D. Merkler

发表

Biosynthesis, degradation and pharmacological importance of the fatty acid amides.

Emma K. Farrell, D. Merkler, 2008, Drug discovery today.

Thiamin Diphosphate Activation in 1-Deoxy-d-xylulose 5-Phosphate Synthase: Insights into the Mechanism and Underlying Intermolecular Interactions.

J. K. White, H. Woodcock, S. L. Vankayala, 2016, The journal of physical chemistry. B.

N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides.

J. Vederas, D. Boger, D. Merkler, 1999, Biochemistry.

Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells1[S]

Emma K. Farrell, D. Merkler, Yuden Chen, 2012, Journal of Lipid Research.

Induction of Peptidylglycine α-Amidating Monooxygenase in N18TG2 Cells: A Model for Studying Oleamide Biosynthesis

D. Merkler, W. Driscoll, K. Ritenour-Rodgers, 2000 .

Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells.

D. Merkler, Mitchell E. Johnson, G. Chew, 2004, Biochemistry.

Production of Recombinant Salmon Calcitonin by In Vitro Amidation of an Escherichia coli Produced Precursor Peptide

D. Merkler, P. P. Shields, M. V. Ray, 1993, Bio/Technology.

Mammalian Fatty Acid Amides of the Brain and CNS

D. R. Dempsey, Emma K. Farrell, D. Merkler, 2014 .

Ubiquitin and ubiquitin‐derived peptides as substrates for peptidylglycine α‐amidating monooxygenase

Neil R. McIntyre, Scott A. Miller, D. Wright, 2005, FEBS letters.

Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase.

K. W. Jung, D. Merkler, G. Chew, 2003, Archives of biochemistry and biophysics.

The enzymatic formation of novel bile acid primary amides.

J. Vederas, S. Barnes, D. Merkler, 2000, Archives of biochemistry and biophysics.

The Enzymology of Peptide Amidation

J. Freeman, J. Villafranca, D. Merkler, 1993 .

Selective inactivation of the hydroxylase activity of bifunctional rat peptidylglycine alpha-amidating enzyme.

D. Merkler, P. Tamburini, S. D. Young, 1992, Archives of biochemistry and biophysics.

Recombinant type A rat 75-kDa α-amidating enzyme catalyzes the conversion of glycine-extended peptides to peptide amides via an α-hydroxyglycine intermediate☆

D. Merkler, S. D. Young, 1991 .

A study for therapeutic treatment against Parkinson's Disease via Chou's 5-steps rule.

D. Merkler, Jianyong Li, Jianqiang Lan, 2019, Current topics in medicinal chemistry.

Production of the catalytic core of human peptidylglycine α-hydroxylating monooxygenase (hPHMcc) in Escherichia coli.

D. Merkler, S. Handa, D. Dempsey, 2012, Protein expression and purification.

Peptidylglycine α‐amidating monooxygenase as a therapeutic target or biomarker for human diseases

R. Mains, B. Eipper, D. Merkler, 2021, British journal of pharmacology.

Binding-based proteomic profiling and the fatty acid amides

D. Merkler, J. W. Leahy, J. Leahy, 2018, Trends in research.

Synthesis and Evaluation of a Novel Adenosine-Ribose Probe for Global-Scale Profiling of Nucleoside and Nucleotide-Binding Proteins

D. Merkler, Shikha Mahajan, Roman Manetsch, 2015, PloS one.

Insect Arylalkylamine N-Acetyltransferases as Potential Targets for Novel Insecticide Design.

D. Merkler, Brian G. O’Flynn, Aidan J Hawley, 2018, Biochemistry & molecular biology journal.

Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids.

C. Falany, D. Merkler, J. Falany, 2005, Methods in enzymology.

Enzymatic formation of C-terminal amides.

D. Merkler, K. Merkler, R. Kulathila, 1999, Natural product reports.

Bifunctional peptidylglcine alpha-amidating enzyme requires two copper atoms for maximum activity.

J. Freeman, J. Villafranca, D. Merkler, 1994, Archives of biochemistry and biophysics.

Bifunctional Peptidylglycine α-Amidating Enzyme Requires 2 Copper Atoms for Maximum Activity

J. Freeman, J. Villafranca, D. Merkler, 1994 .

Bm-iAANAT and its potential role in fatty acid amide biosynthesis in Bombyx mori.

