S. Ghisla

发表

O2 Reactivity of Flavoproteins

K. Schulten, L. Pollegioni, J. Saam, 2010, The Journal of Biological Chemistry.

Plant-type phytoene desaturase: Functional evaluation of structural implications

J. Timmer, M. Fehling-Kaschek, P. Beyer, 2017, PloS one.

Medium-long-chain chimeric human Acyl-CoA dehydrogenase: medium-chain enzyme with the active center base arrangement of long-chain Acyl-CoA dehydrogenase.

P. Bross, I. Rasched, S. Ghisla, 1996, Biochemistry.

Catalytic and redox properties of glycine oxidase from Bacillus subtilis.

L. Pollegioni, M. Pedotti, G. Molla, 2009, Biochimie.

Co-overexpression of bacterial GroESL chaperonins partly overcomes non-productive folding and tetramer assembly of E. coli-expressed human medium-chain acyl-CoA dehydrogenase (MCAD) carrying the prevalent disease-causing K304E mutation.

L. Bolund, P. Bross, T. Jensen, 1993, Biochimica et biophysica acta.

Studies with general acyl-CoA dehydrogenase from pig kidney. Inactivation by a novel type of "suicide" inhibitor, 3,4-pentadienoyl-CoA.

S. Ghisla, C. Thorpe, A. Wenz, 2008, European journal of biochemistry.

Fluorescence properties of reduced flavins and flavoproteins.

A. Visser, S. Ghisla, V. Massey, 1979, European journal of biochemistry.

Electronic effects of 7 and 8 ring substituents as predictors of flavin oxidation-reduction potentials

S. Ghisla, D. Edmondson, 1999 .

On the reaction mechanism of L-lactate oxidase: quantitative structure-activity analysis of the reaction with para-substituted L-mandelates.

K. Janko, S. Ghisla, V. Massey, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Molecular evolution and substrate specificity of acyl-CoA dehydrogenases: chimaeric "medium/long' chain-specific enzyme from medium-chain acyl-CoA dehydrogenase.

S. Ghisla, A. Nandy, B. Küchler, 1996, Biochemical Society transactions.

Characterization of human and pig kidney long-chain-acyl-CoA dehydrogenases and their role in beta-oxidation.

Y. Dong, S. Ghisla, A. Strauss, 1997, European journal of biochemistry.

Biochemical characterization of purified, human recombinant Lys304-->Glu medium-chain acyl-CoA dehydrogenase containing the common disease-causing mutation and comparison with the normal enzyme.

P. Bross, N. Gregersen, I. Rasched, 1997, European journal of biochemistry.

Structure of Phytoene Desaturase Provides Insights into Herbicide Binding and Reaction Mechanisms Involved in Carotene Desaturation.

P. Beyer, S. Ghisla, O. Einsle, 2017, Structure.

On the Structure and Function of the Phytoene Desaturase CRTI from Pantoea ananatis, a Membrane-Peripheral and FAD-Dependent Oxidase/Isomerase

P. Beyer, S. Al‐Babili, S. Ghisla, 2012, PloS one.

The Path from β-Carotene to Carlactone, a Strigolactone-Like Plant Hormone

P. Beyer, S. Al‐Babili, H. Bouwmeester, 2012, Science.

Plant Carotene Cis-Trans Isomerase CRTISO

P. Beyer, S. Ghisla, J. Hirschberg, 2011, The Journal of Biological Chemistry.

The Lycopene Cyclase CrtY from Pantoea ananatis (Formerly Erwinia uredovora) Catalyzes an FADred-dependent Non-redox Reaction*

P. Beyer, S. Al‐Babili, A. Krieger-Liszkay, 2010, The Journal of Biological Chemistry.

Cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum: effect of surfactants and organic solvents on activity

L. Pollegioni, G. Gadda, S. Ghisla, 1999, Biotechnology and applied biochemistry.

Suspected pterin-4a-carbinolamine dehydratase deficiency: Hyperphenylalaninaemia due to inhibition of phenylalanine hydroxylase by tetrahydro-7-biopterin

C. Heizmann, N. Blau, S. Ghisla, 1992, Journal of Inherited Metabolic Disease.

On the Oxygen Reactivity of Flavoprotein Oxidases

L. Pollegioni, M. Pedotti, G. Molla, 2008, Journal of Biological Chemistry.

The synthesis of succinate-dehydrogenase riboflavin.

