P. Schiller

R. Roy, P. Schiller, Alexandrine L Martel, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Synthesis and binding characteristics of [3H] H-Tyr-Ticψ[CH2-NH] Cha-Phe-OH, a highly specific and stable δ-opioid antagonist

P. Schiller, I. Kertész, A. Borsodi, 1999, Peptides.

Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics.

P. Schiller, T. M. Nguyen, C. Lemieux, 1999, Journal of receptor and signal transduction research.

TIPP[ψ], a highly selective δ ligand

G. Pasternak, K. Standifer, P. Schiller, 1994, Neuroscience Letters.

Synthesis and binding characteristics of the highly specific, tritiated delta opioid antagonist [3H]TIPP.

P. Schiller, T. M. Nguyen, A. Borsodi, 1993, Life sciences.

A novel cyclic opioid peptide analog showing high preference for mu-receptors.

P. Schiller, T. M. Nguyen, C. Lemieux, 1985, Biochemical and biophysical research communications.

Novel ligands lacking a positive charge for the δ- and μ-opioid receptors

Amos B. Smith, P. Schiller, C. Lemieux, 2000 .

[Dmt(1)]DALDA analogues with enhanced μ opioid agonist potency and with a mixed μ/κ opioid activity profile.

P. Schiller, N. N. Chung, Ziyuan Li, 2014, Bioorganic & medicinal chemistry.

A cyclic enkephalin analog with high in vitro opiate activity.

J. DiMaio, P. Schiller, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice

P. Schiller, T. M. Nguyen, J. Gutkowska, 2016, Obesity.

Matrix-assisted laser desorption/ionization mass spectrometric quantification of the mu opioid receptor agonist DAMGO in ovine plasma.

J. Clapp, D. Desiderio, P. Schiller, 2000, Journal of mass spectrometry : JMS.

Radiosynthesis and in vivo evaluation of the pseudopeptide δ-opioid antagonist [125I]-ITIPP(ψ)

P. Schiller, R. Waterhouse, T. Collier, 2001 .

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.

A. Misicka, P. Kosson, P. Schiller, 2008, Journal of medicinal chemistry.

Synthesis and in vitro opioid activity profiles of DALDA analogues.

P. Schiller, T. M. Nguyen, C. Lemieux, 2000, European journal of medicinal chemistry.

Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile.

P. Schiller, N. N. Chung, D. Tourwé, 1998, Journal of medicinal chemistry.

Opioid peptide analogs with novel activity profiles as potential therapeutic agents for use in analgesia

P. Schiller, C. Lemieux, T. M. Nguyen, 1999 .

Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using the 4-amino-2-benzazepin-3-one scaffold.

P. Kosson, P. Schiller, A. Lipkowski, 2005, The journal of peptide research : official journal of the American Peptide Society.

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.

F. Sommen, T. Meert, P. Kosson, 2015, ACS medicinal chemistry letters.

One-Pot Isomerization–Cross Metathesis–Reduction (ICMR) Synthesis of Lipophilic Tetrapeptides

P. Schiller, D. Tourwé, S. Ballet, 2014, ACS combinatorial science.

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.

M. Cooper, P. Schiller, E. Wynendaele, 2012, Journal of medicinal chemistry.

Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.

P. Schiller, J. Vanden Broeck, F. Porreca, 2011, Journal of medicinal chemistry.

[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.

P. Schiller, Y. Lu, T. M. Nguyen, 2001, Journal of medicinal chemistry.

Opioid peptide-derived analgesics

P. Schiller, 2005, The AAPS Journal.

The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.

P. Schiller, T. M. Nguyen, C. Lemieux, 1999, Biopolymers.

β-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent δ opioid antagonists

P. Schiller, N. N. Chung, D. Tourwé, 2007 .

Renal effects of TAPP, a highly selective μ‐opioid agonist

P. Schiller, J. Gutkowska, 1996, British journal of pharmacology.

Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.

G. Pasternak, C. Neilan, P. Schiller, 2001, European journal of pharmacology.

Protective Effect of a Mitochondria-Targeted Peptide against the Development of Chemotherapy-Induced Peripheral Neuropathy in Mice.

H. Szeto, P. Schiller, M. Shimoyama, 2018, ACS chemical neuroscience.

Transcellular Transport of a Highly Polar 3+ Net Charge Opioid Tetrapeptide

H. Szeto, P. Schiller, Kesheng Zhao, 2003, Journal of Pharmacology and Experimental Therapeutics.

Morphine-like activity of sheep β-lipotropin and of its tryptic fragments

N. Seidah, S. Benjannet, M. Chrétien, 1977 .

species. Localization of immunoreactive synthetic atrial natriuretic factor (ANF) in the heart of various animal

M. Cantin, P. Schiller, J. Gutkowska, 2011 .

A murine monoclonal antibody against rat atrial natriuretic factor (ANF) which cross-reacts with mouse ANF.

M. Cantin, P. Schiller, J. Gutkowska, 1987, Molecular immunology.

Localization of immunoreactive synthetic atrial natriuretic factor (ANF) in the heart of various animal species.

M. Cantin, P. Schiller, J. Gutkowska, 1985, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Natriuretic Factor (ANF) in the Heart of Various

M. Cantin, P. Schiller, J. Gutkowska, 1985 .

Isolated adrenal cells: ACTH11–24, a competitive antagonist of ACTH1–39 and ACTH1–10

R. Schwyzer, P. Schiller, S. Seelig, 1971, FEBS letters.

Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity.

P. Schiller, T. M. Nguyen, C. Lemieux, 1991, Journal of medicinal chemistry.

Endocytic Profiles of δ-Opioid Receptor Ligands Determine the Duration of Rapid but Not Sustained cAMP Responses

G. Piñeyro, P. Schiller, D. Robertson, 2014, Molecular Pharmacology.

Endocytic Profiles of d-Opioid Receptor Ligands Determine the Duration of Rapid but Not Sustained cAMP Responses s

G. Piñeyro, P. Schiller, D. Robertson, 2013 .

[35S]GTPγS binding stimulated by endomorphin-2 and morphiceptin analogs

J. Fichna, A. Janecka, J. do-Rego, 2006 .

Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogs.

J. Fichna, A. Janecka, J. do-Rego, 2004, Biochemical and biophysical research communications.

Enkephalin analogs containing 4,4‐difluoro‐2‐aminobutyric acid: Synthesis and fluorine effect on the biological activity

P. Schiller, N. N. Chung, N. Sewald, 1998, Journal of peptide science : an official publication of the European Peptide Society.

