S. Husbands

发表

Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.

S. Breeden, M. Aceto, C. Neilan, 2004, European journal of pharmacology.

Structural insights into μ-opioid receptor activation

Stephen M. Husbands, A. J. Venkatakrishnan, Ron O. Dror, 2015, Nature.

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2‐(4,5‐Dihydro‐1H‐imidazol‐2‐yl)‐1‐ methyl‐1H‐indole), for the imidazoline2 binding site

E. Robinson, D. Nutt, A. Hudson, 2012, Synapse.

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain

Yiyun Huang, D. Nutt, R. Carson, 2014, The Journal of Nuclear Medicine.

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Site in Human Brain

D. Nutt, J. Passchier, E. Rabiner, 2014, The Journal of Nuclear Medicine.

Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter.

W. Bowen, A. Newman, S. Husbands, 1997, Journal of medicinal chemistry.

Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.

W. Bowen, A. Newman, S. Husbands, 1999, Journal of medicinal chemistry.

The therapeutic potential of small-molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel

S. Husbands, D. Sheppard, P. Khuituan, 2014 .

Novel Selective Compounds for the Investigation of Imidazoline Receptors a

D. Nutt, A. Hudson, R. Tyacke, 1999, Annals of the New York Academy of Sciences.

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.

P. W. Czoty, F. Hsu, S. Husbands, 2019, British journal of anaesthesia.

A non‐rewarding, non‐aversive buprenorphine/naltrexone combination attenuates drug‐primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm

R. Guy, M. Delgado-Charro, S. Husbands, 2014, Addiction biology.

Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity

I. Pogozheva, Vinod Kumar, H. Mosberg, 2014, Journal of medicinal chemistry.

Pharmacology of mixed NOP/mu ligands

S. Husbands, N. Zaveri, L. Toll, 2013 .

Effects of Spinally Administered Bifunctional Nociceptin/Orphanin FQ Peptide Receptor/μ-Opioid Receptor Ligands in Mouse Models of Neuropathic and Inflammatory Pain

S. Husbands, N. Zaveri, M. Ko, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Buprenorphine and related orvinols

S. Husbands, 2013 .

Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine.

S. Husbands, L. Toll, W. Polgar, 2011, Journal of medicinal chemistry.

Activities of mixed NOP and μ‐opioid receptor ligands

G. Calo’, S. Husbands, J. Lewis, 2008, British journal of pharmacology.

Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.

A. Newman, S. Husbands, A. Thurkauf, 2001, Journal of medicinal chemistry.

Fast analytical methods to profile three seized ketamine samples

I. S. Blagbrough, S. Husbands, M. Alotaibi, 2011 .

Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins.

Richard R Neubig, R. Neubig, Levi L. Blazer, 2012, ACS medicinal chemistry letters.

A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins.

R. Neubig, Levi L. Blazer, S. Husbands, 2011, Biochemistry.

Immunopharmacology and in fl ammation Anti-in fl ammatory effect of dual nociceptin and opioid receptor agonist , BU 08070 , in experimental colitis in mice

R. Kordek, J. Fichna, S. Husbands, 2015 .

BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism.

S. Breeden, M. Aceto, C. Neilan, 2005, European journal of pharmacology.

Derivatives of flavonepenthone: Kappa opioid receptor selectivity in an N-methylmorphinan

S. Husbands, J. Lewis, F. Bermejo, 1999 .

Structural determinants of opioid activity in the orvinols and related structures: ethers of orvinol and isoorvinol.

A. Coop, S. Husbands, L. Toll, 2000, Journal of medicinal chemistry.

14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles.

S. Husbands, J. Lewis, J. Traynor, 2003, Journal of medicinal chemistry.

Opioid binding and in vitro profiles of a series of 4-hdroxy-3-methoxyindolomorphinans. Transformation of a delta-selective ligand into a high affinity kappa-selective ligand by introduction of a 5,14-substituted bridge.

S. Husbands, J. Lewis, P. Grundt, 2003, Journal of Medicinal Chemistry.

The novel μ‐opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

S. Husbands, W. Dewey, E. Kelly, 2018, British journal of pharmacology.

Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan.