D. Merkler, M. Battistini, Brian G. O’Flynn, 2018, Prostaglandins, leukotrienes, and essential fatty acids.

A mass spectrometry‐based method to screen for α‐amidated peptides

D. Merkler, J. Koomen, Yudan Chen, 2012, Proteomics.

C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity.

D. Merkler, D J Merkler, 1994, Enzyme and microbial technology.

The irreversible inactivation of two copper‐dependent monooxygenases by sulfite: peptidylglycine α‐amidating enzyme and dopamine β‐monooxygenase

D. Merkler, D. Ash, R. Kulathila, 1995 .

C‐Terminal Amidated Peptides: Production by the in vitro Enzymic Amidation of Glycine‐Extended Peptides and the Importance of the Amide to Bioactivity

D. Merkler, 1994 .

Production of recombinant calcitonin gene related peptide by in vitro amidation of an E. coli produced peptide

A. Bertelsen, D. Merkler, P. P. Shields, 1991, Regulatory Peptides.

An enzyme-coupled assay for glyoxylic acid.

D. Merkler, S. E. Carpenter, 2003, Analytical biochemistry.

Amidation of salicyluric acid and gentisuric acid: a possible role for peptidylglycine alpha-amidating monooxygenase in the metabolism of aspirin.

J. Vederas, D. Merkler, J. L. DeBlassio, 2000, Archives of biochemistry and biophysics.

N-FATTY ACYLGLYCINES: UNDERAPPRECIATED ENDOCANNABINOID-LIKE FATTY ACID AMIDES?

D. Merkler, Ryan L. Anderson, 2017, Journal of biology and nature.

The Biosynthesis and Metabolism of the N-Acylated Aromatic Amino Acids: N-Acylphenylalanine, N-Acyltyrosine, N-Acyltryptophan, and N-Acylhistidine

D. Merkler, K. S. Bisht, Suzeeta Bhandari, 2022, Frontiers in Molecular Biosciences.

A pathway for the biosynthesis of fatty acid amides.

J. Vederas, D. Merkler, B. J. Wilcox, 1999, Advances in experimental medicine and biology.

Rapid fluorimetric assay for the detection of the peptidyl alpha-amidating enzyme intermediate using high-performance liquid chromatography.

D. Merkler, S. D. Young, A. Consalvo, 1992, Journal of chromatography.

Oxygen-18 isotopic carbon-13 NMR shift as proof that bifunctional peptidylglycine .alpha.-amidating enzyme is a monooxygenase

D. Merkler, D. Ash, S. D. Young, 1992 .

Alpha-Amidating Enzyme Catalyzed Synthesis of Peptide-Amides from Glycine-Extended Precursors: Human Growth Hormone Releasing Factor and Analogs as Examples,

R. Campbell, D. Merkler, A. Felix, 1992 .

Synthesis, Quantification, and Characterization of Fatty Acid Amides from In Vitro and In Vivo Sources

D. Merkler, K. S. Bisht, Ruidong Ni, 2021, Molecules.

Expression, purification, and characterization of mouse glycine N-acyltransferase in Escherichia coli.

D. Merkler, J. Bond, Anne-Marie Carpenter, 2014, Protein expression and purification.

Identification of an arylalkylamine N‐acyltransferase from Drosophila melanogaster that catalyzes the formation of long‐chain N‐acylserotonins

D. Merkler, K. A. Jeffries, Anne-Marie Carpenter, 2014, FEBS letters.

Structural investigations on the coordination environment of the active-site copper centers of recombinant bifunctional peptidylglycine alpha-amidating enzyme.

D. Merkler, B. Reedy, N. Blackburn, 1996, Biochemistry.

Investigation of the pathway for inter-copper electron transfer in peptidylglycine alpha-amidating monooxygenase.

J. Klinman, D. Merkler, G. Wille, 2004, Journal of the American Chemical Society.

Involvement of basic amino acids in the activity of a nucleic acid helix-destabilizing protein.

R. Karpel, M. Delahunty, D. Merkler, 1981, Biochimica et biophysica acta.

Kinetic mechanism and intrinsic isotope effects for the peptidylglycine alpha-amidating enzyme reaction.