Opioid peptide analogs as pharmacological tools and as potential drugs

P. Schiller, 1995 .

Glycoconjugates of opioid peptides. Synthesis and biological activity of [Leu5]enkephalin related glycoconjugates with amide type of linkage.

Š. Horvat, P. Schiller, N. N. Chung, 2009, International journal of peptide and protein research.

Synthesis and opioid activity profiles of cyclic dynorphin analogs

P. Schiller, C. Lemieux, T. M. Nguyen, 1988 .

CONFORMATIONAL ASPECTS OF THE ENKEPHALIN–OPIATE RECEPTOR INTERACTION

P. Schiller, 1981 .

FRAGMENT OF SHEEP BETA-LIPOTROPIN WITH MORPHINE-LIKE ACTIVITY

N. Seidah, M. Chrétien, C. Gianoulakis, 1976, The Lancet.

Radioimmunoassay of Atrial Natriuretic Factor (ANF) in Rat Atria

M. Cantin, P. Schiller, P. Januszewicz, 1984, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Impact of the prorenin/renin receptor on the development of obesity and associated cardiometabolic risk factors

R. Rabasa-Lhoret, M. Gauthier, P. Schiller, 2014, Obesity.

Rotational syndrome after central injection of C-terminal 7-peptide of cholecystokinin

P. Schiller, J. Mann, R. Boucher, 1980, Pharmacology Biochemistry and Behavior.

Inverse Agonism and Neutral Antagonism at Wild-Type and Constitutively Active Mutant Delta Opioid Receptors

D. Filliol, K. Befort, P. Schiller, 2005, Journal of Pharmacology and Experimental Therapeutics.

Evidence for agonist-induced interaction of angiotensin receptor with a guanine nucleotide-binding protein in bovine adrenal zona glomerulosa.

P. Schiller, J. Gutkowska, A. De Léan, 1984, Molecular pharmacology.

Structure-Activity Relationships of Atrial Natriuretic Peptides

E. Schiffrin, M. Cantin, P. Schiller, 1987 .

Synthesis and biological activity of a linear fragment of the atrial natriuretic factor (ANF).

M. Cantin, P. Schiller, T. M. Nguyen, 1985, Biochemical and biophysical research communications.

Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling.

W. Kroeze, L. Page, T. Yaksh, 2019, Anesthesiology.

TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.

P. Schiller, T. M. Nguyen, C. Lemieux, 1993, Journal of medicinal chemistry.

Solid-Phase Azopeptide Diels-Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation.

P. Schiller, T. M. Nguyen, N. N. Chung, 2019, The Journal of organic chemistry.

Bi- or multifunctional peptide drugs

P. Schiller, 2010 .

Novel µ opioid antagonists derived from the µ opioid agonists endomorphin and [Dmt1]DALDA (H‐Dmt‐D‐Arg‐Phe‐Lys‐NH2)

P. Schiller, N. N. Chung, Tingyou Li, 2020, Chemical biology & drug design.

Bifunctional μ/δ Opioid Peptides: Variation of the Type and Length of the Linker Connecting the Two Components

P. Schiller, C. Lemieux, N. N. Chung, 2012, Chemical biology & drug design.

N‐Methylated Cyclic Enkephalin Analogues Retain High Opioid Receptor Binding Affinity

P. Schiller, C. Lemieux, N. N. Chung, 2010, Chemical biology & drug design.

Cyclic Opioid Peptide Agonists and Antagonists Obtained Via Ring‐Closing Metathesis

P. Schiller, C. Lemieux, N. N. Chung, 2009, Chemical biology & drug design.

Potent Opioid Peptide Agonists Containing 4′‐[N‐((4′‐phenyl)‐phenethyl)carboxamido]phenylalanine (Bcp) in Place of Tyr

P. Schiller, C. Lemieux, T. M. Nguyen, 2008, Chemical biology & drug design.

Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.

P. Schiller, C. Lemieux, N. N. Chung, 2007, Journal of medicinal chemistry.

Synthesis and Characterization of Potent and Selective μ-Opioid Receptor Antagonists, [Dmt1, d-2-Nal4]endomorphin-1 (Antanal-1) and [Dmt1, d-2-Nal4]endomorphin-2 (Antanal-2)

J. Poels, J. Fichna, A. Janecka, 2007 .

Cyclic enkephalin analogs containing various para-substituted phenylalanine derivatives in place of Tyr1 are potent opioid agonists.

P. Schiller, C. Lemieux, N. N. Chung, 2008, The journal of peptide research : official journal of the American Peptide Society.

Dansylated analogues of the opioid peptide [Dmt1]DALDA: in vitro activity profiles and fluorescence parameters.

P. Schiller, B. Zelent, C. Lemieux, 2004, Acta biochimica Polonica.

Highly potent fluorescent analogues of the opioid peptide [Dmt1]DALDA

H. Szeto, P. Schiller, B. Zelent, 2003, Peptides.

Structural Modifications of the N-terminal Tetrapeptide Segment of [D-Ala2]Deltorphin I: Effects on Opioid Receptor Affinities and Activities In Vitro and on Antinociceptive Potency

P. Schiller, C. Lemieux, N. N. Chung, 1997, Peptides.

Structure-activity relationships of dermorphin analogues containing N-substituted amino acids in the 2-position of the peptide sequence.

C. Horváth, P. Schiller, C. Lemieux, 2009, International journal of peptide and protein research.

Profound Spinal Tolerance after Repeated Exposure to a Highly Selective μ-Opioid Peptide Agonist: Role of δ-Opioid Receptors

H. Szeto, P. Schiller, Dunli Wu, 2002 .

In vivo pharmacokinetics of selective mu-opioid peptide agonists.

H. Szeto, D. Desiderio, P. Schiller, 2001, The Journal of pharmacology and experimental therapeutics.

Design, Anti-Hiv Activity, Cellular Pharmacology and Conformation of BCH-189 [(±)3TC], A Novel Nucleoside Analogue

M. Wainberg, J. Kraus, M. Hershfield, 1992 .

Improving the Utility of a Dynorphin Peptide Analogue Using Mannosylated Glycoliposomes

P. Schiller, T. M. Nguyen, A. Lê, 2021, International journal of molecular sciences.

Spontaneous degradation via diketopiperazine formation of peptides containing a tetrahydroisoquinoline-3-carboxylic acid residue in the 2-position of the peptide sequence.

P. Schiller, T. M. Nguyen, B. Marsden, 2009, International journal of peptide and protein research.

Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes

T. Peng, P. Schiller, Wang Wang, 2014, Cardiovascular Diabetology.

The octapeptide angiotensin II adopts a well-defined structure in a phospholipid environment.