S. Srivastava, M. Aceto, S. Husbands, 2004, Journal of medicinal chemistry.

[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.

A. Newman, S. Husbands, T. Kopajtic, 2001, Bioorganic & medicinal chemistry letters.

β-carboline binding to imidazoline receptors

D. Nutt, R. Glennon, A. Hudson, 2001 .

PPL-138 (BU10038): A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats

S. Husbands, L. Toll, A. Cippitelli, 2022, Neuropharmacology.

Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

E. J. Simon, H. Ueda, M. Bruchas, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Loop diuretics are open‐channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics

S. Husbands, D. Sheppard, P. Khuituan, 2014, British journal of pharmacology.

Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox

S. Husbands, K. Berg, W. Clarke, 2021, Pharmacology research & perspectives.

C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors

Vinod Kumar, S. Husbands, J. Lewis, 2015, Journal of medicinal chemistry.

Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity

Mark P Thomas, M. Aceto, S. Husbands, 2013, Journal of medicinal chemistry.

Research and Development of Opioid-Related Ligands

S. Husbands, M. Ko, 2013 .

Behavioral tasks sensitive to acute abstinence and predictive of smoking cessation success: a systematic review and meta-analysis.

D. Nutt, M. Munafo, M. Fluharty, 2016 .

beta-carboline binding to imidazoline receptors.

D. Nutt, R. Glennon, A. Hudson, 2001, Drug and alcohol dependence.

The Buprenorphine Analogue BU10119 Attenuates Drug-Primed and Stress-Induced Cocaine Reinstatement in Mice

E. Jutkiewicz, S. Husbands, J. Traynor, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible μ Opioid Receptor Antagonist Effects

Mark P Thomas, M. Aceto, L. Harris, 2012, Journal of medicinal chemistry.

OREX-1038: a potential new treatment for pain with low abuse liability and limited adverse effects

S. Husbands, J. Traynor, C. France, 2022, Behavioural pharmacology.

BU 08073 a Buprenorphine Analog with Partial Agonist Activity at mu Receptors in vitro but Long-Lasting Opioid Antagonist Activity in vivo in Mice 1

S. Husbands, N. Fotaki, L. Toll, 2014 .

The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): Characterization of the In Vitro Profile and In Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-Induced Reward

S. Husbands, N. Zaveri, L. Toll, 2011, Journal of Pharmacology and Experimental Therapeutics.

The First Universal Opioid Ligand , ( 2 S )-2-[ ( 5 R , 6 R , 7 R

S. Husbands, N. Zaveri, L. Toll, 2011 .

The First ‘Universal Opioid Ligand’ Characterization of the In Vitro Profile and In Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-induced Reward.

S. Husbands, N. Zaveri, W. Polgar, 2010 .

Proerectile Effects of Dopamine D2-Like Agonists Are Mediated by the D3 Receptor in Rats and Mice

D. Grandy, Shaomeng Wang, R. Sunahara, 2009, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological characterisation of novel α2-adrenoceptor antagonists as potential brain imaging agents

E. Robinson, D. Nutt, A. Hudson, 2004, Neuropharmacology.

BU48: A Novel Buprenorphine Analog That Exhibits δ-Opioid-Mediated Convulsions but Not δ-Opioid-Mediated Antinociception in Mice

A. Coop, S. Husbands, J. Lewis, 2000 .

Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine.

T. Sumpter, S. Husbands, J. Woods, 2000, The Journal of pharmacology and experimental therapeutics.

Identification of ligands selective for central I2-imidazoline binding sites

D. Nutt, A. Hudson, C. Chapleo, 1997, Neurochemistry International.

Pleiotropic Effects of Kappa Opioid Receptor-Related Ligands in Non-human Primates.

S. Husbands, M. Ko, 2020, Handbook of experimental pharmacology.

PPL-138 (BU10038): A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats

S. Husbands, L. Toll, A. Cippitelli, 2022, Neuropharmacology.

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

M. Nader, S. Husbands, H. Ding, 2016, Proceedings of the National Academy of Sciences.

THIS IS THE FINAL DRAFT POST-REFEREEING AND IS ALLOWED TO BE MADE AVAILABLE, WHERE THE HOST INSTITUTION MANDATES IT, AFTER 12 MONTHS EMBARGO

S. Husbands, J. Traynor, Daniel P. Furkert, 2015 .

Characterization of BU09059: a novel potent selective κ-receptor antagonist.

