E. Da Pozzo

发表

The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity.

F. Da Settimo, S. Taliani, C. Martini, 2017, ACS chemical neuroscience.

TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis.

B. Cosimelli, F. Da Settimo, S. Taliani, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy

F. Da Settimo, S. Taliani, C. Martini, 2016, Scientific Reports.

Peripheral Benzodiazepine Receptor: Characterization in Human T-Lymphoma Jurkat Cells

C. Martini, A. Lena, V. Gremigni, 2006, Molecular Pharmacology.

Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK.

C. Martini, E. Da Pozzo, S. Daniele, 2015, Cellular signalling.

An update into the medicinal chemistry of translocator protein (TSPO) ligands.

F. Da Settimo, S. Taliani, C. Martini, 2020, European journal of medicinal chemistry.

Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands.

Talakad G. Lohith, E. Rabiner, R. Gunn, 2011, Journal of medicinal chemistry.

Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.

E. Novellino, F. Da Settimo, C. Martini, 2011, European journal of medicinal chemistry.

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

C. Martini, A. Coluccia, R. Silvestri, 2018, European journal of medicinal chemistry.

Prevention of Excessive Endothelin-1 Release in Sclerotherapy: In Vitro and In Vivo Studies

C. Martini, S. Burchielli, E. Da Pozzo, 2014, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

The Citrus Flavanone Naringenin Produces Cardioprotective Effects in Hearts from 1 Year Old Rat, through Activation of mitoBK Channels

C. Martini, M. Breschi, E. Da Pozzo, 2017, Front. Pharmacol..

Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells.

C. Martini, M. Breschi, S. Fogli, 2015, Anticancer research.

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.

Barbara Costa, Ettore Novellino, Luciana Marinelli, 2014, Journal of medicinal chemistry.

Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.

E. Novellino, B. Cosimelli, G. Greco, 2010, Journal of medicinal chemistry.

Cyclic adenosine monophosphate responsive element binding protein in post-traumatic stress disorder

M. Trincavelli, C. Martini, D. Marazziti, 2013, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage

C. Martini, C. Cavallini, B. Costa, 2017, Oxidative medicine and cellular longevity.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance

F. Da Settimo, S. Taliani, C. Martini, 2014, Apoptosis.

The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1

C. Martini, Simone Brogi, C. Ghelardini, 2020, Oxidative medicine and cellular longevity.

Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study

M. Trincavelli, C. Martini, E. Da Pozzo, 2013, International journal of molecular sciences.

De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein

F. Da Settimo, S. Taliani, C. Martini, 2021, International journal of molecular sciences.

Antioxidant and Antisenescence Effects of Bergamot Juice

L. Milella, C. Martini, C. Cavallini, 2018, Oxidative medicine and cellular longevity.

Human Microglia Extracellular Vesicles Derived from Different Microglia Cell Lines: Similarities and Differences

C. Martini, V. Cappello, L. Marchetti, 2022, ACS omega.

Translocator protein as a promising target for novel anxiolytics.

C. Martini, B. Costa, E. Da Pozzo, 2012, Current topics in medicinal chemistry.

Remarkable Enhancement in Boron Uptake Within Glioblastoma Cells With Carboranyl-Indole Carboxamides.

C. Martini, M. Kassiou, R. Narlawar, 2018, Chemistry, an Asian journal.

Quantum computing algorithms: getting closer to critical problems in computational biology

M. Trincavelli, C. Martini, P. Martelli, 2022, Briefings Bioinform..

Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa).

C. Martini, M. Kassiou, C. Luus, 2012, Current molecular medicine.

Mitochondriotropic and Cardioprotective Effects of Triphenylphosphonium-Conjugated Derivatives of the Diterpenoid Isosteviol

C. Martini, M. Breschi, E. Da Pozzo, 2017, International journal of molecular sciences.

Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.

E. Novellino, B. Cosimelli, G. Greco, 2011, European journal of medicinal chemistry.

p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells.

E. Novellino, B. Cosimelli, G. Greco, 2014, ACS chemical neuroscience.

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein.