P. Schiller, K. Carpenter, B. Wilkes, 1998, European journal of biochemistry.

Aggregation behaviour and Zn2+ binding properties of secretin.

P. Schiller, K. A. Carpenter, 1998, Biochemistry.

Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists

L. Trudeau, G. Balboni, I. Charfi, 2013, Cellular and Molecular Life Sciences.

Structural basis for bifunctional peptide recognition at human δ-Opioid receptor

Anton Barty, Sébastien Boutet, Marc Messerschmidt, 2015, Nature Structural &Molecular Biology.

[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.

P. Schiller, N. N. Chung, Zhen Chen, 2016, Bioorganic & medicinal chemistry letters.

Reverse turn mimics

T. Burks, P. Schiller, R. Walker, 1988 .

Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].

P. Schiller, C. Lemieux, N. N. Chung, 2008, Journal of medicinal chemistry.

Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity.

J. Fichna, A. Janecka, J. do-Rego, 2005, The journal of peptide research : official journal of the American Peptide Society.

Synthesis and biological activities of cyclic lanthionine enkephalin analogues : δ-opioid receptor selective ligands

C. Svensson, T. Yaksh, P. Schiller, 2002 .

Synthesis and activity profiles of atrial natriuretic peptide (ANP) analogs with reduced ring size.

M. Cantin, P. Schiller, A. Deléan, 1986, Biochemical and biophysical research communications.

Conformation-activity relationships of cyclo-constrained mu/delta opioid agonists derived from the N-terminal tetrapeptide segment of dermorphin/deltorphin.

C. Czaplewski, P. Schiller, S. Rodziewicz-Motowidło, 2009, Advances in experimental medicine and biology.

Deltorphin analogs restricted via a urea bridge: structure and opioid activity.

C. Czaplewski, P. Schiller, S. Rodziewicz-Motowidło, 2009, Advances in experimental medicine and biology.

Alterations in biological activities induced by glycation of leucine-enkephalin with different monosaccharide moieties

Š. Horvat, P. Schiller, N. N. Chung, 1996, Letters in Peptide Science.

Synthesis and biological activity profiles of atrial natriuretic factor (ANF) analogs.

M. Cantin, P. Schiller, A. Deléan, 2009, International journal of peptide and protein research.

The Cardiovascular and Renal Effects of the Potent and Highly Selective μ Opioid Agonist [Dmt1]DALDA

P. Schiller, J. Gutkowska, Marek Jankowski, 2004, Journal of cardiovascular pharmacology.

Differential respiratory effects of [Dmt1]DALDA and morphine in mice.

H. Szeto, A. Nakamura, Y. Fukuda, 2005, European journal of pharmacology.

Structure-activity relationships of dynorphin a analogues modified in the address sequence.

P. Schiller, N. N. Chung, J. Cassel, 2003, Journal of medicinal chemistry.

Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure.

J. Poels, J. Fichna, A. Janecka, 2008, Bioorganic & medicinal chemistry letters.

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera

A. Lipkowski, P. Kosson, P. Schiller, 2012, Molecular Brain.

Spectroscopic analysis of [Trp3]-beta-casomorphin analogs. Comparative structure conformation-activity studies.

D. Epps, P. Schiller, N. N. Chung, 2009, International journal of peptide and protein research.

Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA.

N. Shimoyama, H. Szeto, P. Schiller, 2001, The Journal of pharmacology and experimental therapeutics.

Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H‐Dmt‐D‐Arg‐Phe‐Lys‐NH2 in Rat

T. Yaksh, P. Schiller, S. Yamaguchi, 2019, Neuromodulation : journal of the International Neuromodulation Society.

Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor

P. Schiller, T. M. Nguyen, N. N. Chung, 2019, Peptide science.

Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery

T. Yaksh, P. Schiller, T. M. Nguyen, 2018, Scandinavian journal of pain.

A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinity μ Opioid Receptor Antagonists.

J. Wood, T. Coderre, P. Schiller, 2016, Journal of medicinal chemistry.

The bifunctional μ opioid agonist/antioxidant [Dmt(1)]DALDA is a superior analgesic in an animal model of complex regional pain syndrome-type i.

T. Coderre, P. Schiller, T. M. Nguyen, 2015, ACS chemical neuroscience.

Superior Analgesic Effect of H‐Dmt‐D‐Arg‐Phe‐Lys‐NH2 ([Dmt1]DALDA), a Multifunctional Opioid Peptide, Compared to Morphine in a Rat Model of Neuropathic Pain

H. Szeto, P. Schiller, M. Shimoyama, 2012, Chemical biology & drug design.

Bi- or multifunctional opioid peptide drugs.

P. Schiller, 2010, Life sciences.

Differential Analgesic Effects of a Mu-Opioid Peptide, [Dmt1]DALDA, and Morphine

Y. Tagaito, H. Szeto, P. Schiller, 2008, Pharmacology.

Comparison of [Dmt1]DALDA and DAMGO in Binding and G Protein Activation at μ, δ, and κ Opioid Receptors

H. Szeto, P. Schiller, X. Qian, 2003, Journal of Pharmacology and Experimental Therapeutics.

Characterization of the Binding of [3H][Dmt1]H-Dmt-d-Arg-Phe-Lys-NH2, a Highly Potent Opioid Peptide

G. Pasternak, C. Neilan, P. Schiller, 2003, Journal of Pharmacology and Experimental Therapeutics.

Differential sensitivities of mouse strains to morphine and [Dmt1]DALDA analgesia

G. Pasternak, J. Pintar, M. Ansonoff, 2003, Brain Research.

DALDA AND DAMGO IN BINDING AND G PROTEIN ACTIVATION AT MU , DELTA AND KAPPA OPIOID RECEPTORS

H. Szeto, P. Schiller, X. Qian, 2003 .

COMPARISON OF [DMT]DALDA AND DAMGO IN BINDING AND G PROTEIN ACTIVATION AT MU, DELTA AND KAPPA OPIOID RECEPTORS

H. Szeto, P. Schiller, X. Qian, 2003 .

Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity.

P. Schiller, T. M. Nguyen, C. Lemieux, 1989, Journal of medicinal chemistry.

Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.

J. DiMaio, P. Schiller, T. M. Nguyen, 1982, Journal of medicinal chemistry.

Unsulfated C-terminal 7-peptide of cholecystokinin: a new ligand of the opiate receptor.