S. Ghisla, P. Hemmerich, U. Hartmann, 1970, Angewandte Chemie.

Studies on succinate dehydrogenase. 8 -Histidyl-FAD as the active center of succinate dehydrogenase.

S. Ghisla, P. Hemmerich, T. Singer, 1972, European journal of biochemistry.

Properties of flavins where the 8-methyl group is replaced by mercapto- residues.

S. Ghisla, V. Massey, E. Moore, 1979, The Journal of biological chemistry.

New flavins for old: artificial flavins as active site probes of flavoproteins.

S. Ghisla, V. Massey, 1986, The Biochemical journal.

Characterization of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum.

L. Pollegioni, S. Ghisla, S. Zucchelli, 1997, European journal of biochemistry.

A hydrophobic sequence motif common to N-hydroxylating enzymes.

S. Ghisla, P. Macheroux, M. Singh, 1998, Trends in biochemical sciences.

CR-LAAO antileukemic effect against Bcr-Abl(+) cells is mediated by apoptosis and hydrogen peroxide.

S. Ghisla, T. R. Costa, S. Sampaio, 2016, International journal of biological macromolecules.

Mechanism of hypoglycaemic action of methylenecyclopropylglycine.

S. Ghisla, H. Wolf, K. Melde, 1989, The Biochemical journal.

Structure of a novel flavin chromophore from Avena coleoptiles, the possible 'blue light' photoreceptor.

S. Ghisla, P. Hemmerich, T. Kuster, 1984, European journal of biochemistry.

Pterin-4a-Carbinolamine Dehydratase from Pseudomonas aeruginosa: Characterization, Catalytic Mechanism and Comparison to the Human Enzyme

G. Stier, S. Ghisla, H. Curtius, 1998, Biological chemistry.

Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase.

A. Schieber, S. Ghisla, R. Frank, 1992, European journal of biochemistry.

Revisitation of the βCl-Elimination Reaction of d-Amino Acid Oxidase

L. Pollegioni, G. Molla, S. Ghisla, 2011, The Journal of Biological Chemistry.

Studies on the elimination reaction of Rhodotorula gracilis D-Amino acid oxidase with beta-chloro-D-alanine

L. Pollegioni, G. Molla, S. Ghisla, 2002 .

NIH shift in flavin-dependent monooxygenation: mechanistic studies with 2-aminobenzoyl-CoA monooxygenase/reductase.

W. Eisenreich, A. Bacher, C. Hultschig, 1999, Proceedings of the National Academy of Sciences of the United States of America.

ROLE OF CHARGE‐TRANSFER INTERACTIONS IN FLAVOPROTEIN CATALYSIS

S. Ghisla, V. Massey, 1974 .

Fluorescence and optical characteristics of reduced flavines and flavoproteins.

S. Ghisla, V. Massey, S. Mayhew, 1974, Biochemistry.

Optimization of d‐amino acid oxidase for low substrate concentrations – towards a cancer enzyme therapy

L. Pollegioni, R. Orrú, E. Rosini, 2009, The FEBS journal.

Chemical synthesis and some properties of 6-substituted flavins.

W. Kenney, S. Ghisla, T. Singer, 1980, Biochemistry.

Kinetic mechanisms of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum.

L. Pollegioni, S. Ghisla, M. Pilone, 1999, European journal of biochemistry.

l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines

S. Ghisla, S. Sampaio, S. Burin, 2016, Revista brasileira de hematologia e hemoterapia.

Biosynthesis of tetrahydrobiopterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver.

S. Ghisla, H. Curtius, U. Redweik, 1986, European journal of biochemistry.

RECENT ADVANCES IN TETRAHYDROBIOPTERIN BIOSYNTHESIS AND THE TREATMENT OF HUMAN DISEASE

R. Levine, S. Ghisla, A. Niederwieser, 1983 .

Metabolic consequences of methylenecyclopropylglycine poisoning in rats.

S. Ghisla, S. Jackson, K. Bartlett, 1991, The Biochemical journal.

Inactivation of general acyl-CoA dehydrogenase from pig kidney by a metabolite of hypoglycin A.

S. Ghisla, C. Thorpe, A. Wenz, 1981, The Journal of biological chemistry.

Insights into the formation of carlactone from in‐depth analysis of the CCD8‐catalyzed reactions

P. Beyer, S. Al‐Babili, S. Ghisla, 2017, FEBS letters.

6-Azido- and 6-aminoflavins as active-site probes of flavin enzymes.

