D. Bratton

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Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

V. Fadok, D. Voelker, P. Henson, 1992, Journal of immunology.

Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells.

V. Fadok, P. Henson, D. Bratton, 1999, Journal of immunology.

Lipid Rafts Regulate Lipopolysaccharide-induced Activation of Cdc42 and Inflammatory Functions of the Human Neutrophil*

K. Malcolm, J. Nick, M. Fessler, 2004, Journal of Biological Chemistry.

CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3).

V. Fadok, P. Henson, D. Bratton, 1998, Journal of immunology.

Granulocyte macrophage colony-stimulating factor contributes to enhanced monocyte survival in chronic atopic dermatitis.

Q. Hamid, M. Boguniewicz, D. Bratton, 1995, The Journal of clinical investigation.

Oxidant-Mediated Mitochondrial Injury in Eosinophil Apoptosis: Enhancement by Glucocorticoids and Inhibition by Granulocyte-Macrophage Colony-Stimulating Factor1

Ling-Yi L Chang, P. Henson, D. Bratton, 2003, The Journal of Immunology.

Evaluation of Parental Preference for the Treatment of Asthmatic Children Aged 6 to 11 Years with Oral Montelukast or Inhaled Cromolyn: A Randomized, Open-Label, Crossover Study

D. Bratton, J. Edelman, J. Estojak, 2003, The Journal of asthma : official journal of the Association for the Care of Asthma.

Circulating Hematopoietic Progenitor Cells are Decreased in COPD

R. Bowler, W. Janssen, A. Kloepfer, 2013, COPD.

p38 Mitogen-activated Protein Kinase-dependent and -independent Intracellular Signal Transduction Pathways Leading to Apoptosis in Human Neutrophils*

J. Nick, V. Fadok, P. Henson, 1998, The Journal of Biological Chemistry.

PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

W. Janssen, S. Atif, D. Bratton, 2015 .

Antiinflammatory effects of apoptotic cells.

P. Henson, D. Bratton, 2013, The Journal of clinical investigation.

Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation.

S. Wenzel, V. Fadok, P. Henson, 2002, American journal of respiratory cell and molecular biology.

Neutrophil clearance: when the party is over, clean-up begins.

P. Henson, D. Bratton, Peter M. Henson, 2011, Trends in immunology.

Oxidants Selectively Reverse TGF-β Suppression of Proinflammatory Mediator Production1

W. Janssen, P. Henson, D. Bratton, 2006, The Journal of Immunology.

Impaired Phagocytosis of Apoptotic Cells by Macrophages in Chronic Granulomatous Disease Is Reversed by IFN-γ in a Nitric Oxide-Dependent Manner

W. Janssen, M. Dinauer, D. Riches, 2010, The Journal of Immunology.

Oxide-Dependent Manner in a Nitric g Disease Is Reversed by IFN-Macrophages in Chronic Granulomatous Impaired Phagocytosis of Apoptotic Cells by

W. Janssen, M. Dinauer, D. Riches, 2010 .

Transcriptional and Translational Regulation

D. Bratton, C. Freire-de-Lima, Schiemann, 2008 .

Enhanced In Vitro Formation and Antibiotic Resistance of Nonattached Pseudomonas aeruginosa Aggregates through Incorporation of Neutrophil Products

K. Malcolm, J. Nick, D. Bratton, 2014, Antimicrobial Agents and Chemotherapy.

Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages.

G. Downey, W. Janssen, L. Ortiz, 2014, American journal of respiratory cell and molecular biology.

A receptor for phosphatidylserine-specific clearance of apoptotic cells

V. Fadok, P. Henson, D. Bratton, 2000, Nature.

Apoptotic cell removal

V. Fadok, P. Henson, D. Bratton, 2001, Current Biology.

Research in Acute Lung Injury and Pulmonary Fibrosis Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK

W. Janssen, P. Henson, D. Bratton, 2022 .

The Role of Granulocytes in the Pulmonary Response to Group B Streptococcal Toxin in Young Lambs

K. Sandberg, C. Hellerqvist, D. Bratton, 1987, Pediatric Research.

Vitronectin Receptor ( Use Either a Phosphatidylserine Receptor or ThatApoptotic Cells by Human Macrophages CD 36 Is Required for Phagocytosis of

V. Fadok, P. Henson, D. Bratton, 1998 .

Recognition ligands on apoptotic cells: a perspective

P. Henson, D. Bratton, S. Gardai, 2006, Journal of leukocyte biology.

G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ

M. Mack, James J. Lee, S. Colgan, 2016, The Journal of Immunology.

Montelukast, a leukotriene receptor antagonist, for the treatment of persistent asthma in children aged 2 to 5 years.