E. Novellino, G. Greco, F. Da Settimo, 2012, Journal of medicinal chemistry.

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.

E. Novellino, B. Cosimelli, G. Greco, 2008, Journal of medicinal chemistry.

Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO).

Annelaure Damont, Michael Kassiou, David Hibbs, 2010, Bioorganic & medicinal chemistry letters.

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

E. Novellino, L. Di Marcotullio, C. Martini, 2015, Journal of medicinal chemistry.

AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells

C. Martini, M. Breschi, S. Fogli, 2015, Anti-cancer drugs.

18-kDa TranSlocator protein association complexes in the brain: from structure to function.

C. Martini, B. Costa, E. Da Pozzo, 2020, Biochemical pharmacology.

Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173.

F. Da Settimo, S. Taliani, C. Martini, 2016, ACS chemical neuroscience.

Platelet uptake of GABA and glutamate in patients with bipolar disorder.

C. Martini, G. Cassano, M. Abelli, 2012, Bipolar disorders.

Carbonic anhydrase activation profile of indole-based derivatives

F. Da Settimo, S. Taliani, C. Martini, 2021, Journal of enzyme inhibition and medicinal chemistry.

Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation

F. Da Settimo, S. Taliani, C. Martini, 2019, International journal of molecular sciences.

Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

E. Novellino, C. Martini, P. Campiglia, 2015, Scientific Reports.

Human Glioblastoma Multiforme: p53 Reactivation by a Novel MDM2 Inhibitor

Barbara Costa, Ettore Novellino, Sara Bendinelli, 2013, PloS one.

PK 11195 differentially affects cell survival in human wild‐type and 18 kDa translocator protein‐silenced ADF astrocytoma cells

C. Martini, R. Vanacore, A. Lena, 2008, Journal of cellular biochemistry.

Theranostic Properties of a Survivin-Directed Molecular Beacon in Human Melanoma Cells

Francesco Baldini, Ambra Giannetti, Sara Tombelli, 2014, PloS one.

Translocator protein ligands as promising therapeutic tools for anxiety disorders.

F. Da Settimo, S. Taliani, C. Martini, 2009, Current medicinal chemistry.

Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells.

C. Martini, R. Vanacore, A. Lena, 2004, Biochemical pharmacology.

TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance

F. Da Settimo, S. Taliani, C. Martini, 2015, Apoptosis.

Human Neural Stem Cell Aging Is Counteracted by α-Glycerylphosphorylethanolamine.

C. Martini, E. Da Pozzo, S. Daniele, 2016, ACS chemical neuroscience.

A2A Adenosine Receptor Binding Parameters in Platelets from Patients Affected by Pathological Gambling

M. Trincavelli, C. Martini, E. Da Pozzo, 2011, Neuropsychobiology.

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.

C. Martini, A. Coluccia, R. Silvestri, 2019, European journal of medicinal chemistry.

The GABAA-BZR complex as target for the development of anxiolytic drugs.

M. Trincavelli, C. Martini, E. Da Pozzo, 2012, Current topics in medicinal chemistry.

The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.

C. Martini, G. Cassano, A. Lucacchini, 2009, Endocrinology.

Exploiting the 4-Phenylquinazoline Scaffold for the Development of High Affinity Fluorescent Probes for the Translocator Protein (TSPO).

E. Novellino, F. Da Settimo, S. Taliani, 2017, Journal of medicinal chemistry.

Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N‐Dialkyl‐2‐arylindol‐3‐ylglyoxylamides

E. Novellino, F. Da Settimo, S. Taliani, 2017, ChemMedChem.

Intermittent hypoxia treatments cause cellular priming in human microglia

E. Da Pozzo, C. Giacomelli, A. Baccaglini-Frank, 2023, Journal of cellular and molecular medicine.

TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells.