S. Husbands, J. Traynor, Daniel P. Furkert, 2014, ACS chemical neuroscience.

Evaluation of 11 C-BU99008, a Positron Emission Tomography ligand for the Imidazoline 2 binding sites in Rhesus brain

Quelch, Yiyun Huang, D. Nutt, 2013 .

1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Husain A. Naqi, I. S. Blagbrough, S. Husbands, 2019, Analytical Methods.

In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor

S. Husbands, J. Traynor, M. Clark, 2013, Journal of psychopharmacology.

Sex differences in the effect of chronic delivery of the buprenorphine analogue BU08028 on heroin relapse and choice in a rat model of opioid maintenance

Y. Shaham, J. Bossert, S. Husbands, 2021, British journal of pharmacology.

OREX-1019: A Novel Treatment of Opioid Use Disorder and Relapse Prevention

S. Husbands, C. France, G. Cami-Kobeci, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Pyrrolo- and pyridomorphinans: non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists.

S. Husbands, J. Traynor, J. Lewis, 2014, Bioorganic & medicinal chemistry.

Kappa-opioid receptor ligands

S. Husbands, 2004 .

Identification of an imidazoline binding protein: Creatine kinase and an imidazoline-2 binding site

D. Nutt, M. Minchin, A. Hudson, 2009, Brain Research.

Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.

E. Robinson, D. Nutt, A. Hudson, 2000, Bioorganic & medicinal chemistry letters.

19F and 1H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids

Husain A. Naqi, Timothy J. Woodman, I. S. Blagbrough, 2019, Analytical Methods.

Reversal and Prevention of the Respiratory-Depressant Effects of Heroin by the Novel μ-Opioid Receptor Antagonist Methocinnamox in Rhesus Monkeys

S. Husbands, J. Woods, C. France, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Imaging Imidazoline-I2 Binding Sites in Porcine Brain Using 11C-BU99008

D. Nutt, A. Gee, S. Jakobsen, 2013, The Journal of Nuclear Medicine.

Characterization of [3H]Harmane Binding to Rat Whole Brain Membranes

D. Nutt, A. Hudson, P. Delagrange, 2003, Annals of the New York Academy of Sciences.

The effect of 1-(4,5-dihydro-1H-imidazol-2-yl) isoquinoline on monoamine release and turnover in the rat frontal cortex

D. Nutt, A. Hudson, S. Husbands, 2007, Neuroscience Letters.

Morphinan cyclic imines and pyrrolidines containing a constrained phenyl group: High affinity opioid agonists

S. Husbands, J. Lewis, 1995 .

Isolation and Chemical Modification of Clerodane Diterpenoids from Salvia Species as Potential Agonists at the κ‐Opioid Receptor

S. Husbands, J. Traynor, M. Mahon, 2007, Chemistry & biodiversity.

Novel Ligands for the Investigation of Imidazoline Receptors and Their Binding Proteins

E. Robinson, D. Nutt, M. Minchin, 2003, Annals of the New York Academy of Sciences.

Behavioral effects of rimcazole analogues alone and in combination with cocaine.

A. Newman, S. Husbands, T. Kopajtic, 2003, European journal of pharmacology.

Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys

S. Husbands, A. Davenport, M. Ko, 2019, Neuropsychopharmacology.

Effects of Atypical κ-Opioid Receptor Agonists on Intrathecal Morphine-Induced Itch and Analgesia in Primates

S. Husbands, M. Ko, 2009, Journal of Pharmacology and Experimental Therapeutics.

Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile

Mark P Thomas, S. Husbands, L. Toll, 2018, Front. Psychiatry.