N. Santanello, H. Bisgaard, T. Reiss, 2001, Pediatrics.

Emerging roles for lysophosphatidylserine in resolution of inflammation.

D. Bratton, S. Frasch, 2012, Progress in lipid research.

Apoptotic Cells, through Transforming Growth Factor-β, Coordinately Induce Anti-inflammatory and Suppress Pro-inflammatory Eicosanoid and NO Synthesis in Murine Macrophages*

W. Schiemann, P. Henson, D. Bratton, 2006, Journal of Biological Chemistry.

NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Clearance of Activated and Dying Neutrophils via G2A*

C. Leslie, R. Murphy, P. Henson, 2008, Journal of Biological Chemistry.

Neutrophils Regulate Tissue Neutrophilia in Inflammation via the Oxidant-modified Lipid Lysophosphatidylserine*

C. Leslie, J. Nick, R. Murphy, 2013, The Journal of Biological Chemistry.

Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4.

D. Riches, P. Henson, D. Bratton, 2009, Blood.

PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease.

D. Riches, P. Henson, D. Bratton, 2010, Blood.

7 – Cellular Sources of Platelet-Activating Factor and Related Lipids

P. Henson, D. Bratton, K. Clay, 1994 .

Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease.

S. Holland, K. Malcolm, R. Nemenoff, 2015, The Journal of allergy and clinical immunology.

Immune deficiencies , infection , and systemic immune disorders Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease

S. Holland, K. Malcolm, R. Nemenoff, 2022 .

Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells.

W. Janssen, N. Voelkel, Takeshi Tanaka, 2012, American journal of physiology. Lung cellular and molecular physiology.

Exhaled nitric oxide before and after montelukast sodium therapy in school‐age children with chronic asthma: A preliminary study

C. White, D. Bratton, P. Silkoff, 1999, Pediatric pulmonology.

Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta.

K. Malcolm, W. Schiemann, V. Fadok, 2002, The Journal of biological chemistry.

Single‐breath exhaled nitric oxide in preschool children facilitated by a servo‐controlled device maintaining constant flow

D. Bratton, P. Silkoff, C. Bates, 2004, Pediatric pulmonology.

SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice.

D. Bratton, Y. Di, H. Chu, 2011, The American journal of pathology.

Impact of a multidisciplinary day program on disease and healthcare costs in children and adolescents with severe asthma: A two‐year follow‐up study

M. Klinnert, E. Gelfand, D. Bratton, 2001, Pediatric pulmonology.

Migration and accumulation of eosinophils toward regional lymph nodes after airway allergen challenge.

E. Gelfand, A. Dakhama, D. Bratton, 2004, The Journal of allergy and clinical immunology.

NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Clearance of Activated and Dying Neutrophils via G2A*

C. Leslie, R. Murphy, P. Henson, 2008, Journal of Biological Chemistry.

Fas deficiency delays the resolution of airway hyperresponsiveness after allergen sensitization and challenge.

E. Gelfand, L. Shultz, D. Bratton, 2001, The Journal of allergy and clinical immunology.

PPAR (cid:1) activation normalizes resolution of acute sterile inﬂammation in murine chronic granulomatous disease

D. Riches, P. Henson, D. Bratton, 2010 .

Signaling via Macrophage G2A Enhances Efferocytosis of Dying Neutrophils by Augmentation of Rac Activity*

C. Leslie, J. Bonventre, R. Murphy, 2011, The Journal of Biological Chemistry.

Brief report: therapeutic manipulations in severe nocturnal asthma. A nonconventional approach in a severe high-risk asthmatic.