P. Schiller, M. Bodanszky, D. Horrobin, 1978, Biochemical and biophysical research communications.

Systemic and Spinal Analgesic Activity of a δ-Opioid-Selective Lanthionine Enkephalin Analog

C. Svensson, T. Yaksh, P. Schiller, 2003, Journal of Pharmacology and Experimental Therapeutics.

Synthesis of 4-amino-3-oxo-tetrahydroazepino[3,4-b]indoles: new conformationally constrained Trp analogs

A. Misicka, P. Kosson, P. Schiller, 2007 .

Synthesis and Opiate Activity in vitro of Five New p-Nitrophenylalanine4-Enkephalin-like Peptides

J. Fauchère, K. Do, S. Pfenninger, 1983 .

A New Structural Motif for μ-Opioid Antagonists

P. Kosson, P. Schiller, A. Lipkowski, 2005 .

Direct electrophilic fluorination of tyrosine in dermorphin analogues and its effect on biological activity, receptor affinity and selectivity.

P. Schiller, C. Lemieux, K. Kirk, 2009, International journal of peptide and protein research.

Antinociceptive effects of two deltorphins analogs in the tail-immersion test in rats

P. Schiller, N. N. Chung, J. Kotlinska, 2013, Peptides.

Interaction of agonist peptide [3H]Tyr-d-Ala-Phe-Phe-NH2 with μ-opioid receptor in rat brain and CHO-μ/1 cell line

Z. Vogel, P. Schiller, T. M. Nguyen, 1998, Peptides.

Synthesis and bioactivity studies of 1‐adamantanamine derivatives of peptides

Š. Horvat, P. Schiller, A. Pfützner, 1995, Journal of peptide science : an official publication of the European Peptide Society.

Biological and conformational studies of [Val4]morphiceptin and [D-Val4]morphiceptin analogs incorporating cis-2-aminocyclopentane carboxylic acid as a peptidomimetic for proline.

T. Yamazaki, P. Schiller, M. Goodman, 2009, International journal of peptide and protein research.

Morphiceptin analogs containing 2-aminocyclopentane carboxylic acid as a peptidomimetic for proline.

P. Schiller, D. Mierke, M. Goodman, 2009, International journal of peptide and protein research.

Enantiospecific synthesis of D-α, ω-diaminoalkanoic acids

P. Beaulieu, P. Schiller, 1988 .

Synthesis of the diastereomers of β-Me-Tyr and β-Me-Phe and their effect on the biological properties of the delta opioid receptor antagonist TIPP

P. Schiller, N. N. Chung, D. Tourwé, 1995, Letters in Peptide Science.

Synthesis of peptidomimetics: An evaluation of the p-nitrophenyl carbamate of ethylenediamine

P. Schiller, N. N. Chung, J. Izdebski, 2004, Letters in Peptide Science.

Synthesis of 8-L-tryptophan-oxytocin and determination of one of its conformational parameters.

M. Bednarek, J. Tolle, P. Schiller, 2009, International journal of peptide and protein research.

Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).

P. Schiller, C. Lemieux, N. N. Chung, 2009, Journal of medicinal chemistry.

Quantitative analysis of [Dmt1]DALDA in ovine plasma by capillary liquid chromatography-nanospray ion-trap mass spectrometry

H. Szeto, D. Desiderio, P. Schiller, 2004 .

Development of Receptor-Selective Opioid Peptide Analogs as Pharmacologic Tools and as Potential Drugs

P. Schiller, 1993 .

Development of receptor-specific opioid peptide analogues.

P. Schiller, 1991, Progress in medicinal chemistry.

Determination of the average end-to-end distance of two angiotensin II analogs by resonance energy transfer.

P. Schiller, 2009, International journal of peptide and protein research.

Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations.

Jean‐François Hernandez, P. Schiller, N. N. Chung, 2013, Journal of medicinal chemistry.

Cyclic enkephalin-deltorphin hybrids containing a carbonyl bridge: structure and opioid activity.

P. Schiller, N. N. Chung, J. Wójcik, 2011, Acta biochimica Polonica.

Isolated adrenal cells: Log dose response curves for steroidogenesis induced by ACTH1–24, ACTH1–10, ACTH4–10 and ACTH5–10

R. Schwyzer, P. Schiller, S. Seelig, 1971, FEBS letters.

Covalent attachment of fluorescent probes to the X-base of Escherichia coli phenylalanine transfer ribonucleic acid.

A. Schechter, P. Schiller, 1977, Nucleic acids research.

Attenuation of morphine tolerance and dependence with the highly selective δ-opioid receptor antagonist TIPP[ψ]

T. Coderre, P. Schiller, M. Fundytus, 1995 .

Conformational Analysis of Enkephalin and Conformation – Activity Relationships

Peter W. Schiller, P. Schiller, 1984 .

Receptor binding, biological, and immunological properties of chemically deglycosylated pituitary lutropin.

P. Schiller, M. Sairam, 1979, Archives of biochemistry and biophysics.

Synthesis and pharmacological characterization of a cyclic β-casomorphin analog with mixed μ agonist/δ antagonist properties

P. Schiller, C. Lemieux, N. N. Chung, 1994 .

Chemical deglycosylation of ovine pituitary lutropin. A study of the reaction conditions and effects on biochemical, biophysical and biological properties of the hormone.

P. Schiller, M. Sairam, P. Manjunath, 1982, The Biochemical journal.

Highly potent side‐chain to side‐chain cyclized enkephalin analogues containing a carbonyl bridge: synthesis, biology and conformation

P. Schiller, N. N. Chung, J. Wójcik, 2001, Journal of peptide science : an official publication of the European Peptide Society.

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.

P. Schiller, J. Vanden Broeck, A. Lipkowski, 2015, European journal of medicinal chemistry.

Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.

F. Simonin, B. Mégarbane, P. Kosson, 2016, Journal of medicinal chemistry.

Enkephalin analogues containing β‐naphthylalanine at the fourth position

P. Schiller, D. Mierke, M. Goodman, 1990 .

1H n.m.r. investigation of conformational features of cyclic enkephalinamide analogs.

H. Mosberg, P. Schiller, 2009, International journal of peptide and protein research.

Cyclic enkephalin analogs containing a cystine bridge.

J. DiMaio, P. Schiller, C. Lemieux, 1981, Biochemical and biophysical research communications.

Determination of the intramolecular tyrosine-tryptophan distance in a 7-peptide related to the C-terminal sequence of cholecystokinin.