C. Martini, A. Lena, V. Gremigni, 2008, Biochimica et biophysica acta.

PIGA (N,N‐Di‐n‐butyl‐5‐chloro‐2‐(4‐chlorophenyl)indol‐3‐ylglyoxylamide), a New Mitochondrial Benzodiazepine‐Receptor Ligand, Induces Apoptosis in C6 glioma Cells

F. Da Settimo, C. Martini, R. Vanacore, 2005, Chembiochem : a European journal of chemical biology.

Differential effects of fondaparinux and bemiparin on angiogenic and vasculogenesis-like processes.

C. Martini, A. Balbarini, E. Da Pozzo, 2012, Thrombosis research.

Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis

S. Taliani, C. Cavallini, Chiara Tremolanti, 2022, Molecular Neurobiology.

Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations.

E. Novellino, F. Da Settimo, S. Taliani, 2019, ACS chemical neuroscience.

TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being

F. Da Settimo, S. Taliani, C. Martini, 2016, International journal of molecular sciences.

Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas.

E. Novellino, F. Da Settimo, S. Taliani, 2016, Journal of medicinal chemistry.

Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides.

E. Novellino, B. Cosimelli, G. Greco, 2015, Journal of medicinal chemistry.

Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO).

Shane M. Wilkinson, C. Martini, M. Kassiou, 2015, European journal of medicinal chemistry.

Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma

E. Novellino, F. Da Settimo, S. Taliani, 2014, Scientific Reports.

Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments.

C. Martini, D. Marazziti, E. Da Pozzo, 2008, Journal of affective disorders.

Cytokine secretion responsiveness of lymphomonocytes following cortisol cell exposure: Sex differences

C. Martini, C. Cavallini, E. Da Pozzo, 2018, PloS one.

Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection.

S. Taliani, C. Martini, B. Costa, 2015, Biochemical Society transactions.

Gender differences in the correlations between cortisol levels or DHEA-S/cortisol ratio and panic-agoraphobic dimensions in healthy subjects

C. Martini, D. Marazziti, C. Conversano, 2011, European Psychiatry.

Translocator protein and steroidogenesis.

C. Martini, B. Costa, E. Da Pozzo, 2018, The Biochemical journal.

Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.

C. Martini, A. Coluccia, R. Silvestri, 2021, European journal of medicinal chemistry.

The human microglial surveillant phenotype is preserved by de novo neurosteroidogenesis through the control of cholesterol homeostasis: Crucial role of 18 kDa Translocator Protein.

F. Da Settimo, S. Taliani, C. Martini, 2023, Biochimica et biophysica acta. Molecular basis of disease.

An insight into hypothesized biological mechanisms contributing to the Flash effect

V. Tozzini, E. Da Pozzo, A. Gonnelli, 2023, Frontiers in Physics.

Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization.

C. Martini, E. Stura, L. Vera, 2017, ACS medicinal chemistry letters.

Translocator protein (TSPO) and neurosteroids: implications in psychiatric disorders.

C. Martini, B. Costa, E. Da Pozzo, 2012, Current molecular medicine.

Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.

Annelaure Damont, Raphaël Boisgard, Bertrand Tavitian, 2011, Bioorganic & medicinal chemistry letters.

An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein.

E. Novellino, C. Martini, P. Campiglia, 2013, Drug testing and analysis.

AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells

C. Martini, M. Breschi, S. Fogli, 2015, Anti-cancer drugs.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

Gender effect on the relationship between stress hormones and panic-agoraphobic spectrum dimensions in healthy subjects

C. Martini, D. Marazziti, C. Conversano, 2012, CNS Spectrums.

Drug Mechanism: A bioinformatic update.

E. Da Pozzo, P. Milazzo, Maria Letizia Trincavelli, 2024, Biochemical pharmacology.

Human oligodendrocyte-like cell differentiation is promoted by TSPO-mediated endogenous steroidogenesis.

F. Da Settimo, S. Taliani, Chiara Tremolanti, 2024, Biochimica et biophysica acta. Molecular basis of disease.

Planarian Mucus: A Novel Source of Pleiotropic Cytotoxic and Cytostatic Agents against Cancer Cells

E. Da Pozzo, G. Gambino, L. Rossi, 2024, Biomolecules.