S. Szefler, D. Bratton, R. Zaragoza, 1992, The Journal of asthma : official journal of the Association for the Care of Asthma.

Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes.

R. Kolde, R. Xavier, Yoko Ito, 2016, American journal of respiratory and critical care medicine.

Effects of platelet activating factor on calcium-lipid interactions and lateral phase separations in phospholipid vesicles.

R. Harris, P. Henson, D. Bratton, 1988, Biochimica et biophysica acta.

Effects of platelet activating factor and related lipids on phase transition of dipalmitoylphosphatidylcholine.

R. Harris, P. Henson, D. Bratton, 1988, Biochimica et biophysica acta.

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

V. Fadok, J. Westcott, P. Henson, 1998, The Journal of clinical investigation.

Induction of TGF-β1 Synthesis by Macrophages in Response to Apoptotic Cells Requires Activation of the Scavenger Receptor CD36

P. Henson, D. Bratton, S. Frasch, 2013, PloS one.

Autoimmunity and apoptosis: refusing to go quietly

P. Henson, D. Bratton, 2005, Nature Medicine.

Cytokines : Role of Proteases Lysed Cells on Macrophage Production of Differential Effects of Apoptotic Versus

V. Fadok, P. Henson, D. Bratton, 2001 .

Polyamine Regulation of Plasma Membrane Phospholipid Flip-Flop during Apoptosis*

V. Fadok, P. Henson, D. Bratton, 1999, The Journal of Biological Chemistry.

"Their's but to do and die": eosinophil longevity in asthma.

V. Fadok, D. Bratton, 1999, The Journal of allergy and clinical immunology.

The Atopic Dermatitis Quickscore (ADQ): validation of a new parent-administered atopic dermatitis scoring tool.

M. Klinnert, E. Gelfand, M. Strand, 2008, Annals of Allergy, Asthma & Immunology.

Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells

W. Janssen, J. Reisz, P. Henson, 2022, Cell reports.

×Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils*

David A Hildeman, S. K. Frankel, P. Henson, 2004, Journal of Biological Chemistry.

Lysophospholipids of Different Classes Mobilize Neutrophil Secretory Vesicles and Induce Redundant Signaling through G2A1

R. Murphy, P. Henson, D. Bratton, 2007, The Journal of Immunology.

Induce Redundant Signaling through G2A Mobilize Neutrophil Secretory Vesicles and Lysophospholipids of Different Classes

R. Murphy, P. Henson, D. Bratton, 2007 .

Loss of Phospholipid Asymmetry and Surface Exposure of Phosphatidylserine Is Required for Phagocytosis of Apoptotic Cells by Macrophages and Fibroblasts*

V. Fadok, P. Henson, D. Bratton, 2001, The Journal of Biological Chemistry.

Myeloid Cell Turnover and Clearance

W. Janssen, P. Henson, D. Bratton, 2016, Microbiology spectrum.

Laparoscopic fundoplication to enhance pulmonary function in children with severe reactive airway disease and gastroesopheagal reflux disease

R. Deterding, M. Boguniewicz, J. Chang, 1997, Surgical Endoscopy.

The effects of laparoscopic Nissen fundoplication to enhance pulmonary function in the treatment of a patient with severe asthma and gastroesophageal reflux disease.

D. Bratton, S. Rothenberg, 2008, The Journal of allergy and clinical immunology.

Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury

W. Janssen, T. Fingerlin, A. D’Alessandro, 2017, American journal of respiratory cell and molecular biology.

Role of gp91phox in hepatic macrophage programming and alcoholic liver disease

Liangguo Xu, D. Frank, D. Bratton, 2017, Hepatology communications.

IgG Autoantibodies against Deposited C3 Inhibit Macrophage-Mediated Apoptotic Cell Engulfment in Systemic Autoimmunity

J. Thurman, J. Kappler, P. Henson, 2011, The Journal of Immunology.

Regulation of Phospholipid Scramblase Activity during Apoptosis and Cell Activation by Protein Kinase Cδ*

V. Fadok, P. Henson, D. Bratton, 2000, The Journal of Biological Chemistry.

Prevention of symptomatic patent ductus arteriosus with a single dose of indomethacin.