P. Schiller, M. Bodanszky, S. Natarajan, 2009, International journal of peptide and protein research.

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

A. Mollica, P. Schiller, J. Streicher, 2017, ACS chemical neuroscience.

Synthesis and biological activity profile of new analogues of the cyclic opioid peptide H‐Tyr‐c[D‐Cys‐Gly‐Phe(pNO2)‐D‐Cys]‐NH2 containing (S)‐α‐hydroxymethylcysteine in place of cysteine

J. Zabrocki, P. Schiller, N. N. Chung, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Synthesis and binding characteristics of tritiated TIPP[psi], a highly specific and stable delta opioid antagonist.

P. Schiller, A. Borsodi, S. Nevin, 1995, Life sciences.

Side chain to side chain cyclization of an enkephalin analog results in loss of opioid receptor selectivity.

P. Schiller, C. Lemieux, L. Maziak, 2009, International journal of peptide and protein research.

The effect of phenylalanine derivatives on the solubility of deoxyhemoglobin S. A model class of gelation inhibitors.

A. Schechter, J. DiMaio, P. Schiller, 1983, Molecular Pharmacology.

An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.

J M Bidlack, G. Pasternak, C. Dooley, 1994, Science.

New Concepts in Peptide Analog Design

P. Schiller, 1988 .

Characterization of specific receptors for atrial natriuretic factor in bovine adrenal zona glomerulosa.

M. Cantin, P. Schiller, J. Gutkowska, 1984, Life sciences.

MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1.

T. Peng, P. Schiller, Huaqing Zhu, 2011, Cardiovascular research.

Affinity chromatography of phenylalanyl-tRNA synthetase.

A. Schechter, P. Schiller, 1974, Methods in enzymology.

Opiate receptor subclasses differ in their conformational requirements

Peter W. Schiller, J. DiMaio, P. Schiller, 1982, Nature.

Generalization tests with intraventricularly applied pro-enkephalin B-derived peptides in rats trained to discriminate the opioid kappa receptor agonist ethylketocyclazocine

R. Schulz, P. Schiller, A. Herz, 2004, Psychopharmacology.

Fluorescence study on the solution conformation to dynorphin in comparison of enkephalin.

P. Schiller, 2009, International journal of peptide and protein research.

Comparative structure-function studies with analogs of dynorphin-(1-13) and [Leu5]enkephalin.

P. Schiller, B. Eggimann, T. Nguyen, 1982, Life sciences.

In vitro activity profiles of cyclic and linear enkephalin pseudopeptide analogs.

J. V. Edwards, P. Schiller, C. Lemieux, 1986, Biochemical and biophysical research communications.

Comparison of μ-, δ- and κ-receptor binding sites through pharmacologic evaluation of p-nitrophenylalanine analogs of opioid peptides

J. DiMaio, P. Schiller, C. Lemieux, 1983 .

Substrate Specificity of Tonin from Rat Submaxillary Gland

P. Schiller, R. Boucher, S. Demassieux, 1976, Circulation research.

[Aladan3]TIPP: A fluorescent δ‐opioid antagonist with high δ‐receptor binding affinity and δ selectivity

J. Vanderkooi, I. Gryczynski, P. Schiller, 2005, Biopolymers.

Acetylated glucopyranosyl esters of enkephalins.

Š. Horvat, P. Schiller, N. N. Chung, 2009, International journal of peptide and protein research.

Orientation of the tryptophanyl side chain in [(d)TrpA1] and [TrpA1]insulin

P. Schiller, R. Geiger, 1983 .

[D‐Ala2, Phe (p‐NO2)4, Leu5]Enkephalin Amide and Nα‐[D‐Ala2, Leu5]‐Enkephalyl‐Nε‐Acetyl‐Lysine Amide: Synthesis and Biological Properties of Prospective Enkephalin Cooperative‐Affinity and Photoaffinity Labels. Preliminary communication

K. Do, J. Castell, R. Schwyzer, 1979 .

N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.

P. Schiller, T. M. Nguyen, N. N. Chung, 2013, Bioorganic & medicinal chemistry letters.

The Opioid μ Agonist/δ Antagonist DIPP-NH2[Ψ] Produces a Potent Analgesic Effect, No Physical Dependence, and Less Tolerance than Morphine in Rats

Peter W. Schiller, Terence J. Coderre, T. Coderre, 1999 .

Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

P. Schiller, C. Lemieux, T. M. Nguyen, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Deltorphin analogs restricted via a urea bridge: structure and opioid activity

C. Czaplewski, P. Schiller, S. Rodziewicz-Motowidło, 2008, Journal of peptide science : an official publication of the European Peptide Society.

A topochemical approach to explain morphiceptin bioactivity.

T. Yamazaki, P. Schiller, N. N. Chung, 1993, Journal of medicinal chemistry.

Conformational Dynamics of Kir3.1/Kir3.2 Channel Activation Via δ-Opioid Receptors

G. Balboni, M. Bouvier, Mélissa Richard-Lalonde, 2013, Molecular Pharmacology.

Synthesis and In Vitro Opioid Activity Profiles of Novel Cyclic Enkephalin Analogs

P. Schiller, C. Lemieux, N. N. Chung, 2006 .

Cyclic dermorphin tetrapeptide analogues obtained via ring-closing metathesis.

P. Schiller, C. Lemieux, N. N. Chung, 2006, Acta biochimica Polonica.

Influence of new deltorphin analogues on reinstatement of cocaine-induced conditioned place preference in rats

P. Schiller, N. N. Chung, J. Kotlinska, 2010, Behavioural pharmacology.

Synthesis and biological activity of homoarginine‐containing opioid peptides

P. Schiller, N. N. Chung, J. Izdebski, 2007, Journal of peptide science : an official publication of the European Peptide Society.

Conversion of δ-, κ- and μ-receptor selective opioid peptide agonists into δ-, κ- and μ-selective antagonists

P. Schiller, C. Lemieux, T. M. Nguyen, 2003 .

14-membered cyclic opioids related to dermorphin and their partially retro-inverso modified analogues. I. Synthesis and biological activity.

T. Yamazaki, E. Felder, P. Schiller, 2009, International journal of peptide and protein research.

Strengthening peptide-based drug activity with novel glyconanoparticle

R. Roy, P. Schiller, T. M. Nguyen, 2018, PloS one.

Fluorescent dyes alter intracellular targeting and function of cell‐penetrating tetrapeptides

H. Szeto, P. Schiller, Kesheng Zhao, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Methionine-enkephalin related glycoconjugates. Synthesis and biological activity.

Š. Horvat, K. Pavelić, P. Schiller, 2009, International journal of peptide and protein research.

