A. Wollmer

发表

Targeted Molecular Dynamics Simulation of Conformational Change-Application to the T ↔ R Transition in Insulin

Jürgen Schlitter, Axel Wollmer, E. Jacoby, 1993 .

Human ciliary neurotrophic factor: a structure-function analysis.

M. Comeau, P. Heinrich, J. Weis, 1995, The Biochemical journal.

Structure-function studies of an IGF-I analogue that can be chemically cleaved to a two-chain mini-IGF-I.

J. Pitts, S. Wood, A. Wollmer, 2001, Protein Engineering.

A myoglobin-type haemoglobin of Chironomus thummi thummi.

K. Gersonde, A. Wollmer, G. Buse, 1972, European journal of biochemistry.

Tryptophanyl circular dichroism in a special hemoglobin

A. Wollmer, G. Buse, 1971, FEBS letters.

An algorithm for the selection of representative fourier coefficients in smoothing CD spectra

A. Wollmer, W. Strassburger, U. Glatter, 1981, Biophysics of structure and mechanism.

Comparative studies on the dynamics of crosslinked insulin

P. Krüger, A. Wollmer, J. Hahnen, 2005, European Biophysics Journal.

Two mutant forms of human insulin. Structural consequences of the substitution of invariant B24- or B25-phenylalanine by leucine.

A. Wollmer, G. Dodson, W. Strassburger, 1981, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Receptor-binding assay of chemically modified insulins

A. Wollmer, P. Freychet, D. Brandenburg, 1974, Diabetologia.

The relation of conformation and association of insulin to receptor binding; x-ray and circular-dichroism studies on bovine and hystricomorph insulins.

T. Blundell, S. Wood, A. Wollmer, 1975, European journal of biochemistry.

Insulin polymorphism: some physical and biological properties of rat insulins.

T. Blundell, D. Steiner, S. Wood, 1978, Archives of biochemistry and biophysics.

The role of the C-terminus of the insulin B-chain in modulating structural and functional properties of the hormone.

H. Höcker, A. Wollmer, M. Leithäuser, 2009, International journal of peptide and protein research.

A solution equivalent of the 2Zn----4Zn transformation of insulin in the crystal.

D. Mercola, A. Wollmer, G. Dodson, 1984, European journal of biochemistry.

A monomeric insulin from the porcupine (Hystrix cristata), an Old World hystricomorph

T. Blundell, A. Wollmer, R. Horuk, 1980, Nature.

Exclusion of bioactive contaminations in Streptococcus pyogenes erythrogenic toxin A preparations by recombinant expression in Escherichia coli

U. Hahn, L. Rink, H. Kirchner, 1997, Infection and immunity.

The Membrane Proximal Cytokine Receptor Domain of the Human Interleukin-6 Receptor Is Sufficient for Ligand Binding but Not for gp130 Association*

S. Rose-John, A. Wollmer, J. Grötzinger, 1998, The Journal of Biological Chemistry.

Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.

S. Rose-John, Jingwen Liu, A. Wollmer, 1994, Journal of immunology.

Shortened insulin with enhanced in vitro potency.

A. Wollmer, M. Spoden, H. Zahn, 1987, Biological chemistry Hoppe-Seyler.

Semisynthetic des-(B27-B30)-insulins with modified B26-tyrosine.

H. Höcker, M. Engels, A. Wollmer, 1991, Biological chemistry Hoppe-Seyler.

Cobalt probing of structural alternatives for insulin in solution.

A. Wollmer, B. Thomas, Barbara Thomas, 1989, Biological chemistry Hoppe-Seyler.

Structural transition in the metal-free hexamer of protein-engineered [B13 Gln]insulin.

A. Wollmer, S. Melberg, J. Stahl, 1989, Biological chemistry Hoppe-Seyler.

A shortened insulin with full in vitro potency.

W. Fischer, A. Wollmer, H. Zahn, 1985, Biological chemistry Hoppe-Seyler.

Combining Two Mutations of Human Interleukin-6 That Affect gp130 Activation Results in a Potent Interleukin-6 Receptor Antagonist on Human Myeloma Cells (*)

S. Rose-John, A. Wollmer, J. Grötzinger, 1995, The Journal of Biological Chemistry.

Determination of subnanosecond fluorescence decays of chlorobenzene, tryptophan and the benzene-triethylamine exciplex using a nanosecond flashlamp

A. Wollmer, W. Strassburger, H. Scharf, 1983 .

Synthesis and properties of [A19-(p-fluorophenylalanine)] insulin.

S. Stoev, A. Wollmer, E. Golovinsky, 1988, Biological chemistry Hoppe-Seyler.

Structure-function relationships of shortened [LeuB25]insulins, semisynthetic analogues of a mutant human insulin.