J. Klinman, D. Merkler, N. Blackburn, 1998, Biochemistry.

Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine α‐amidating monooxygenase (PAM)

Edward W. Lowe, Neil R. McIntyre, D. Merkler, 2006, FEBS letters.

A new proposal for the mechanism of glycine hydroxylation as catalyzed by peptidylglycine alpha-hydroxylating monooxygenase (PHM).

D. Merkler, T. C. Owen, 2004, Medical hypotheses.

The development of molecular clamps as drugs.

Neil R. McIntyre, D. Merkler, M. McLaughlin, 2006, Drug discovery today.

Catalytic mechanism of yeast adenosine 5'-monophosphate deaminase. Zinc content, substrate specificity, pH studies, and solvent isotope effects.

V. Schramm, D. Merkler, 1993, Biochemistry.

N-acylethanolamines as novel alcohol dehydrogenase 3 substrates.

Edward W. Lowe, D. Merkler, S. Handa, 2011, Archives of biochemistry and biophysics.

Use of reversed phase HP liquid chromatography to assay conversion of N-acylglycines to primary fatty acid amides by peptidylglycine-alpha-amidating monooxygenase.

Pallavi Deshpande, D. Merkler, Mitchell E. Johnson, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).

Edward W. Lowe, Neil R. McIntyre, R. Kendig, 2008, Bioorganic & medicinal chemistry.

Characterization of a bifunctional peptidylglycine alpha-amidating enzyme expressed in Chinese hamster ovary cells.

D. Miller, G. A. Beaudry, A. Bertelsen, 1992, Archives of Biochemistry and Biophysics.

Inactivation of peptidylglycine α-hydroxylating monooxygenase by cinnamic acid analogs

Edward W. Lowe, Neil R. McIntyre, D. Merkler, 2016, Journal of enzyme inhibition and medicinal chemistry.

Imino-oxy acetic acid dealkylation as evidence for an inner-sphere alcohol intermediate in the reaction catalyzed by peptidylglycine alpha-hydroxylating monooxygenase.

Edward W. Lowe, Neil R. McIntyre, D. Merkler, 2009, Journal of the American Chemical Society.

Transition-state analysis of AMP deaminase.

V. Schramm, D. Merkler, P. Weiss, 1993, Biochemistry.

Enzymatic transition states and inhibitor design from principles of classical and quantum chemistry

V. Schramm, P. Berti, S. Schwartz, 1996 .

Mechanistic binding insights for 1-deoxy-D-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax.

L. Breydo, D. Merkler, S. Handa, 2016, Protein expression and purification.

Characterization of Arylalkylamine N-Acyltransferase from Tribolium castaneum: An investigation into a potential next-generation insecticide target.

Yu Chen, D. Merkler, J. W. Leahy, 2020, ACS chemical biology.

Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine.

L. Breydo, D. Merkler, S. Handa, 2015, Biochemistry.

Mechanistic and Structural Analysis of Drosophila melanogaster Arylalkylamine N-Acetyltransferases

L. Breydo, D. Merkler, J. Bond, 2014, Biochemistry.

AMP deaminase from yeast. Role in AMP degradation, large scale purification, and properties of the native and proteolyzed enzyme.

V. Schramm, J. Taylor, D. Merkler, 1989, The Journal of biological chemistry.

Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine

Yu Chen, D. Merkler, Xiujun Zhang, 2017, Scientific Reports.

Plasmodium vivax 1-deoxy-D-xylulose-5-phosphate synthase: HomologyModeling, Domain Swapping,and Virtual Screening

W. Guida, Divya Ramamoorthy, D. Merkler, 2014 .

Production of recombinant 1-deoxy-d-xylulose-5-phosphate synthase from Plasmodium vivax in Escherichia coli☆

W. Guida, Divya Ramamoorthy, D. Merkler, 2013, FEBS open bio.

Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2.

D. Merkler, Anne-Marie Carpenter, Daniel R. Dempsey, 2015, Insect biochemistry and molecular biology.

Synergistic ligand protection and intermediates in the denaturation of extremely thermophilic glutamine synthetase

D. Merkler, K. Srikumar, F. Wedler, 1987 .

Characterization and Quantification of the Fatty Acid Amidome

Emma K. Farrell, D. Merkler, Gabriela Suarez, 2020 .

The rate constant describing slow-onset inhibition of yeast AMP deaminase by coformycin analogues is independent of inhibitor structure.