Synthesis and biological activity of [Leu5]enkephalin derivatives containing D-glucose.

Š. Horvat, P. Schiller, C. Lemieux, 2009, International journal of peptide and protein research.

Synthesis and biological activity of some glucose-enkephalin conjugates.

Š. Horvat, P. Schiller, C. Lemieux, 2009, International journal of peptide and protein research.

In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt1-DALDA Analogues.

P. Schiller, A. Lipkowski, B. Brodin, 2014, ACS medicinal chemistry letters.

Synthesis and opioid activity profile of some glycoconjugates of methionine-enkephalin and related peptides

Š. Horvat, P. Schiller, N. N. Chung, 1993 .

Internalization and Src Activity Regulate the Time Course of ERK Activation by Delta Opioid Receptor Ligands*

G. Piñeyro, N. Audet, P. Schiller, 2005, Journal of Biological Chemistry.

Novel ligands lacking a positive charge for the delta- and mu-opioid receptors.

P. Schiller, C. Lemieux, N. N. Chung, 2000, Journal of medicinal chemistry.

Comparison of [Dmt 1 ]DALDA and DAMGO in Binding and G Protein Activation at (cid:1) , (cid:2) , and (cid:3) Opioid Receptors

H. Szeto, P. Schiller, X. Qian, 2003 .

Profound spinal tolerance after repeated exposure to a highly selective mu-opioid peptide agonist: role of delta-opioid receptors.

H. Szeto, P. Schiller, Dunli Wu, 2002, The Journal of pharmacology and experimental therapeutics.

Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity.

N. Seidah, M. Chrétien, P. Schiller, 1984, Science.

Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists.

P. Schiller, C. Lemieux, N. N. Chung, 2012, Bioorganic & medicinal chemistry letters.

Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins*

M. Bouvier, G. Piñeyro, N. Audet, 2008, Journal of Biological Chemistry.

Study of adrenocorticotropic hormone conformation by evaluation of intramolecular resonance energy transfer in N -dansyllysine 21 -ACTH-(1-24)-tetrakosipeptide.

P. Schiller, 1972, Proceedings of the National Academy of Sciences of the United States of America.

[Hormone-receptor-relationships: synthesis and characteristics of N-epsilon-dansyllysine 21-adrenocorticotropin-(1-24)-tetrakosipeptide].

R. Schwyzer, P. Schiller, 1971, Helvetica chimica acta.

Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.

H. V. van Vlijmen, L. Gendron, P. Schiller, 2018, Bioorganic & Medicinal Chemistry Letters.

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera

P. Kosson, P. Schiller, A. Lipkowski, 2012, Molecular Brain.

[Dmt1, d-1-Nal3]morphiceptin, a novel opioid peptide analog with high analgesic activity

J. Fichna, A. Janecka, J. Costentin, 2008, Peptides.

Type and location of fluorescent probes incorporated into the potent mu-opioid peptide [Dmt]DALDA affect potency, receptor selectivity and intrinsic efficacy.

P. Schiller, C. Lemieux, N. N. Chung, 2005, The journal of peptide research : official journal of the American Peptide Society.

A novel cyclic enkephalin analogue with potent opioid antagonist activity.

P. Schiller, C. Lemieux, N. N. Chung, 2004, Bioorganic & medicinal chemistry letters.

Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide.

P. Schiller, Y. Lu, C. Lemieux, 2001, Bioorganic & medicinal chemistry letters.

A Novel Cyclic Opioid Peptide Antagonist Containing a Hydroxy Group in Place of the N-Terminal Amino Function

P. Schiller, C. Lemieux, N. N. Chung, 2001 .

An enzymatically stable kyotorphin analog induces pain in subattomol doses☆

H. Ueda, P. Schiller, G. Weltrowska, 2000, Peptides.

Brain receptor binding and central actions of angiotensin analogs in rats.

E. Schiffrin, P. Schiller, J. Mann, 1981, The American journal of physiology.

Role of the conformational element in peptide-receptor interactions. Studies with cyclic opioid peptide analogs.

P. Schiller, 1988, Biophysical chemistry.

SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION IN VITRO OF CYCLIC ENKEPHALIN ANALOGS: EFFECT OF CONFORMATIONAL CONSTRAINTS ON OPIATE RECEPTOR SELECTIVITY

J. DiMaio, P. Schiller, C. Lemieux, 1983 .

The receptor-bound conformation of H-Tyr-Tic-(Phe-Phe)-OH-related delta-opioid antagonists contains all trans peptide bonds.

P. Schiller, C. Lemieux, N. N. Chung, 2009, The journal of peptide research : official journal of the American Peptide Society.

Tyrosine-iodination converts the δ-opioid peptide antagonist TIPP to an agonist

P. Schiller, T. M. Nguyen, N. N. Chung, 1995 .

FOUR DIFFERENT TYPES OF OPIOID PEPTIDES WITH MIXED μ AGONIST/δ ANTAGONIST PROPERTIES

P. Schiller, C. Lemieux, T. M. Nguyen, 1995 .

Comparative analysis of various proposed models of the receptor‐bound conformation of H‐tyr‐Tic‐Phe OH related δ‐opioid antagonists

P. Schiller, B. Wilkes, 1995, Biopolymers.

Theoretical conformational analysis of the opioid δ antagonist H‐Tyr‐Tic‐Phe‐OH and the μ agonist H‐Tyr‐D‐Tic‐Phe‐NH2

P. Schiller, B. Wilkes, 1994 .

Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.

P. Schiller, C. Lemieux, N. N. Chung, 1994, Journal of medicinal chemistry.

Conformationally restricted deltorphin analogues.

P. Schiller, C. Lemieux, N. N. Chung, 1992, Journal of medicinal chemistry.

"Carba"-analogues of fentanyl are opioid receptor agonists.

P. Schiller, C. Lemieux, N. N. Chung, 2010, Journal of Medicinal Chemistry.

Stereoselective synthesis of (3S)- and (3R)-3-hydroxy-3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acid and its incorporation into a cyclic enkephalin analogue.

P. Schiller, C. Lemieux, N. N. Chung, 2009, Advances in experimental medicine and biology.

Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.

P. Schiller, C. Lemieux, B. Wilkes, 1987, Journal of medicinal chemistry.

A General New Concept for the Development of Opioid Peptide Derived μ-, δ- and κ-Antagonists

P. Schiller, C. Lemieux, T. M. Nguyen, 2001 .

Chapter 3 – Application of Fluorescence Techniques in Studies of Peptide Conformations and Interactions

P. Schiller, 1985 .

Tolerance develops in spinal cord, but not in brain with chronic [Dmt1]DALDA treatment

P. Schiller, N. Lee, Y. Ben, 2004, British journal of pharmacology.

[Dmt(1)]DALDA is highly selective and potent at mu opioid receptors, but is not cross-tolerant with systemic morphine.

