D. Soergel

发表

Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

Lynn R. Webster, J. Violin, L. Webster, 2014, PAIN®.

A randomized, phase 2 study investigating TRV130, a biased ligand of the &mgr;-opioid receptor, for the intravenous treatment of acute pain

J. Bolognese, L. Webster, E. Viscusi, 2016, Pain.

GPCR biased ligands as novel heart failure therapeutics.

J. Violin, M. Lark, D. Soergel, 2013, Trends in cardiovascular medicine.

Beta-arrestin-biased ligands at the AT1R: a novel approach to the treatment of acute heart failure

J. Violin, M. Lark, D. Soergel, 2012 .

The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium.

J. Violin, D. Soergel, R. Solaro, 2013, American journal of physiology. Heart and circulatory physiology.

First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

J. Violin, C. Cowan, M. Lark, 2014, Journal of clinical pharmacology.

Biased ligand of the angiotensin II type 1 receptor in patients with acute heart failure: a randomized, double-blind, placebo-controlled, phase IIB, dose ranging trial (BLAST-AHF)

P. Ponikowski, G. Filippatos, G. Felker, 2017, European heart journal.

Biased ligands at G-protein-coupled receptors: promise and progress.

J. Violin, M. Lark, D. Soergel, 2014, Trends in pharmacological sciences.

First Clinical Experience with TRV027: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

J. Violin, C. Cowan, M. Lark, 2013, Journal of clinical pharmacology.

Is plasma renin activity associated with worse outcomes in acute heart failure? A secondary analysis from the BLASTâ•’AHF trial

G. Filippatos, G. Felker, M. Metra, 2019 .

Treatment of spontaneous preterm labour with retosiban: a phase II pilot dose‐ranging study

Timothy H. Montague, D. Soergel, S. Thornton, 2017, British journal of clinical pharmacology.

Maintained contractile reserve in a transgenic mouse model of myocardial stunning.

E. Marbán, D. Soergel, A. Murphy, 2001, American Journal of Physiology. Heart and Circulatory Physiology.

Oliceridine, a Novel G Protein–Biased Ligand at the μ‐Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. II: Simulation of Potential Phase 3 Study Designs Using a Pharmacokinetic/Pharmacodynamic Model

D. Soergel, B. Sadler, F. Skobieranda, 2018, Journal of clinical pharmacology.

TRVO27, A BETA-ARRESTIN BIASED LIGAND AT THE ANGIOTENSIN 2 TYPE 1 RECEPTOR, PRODUCES RAPID, REVERSIBLE CHANGES IN HEMODYNAMICS IN PATIENTS WITH STABLE SYSTOLIC HEART FAILURE

C. Cowan, M. Lark, D. Soergel, 2013 .

(432) Respiratory safety signal with oliceridine (TRV130), a novel μ receptor G protein pathway selective modulator (μ-GPS), vs morphine: a safety analysis of a Phase 2b randomized clinical trial.

N. Singla, D. Soergel, F. Skobieranda, 2016, The journal of pain : official journal of the American Pain Society.

Two‐Part Phase 1 Multiple‐Ascending‐Dose Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of TRV734 in Healthy Adults

D. Soergel, I. James, F. Skobieranda, 2021, Clinical pharmacology in drug development.

A First‐in‐Human Clinical Study With TRV734, an Orally Bioavailable G‐Protein–Biased Ligand at the μ‐Opioid Receptor

D. Soergel, I. James, F. Skobieranda, 2019, Clinical pharmacology in drug development.

APOLLO‐2: A Randomized, Placebo and Active‐Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein–Biased Ligand at the μ‐Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty

M. Demitrack, E. Viscusi, N. Singla, 2019, Pain practice : the official journal of World Institute of Pain.

APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy

E. Viscusi, N. Singla, D. Soergel, 2019, Journal of pain research.

Oliceridine (TRV130), a Novel G Protein–Biased Ligand at the μ‐Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. I: Development of a Pharmacokinetic/Pharmacodynamic Model

D. Soergel, B. Sadler, F. Skobieranda, 2018, Journal of clinical pharmacology.

A randomized, Phase IIb study investigating oliceridine (TRV130), a novel µ-receptor G-protein pathway selective (μ-GPS) modulator, for the management of moderate to severe acute pain following abdominoplasty