V. Schramm, M. Brenowitz, D. Merkler, 1990, Biochemistry.

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer’s Disease biomarker discovery cohort

K. Blennow, J. Molinuevo, P. Scheltens, 2019, Alzheimer's & Dementia.

Knockdown of arylalkylamine N-acetyltransferase-like 2 in Drosophila melanogaster.

D. Merkler, Ryan L. Anderson, Dean Holliday, 2019, Archives of insect biochemistry and physiology.

Aggregation and thermo-inactivation of glutamine synthetase from an extreme thermophile, Bacillus caldolyticus.

D. Merkler, K. Srikumar, F. Wedler, 1988, Biochimica et biophysica acta.

Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells[S]

Emma K. Farrell, D. Merkler, Ryan L. Anderson, 2016, Journal of Lipid Research.

Drosophila melanogaster as a model system to study long‐chain fatty acid amide metabolism

D. Merkler, Ryan L. Anderson, K. Jeffries, 2014, FEBS letters.

Evidence for substrate preorganization in the peptidylglycine α-amidating monooxygenase reaction describing the contribution of ground state structure to hydrogen tunneling.

Edward W. Lowe, Neil R. McIntyre, Brian Space, 2010, Journal of the American Chemical Society.

Catalytic and regulatory site composition of yeast AMP deaminase by comparative binding and rate studies. Resolution of the cooperative mechanism.

V. Schramm, D. Merkler, V L Schramm, 1990, The Journal of biological chemistry.

Thermostabilization of Bacillus caldolyticus glutamine synthetase by intrinsic and extrinsic factors.

D. Merkler, F. Wedler, 1985, Current topics in cellular regulation.

Yeast AMP deaminase. Catalytic activity in Schizosaccharomyces pombe and chromosomal location in Saccharomyces cerevisiae.

V. Schramm, D. Merkler, P. Sollitti, 1993, The Journal of biological chemistry.

Protein thermostability. Correlations between calculated macroscopic parameters and growth temperature for closely related thermophilic and mesophilic bacilli.

G. Farrington, D. Merkler, F. Wedler, 2009, International journal of peptide and protein research.

Evolutionary genomics analysis reveals gene expansion and functional diversity of arylalkylamine N‐acetyltransferases in the Culicinae subfamily of mosquitoes

Huaqing Chen, D. Merkler, A. Upadhyay, 2022, Insect science.

Bm-iAANAT3: Expression and characterization of a novel arylalkylamine N-acyltransferase from Bombyx mori.

D. Merkler, L. Galloway, M. Battistini, 2019, Archives of biochemistry and biophysics.

Insect Arylalkylamine N-Acyltransferases: Mechanism and Role in Fatty Acid Amide Biosynthesis

D. Merkler, Brian G. O’Flynn, Aidan J Hawley, 2018, Front. Mol. Biosci..

18O isotopic 13C NMR shift as proof that bifunctional peptidylglycine alpha-amidating enzyme is a monooxygenase.

D. Merkler, D. Ash, S. D. Young, 1992, Biochemistry.

Structural and functional investigations on the role of zinc in bifunctional rat peptidylglycine alpha-amidating enzyme.

D. Merkler, L. Snyder, D. Ash, 1997, Biochemistry.

Redox cycling of enzyme-bound copper during peptide amidation

J. Freeman, J. Villafranca, D. Merkler, 1993 .

Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Deinococcus radiodurans

J. K. White, W. Guida, H. Woodcock, 2018, Biochemistry & molecular biology journal.

Mechanistic Studies of

J. K. White, W. Guida, H. Woodcock, 2018 .

Acetyl group coordinated progression through the catalytic cycle of an arylalkylamine N-acetyltransferase

D. Merkler, Ziming Zhang, Ioannis Gelis, 2017, PloS one.

Elongases of Long-Chain Fatty Acids ELO2 and ELO9 Are Involved in Cuticle Formation and Function in Fecundity in the Yellow Fever Mosquito, Aedes aegypti

D. Merkler, Chenghong Liao, Qian Han, 2023, Insects.

Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase.

F. Fleming, D. Merkler, K. Merkler, 1996, Archives of biochemistry and biophysics.

Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine

Yu Chen, D. Merkler, Xiujun Zhang, 2017, Scientific Reports.