Synthesis of novel 1‐substituted [1,3]thiazolo[3,2‐a]‐[1,5]benzodiazepine derivatives from 1,5‐benzodiazepine‐2‐thiones and α‐halogen carbonyl compounds

S. Husbands, R. Jančienė, B. Puodžiūnaitė, 2006 .

Extension of the Nenitzescu reaction to simple ketones provides an efficient route to 1'-alkyl-5'-hydroxynaltrindole analogues, potent and selective delta-opioid receptor antagonists.

S. Srivastava, S. Husbands, J. Lewis, 2005, Journal of medicinal chemistry.

19th international isotope society (UK group) symposium: synthesis & applications of labelled compounds 2010

S. Kitson, J. Herbert, S. Husbands, 2005 .

First asymmetric synthesis of trans-3,4-dimethyl-4-arylpiperidines.

S. Husbands, Daniel P. Furkert, 2007, Organic letters.

Ring constrained analogues of the thevinones; Diels-Alder reactions of thebaines with 1-indenone and methylene cycloalkanones

A. Coop, S. Husbands, J. Lewis, 1995 .

Palladium-mediated oxidative carbonylation reactions for the synthesis of (11) C-radiolabelled ureas.

J. Passchier, A. Gee, S. Husbands, 2014, Journal of labelled compounds & radiopharmaceuticals.

Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer.

Steven Kealey, Christophe Plisson, Nicholas J Long, 2011, Organic & biomolecular chemistry.

Synthesis and in vivo brain distribution of carbon-11-labeled δ-opioid receptor agonists.

Michael R Kilbourn, D. Jewett, S. Husbands, 2010, Nuclear medicine and biology.

4'-Arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity.

S. Srivastava, M. Aceto, S. Husbands, 2002, Journal of medicinal chemistry.

Pharmacological Properties of δ-Opioid Receptor–Mediated Behaviors: Agonist Efficacy and Receptor Reserve

Kathryn E. Livingston, E. Jutkiewicz, K. Rice, 2020, The Journal of Pharmacology and Experimental Therapeutics.

In vitro and ex vivo distribution of [3H]harmane, an endogenous β-carboline, in rat brain

E. Robinson, D. Nutt, A. Hudson, 2006, Neuropharmacology.

Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys

M. Javors, S. Husbands, C. France, 2020, Neuropsychopharmacology.

Methocinnamox Produces Long-Lasting Antagonism of the Behavioral Effects of µ-Opioid Receptor Agonists but Not Prolonged Precipitated Withdrawal in Rats

S. Husbands, C. France, Vanessa Minervini, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Methyl-orvinol—Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome

J. Fichna, S. Husbands, A. Wasilewski, 2017, Pharmacological reports : PR.

Novel mixed NOP/MOP agonist BU08070 alleviates pain and inhibits gastrointestinal motility in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms.

J. Fichna, S. Husbands, M. Sobczak, 2014, European journal of pharmacology.

The orvinols and related opioids--high affinity ligands with diverse efficacy profiles.

S. Husbands, J. Lewis, Stephen M Husbands, 2004, Current pharmaceutical design.

Countermeasures for Preventing and Treating Opioid Overdose

E. Snyder, P. Skolnick, E. Lau, 2020, Clinical pharmacology and therapeutics.

Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors.

R. Neubig, Xi-Ping Huang, Qin Wang, 2015, ACS chemical neuroscience.

Long-Lasting Effects of Methocinnamox on Opioid Self-Administration in Rhesus Monkeys

S. Husbands, J. Woods, C. France, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins

R. Neubig, Levi L. Blazer, S. Husbands, 2010, Molecular Pharmacology.

Guanidino N-Substituted and N,N-Disubstituted Derivatives of the κ-Opioid Antagonist GNTI

S. Husbands, J. Lewis, J. Traynor, 2003 .

Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring.

S. Husbands, J. Lewis, J. Traynor, 2006, Journal of medicinal chemistry.

Transdermal delivery of a buprenorphine/naltrexone combination for the treatment of polydrug abuse

R. Guy, S. Husbands, C. Bailey, 2011 .

Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice

S. Husbands, C. Bailey, S. Bailey, 2015, Journal of psychopharmacology.

A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase

S. Schulz, S. Husbands, L. Toll, 2020, British journal of pharmacology.

Additive Effects of 3,4-Methylenedioxymethamphetamine (MDMA) and Compassionate Imagery on Self-Compassion in Recreational Users of Ecstasy

Sunjeev K Kamboj, C. J. Falconer, I. S. Blagbrough, 2017, Mindfulness.