R. Cotton, M. Mellander, D. Bratton, 1987, The Journal of pediatrics.

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences.

V. Fadok, P. Henson, D. Bratton, 2001, The Journal of clinical investigation.

The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

V. Fadok, P. Henson, D. Bratton, 1998, Cell Death and Differentiation.

Staphylococcal toxic shock syndrome toxin-1 inhibits monocyte apoptosis.

D. Bratton, D. Leung, D. Doherty, 1999, The Journal of allergy and clinical immunology.

Letter to the Editor Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia

S. Holland, C. Zerbe, P. Henson, 2015 .

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

W. Janssen, M. Michalak, P. Henson, 2005, Cell.

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

V. Fadok, P. Henson, D. Bratton, 2001, The Journal of experimental medicine.

A model for the extracellular release of PAF: the influence of plasma membrane phospholipid asymmetry.

P. Henson, D. Bratton, K. Clay, 1991, Biochimica et biophysica acta.

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

C. Haslett, V. Fadok, P. Henson, 1992, Journal of immunology.

Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases1

V. Fadok, P. Henson, D. Bratton, 2001, The Journal of Immunology.

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

S. Colgan, D. Bratton, H. Eltzschig, 2014, Nature Reviews Drug Discovery.

Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation

Christina C. Leslie, Joseph V. Bonventre, C. Leslie, 2013, PloS one.

CD36 Is Required for Phagocytosis of Apoptotic Cells by Human Macrophages That Use Either a Phosphatidylserine Receptor or the Vitronectin Receptor (αvβ3)

V. Fadok, P. Henson, D. Bratton, 1998, The Journal of Immunology.

Three Unique Interstitial Macrophages in the Murine Lung at Steady State

W. Janssen, P. Henson, S. Atif, 2017, American journal of respiratory cell and molecular biology.

Transcriptional and Translational Regulation of TGF-β Production in Response to Apoptotic Cells1

W. Schiemann, P. Henson, D. Bratton, 2008, The Journal of Immunology.

Apoptotic Cells Production in Response to b of TGF-Transcriptional and Translational Regulation

W. Schiemann, P. Henson, D. Bratton, 2008 .

Appearance of Phosphatidylserine on Apoptotic Cells Requires Calcium-mediated Nonspecific Flip-Flop and Is Enhanced by Loss of the Aminophospholipid Translocase*

V. Fadok, P. Henson, D. Bratton, 1997, The Journal of Biological Chemistry.

Gastroesophageal Reflux in Severe Asthma

D. Bratton, Philip Hanna, 2001 .

Effects of temperature on cholinergic contractility of rabbit airway muscle.

M. Grunstein, D. Bratton, D. T. Tanaka, 1987, Journal of applied physiology.

The phosphatidylserine receptor: a crucial molecular switch?

V. Fadok, P. Henson, D. Bratton, 2001, Nature Reviews Molecular Cell Biology.

Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells

A. Ridley, V. Fadok, Y. Leverrier, 2001, The Journal of cell biology.

Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress.

R. Bowler, D. Riches, R. Oberley-Deegan, 2010, Free radical biology & medicine.

Cross-talk between ERK and p38 MAPK Mediates Selective Suppression of Pro-inflammatory Cytokines by Transforming Growth Factor-β*

K. Malcolm, W. Schiemann, V. Fadok, 2002, The Journal of Biological Chemistry.

Recognition and Removal of Apoptotic Cells

P. Henson, D. Bratton, 2009 .

Release of platelet activation factor from activated neutrophils. Transglutaminase-dependent enhancement of transbilayer movement across the plasma membrane.

D. Bratton, 1993, The Journal of biological chemistry.

Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.

K. Brown, F. Accurso, V. Fadok, 2002, The Journal of clinical investigation.

TNF-α Inhibits Macrophage Clearance of Apoptotic Cells via Cytosolic Phospholipase A2 and Oxidant-Dependent Mechanisms1

W. Janssen, P. Henson, D. Bratton, 2007, The Journal of Immunology.

Phospholipid Flip-Flop and Phospholipid Scramblase 1 (PLSCR1) Co-localize to Uropod Rafts in Formylated Met-Leu-Phe-stimulated Neutrophils*

M. Fessler, P. Henson, D. Bratton, 2004, Journal of Biological Chemistry.

Adverse Reactions to Cromolyn Sodium: Patient Report and Review of the Literature

D. Bratton, M. Lester, 1997, Clinical pediatrics.

The effect of montelukast versus usual care on health care resource utilization in children aged 2 to 5 years with asthma.