W. Fischer, A. Wollmer, G. Dodson, 1986, Biological Chemistry Hoppe-Seyler.

(A14-phenylalanine)insulin: a new synthetic analogue.

A. Wollmer, W. Danho, A. Sasaki, 1980, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Models of G-protein coupled receptors revised for family-wide compliance with experimental data. A new sequence accommodation suggested for helix G.

P. Krüger, A. Wollmer, J. Grötzinger, 1995, Receptors & channels.

Phenol-promoted structural transformation of insulin in solution.

A. Wollmer, B. R. Johansen, P. Balschmidt, 1987, Biological chemistry Hoppe-Seyler.

Insulin : chemistry, structure and function of insulin and related hormones : proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4-7, 1979

A. Wollmer, D. Brandenburg, 1980 .

Crosslinked Insulins: Preparation, Properties, and Applications

A. Wollmer, H. Gattner, D. Brandenburg, 1977 .

Side-chain mobility and the calculation of tyrosyl circular dichroism of proteins. Implications of a test with insulin and des-B1-phenylalanine insulin.

A. Wollmer, W. Strassburger, J. Fleischhauer, 1977, Biophysical journal.

T-R Transition

A. Wollmer, 2002 .

Interaction ofthep85subunit ofPi3-kinase andits N-terminal SH2domainwitha PDGFreceptor phosphorylation site: structural features andanalysis of conformational changes

I. Gout, M. Waterfield, M. Federwisch, 1992 .

INSULIN STRUCTURE AND DIABETES TREATMENT

J. Finch, J. Brange, D. J. Edwards, 1997 .

Determination of interspin distances between spin labels attached to insulin: comparison of electron paramagnetic resonance data with the X-ray structure.

H. Steinhoff, A. Antson, A. Wollmer, 1997, Biophysical journal.

Enhanced biopotency of synthetic C3a analogues by membrane binding. A fluorescence anisotropy decay study.

M. Federwisch, D. Bitter‐Suermann, R. Gerardy-Schahn, 1992, Biophysical chemistry.

Site-Directed Mutagenesis of Conserved Charged Residues in the Helical Region of the Human C5a Receptor

J. Köhl, A. Klos, W. Bautsch, 1996 .

Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities.

A. Svendsen, M. Engels, A. Wollmer, 1991, European journal of biochemistry.

Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease

R. Nitsch, C. Hock, J. Streffer, 2002, Nature Medicine.

Structure‐function analysis of human interleukin‐6

T. Hirano, P. Heinrich, S. Rose-John, 1990, FEBS letters.

Ligand-dependent Bohr effect of Chrionomus hemoglobins.

A. Wollmer, G. Buse, G. Steffens, 1977, European journal of biochemistry.

Proton-dependent dissociation equilibrium of hemoglobin. 1. A 700-nanometer light-scattering study on horse methemoglobin in the pH range 4.8 to 7.2.

A. Wollmer, H. Ohlenbusch, E. Schroeder, 1976, Biochemistry.

Calculations of the CD spectrum of bovine pancreatic ribonuclease.

R. Woody, P. Krüger, A. Wollmer, 1997, Biopolymers.

[The structure of proteoglycans from the cornea].

A. Wollmer, H. Greiling, H. Stuhlsatz, 1971, Hoppe-Seyler´s Zeitschrift für physiologische Chemie.

The effect of N-terminal extension on the structure and function of human interleukin-1 beta.

H. Worsaae, A. Wollmer, J. Mølvig, 1990, Biological Chemistry Hoppe-Seyler.

The conformational protential of porcine proinsulin C-peptide.

A. Wollmer, H. Zahn, V. Naithani, 1976, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Recombinant human O 6‐alkylguanine‐DNA alkyltransferase induces conformational change in bound DNA

U. Hassiepen, M. Federwisch, A. Wollmer, 1997, FEBS letters.

Calcium-dependent distance changes in binary and ternary complexes of troponin.

D. Mercola, A. Wollmer, J. Fleischhauer, 1990, European journal of biochemistry.

The lifetime of insulin hexamers.

U. Hassiepen, M. Federwisch, A. Wollmer, 1999, Biophysical journal.

Tryptophan mutants of human C5a anaphylatoxin: a fluorescence anisotropy decay and energy transfer study.

J. Köhl, T. Melcher, M. Federwisch, 1993, Biophysical chemistry.

Interaction of parvalbumin of pike II with calcium and terbium ions.

C. Gerday, A. Wollmer, W. Strassburger, 1988, Biochimica et biophysica acta.

Conformational studies on the pancreatic polypeptide hormone family.