Behavioural tasks sensitive to acute abstinence and predictive of smoking cessation success: a systematic review and meta‐analysis

D. Nutt, M. Munafo, M. Fluharty, 2016, Addiction.

Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists

Shaomeng Wang, Jianyong Chen, A. Newman, 2007, Psychopharmacology.

Proerectile Effects of Dopamine D2-Like Agonists Are Mediated by the D3 Receptor in Rats and Mice

D. Grandy, Shaomeng Wang, R. Sunahara, 2009, Journal of Pharmacology and Experimental Therapeutics.

¹H, ¹³C, ¹⁵N HMBC, and ¹⁹F NMR spectroscopic characterisation of seized flephedrone, cut with benzocaine.

I. S. Blagbrough, S. Husbands, M. Alotaibi, 2015, Journal of pharmaceutical and biomedical analysis.

Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed kappa/mu opioid receptor antagonist properties, in mice

S. Husbands, C. Bailey, S. Bailey, 2017 .

Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters

W. Bowen, A. Newman, S. Husbands, 2001, Neuropharmacology.

BU08073 a buprenorphine analogue with partial agonist activity at μ‐receptors in vitro but long‐lasting opioid antagonist activity in vivo in mice

S. Husbands, N. Fotaki, L. Toll, 2015, British journal of pharmacology.

Crystal structure of active mu-opioid receptor bound to the agonist BU72

Kathryn E. Livingston, Evan N. Feinberg, R. Dror, 2015 .

Role of G Protein–Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

Sarah L. Withey, C. Chavkin, S. Husbands, 2015, Molecular Pharmacology.

Synthetic Cannabinoid Receptor Agonists Detection Using Fluorescence Spectral Fingerprinting

Benedict C. May, Husain A. Naqi, C. Pudney, 2019, Analytical chemistry.

Functional Studies of Specific Imidazoline‐2 Receptor Ligands

D. Nutt, A. Hudson, S. Husbands, 1995, Annals of the New York Academy of Sciences.

Harmane and harmalan are bioactive components of classical clonidine-displacing substance.

E. Robinson, M. P. Dillon, D. Nutt, 2004, Biochemistry.

Targeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists?

S. Husbands, S. Bailey, S. Bailey, 2018, Neuronal signaling.

Cinnamoyl Derivatives of 7α-Aminomethyl-6,14-endoethanotetrahydrothebaine and 7α-Aminomethyl-6,14-endoethanotetrahydrooripavine and Related Opioid Ligands

A. Neal, M. Aceto, S. Husbands, 2007 .

Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.

A. Neal, M. Aceto, S. Husbands, 2007, Journal of Medicinal Chemistry.

Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones.

S. Husbands, J. Lewis, J. Woods, 2006, Journal of medicinal chemistry.

Cinnamoyl Derivatives of 7α‐Amino‐ and 7α‐(Aminomethyl)‐ N‐(cyclopropylmethyl)‐6,14‐endo‐ethanotetrahydronororipavines are High‐Potency Opioid Antagonists

S. Husbands, J. Lewis, J. Woods, 2000 .

Opioid ligands having delayed long-term antagonist activity: potential pharmacotherapies for opioid abuse.

S. Husbands, J. Lewis, 2003, Mini reviews in medicinal chemistry.

14-Amino-4,5-epoxymorphinan derivatives and their pharmacological actions.

S. Husbands, J. Lewis, 2011, Topics in current chemistry.

14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity.

S. Husbands, J. Woods, J. Traynor, 2009, Journal of medicinal chemistry.

Selective δ-opioid receptor ligands: potential PET ligands based on naltrindole

D. Nutt, A. Hudson, R. Tyacke, 2001 .

3-Deoxyclocinnamox: the first high-affinity, nonpeptide mu-opioid antagonist lacking a phenolic hydroxyl group.

