B. Cantrell

发表

Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.

F I Carroll, S W Mascarella, James B. Thomas, 2001, Journal of medicinal chemistry.

Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.

James B. Thomas, S. Mascarella, F. Carroll, 2003, Journal of medicinal chemistry.

Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists.

P. Hipskind, P. Ornstein, B. Cantrell, 1998, Journal of medicinal chemistry.

Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists.

P. Hipskind, P. Ornstein, B. Cantrell, 1998, Bioorganic & medicinal chemistry letters.

Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists.

P. Hipskind, P. Ornstein, B. Cantrell, 1999, Bioorganic & medicinal chemistry letters.

Rapid parallel synthesis applied to the optimization of a series of potent nonpeptide neuropeptide Y-1 receptor antagonists

M. Siegel, P. Ornstein, M. Clay, 1999 .

Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.

S. Mascarella, F. Carroll, J. B. Thomas, 1998, Journal of medicinal chemistry.

Importance of phenolic address groups in opioid kappa receptor selective antagonists.

James B. Thomas, S. Mascarella, F. Carroll, 2004, Journal of medicinal chemistry.

Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.

S. Mascarella, F. Carroll, J. B. Thomas, 1998, Journal of medicinal chemistry.

Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors.

G. Stephenson, D. Bleakman, B. Cantrell, 2002, Journal of medicinal chemistry.

Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.

J. Gidda, D. Schoepp, B. Cantrell, 1994, Journal of medicinal chemistry.

3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.

D. Wong, C. Mitch, A. Takemori, 1993, Journal of medicinal chemistry.

Synthesis of 9β-methyl-2-alkyl-7-oxo-5-arylmorphans

James B. Thomas, L. Brieaddy, S. Mascarella, 1998 .

N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.

C. George, J. Flippen-Anderson, S. Mascarella, 1998, Journal of medicinal chemistry.

A stereoselective synthetic approach to N-alkyl-4β-methyl-5-phenylmorphans

James B. Thomas, S. Mascarella, F. Carroll, 1999 .

Structural requirements for affinity and intrinsic activity at the opiate receptor defined in 4-phenylpiperidine and related series.

B. Cantrell, M. Hynes, R. Nickander, 1982, NIDA research monograph.

Discovery of the First N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphan To Possess Highly Potent and Selective Opioid δ Receptor Antagonist Activity

James B. Thomas, S. Mascarella, H. Navarro, 2004 .

N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.

C. George, J. Flippen-Anderson, S. Mascarella, 1998, Bioorganic & medicinal chemistry letters.

Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors.

P. Ornstein, D. Bleakman, B. Cantrell, 2000, Journal of medicinal chemistry.