C. Cowan

发表

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Guodong Liu, Catherine Yuan, J. Violin, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Long-Term Biased &bgr;-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy

B. Russell, B. Wolska, C. Cowan, 2017, Circulation.

Biased ligands: pathway validation for novel GPCR therapeutics.

J. Violin, D. Rominger, C. Cowan, 2014, Current opinion in pharmacology.

Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.

J. Violin, B. Wolska, C. Cowan, 2015, Cardiovascular research.

First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

J. Violin, C. Cowan, M. Lark, 2014, Journal of clinical pharmacology.

Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids.

K. Brown, C. Cowan, K. Adkison, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.

C. Cowan, K. Adkison, D. Uehling, 2002, Journal of medicinal chemistry.

Lysophosphatidylcholine inhibits relaxation of rabbit abdominal aorta mediated by endothelium-derived nitric oxide and endothelium-derived hyperpolarizing factor independent of protein kinase C activation.

C. Cowan, R. Steffen, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation*

R. Lefkowitz, Seungkirl Ahn, L. Luttrell, 2006, Journal of Biological Chemistry.

First Clinical Experience with TRV027: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

J. Violin, C. Cowan, M. Lark, 2013, Journal of clinical pharmacology.

Universal Cell-Based Assay for Screening G-Protein-Coupled Receptors

Christine C. Hudson, C. Hudson, C. Cowan, 2006 .

TRANSFLUOR® Provides a Universal Cell-Based Assay for Screening G-Protein–Coupled Receptors

Christine C. Hudson, C. Hudson, C. Cowan, 2005 .

TRVO27, A BETA-ARRESTIN BIASED LIGAND AT THE ANGIOTENSIN 2 TYPE 1 RECEPTOR, PRODUCES RAPID, REVERSIBLE CHANGES IN HEMODYNAMICS IN PATIENTS WITH STABLE SYSTOLIC HEART FAILURE

C. Cowan, M. Lark, D. Soergel, 2013 .

. 5 ] decan-9-yl ] ethyl } ) amine ( TRV 130 ) , for the Treatment of Acute Severe Pain

J. Violin, S. Dewire, D. Yamashita, 2013 .

Quantitative Cell-Based High-Content Screening for Vasopressin Receptor Agonists Using Transfluor®Technology

Christine C. Hudson, R. Ghosh, C. Hudson, 2005, Journal of biomolecular screening.

Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.

J. Violin, S. Dewire, D. Yamashita, 2013, Journal of medicinal chemistry.

4-(Heteroarylthio)-2-biphenylyltetrazoles as nonpeptide angiotensin II antagonists.

C. Cowan, R. Steffen, C. Andrews, 1995, Journal of Medicinal Chemistry.

TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration

J. Violin, D. Rominger, C. Cowan, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists.

K. Brown, C. Cowan, N. Cariello, 2006, Journal of medicinal chemistry.

Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.

S. Dewire, D. Yamashita, D. Rominger, 2013, Journal of medicinal chemistry.