chemistry.

The effect of charge reversal mutations in the α-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids

R. Hagan, D. Wilton, J. K. Davies, 2002, Molecular and Cellular Biochemistry.

The stereochemistry of the reduction of mevaldic acid‐coenzyme A hemithioacetal by rat liver 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase

D. Wilton, A. Beedle, K. A. Munday, 1972, FEBS letters.

The mechanism of the bond forming events in pyridine nucleotide linked oxidoreductases. Studies with epoxide inhibitors of lactic dehydrogenase and beta-hydroxybutyrate dehydrogenase.

D. Wilton, D. Bloxham, I. Giles, 1975, Biochemistry.

Cloning and Expression of Cytosolic Phospholipase A2 (cPLA2) and a Naturally Occurring Variant

I. Taylor, G. A. Ritchie, D. Campbell, 1996 .

Cloning and expression of cystolic phospholipase A2 (cPLA2) and a naturally occurring variant. Phosphorylation of Ser505 of recombinant cPLA2 by p42 mitogen-activated protein kinase results in an increase in specific activity.

I. Taylor, R. Gordon, G. A. Ritchie, 1996, European journal of biochemistry.

The formation and reduction of the 14,15-double bond in cholesterol biosynthesis.

D. Wilton, K. A. Munday, M. Akhtar, 1971, The Biochemical journal.

The pathway for the removal of the 15α-methyl group of lanosterol: The role of Lanost-8-ene-3β,32-diol in cholesterol biosynthesis

D. Wilton, M. Akhtar, R. B. Boar, 1977 .

Mechanism of reduction of double bonds in biological systems: conversion of desmosterol into cholesterol

D. Wilton, A. Rahimtula, K. A. Munday, 1969 .

Rat liver mitochondrial phospholipase A2 is an endotoxin-stimulated membrane-associated enzyme of Kupffer cells which is released during liver perfusion.

D. Vance, G. Hatch, D. Wilton, 1993, The Biochemical journal.

Substrate activation in pyridine nucleotide-linked reactions: illustrations from the steroid field

D. Wilton, A. Rahimtula, M. Akhtar, 1972, Proceedings of the Royal Society of London. Series B. Biological Sciences.

The stereochemistry of hydrogen transfer from reduced nicotinamide-adenine dinucleotide phosphate in the reduction of ethylenic linkages during cholesterol biosynthesis.

D. Wilton, M. Akhtar, I. Watkinson, 1970, Biochemical Journal.

The stereochemistry of hydrogen transfer from NADPH catalysed by 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver.

D. Wilton, A. Beedle, K. A. Munday, 1972, European journal of biochemistry.

Modification of pig heart lactate dehydrogenase with methyl methanethiosulphonate to produce an enzyme with altered catalytic activity.

D. Wilton, D. Bloxham, 1977, The Biochemical journal.

The substrate activation in some pyridine nucleotide linked enzymic reactions. The conversion of desmosterol into cholesterol.

D. Wilton, A. Rahimtula, M. Akhtar, 1971, European journal of biochemistry.

Studies on the mechanism and regulation of C-4 demethylation in cholesterol biosynthesis. The role of adenosine 3':5'-cyclic monophosphate.

D. Wilton, D. Bloxham, M. Akhtar, 1971, The Biochemical journal.

The interaction of liver fatty-acid-binding protein (FABP) with anionic phospholipid vesicles: is there extended phospholipid anchorage under these conditions?

R. Hagan, D. Wilton, Jane Worner-Gibbs, 2008, The Biochemical journal.

Tryptophan Insertion Mutagenesis of Liver Fatty Acid-binding Protein

R. Hagan, D. Wilton, Jane Worner-Gibbs, 2005, Journal of Biological Chemistry.

Effect of Charge Reversal Mutations on the Ligand- and Membrane-binding Properties of Liver Fatty Acid-binding Protein*

R. Hagan, D. Wilton, J. K. Davies, 2002, The Journal of Biological Chemistry.

Binding of recombinant rat liver fatty acid-binding protein to small anionic phospholipid vesicles results in ligand release: a model for interfacial binding and fatty acid targeting.

D. Wilton, A. Thumser, J. K. Davies, 1999, Biochemistry.

Studies on fatty-acid-binding proteins. The purification of rat liver fatty-acid-binding protein and the role of cysteine-69 in fatty acid binding.

