C. Yuan

发表

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Guodong Liu, Catherine Yuan, J. Violin, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic.

K. Ward, K. Erhard, R. Calvo, 2000, Journal of medicinal chemistry.

Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles.

N. Aiyar, D. Behm, S. Douglas, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents

Martha S. Head, Xiayang Qiu, Cheryl A. Janson, 2002, Antimicrobial Agents and Chemotherapy.

Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists

K. Ward, R. Willette, T. Yue, 2003 .

. 5 ] decan-9-yl ] ethyl } ) amine ( TRV 130 ) , for the Treatment of Acute Severe Pain

J. Violin, S. Dewire, D. Yamashita, 2013 .

AN ALTERNATE ENANTIOSPECIFIC SYNTHESIS OF METHYL (S)-7-TERT-BUTOXYCARBONYL-2,3,4,5-TETRAHYDRO-4-METHYL-3-OXO-1H-1,4-BENZODIAZEPINE-2-ACETATE

K. Erhard, C. Yuan, W. Bondinell, 1997 .

Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics.

B. R. Smith, R. Keenan, C. Yuan, 1999, Bioorganic & medicinal chemistry letters.

Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonist with efficacy in a restenosis model

B. Smith, T. Yue, E. Ohlstein, 1998 .

Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists

B. Smith, R. Calvo, R. Keenan, 1998 .

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).

Xiayang Qiu, David J Payne, M. Head, 2002, Journal of medicinal chemistry.

Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series

R. Calvo, R. Keenan, C. Yuan, 1996 .

Regioselective alkylation at the N4 positionof a 3-oxo-1,4-benzodiazepine on solid support

C. Yuan, S. Ross, F. Ali, 2004, Molecular Diversity.

Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.

J. Violin, S. Dewire, D. Yamashita, 2013, Journal of medicinal chemistry.

Substituted oxanes as opioid receptor ligands and methods of using and making same

D. Yamashita, Guodong Liu, Xiao-tao Chen, 2012 .

Development of potent and selective small-molecule human Urotensin-II antagonists.

N. Aiyar, D. Behm, S. Douglas, 2008, Bioorganic & medicinal chemistry letters.

Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.

S. Dewire, D. Yamashita, D. Rominger, 2013, Journal of medicinal chemistry.