N. Singla, D. Soergel, R. Subach, 2017, Journal of pain research.

agonism of the l-opioid receptor by TRV 130 increases analgesia and reduces on-target adverse effects versus morphine : A randomized , double-blind , placebo-controlled , crossover study in healthy

J. Violin, L. Webster, M. Lark, 2014 .

Erratum: Biased ligands at G protein-coupled receptors: promise and progress:[Trends in Pharmacological Sciences 35 (2014) 308-316]

J. Violin, M. Lark, D. Soergel, 2014 .

Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry.

F. Gusovsky, J. Daly, D. Soergel, 1992, Molecular pharmacology.

Frequency- and Afterload-Dependent Cardiac Modulation In Vivo by Troponin I With Constitutively Active Protein Kinase A Phosphorylation Sites

D. Kass, E. Takimoto, D. Soergel, 2004, Circulation research.

Stimulatory effects of maitotoxin on insulin release in insulinoma HIT cells: role of calcium uptake and phosphoinositide breakdown.

F. Gusovsky, J. Daly, D. Soergel, 1990, The Journal of pharmacology and experimental therapeutics.

Cardiorenal Actions of TRV120027, a Novel ß-Arrestin–Biased Ligand at the Angiotensin II Type I Receptor, in Healthy and Heart Failure Canines: A Novel Therapeutic Strategy for Acute Heart Failure

J. Violin, E. Whalen, M. Lark, 2011, Circulation. Heart failure.

Is plasma renin activity associated with worse outcomes in acute heart failure? A secondary analysis from the BLAST‐AHF trial

P. Ponikowski, G. Filippatos, G. Felker, 2019, European journal of heart failure.

TRV120027, a Novel &bgr;-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

J. Violin, M. Lark, D. Soergel, 2012, Circulation. Heart failure.

TRV120027, a Novel Beta-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

M. Lark, D. Soergel, J. Burnett, 2011 .

Augmented systolic response to the calcium sensitizer EMD-57033 in a transgenic model with troponin I truncation.

D. Kass, D. Soergel, A. Murphy, 2004, American journal of physiology. Heart and circulatory physiology.

Heart failure therapeutics on the basis of a biased ligand of the angiotensin-2 type 1 receptor. Rationale and design of the BLAST-AHF study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure).

P. Ponikowski, G. Filippatos, J. Violin, 2015, JACC. Heart failure.

(435) Nausea and vomiting with oliceridine (TRV130), a novel μ receptor G protein Pathway Selective modulator (μ-GPS), vs morphine: an analysis of tolerability from a phase 2b randomized clinical trial.

N. Singla, D. Soergel, F. Skobieranda, 2016, The journal of pain : official journal of the American Pain Society.

Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: an exploratory subgroup analysis of BLAST-AHF

P. Ponikowski, G. Filippatos, G. Felker, 2018, Clinical Research in Cardiology.

Effects of mastoparan and related peptides on phosphoinositide breakdown in HL-60 cells and cell-free preparations.

F. Gusovsky, J. Daly, D. Soergel, 1991, European journal of pharmacology.

Cardiorenal Actions of TRV 120027 , a Novel ß-Arrestin – Biased Ligand at the Angiotensin II Type I Receptor , in Healthy and Heart Failure Canines A Novel Therapeutic Strategy for Acute Heart Failure

J. Violin, E. Whalen, M. Lark, 2011 .

Biased ligands at G-protein-coupled receptors: promise and progress.

M. Lark, D. Soergel, Jonathan D. Violin, 2014, Trends in pharmacological sciences.

Gemini: A Family of Highly Capable Multimodal Models

Tara N. Sainath, Dalia El Badawy, Reinald Kim Amplayo, 2023, ArXiv.

P. Ponikowski, G. Filippatos, G. Felker, 2015, JACC. Heart failure.

Gemini: A Family of Highly Capable Multimodal Models

Tara N. Sainath, Dalia El Badawy, Reinald Kim Amplayo, 2023, ArXiv.

E. Viscusi, N. Singla, D. Soergel, 2019, Journal of pain research.