D. Wilton, 1989, The Biochemical journal.

Anionic phospholipids, interfacial binding and the regulation of cell functions.

D. Wilton, A. Buckland, A. G. Buckland, 2000, Biochimica et biophysica acta.

Monoacylglycerol binding to human serum albumin: evidence that monooleoylglycerol binds at the dansylsarcosine site.

D. Wilton, A. Thumser, A. Buckland, 1998, Journal of lipid research.

Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2.

M. Gelb, D. Wilton, N. Giles, 2003, Biochemistry.

Compartmentalisation and characteristics of a Ca2+-dependent phospholipase A2 in human colon mucosa.

D. Wilton, K. Hillier, A. Kinkaid, 1997, Biochemical pharmacology.

Site-directed mutagenesis of citrate synthase; the role of the active-site aspartate in the binding of acetyl-CoA but not oxaloacetate.

P. Handford, D. Wilton, S. S. Ner, 1988, Biochimica et biophysica acta.

Immunological identity of rat liver cytosolic heme-binding protein with purified and recombinant liver fatty acid binding protein by western blots of two-dimensional gels.

D. Wilton, U. Muller-eberhard, S. Iwahara, 1994, Biochemical and biophysical research communications.

Spectroscopic resolution of drug binding sites in biological membranes

D. Wilton, K. P. Ghiggino, D. Phillips, 1978 .

Age, obesity and hyperglycaemia: Activation of innate immunity initiates a series of molecular interactions involving anionic surfaces leading to COVID-19 morbidity and mortality

D. Wilton, Charles N. Birts, 2021, Medical Hypotheses.

A novel olefinic rearrangement. The enzymic conversion of cholesta-7,9-dien-3 -ol into cholesta-8,14-dien-3 -ol.

D. Wilton, A. Rahimtula, M. Akhtar, 1972, The Biochemical journal.

The obligatory intermediacy of a cholesta-5,7-diene system in the hepatic biosynthesis of cholesterol.

D. Wilton, K. A. Munday, M. Akhtar, 1966, The Biochemical journal.

The organisation of cholesterol and ergosterol in lipid bilayers based on studies using non-perturbing fluorescent sterol probes.

D. Wilton, J. Rogers, A. Lee, 1979, Biochimica et biophysica acta.

The chemical modification of cysteine-69 of rat liver fatty acid-binding protein (FABP): a fluorescence approach to FABP structure and function

D. Wilton, C. Evans, 2004, Molecular and Cellular Biochemistry.

A fluorescence displacement assay for the measurement of arachidonoyl ethanolamide (anandamide) and oleoyl amide (octadecenoamide) hydrolysis.

D. Wilton, A. Thumser, J. Voysey, 1997, Biochemical pharmacology.

Anionic phospholipids and the regulation of cell functions.

D. Wilton, 1998, Biochemical Society transactions.

The incorporation of a 15β-hydrogen atom from the medium in cholesterol biosynthesis

D. Wilton, A. Rahimtula, M. Akhtar, 1969 .

The stereochemistry of hydrogen elimination from C-7 in cholesterol and ergosterol biosynthesis.

D. Wilton, A. Rahimtula, D C Wilton, 1970, The Biochemical journal.

The removal of the 14-methyl group in cholesterol biosynthesis

D. Wilton, A. Rahimtula, K. A. Munday, 1968 .

The status of C-6, C-7, C-15 and C-16 hydrogen atoms in cholesterol biosynthesis.

D. Wilton, A. Rahimtula, K. A. Munday, 1969, European journal of biochemistry.

The reversibility of the Δ8-cholestenol–Δ7-cholestenol isomerase reaction in cholesterol biosynthesis

David C. Wilton, D. Wilton, A. Rahimtula, 1969 .

Potentiation of Tumor Necrosis Factor α-induced Secreted Phospholipase A2 (sPLA2)-IIA Expression in Mesangial Cells by an Autocrine Loop Involving sPLA2 and Peroxisome Proliferator-activated Receptor α Activation*

M. Gelb, J. Pfeilschifter, G. Lambeau, 2003, Journal of Biological Chemistry.

Effect of lipid composition on lipoprotein lipase activity measured by a continuous fluorescence assay: effect of cholesterol supports an interfacial surface penetration model.

D. Wilton, L. I. Lobo, 1997, The Biochemical journal.

The inhibition of cholesterol biosynthesis in MRC-5 fibroblasts in culture by cholesta-5,7,9-trien-3 beta-ol.