T. Blundell, D. Barlow, J. Pitts, 1984, European journal of biochemistry.

Molecular Modeling-guided Mutagenesis of the Extracellular Part of gp130 Leads to the Identification of Contact Sites in the Interleukin-6 (IL-6)·IL-6 receptor·gp130 Complex*

P. Heinrich, G. Müller-Newen, A. Wollmer, 1997, The Journal of Biological Chemistry.

Analysis of the human interleukin-6/human interleukin-6 receptor binding interface at the amino acid level: proposed mechanism of interaction.

A. Wollmer, J. Grötzinger, V. Fontaine, 1997, Blood.

Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor.

P. Heinrich, S. Rose-John, A. Wollmer, 1996, European journal of biochemistry.

Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

Axel Wollmer, Peter C. Heinrich, James E. Darnell, 1996, The Journal of Biological Chemistry.

Interaction of the p85 subunit of PI 3‐kinase and its N‐terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes.

G. Panayotou, I. Gout, M. Waterfield, 1992, The EMBO journal.

Use of immobilized synthetic peptides for the identification of contact sites between human interleukin‐6 and its receptor

J. Schneider-Mergener, P. Heinrich, A. Wollmer, 1996, FEBS letters.

The signal transducer gp130: Solution structure of the carboxy‐terminal domain of the cytokine receptor homology region

S. Grzesiek, P. Heinrich, G. Müller-Newen, 2008, Protein science : a publication of the Protein Society.

Analysis of the mechanism of action of anti-human interleukin-6 and anti-human interleukin-6 receptor-neutralising monoclonal antibodies.

A. Wollmer, J. Grötzinger, V. Fontaine, 1997, European journal of biochemistry.

Cyclic disulfide analogues of the complement component C3a. Synthesis and conformational investigations.

H. Höcker, D. Bitter‐Suermann, A. Wollmer, 2009, International journal of peptide and protein research.

Calcium binding by troponin-C and homologs is correlated with the position and linear density of "beta-turn forming" residues.

D. Mercola, A. Wollmer, B. Bullard, 1979, Journal of theoretical biology.

The solution structure of a superpotent b‐chain‐shortened single‐replacement insulin analogue

A. Wollmer, J. Grötzinger, G. Kurapkat, 2008, Protein science : a publication of the Protein Society.

Receptor-binding region of insulin

T. Blundell, S. Gammeltoft, S. Wood, 1976, Nature.

Distinction of structural reorganisation and ligand binding in the T<==>R transition of insulin on the basis of allosteric models.

E. Jacoby, P. Krüger, Y. Karatas, 1993, Biological chemistry Hoppe-Seyler.

Inactive conformation of an insulin despite its wild‐type sequence

A. Wollmer, G. Kurapkat, J. Grotzinger, 1997, Protein science : a publication of the Protein Society.

Solution structure of a mini IGF‐1

J. Pitts, A. Wollmer, J. Grötzinger, 1996, Protein science : a publication of the Protein Society.

Cooperativity and intermediate states in the T----R-structural transformation of insulin.

P. Krüger, A. Wollmer, G. Gilge, 1990, Biological chemistry Hoppe-Seyler.

Adaptation of plasminogen activator sequences to known protease structures

T. Blundell, J. Pitts, L. Flohé, 1983, FEBS Letters.

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

E. Obberghen, J. Roth, A. Wollmer, 1978, Nature.

Inequivalent conformational response of Chironomus hemoglobins to ligation with O2 and CO. A circular-dichrosim and infrared-spectroscopic study.

A. Wollmer, G. Buse, G. Steffens, 1977, European journal of biochemistry.

Isolation of Corneal Keratan-Chondroproteoglycans and Their Composition

A. Wollmer, H. Greiling, H. Stuhlsatz, 1974 .

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

S. Rose-John, C. Peschel, A. Wollmer, 1997, Nature Biotechnology.

Epidermal growth factor binding induces a conformational change in the external domain of its receptor.

M. Waterfield, N. McDonald, M. Federwisch, 1989, The EMBO journal.

Design and biological activity of a new generation of synthetic C3a analogues by combination of peptidic and non-peptidic elements.

D. Bitter‐Suermann, R. Gerardy-Schahn, A. Wollmer, 1988, The Biochemical journal.

Structure-activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants.

G. Haegeman, J. Murray-Rust, N. McDonald, 2001, European journal of biochemistry.

Characterization and Binding Specificity of the Monomeric STAT3-SH2 Domain*

J. Schneider-Mergener, P. Heinrich, S. Haan, 1999, The Journal of Biological Chemistry.

X-ray analysis and circular dichroism of the acid protease from Endothia parasitica and chymosin.