N. Santanello, E. Dasbach, D. Bratton, 2004, Clinical therapeutics.

Obesity impairs apoptotic cell clearance in asthma.

E. R. Sutherland, D. Riches, D. Bratton, 2013, The Journal of allergy and clinical immunology.

The ability to recognize phosphatidylserine on apoptotic cells is an inducible function in murine bone marrow-derived macrophages.

D. Riches, V. Fadok, D. Voelker, 1993, Chest.

Apoptotic Cell Recognition: Will the Real Phosphatidylserine Receptor(s) Please Stand up?

P. Henson, D. Bratton, 2008, Current Biology.

Modulation of Macrophage Efferocytosis in Inflammation

A. Bierhaus, P. Henson, D. Bratton, 2011, Front. Immun..

Allergy: Airway Epithelial Rac1 Suppresses Allergic Inflammation

P. Henson, D. Bratton, Donna L. Bratton, 2013, Current Biology.

Polyamine inhibition of transbilayer movement of plasma membrane phospholipids in the erythrocyte ghost.

D. Bratton, 1994, The Journal of biological chemistry.

Caregiver negative affect is a primary determinant of caregiver report of pediatric asthma quality of life.

M. Klinnert, D. Bratton, M. Price, 2002, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Mycobacterium abscessus Induces a Limited Pattern of Neutrophil Activation That Promotes Pathogen Survival

P. Reynolds, E. Chan, K. Malcolm, 2013, PloS one.

Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms

L. Kremer, K. Malcolm, J. Nick, 2018, PloS one.

Regulation of macrophage cytokine production by phagocytosis of apoptotic and post-apoptotic cells.

V. Fadok, P. Henson, D. Bratton, 1998, Biochemical Society transactions.

The mechanism of internalization of platelet-activating factor in activated human neutrophils. Enhanced transbilayer movement across the plasma membrane.

V. Fadok, P. Henson, D. Bratton, 1992, Journal of immunology.

Ingested Apoptotic Cells in Macrophages That β Endogenous TGF-of Inflammatory Mediator Production by Transcriptional and Translational Regulation

V. Fadok, P. Henson, D. Bratton, 1999 .

Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment.

S. Holland, C. Zerbe, P. Henson, 2015, The Journal of allergy and clinical immunology.

A case of recurrent facial angioedema associated with elevated tree pollen counts.

N. Rabinovitch, D. Jayaraman, D. Bratton, 2017, The journal of allergy and clinical immunology. In practice.

Engulfment in Systemic Autoimmunity CellInhibit Macrophage-Mediated Apoptotic IgG Autoantibodies against Deposited C 3 Boackle and

J. Thurman, J. Kappler, P. Henson, 2011 .

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

V. Fadok, P. Henson, D. Bratton, 2001, The Journal of experimental medicine.

Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4.

D. Riches, P. Henson, D. Bratton, 2009, Blood.

Neutrophil Clearance: when the party’s over, cleanup begins

D. Bratton, 2011 .

A receptor for phosphatidylserine-specific clearance of apoptotic cells

V. Fadok, P. Henson, D. Bratton, 2000, Nature.

A LTB4/CD11b self-amplifying loop drives pyogranuloma formation in chronic granulomatous disease

D. Bratton, Sophie L Gibbings, Peter M. Henson, 2024, iScience.

TNFα: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease

D. Bratton, E. Redente, Sophie L Gibbings, 2024, Frontiers in immunology.

A receptor for phosphatidylserine-speci ® c clearance of apoptotic cells

H. Hydén, A. Hamberger, H. Hansson, 2000 .

INFLUENCE OF EARLY INDOMETHACIN ON VENOUS ADMIXTURE IN INFANTS WITH HMD

R. Cotton, M. Mellander, D. Bratton, 1984, Pediatric Research.