K. Yagi, S. Ghisla, V. Massey, 1986, Biochemistry.

Cholesterol oxidase: biochemistry and structural features

S. Ghisla, A. Vrielink, 2009, The FEBS journal.

BORONIC ACIDS AS MECHANISTIC PROBES FOR THE BACTERIAL LUCIFERASE REACTION

B. Branchaud, S. Ghisla, P. Macheroux, 1991 .

Structure of the oxygen adduct intermediate in the bacterial luciferase reaction: C nuclear magnetic resonance determination.

J. W. Hastings, S. Ghisla, V. Favaudon, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum. Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FAD semiquinone/hydroxyethyl-ThDP radical pair.

R. Golbik, K. Tittmann, S. Ghisla, 2005, Biochemistry.

Activation of thiamin diphosphate in enzymes.

G. Schneider, D. Kern, K. Tittmann, 1998, Biochimica et biophysica acta.

On the structure of flavin-oxygen intermediates involved in enzymatic reactions.

S. Ghisla, B. Entsch, V. Massey, 1977, European journal of biochemistry.

Structural and mechanistic studies with pterin-4a-carbinolamine dehydratase from Pseudomonas aeruginosa : three-dimensional structure and comparison with the human enzyme

U. Sauer, D. Suck, G. Stier, 1997 .

Three Histidines in Pterin -4a -carbinolamine Dehydratase are the Important Residues for Substrate Binding and Catalysis

D. Suck, G. Stier, R. Ficner, 1996 .

Human pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1 alpha. Characterization and kinetic analysis of wild-type and mutant enzymes.

C. Heizmann, B. Thöny, S. Ghisla, 1995, European journal of biochemistry.

Human Pterin‐4α‐Carbinolamine Dehydratase/Dimerization Cofactor of Hepatocyte Nuclear Factor‐1α

C. Heizmann, B. Thöny, S. Ghisla, 1995 .

Characterization of Human Pterin-4a-carbinolamine Dehydratase/Dimerization Cofactor of Hepatocyte Nuclear Factor-1α, and of the Cys81-mutant Involved in Hyperphenylalanincemia

C. Heizmann, B. Thöny, S. Ghisla, 1995 .

Studies with Flavin Analogs Provide Evidence That a Protonated Reduced FMN Is the Substrate-induced Transient Intermediate in the Reaction of Escherichia coli Chorismate Synthase*

S. Bornemann, S. Ghisla, P. Macheroux, 1996, The Journal of Biological Chemistry.

Purification of 6-pyruvoyl-tetrahydropterin synthase from human liver.

S. Ghisla, H. Curtius, U. Redweik, 1986, Biochemical and biophysical research communications.

Bioluminescence emission from the reaction of luciferase-flavin mononucleotide radical with O2-..

J. W. Hastings, S. Ghisla, M. Kurfürst, 1983, Biochemistry.

Structure and catalytic inactivity of the bacterial luciferase neutral flavin radical.

J. W. Hastings, S. Ghisla, M. Kurfürst, 1982, European journal of biochemistry.

Fluorescence Properties of Luciferase Peroxyflavins Prepared with ISO-FMN and 2-THIO FMN

J. W. Hastings, S. Ghisla, P. Hemmerich, 1981 .

Kinetic mechanism of D-amino acid oxidases from Rhodotorula gracilis and Trigonopsis variabilis.

L. Pollegioni, S. Ghisla, W. Tischer, 1993, The Journal of biological chemistry.

Fluorescence and optical characteristics of reduced flavins and flavoproteins.

S. Ghisla, 1980, Methods in enzymology.

Studies on the bacterial luciferase reaction : Isotope effects on the light emission

J. W. Hastings, S. Ghisla, P. Macheroux, 1984 .

Characterization and postulated structure of the primary emitter in the bacterial luciferase reaction.

J. W. Hastings, S. Ghisla, M. Kurfürst, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Medium-chain acyl coenzyme A dehydrogenase from pig kidney has intrinsic enoyl coenzyme A hydratase activity.

