Wei Li

发表

The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics

Wei-Chang Fu, Bangyi Zhao, Wei Li, 2020, Frontiers in Chemistry.

Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.

Wei Li, Xicheng Yang, Jian Shen, 2018, European journal of medicinal chemistry.

Discovery of aryl-piperidine derivatives as potential antipsychotic agents using molecular hybridization strategy.

Wei-Chang Fu, Bangyi Zhao, Wei Li, 2020, European journal of medicinal chemistry.

Microwave‐Assisted Radical Insertion/Cyclization of Vinyl Isocyanides for the Synthesis of Multi‐Substituted Isoquinolines

Wei Li, Hao Chen, Lin-qian Yu, 2017 .

Microwave-Assisted Synthesis of Phenanthridines by Radical Insertion/Cyclization of Biphenyl Isocyanides.

Wei Li, Qiong Xie, Liming Shao, 2016, The Journal of organic chemistry.

Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.

Wei-Chang Fu, Wei Li, Lin-qian Yu, 2021, Journal of medicinal chemistry.

Discovery of Potent and Selective Agonists of δ Opioid Receptor by Revisiting the "Message-Address" Concept.

Wei-Chang Fu, Wei Li, Xiaoqin Huang, 2016, ACS medicinal chemistry letters.

3D–QSAR studies of orvinol analogs as κ-opioid agonists

Qiong Xie, Yun Tang, Wei Li, 2006 .

Synthesis and evaluation of κ-opioid receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7α-phenyl-6α,14α-endo-etheno-tetrahydrothebaine with substituted o-, m- and p-amino group

Yun Tang, Hong-Zhuan Chen, Yu Qiu, 2011, Medicinal Chemistry Research.

Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion

Wei Li, Jing Chen, Liming Shao, 2021, Acta Pharmacologica Sinica.

The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent κ-Opioid Agonistic Activities.

Wei-Chang Fu, Yonghui Wang, Wei Li, 2017, ACS chemical neuroscience.

Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands

Wei-Chang Fu, Wei Li, Jing-Gen Liu, 2015, Acta Pharmacologica Sinica.

Functional reversal of (−)‐Stepholidine analogues by replacement of benzazepine substructure using the ring‐expansion strategy

Lili Xu, Xuechu Zhen, Wei-Chang Fu, 2016, Chemical biology & drug design.

SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity.

Wei-Chang Fu, Wei Li, Siyuan Tang, 2022, Journal of medicinal chemistry.

7β-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues.

Wei-Chang Fu, Wei Li, Deng-Qi Xue, 2018, Bioorganic & medicinal chemistry.

Theoretical and NMR investigations on the conformations of ( − )-meptazinol hydrochloride in solution

Yun Tang, C. Lau, Lili Xu, 2013 .

A convenient aqueous copper-catalyzed synthesis of quinazolinones

Yonghui Wang, Wei Li, Qiong Xie, 2015 .

Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.

Wei-Chang Fu, Wei Li, Chen Zhu, 2020, European journal of medicinal chemistry.

Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis

Wei-Chang Fu, Hong-Zhuan Chen, Z. Xia, 2017, Journal of enzyme inhibition and medicinal chemistry.

Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.

Yun Tang, Wei-Chang Fu, Wei Zhou, 2008, Journal of medicinal chemistry.

Microwave-assisted synthesis of hydroxyl-containing isoquinolines by metal-free radical cyclization of vinyl isocyanides with alcohols.

Wei Li, Haihua Yu, Hao Chen, 2017, Organic & biomolecular chemistry.

Conformational re-analysis of (+)-meptazinol: an opioid with mixed analgesic pharmacophores

C. Lau, Wei Li, Qiong Xie, 2006, Acta Pharmacologica Sinica.

Structural comparisons of meptazinol with opioid analgesics

Wei Li, Yan Chen, Z. Qiu, 2005, Acta Pharmacologica Sinica.

Molecular modeling and 3D-QSAR studies of indolomorphinan derivatives as kappa opioid antagonists.

Yun Tang, Zhui-Bai Qiu, Yun Tang, 2006, Bioorganic & medicinal chemistry.

Major Depressive Disorder and Kappa Opioid Receptor Antagonists

Wei Li, Renyu Liu, Xicheng Yang, 2016, Translational perioperative and pain medicine.

Investigation of the binding mode of (−)-meptazinol and bis-meptazinol derivatives on acetylcholinesterase using a molecular docking method

Yun Tang, Wei Li, Qiong Xie, 2006, Journal of molecular modeling.

Synthetic access to isoxazoline-functionalized isoquinolines via microwave-assisted iminoxyl radical-participated cascade cyclization of vinyl isocyanides.

Wei Li, Hao Chen, Lin-qian Yu, 2018, Organic & biomolecular chemistry.

Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands

Wei Li, Hui Sun, Xicheng Yang, 2016, Acta Pharmacologica Sinica.

Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.

Yun Tang, Wei-Chang Fu, Wei Li, 2010, Bioorganic & medicinal chemistry letters.

Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property.

Wei Zhou, Z. Xia, Wei Li, 2012, Toxicology and applied pharmacology.

Design, Synthesis, and Structure-Activity Relationship Studies of Novel Indolyalkylpiperazine Derivatives as Selective 5-HT1A Receptor Agonists

Chen Zhu, Weiqing Peng, Wenli Wang, 2020, J. Chem. Inf. Model..

Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone.

Wei-Chang Fu, Wei Li, Qiong Xie, 2023, European journal of medicinal chemistry.

Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic.

Wei-Chang Fu, Wei Li, Xiangguo Meng, 2021, Journal of Medicinal Chemistry.

Triple reuptake inhibitors: a patent review (2006 – 2012)

Wei Li, H. Yin, Qiong Xie, 2014, Expert opinion on therapeutic patents.

Molecular insights into the D1R agonist and D2R/D3R antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations.

Wei-Chang Fu, Wei Li, Peng Du, 2012, The journal of physical chemistry. B.

Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based κ Opioid Receptor (κOR) Agonists Using the Strategy of Bridging.

Wei-Chang Fu, Wei Li, Li-ying Xiao, 2021, ACS chemical neuroscience.

Additive-Free Radical Cascade Reaction of Oxime Esters：Synthesis of Pyrroline-Functionalized Phenanthridines.

Wei Li, L. Shao, Qian He, 2020, The Journal of organic chemistry.

Molecular insights into the D1R agonist and D2R/D3R antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations.

Wei-Chang Fu, Wei Li, Peng Du, 2012, The journal of physical chemistry. B.

Discovery of an Ortho-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect.

Wei Li, Liming Shao, Qian He, 2024, Journal of medicinal chemistry.