C. Neilan, S. Husbands, J. Woods, 2000, Journal of medicinal chemistry.

3-Alkyl ethers of clocinnamox : Delayed long-term μ-antagonists with variable μ efficacy

M. Aceto, L. Harris, S. Husbands, 1998 .

Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.

W. Bowen, C. George, A. Newman, 2003, Journal of medicinal chemistry.

Author Correction: Structural insights into μ-opioid receptor activation

Kathryn E. Livingston, Evan N. Feinberg, R. Dror, 2020, Nature.

Opioid receptors in GtoPdb v.2023.1 Opioid receptors in GtoPdb v.2023.1

E. J. Simon, H. Ueda, M. Bruchas, 2023 .

Novel approaches for the treatment of psychostimulant and opioid abuse – focus on opioid receptor-based therapies

S. Husbands, C. Bailey, 2014, Expert opinion on drug discovery.

Role of G Protein – Coupled Receptor Kinases 2 and 3 in m-Opioid Receptor Desensitization and Internalization s

Sarah L. Withey, C. Chavkin, S. Husbands, 2015 .

BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice.

A. Coop, S. Husbands, J. Woods, 2000, The Journal of pharmacology and experimental therapeutics.

The development and validation of a human screening model of tobacco abstinence.

D. Nutt, M. Munafo, H. Curran, 2019, Drug and alcohol dependence.

Human Screening Model of Tobacco Abstinence

D. Nutt, M. Munafo, H. Curran, 2019 .

Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series.

S. Husbands, J. Lewis, A. Jales, 2000, Bioorganic & medicinal chemistry letters.

Perchloric acid induced epimerisation of the thevinones: an improved synthesis of 7β-dihydrothevinones

A. Coop, S. Husbands, J. Lewis, 2000 .

The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats

Mikhail N. Koffarnus, A. Newman, S. Husbands, 2009, Psychopharmacology.

The role of the side chain in determining relative delta- and kappa-affinity in C5'-substituted analogues of naltrindole.

S. Husbands, J. Lewis, W. Brandt, 2003, Journal of medicinal chemistry.

Methylation of the enolates of thevinone and some analogues

A. Coop, S. Husbands, J. Lewis, 1995 .

Latent inhibitors part 11. The synthesis of 5-spirocyclopropyl dihydroorotic acid

S. Husbands, W. Fraser, C. Suckling, 1995 .

Opioid receptors in GtoPdb v.2021.3

E. J. Simon, H. Ueda, M. Bruchas, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Photochemical Fingerprinting Is a Sensitive Probe for the Detection of Synthetic Cannabinoid Receptor Agonists; toward Robust Point-of-Care Detection

Benedict C. May, Matthew N. Grayson, R. Crespo‐Otero, 2023, Analytical chemistry.

Latent inhibitors Part 10. The inhibition of carboxypeptidase a by tetrapeptide analogues based on 1-aminocyclopropane carboxylic acid

S. Husbands, C. Suckling, Christopher A. Suckling, 1994 .

Antidepressant‐like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice

S. Husbands, C. Bailey, S. Bailey, 2018, British journal of pharmacology.

Effects of the long-lasting kappa opioid 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl) ethyl] acetamide in a drug discrimination and warm water tail-withdrawal procedure

S. Husbands, J. Lewis, M. Picker, 2005, Behavioural pharmacology.

Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice

S. Husbands, C. Bailey, S. Bailey, 2015, Journal of psychopharmacology.

Pharmacological Properties of d -Opioid Receptor – Mediated Behaviors: Agonist Efficacy and Receptor Reserve s

Kathryn E. Livingston, E. Jutkiewicz, K. Rice, 2020 .

A non‐rewarding, non‐aversive buprenorphine/naltrexone combination attenuates drug‐primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm

R. Guy, M. Delgado-Charro, S. Husbands, 2014, Addiction biology.

In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor

S. Husbands, J. Traynor, M. Clark, 2013, Journal of psychopharmacology.

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain

Yiyun Huang, D. Nutt, R. Carson, 2014, The Journal of Nuclear Medicine.