P. Schiller, N. Lee, T. M. Nguyen, 2002, Current medicinal chemistry.

Isolation and identification of peptide conformers by reversed-phase high-performance liquid chromatography and NMR at low temperature.

C. Horváth, P. Schiller, R. Schmidt, 1996, Journal of chromatography. A.

Distinct conformational preferences of three cyclic beta-casomorphin-5 analogs determined using NMR spectroscopy and theoretical analysis.

P. Schiller, K. Carpenter, R. Schmidt, 2009, International journal of peptide and protein research.

Molecular dynamics simulations of opioid peptide analogs containing multiple conformational restrictions.

P. Schiller, B. Wilkes, 2009, International journal of peptide and protein research.

Role of hydrophobic substituents in the interaction of opioid Tyr-Tic dipeptide analogs with dodecylphosphocholine micelles. Molecular partitioning in model membrane systems.

P. Schiller, K. Carpenter, B. Wilkes, 1996, European journal of biochemistry.

Conformational studies of stereoisomeric 14‐membered cyclic enkephalin analogues containing 1‐naphthyialanine at the fourth position: Chirality effect of leucine at the fifth position on biological activity and receptor selectivity

T. Yamazaki, P. Schiller, O. Said-Nejad, 1991, Biopolymers.

N‐(ureidoethyl)amides of cyclic enkephalin analogs

P. Schiller, N. N. Chung, J. Wójcik, 2009, Journal of peptide science : an official publication of the European Peptide Society.

p‐Nitrophenoxycarbonyl derivatives of Boc‐protected diaminoalkanes in the synthesis of enkephalin peptidomimetics

P. Schiller, N. N. Chung, J. Izdebski, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Cyclic enkephalin and dermorphin analogues containing a carbonyl bridge

P. Schiller, N. N. Chung, J. Wójcik, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Ureido group containing cyclic dermorphin(1–7) analogues: synthesis, biology and conformation

P. Schiller, N. N. Chung, J. Wójcik, 2007, Journal of peptide science : an official publication of the European Peptide Society.

Potent side‐chain to side‐chain cyclized dermorphin analogues containing a carbonyl bridge

P. Schiller, N. N. Chung, J. Wójcik, 2003, Journal of peptide science : an official publication of the European Peptide Society.

Influence of sample pH on the conformational backbone dynamics of a pseudotripeptide (H‐Tyr‐TicΨ[CH2‐NH] Phe‐OH) incorporating a reduced peptide bond: An NMR investigation

P. Schiller, K. Carpenter, B. Wilkes, 1995, Biopolymers.

'Carba'-carfentanil (trans isomer): a μ opioid receptor (MOR) partial agonist with a distinct binding mode.

P. Schiller, C. Lemieux, N. N. Chung, 2014, Bioorganic & medicinal chemistry.

Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog.

C. Svensson, T. Yaksh, P. Schiller, 2003, The Journal of pharmacology and experimental therapeutics.

Short-term inverse-agonist treatment induces reciprocal changes in delta-opioid agonist and inverse-agonist binding capacity.

M. Bouvier, G. Piñeyro, P. Schiller, 2001, Molecular pharmacology.

Hydrophobic forces are responsible for the folding of a highly potent natriuretic peptide analogue at a membrane mimetic surface: an NMR study.

A. Fournier, P. Schiller, A. De Léan, 1997, Biopolymers.

Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists

L. Trudeau, G. Balboni, I. Charfi, 2014, Cellular and Molecular Life Sciences.

TIPP opioid peptides: Development of extraordinarily potent and selective δ antagonists and observation of astonishing structure-intrinsic activity relationships

P. Schiller, C. Lemieux, T. M. Nguyen, 1994 .

Synthesis and pharmacological evaluation of highly potent [Dmt1]DALDA analogs.

P. Schiller, A. Lewin, P. Reddy, 2009, Advances in experimental medicine and biology.

Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.

M. Mutter, M. Keller, P. Schiller, 2001, Journal of medicinal chemistry.

Synthesis and biological activity of linear and cyclic enkephalins modified at the Gly3‐Phe4amide bond

P. Schiller, T. M. Nguyen, M. Goodman, 2009 .

Conformational studies of diastereomeric cyclic enkephalins by 1H‐NMR and computer simulations

P. Schiller, D. Mierke, M. Goodman, 1987, Biopolymers.

Cyclic and acyclic partial retro-inverso enkephalinamides: Mu receptor selective enzyme resistant analogs.

P. Schiller, M. Goodman, J. Berman, 1983, Biochemical and biophysical research communications.

Conformational comparison of (Val5, Trp8)-angiotensin II and (Val4, Trp7)-angiotensin III by fluorescence measurements.

P. Schiller, 1979, Canadian journal of biochemistry.

Synthesis and solution conformation of [Trp1, Val5]-angiotensin II.

P. Schiller, 1977, Canadian journal of biochemistry.

SYNTHESIS AND OPIOID ACTIVITY PROFILES OF PROENKEPHALIN (100-111) ANALOGS

J. Bondaruk, P. Schiller, N. N. Chung, 2010 .

Comparative conformational analysis of % MathType!MTEF!2!1!+-% feaafeart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaa

Brian C. Wilkes, Peter W. Schiller, P. Schiller, 1991 .

Comparative conformational analysis of [D-Pen2, D-Pen5]enkephalin (DPDPE): A molecular mechanics study

Brian C. Wilkes, Peter W. Schiller, P. Schiller, 1991, J. Comput. Aided Mol. Des..

Effect of aromatic amino acid substitutions in the 3‐position of cyclic β‐casomorphin analogues on μ‐opioid agonist/δ‐opioid antagonist properties*

P. Schiller, C. Lemieux, N. N. Chung, 2009 .

Synthesis of cyclic dipeptide templates, their incorporation into peptides and studies on their conformational and biological properties.

H. Briem, H. Nar, P. Schiller, 2009, Journal of Peptide Research.

A chimeric opioid peptide with mixed μ agonist/δ antagonist properties

P. Schiller, C. Lemieux, N. N. Chung, 2004 .

Evidence for topographical analogy between methionine-enkephalin and morphine derivatives.

P. Schiller, P W Schiller, C F Yam, 1977, Biochemistry.

[Pro(3)]Dyn A(1-11)-NH(2): a dynorphin analogue with high selectivity for the kappa opioid receptor.