S. Ghisla, C. Thorpe, P. Powell, 1986, Biochemistry.

Oligomerization and aggregation of lysine N6-hydroxylase : an enzyme of the bacterial aerobactin biosynthesis

W. Welte, S. Ghisla, P. Macheroux, 1999 .

Reduced Flavin: NMR investigation of N(5)-H exchange mechanism, estimation of ionisation constants and assessment of properties as biological catalyst

H. Rüterjans, S. Ghisla, P. Macheroux, 2005, BMC Biochemistry.

Mechanistic studies with general acyl-CoA dehydrogenase and butyryl-CoA dehydrogenase: evidence for the transfer of the beta-hydrogen to the flavin N(5)-position as a hydride.

S. Ghisla, C. Thorpe, V. Massey, 1984, Biochemistry.

Kinetic studies on the inactivation of L-lactate oxidase by [the acetylenic suicide substrate] 2-hydroxy-3-butynoate.

C. Walsh, S. Ghisla, V. Massey, 1976, Biochemistry.

Mechanisms of flavoprotein-catalyzed reactions.

S. Ghisla, V. Massey, 1989, European journal of biochemistry.

Studies on the catalytic mechanism of lactate oxidase. Formation of enantiomeric flavin-N(5)-glycollyl adducts via carbanion intermediates.

S. Ghisla, V. Massey, 1980, The Journal of biological chemistry.

Studies on succinate dehydrogenase. Site of attachment of the covalently-bound flavin to the peptide chain.

S. Ghisla, P. Hemmerich, A. Ehrenberg, 1972, European journal of biochemistry.

8-Azidoflavins as photoaffinity labels for flavoproteins.

S. Ghisla, V. Massey, P. Fitzpatrick, 1985, The Journal of biological chemistry.

8-Mercaptoflavins as active site probes of flavoenzymes.

S. Ghisla, V. Massey, E. Moore, 1979, The Journal of biological chemistry.

THE COVALENTLY BOUND FLAVIN ACTIVE CENTER OF SUCCINATE DEHYDROGENASE

W. Kenney, S. Ghisla, P. Hemmerich, 1972 .

The structure of the covalent flavin adduct formed between lactate oxidase and the suicide substrate 2-hydroxy-3-butynoate.

C. Walsh, S. Ghisla, V. Massey, 1976, Biochemistry.

Studies on the mechanism of action of the flavoenzyme lactate oxidase. Proton uptake and release during the binding of transition state analogs.

S. Ghisla, V. Massey, 1977, The Journal of biological chemistry.

Characterization of a disease-causing Lys329 to Glu mutation in 16 patients with medium-chain Acyl-CoA dehydrogenase deficiency

L. Bolund, P. Bross, B. Andresen, 1991, Journal of Inherited Metabolic Disease.

Molecular characterization of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: identification of a lys329 to glu mutation in the MCAD gene, and expression of inactive mutant enzyme protein in E. coli

L. Bolund, P. Bross, B. Andresen, 1991, Human Genetics.

Effects of Two Mutations Detected in Medium Chain Acyl-CoA Dehydrogenase (MCAD)-deficient Patients on Folding, Oligomer Assembly, and Stability of MCAD Enzyme (*)

L. Bolund, P. Bross, T. Jensen, 1995, The Journal of Biological Chemistry.

Immunochemical and molecular analysis of medium-chain acyl CoA dehydrogenase deficiency

S. Udaka, K. Yagi, N. Ohishi, 1990 .

Acyl-CoA dehydrogenases. A mechanistic overview.

S. Ghisla, C. Thorpe, 2004, European journal of biochemistry.

A mechanistic overview

S. Ghisla, C. Thorpe, 2004 .

7-Substituted pterins: formation during phenylalanine hydroxylation in the absence of dehydratase.

C. Heizmann, S. Ghisla, I. Rebrin, 1990, Biochemical and biophysical research communications.

Identification and properties of 8-hydroxyflavin--adenine dinucleotide in electron-transferring flavoprotein from Peptostreptococcus elsdenii.

S. Ghisla, S. Mayhew, 1976, European Journal of Biochemistry.

1H-NMR studies with tetrahydrobiopterins, evidence for the structure of 6-pyruvoyltetrahydropterin, an intermediate in the biosynthesis of tetrahydrobiopterin

N. Blau, S. Ghisla, H. Curtius, 1987 .

1H-NMR and mass spectrometric studies of tetrahydropterins. Evidence for the structure of 6-pyruvoyl tetrahydropterin, an intermediate in the biosynthesis of tetrahydrobiopterin.