D. Wilton, V. Shakespeare, 1980, Biochemical and biophysical research communications.

A study of the 14 kDa phospholipase A2 from rat liver using a continuous fluorescent displacement assay for the enzyme.

D. Wilton, A. Kinkaid, 1992, Biochemical Society transactions.

A continuous fluorescence displacement assay for the measurement of phospholipase A2 and other lipases that release long-chain fatty acids.

D. Wilton, 1990, The Biochemical journal.

The hydrolysis of phosphatidyl-alcohols by phospholipases A2: effect of head group size and polarity.

D. Wilton, A. Kinkaid, 1997, Biochemical pharmacology.

Rapid, Sensitive FluorometricDeterminationof Serum Triglycerideby Measuring Lipase-LiberatedFatty Acids

D. Wilton, J. Voysey, 1994 .

Rapid, sensitive fluorometric determination of serum triglyceride by measuring lipase-liberated fatty acids.

D. Wilton, J. Voysey, 1994, Clinical chemistry.

A continuous fluorescence-displacement assay for triacylglycerol lipase and phospholipase C that also allows the measurement of acylglycerols.

D. Wilton, 1991, The Biochemical journal.

Natural ligand binding and transfer from liver fatty acid binding protein (LFABP) to membranes.

R. Hagan, D. Wilton, B. Córsico, 2010, Biochimica et biophysica acta.

Studies on fatty acid-binding proteins. The binding properties of rat liver fatty acid-binding protein.

D. Wilton, T. C. Wilkinson, 1987, The Biochemical journal.

Comparison of the properties of human group II phospholipase A2 with other secretory phospholipases.

D. Wilton, A. Kinkaid, 1994, Biochemical Society transactions.

The role of a cholesta-8,14-dien-3β-ol system in cholesterol biosynthesis

D. Wilton, A. Rahimtula, K. A. Munday, 1969 .

Studies on the biosynthesis of tetrahymanol in Tetrahymena pyriformis. The mechanism of inhibition by cholesterol.

D. Wilton, A. Beedle, K. A. Munday, 1974, Biochemical Journal.

The role of squalene synthetase in the inhibition of tetrahymanol biosynthesis by cholesterol inTetrahymena pyriformis

D. Wilton, Colin F. Warburg, Marwa Wakeel, 1982, Lipids.

The reversibility of the delta8-cholestenol-delta7-cholestenol isomerase reaction in cholesterol biosynthesis.

D. Wilton, A. Rahimtula, M. Akhtar, 1969, The Biochemical journal.

The fatty acid analogue 11-(dansylamino)undecanoic acid is a fluorescent probe for the bilirubin-binding sites of albumin and not for the high-affinity fatty acid-binding sites.

D. Wilton, David C. Wilton, 1990, The Biochemical journal.

Liver fatty acid binding protein (FABP) binds to anionic phospholipid vesicles with release of ligand.

D. Wilton, A. Thumser, J. K. Davies, 1998, Biochemical Society transactions.

An apparent lack of stereospecificity in the reaction catalysed by deoxyribose 5-phosphate aldolase due to methyl-group rotation and enolization before product release.

D. Wilton, D. Corina, 1976, Biochemical Journal.

The binding of cholesterol and bile salts to recombinant rat liver fatty acid-binding protein.

D. Wilton, A. Thumser, 1996, Biochemical Journal.

Natural ligand binding and transfer from liver fatty acid binding protein (LFABP) to membranes.

R. Hagan, D. Wilton, B. Córsico, 2010, Biochimica et biophysica acta.

A detailed investigation of the properties of lactate dehydrogenase in which the 'Essential' cysteine-165 is modified by thioalkylation.

D. Wilton, D. Bloxham, R. Sharma, 1979, The Biochemical journal.

CHAPTER 11 – Phospholipases

D. Wilton, 2008 .

The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism.

S. Wood, S. Baker, D. Wilton, 2002, Biochemistry.

Studies on fatty acid-binding proteins. Changes in the concentration of hepatic fatty acid-binding protein during development in the rat.

D. Wilton, T. C. Wilkinson, M. Sheridan, 1987, The Biochemical journal.

Could anionic LDL be a ligand for RAGE and TREM2 in addition to LOX-1 and thus exacerbate lung disease and dementia?

D. Wilton, Charles N. Birts, 2023, Biochimica et biophysica acta. Molecular basis of disease.