P. Schiller, N. N. Chung, J. Cassel, 2000, Journal of medicinal chemistry.

Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5.

P. Schiller, R. Walker, C. Lemieux, 1989, Journal of medicinal chemistry.

A novel side‐chain‐linked antiparallel cyclic dimer of enkephalin

P. Schiller, C. Lemieux, T. M. Nguyen, 1985, FEBS letters.

Conformation‐Activity relationships of cyclic dermorphin analogues

P. Schiller, B. Wilkes, 1990, Biopolymers.

Evidence of a peptide backbone contribution toward selective receptor recognition for leucine enkephalin thioamide analogs.

K. Clausen, P. Schiller, C. Lemieux, 1984, Biochemical and biophysical research communications.

Theoretical conformational analysis of a μ‐selective cyclic opioid peptide analog

P. Schiller, B. Wilkes, 1987, Biopolymers.

Conformational behavior of [Trp4, Met5]-enkephalin: comparison of fluorescence parameters at different Ph.

P. Schiller, 1977, Biochemical and biophysical research communications.

Biological activities of cyclic enkephalin pseudopeptides containing thioamides as amide bond replacements.

T. Burks, P. Schiller, D. Sherman, 1989, Biochemical and biophysical research communications.

Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers.

P. Schiller, C. Lemieux, L. Maziak, 1985, Journal of medicinal chemistry.

Synthesis and characterization of ruthenium complexes containing tridentate P3O93-, Nb2W4O194-, and Cp*TiW5O183- ligands

R. Planalp, P. Schiller, V. Day, 1993 .

Analogs of the δ opioid antagonist TIPP with increased lipophilic character

P. Schiller, C. Lemieux, T. M. Nguyen, 2002 .

Cyclic morphiceptin analogs: cyclization studies and opioid activities in vitro.

P. Schiller, H. Demuth, N. N. Chung, 2009, International journal of peptide and protein research.

Structure-activity relationships of cyclic β-casomorphin-5 analogues

P. Schiller, N. N. Chung, M. Schnittler, 1991, Peptides.

Proton NMR Conformational Analysis of Cyclic β‐Casomorphin Analogues of the Type Tyr‐cyclo[‐Nω‐D‐Orn‐Xaa‐Yaa‐Gly‐]

P. Schiller, W. Brandt, K. Neubert, 1996 .

Highly potent side chain–main chain cyclized dermorphin–deltorphin analogues: An integrated approach including synthesis, bioassays, NMR spectroscopy and molecular modelling

A. Malmberg, T. Burks, T. Yaksh, 1995, Journal of peptide science : an official publication of the European Peptide Society.

Effects of morphine, H‐Tyr‐d‐Arg‐Phe‐Lys‐NH2 (DALDA) and B‐HT920 on non‐cholinergic nerve‐mediated bronchoconstriction in pithed guinea‐pigs

P. Schiller, R. King, A. Boura, 1990, British journal of pharmacology.

Synthesis, conformational analysis, and biological activity of opioid peptide analogs containing side chain fluorinated amino acids

P. Schiller, M. Thormann, N. N. Chung, 1999 .

In vivo disposition of dermorphin analog (DALDA) in nonpregnant and pregnant sheep.

R. Becklin, J. Clapp, H. Szeto, 1998, The Journal of pharmacology and experimental therapeutics.

Antagonism as a consequence of side chain conformational restriction: A new class of potent, δ opioid receptor-selective peptide antagonists

P. Schiller, C. Lemieux, T. M. Nguyen, 1993 .

Synthesis of side-chain to side-chain cyclized peptide analogs on solid supports

P. Schiller, T. M. Nguyen, Jack M. Miller, 2009 .

SPONTANEOUS DIKETOPIPERAZINE FORMATION VIA END-TO-END CYCLIZATION OF A NONACTIVATED LINEAR TRIPEPTIDE : AN UNUSUAL CHEMICAL REACTION

Brian C. Wilkes, P. Schiller, Katharine A. Carpenter, 1994 .

Impact of the prorenin/renin receptor on the development of obesity and associated cardiometabolic risk factors

M. Gauthier, P. Schiller, T. M. Nguyen, 2014, Obesity.

Synthesis and biological activities of cyclic lanthionine enkephalin analogues : δ-opioid receptor selective ligands

C. Svensson, T. Yaksh, P. Schiller, 2002 .

MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1.

T. Peng, P. Schiller, Jianmin Li, 2011, Cardiovascular research.

Opioid dipeptide derivatives with a mixed μ antagonist/δ antagonist, partial μ agonist/δ antagonist or μ agonist/partial δ agonist profile

P. Schiller, C. Lemieux, T. M. Nguyen, 2002 .

The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.

T. Coderre, P. Schiller, C. Lemieux, 1999, Journal of medicinal chemistry.

Effect of aromatic amino acid substitutions in the 3-position of cyclic beta-casomorphin analogues on mu-opioid agonist/delta-opioid antagonist properties.

P. Schiller, C. Lemieux, N. N. Chung, 1996, International journal of peptide & protein research.

Bifunctional μ/δ Opioid Peptides: Variation of the Type and Length of the Linker Connecting the Two Components

P. Schiller, C. Lemieux, N. N. Chung, 2012, Chemical biology & drug design.

"Carba"-analogues of fentanyl are opioid receptor agonists.

P. Schiller, C. Lemieux, N. N. Chung, 2010, Journal of medicinal chemistry.

Optically active aromatic amino acids. Part VI. Synthesis and properties of [Leu5]‐enkephalin analogues containing O‐methyl‐L‐tyrosine1 with ring substitution at position 3′

P. Schiller, Z. Arnold, 2000, Journal of peptide science : an official publication of the European Peptide Society.

Synthesis, Characterization, and Biological Properties of Five Enkephalin‐like Pentapeptides Containing p‐Nitrophenylalanine

J. Fauchère, P. Schiller, 1981 .

Electronic, steric, and hydrophobic factors influencing the action of enkephalin-like peptides on opiate receptors.

J. Fauchère, K. Do, R. Schwyzer, 1981, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery

T. Yaksh, P. Schiller, T. M. Nguyen, 2018, Scandinavian journal of pain.

Superactive analogs of the atrial natriuretic peptide (ANP).

M. Cantin, P. Schiller, J. Godin, 1987, Biochemical and biophysical research communications.

Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure.

J. Poels, J. Fichna, A. Janecka, 2008, Bioorganic & medicinal chemistry letters.