C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors

Vinod Kumar, S. Husbands, J. Lewis, 2015, Journal of medicinal chemistry.

Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice.

R. Kordek, J. Fichna, S. Husbands, 2015, European journal of pharmacology.

Methocinnamox (MCAM) antagonizes the behavioral suppressant effects of morphine without impairing delayed matching-to-sample accuracy in rhesus monkeys

S. Husbands, C. France, Vanessa Minervini, 2020, Psychopharmacology.

MOLECULAR MODELLING OF FUMARAMIDO AND CINNAMOYLAMIDO DERIVATIVES IN EPOXY-MORPHINANS. CORRELATION WITH PHARMACOLOGICAL PROFILES.

S. Husbands, J. Woods, H. Moynihan, 1995 .

Opus: University of Bath Online Publication Store

S. Husbands, J. Traynor, Mary J. Clark, 2022 .

Pharmaceutical Biomedical Analysis 1 H, 13 C, 15 N HMBC, and 19 F NMR spectroscopic characterisation of seized ﬂephedrone, cut with benzocaine

I. S. Blagbrough, S. Husbands, 2015 .

1H, 13C, 15N HMBC, and 19F NMR spectroscopic characterisation of seized flephedrone, cut with benzocaine

I. S. Blagbrough, S. Husbands, 2015 .

Opus: University of Bath Online Publication Store Article in Press G Model Journal of Pharmaceutical and Biomedical Analysis F Nmr Spectroscopic Characterisation of Seized Flephedrone, Cut with Benzocaine

I. S. Blagbrough, S. Husbands, M. Alotaibi, 2022 .

Opus: University of Bath Online Publication Store This Blockinis Blockinthe Blockinfinal Blockindraft Blockinpost-refereeing Blockinand Blockinis Allowed Blockinto Blockinbe Blockinmade Blockinavailable, Blockinwhere Blockinthe Blockinhost Institution Blockinmandates Blockinit, Blockinafter Blockin1

S. Husbands, J. Traynor, Daniel P. Furkert, 2022 .

Isolation and Chemical Modification of Clerodane Diterpenoids from Salvia Species as Potential Agonists at the κ‐Opioid Receptor

S. Husbands, J. Traynor, M. Mahon, 2007, Chemistry & biodiversity.

Opus: University of Bath Online Publication Store a Non-rewarding, Non-aversive Buprenorphine/naltrexone Combination Attenuates Drug- Primed Reinstatement to Cocaine and Morphine in Rats in a Conditioned Place Preference Paradigm

S. Husbands, A. Taverner, I. E. Ridzwan, 2022 .

Role of G Protein–Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

Sarah L. Withey, C. Chavkin, S. Husbands, 2015, Molecular Pharmacology.

Effects of sex and hydration status on kappa opioid receptor‐mediated diuresis in rats

S. Husbands, Hasnain Lalji, S. Bailey, 2024, Basic & clinical pharmacology & toxicology.

Synthetic cannabinoid receptor agonists are monoamine oxidase‐A selective inhibitors

M. W. van der Kamp, C. Pudney, M. Danson, 2023, The FEBS journal.

Loop diuretics are open‐channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics

S. Husbands, P. Khuituan, Z. Cai, 2014, British Journal of Pharmacology.

BU08073 a buprenorphine analogue with partial agonist activity at μ‐receptors in vitro but long‐lasting opioid antagonist activity in vivo in mice

S. Husbands, N. Fotaki, L. Toll, 2015, British journal of pharmacology.

Opus: University of Bath Online Publication Store Bu08073 a Buprenorphine Analog with Partial Agonist Activity at Mu Receptors in Vitro but Long- Lasting Opioid Antagonist Activity in Vivo in Mice

S. Husbands, W. Polgar, G. Cami-Kobeci, 2022 .

N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) potential delta-opioid receptor PET ligands.

E. Robinson, D. Nutt, A. Hudson, 2002, Nuclear medicine and biology.

Opus: University of Bath Online Publication Store Combined Administration of Buprenorphine and Naltrexone Produces Antidepressant-like Effects in Mice

S. Husbands, C. Bailey, A. Almatroudi, 2022 .