J. B. Thomas

发表

Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.

F I Carroll, S W Mascarella, James B. Thomas, 2001, Journal of medicinal chemistry.

Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.

S. Mascarella, F. Carroll, J. B. Thomas, 1998, Journal of medicinal chemistry.

Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.

S. Mascarella, F. Carroll, J. B. Thomas, 1998, Journal of medicinal chemistry.

Opioid peptide receptor studies. 15. Relative efficacy of 4‐[(N‐allyl‐3‐methyl‐4‐piperidinyl)phenylamino]‐N,N‐diethylbenzamide and related compounds at the cloned human δ‐opioid receptor

K. Rice, James B. Thomas, F. Carroll, 2001, Synapse.

Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [35S]GTP‐γ‐S functional binding assay

K. Rice, James B. Thomas, F. Carroll, 2001, Synapse.

N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.

C. George, J. Flippen-Anderson, S. Mascarella, 1998, Journal of medicinal chemistry.

Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.

S. Mascarella, F. Carroll, J. B. Thomas, 1999, Bioorganic & medicinal chemistry letters.

(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.

S. Mascarella, F. Carroll, J. B. Thomas, 1999, Bioorganic & medicinal chemistry letters.

Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation.

F. Carroll, J. B. Thomas, C. Evans, 2001, The Journal of pharmacology and experimental therapeutics.

Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.

C. George, J. Flippen-Anderson, S. Mascarella, 2001, Journal of medicinal chemistry.

N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.

C. George, J. Flippen-Anderson, S. Mascarella, 1998, Bioorganic & medicinal chemistry letters.