T. Blundell, A. Wollmer, T. Sewell, 1977, Advances in experimental medicine and biology.

Calculation of the circular dichroism spectrum of cyclo-(L-tyr-L-tyr) based on a molecular dynamics simulation.

R. Woody, P. Krüger, A. Wollmer, 1994, Biophysical chemistry.

The family of the IL‐6‐Type cytokines: Specificity and promiscuity of the receptor complexes

S. Rose-John, A. Wollmer, G. Kurapkat, 1997, Proteins.

Inhaled Loxapine for Acute Treatment of Agitation in Patients With Borderline Personality Disorder: A Case Series.

K. Kahl, A. Wollmer, T. Kruger, 2015, Journal of clinical psychopharmacology.

Reversible dissociation and unfolding of pyruvate decarboxylase from Zymomonas mobilis.

M. Kula, A. Wollmer, J. Grötzinger, 1994, European journal of biochemistry.

Heterotropic allosterism of monomeric haemoglobins of Chironomus thummi thummi.

K. Gersonde, A. Wollmer, G. Buse, 1972, European journal of biochemistry.

Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor.

J. Köhl, A. Klos, W. Bautsch, 1994, European journal of biochemistry.

Analysis of protein self-association at constant concentration by fluorescence-energy transfer.

U. Hassiepen, M. Federwisch, P. Krüger, 1998, European journal of biochemistry.

Proteolyses of a fluorogenic insulin derivative and native insulin in reversed micelles monitored by fluorescence emission, reversed-phase high-performance liquid chromatography, and capillary zone electrophoresis.

H. Höcker, A. Wollmer, M. Leithäuser, 1994, Analytical biochemistry.

Interleukin-6 and related cytokines: effect on the acute phase reaction.

I. Kerr, P. Heinrich, G. Müller-Newen, 1998, Zeitschrift fur Ernahrungswissenschaft.

Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid

A. Wollmer, G. Dodson, D. Brandenburg, 1980 .

Self-Association of Insulin Reconsidered

A. Wollmer, T. Muelders, 2002 .

A comparison of the structure and dynamics of avian pancreatic polypeptide hormone in solution and in the crystal

W. F. Gunsteren, P. Krüger, A. Wollmer, 1985, European Biophysics Journal.

Calculated tyrosyl circular dichroism of proteins

T. Blundell, D. Mercola, J. Pitts, 1982, FEBS letters.

The effect of a non-peptide interchain crosslink on the reoxidation of reduced insulin.

A. Wollmer, D. Brandenburg, 1973, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

MD simulation of protein-ligand interaction: formation and dissociation of an insulin-phenol complex.

Jürgen Schlitter, Axel Wollmer, Peter Krüger, 2003, Biophysical journal.

Yeast pyruvate decarboxylase: spectral studies of the recombination of the apoenzyme with thiamine pyrophosphate and magnesium.

A. Wollmer, J. Ullrich, 1971, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Structural organization of the human insulin receptor ectodomain.

H. Erickson, M. Federwisch, A. Wollmer, 1992, The Journal of biological chemistry.

Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding.

B. Ursø, J. Pitts, C. Verma, 1999, Protein engineering.

Development of an optimized refolding process for recombinant Ala-Glu-IGF-1.

H. H. Sørensen, A. Wollmer, S. Bayne, 1992, Protein Engineering.

Modeling of G-protein coupled receptors with bacteriorhodopsin as a template. A novel approach based on interaction energy differences.

E. Jacoby, P. Krüger, M. Engels, 1994, Journal of receptor research.

Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin.

E J Dodson, G G Dodson, A. Wilkinson, 1992, Journal of molecular biology.

Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding.

B. Ursø, J. Pitts, J. Murray-Rust, 1996, Protein engineering.

Signal transducer gp130: biochemical characterization of the three membrane-proximal extracellular domains and evaluation of their oligomerization potential.

P. Heinrich, G. Müller-Newen, A. Herrmann, 2001, The Biochemical journal.

An insulin with the native sequence but virtually no activity.

A. Wollmer, H. Gattner, D. Brandenburg, 1994, Biological chemistry Hoppe-Seyler.

Site-directed mutagenesis of conserved charged residues in the helical region of the human C5a receptor. Arg2O6 determines high-affinity binding sites of C5a receptor.

J. Köhl, A. Klos, W. Bautsch, 1996, European journal of biochemistry.

Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin.

S. Gammeltoft, J. Pitts, S. Wood, 1986, Biochemical Journal.

Recombinant human O6-alkylguanine-DNA alkyltransferase (AGT), Cys145-alkylated AGT and Cys145 --> Met145 mutant AGT: comparison by isoelectric focusing, CD and time-resolved fluorescence spectroscopy.

M. Dewor, U. Hassiepen, M. Federwisch, 1997, The Biochemical journal.