S. Ghisla, W. Richter, T. Kuster, 1990, European journal of biochemistry.

Flavoenzyme structure and function. Approaches using flavin analogues.

S. Ghisla, D. Edmondson, 1999, Methods in molecular biology.

4-Thioflavins as active site probes of flavoproteins. General properties.

S. Ghisla, V. Massey, A. Claiborne, 1984, The Journal of biological chemistry.

Identification and properties of new flavins in electron-transferring flavoprotein from Peptostreptococcus elsdenii and pig-liver glycolate oxidase.

S. Ghisla, S. Mayhew, C. Whitfield, 1974, European journal of biochemistry.

Structural, spectroscopic and catalytic activity studies on glutathione reductase reconstituted with FAD analogues.

G. Schulz, U. Ermler, S. Ghisla, 1991, European journal of biochemistry.

6-Thiocyanatoflavins and 6-mercaptoflavins as active-site probes of flavoproteins.

K. Yagi, S. Ghisla, V. Massey, 1986, Biochemistry.

Preparation and some properties of 6-substituted flavins as active site probes for flavin enzymes.

K. Yagi, S. Ghisla, V. Massey, 1986, Biochemistry.

[35] Isolation, synthesis, and properties of 8-hydroxyflavins

S. Ghisla, S. Mayhew, 1980 .

Identification and structure of a novel flavin prosthetic group associated with reduced nicotinamide adenine dinucleotide dehydrogenase from Peptostreptococcus elsdenii.

S. Ghisla, S. Mayhew, 1973, The Journal of biological chemistry.

Studies in the flavin series. Part XVI. Alkylation and rearrangement reactions of dihydroalloxazines

C. Jefcoate, S. Ghisla, P. Hemmerich, 1971 .

Biochemical characterization of a variant human medium-chain acyl-CoA dehydrogenase with a disease-associated mutation localized in the active site.

P. Bross, I. Rasched, S. Ghisla, 1999, The Biochemical journal.

Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved.

S. Ghisla, T. Kuster, H. Curtius, 1985, European journal of biochemistry.

Flavin-dependent alcohol oxidase from yeast. Studies on the catalytic mechanism and inactivation during turnover.

S. Ghisla, P. Kroneck, J. Geissler, 1986, European journal of biochemistry.

Absorption and emission spectroscopic characterisation of 8-amino-riboflavin

P. Hegemann, P. Zirak, A. Penzkofer, 2009 .

Stereochemistry and accessibility of prosthetic groups in flavoproteins.

E. Pai, D. Manstein, S. Ghisla, 1988, Biochemistry.

Structure of the flavin adduct formed in the suicide reaction of alpha-hydroxybutynoate with D-lactate dehydrogenase.

S. Olson, S. Ghisla, V. Massey, 1979, Biochemistry.

NMR.-Study of nitrogen inversion and conformation of 1,5-dihydro-isoalloxazines ("reduced flavin"). Studies in the flavin series, XIX.

L. Tauscher, S. Ghisla, P. Hemmerich, 1973, Helvetica chimica acta.

Cholesterol Oxidase from Brevibacterium sterolicum

L. Pollegioni, G. Molla, S. Ghisla, 2001, The Journal of Biological Chemistry.

Yeast D-amino acid oxidase: structural basis of its catalytic properties.

K. Diederichs, L. Pollegioni, W. Welte, 2002, Journal of molecular biology.

Studies on glycollate oxidase from pea leaves determination of stereospecificity and mode of inhibition by α-hydroxybutynoate

G. Fendrich, S. Ghisla, 1982 .

Beta-oxidation of fatty acids. A century of discovery.

S. Ghisla, 2004, European journal of biochemistry.

A century of discovery

S. Ghisla, 2004 .

New aspects in biopterin biosynthesis in man

S. Ghisla, H. Curtius, A. Niederwieser, 1981, FEBS letters.

pH and kinetic isotope effects in d-amino acid oxidase catalysis.

L. Pollegioni, S. Ghisla, C. Harris, 2001, European journal of biochemistry.

Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver. Purification, characterization, and complete amino acid sequence.

C. Heizmann, N. Blau, B. Thöny, 1993, The Journal of biological chemistry.

2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Identification of the reaction products.

S. Ghisla, G. Fuchs, K. Ziegler, 1990, European journal of biochemistry.

2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Studies on the stoichiometry and the course of the reaction.

S. Ghisla, G. Fuchs, K. Ziegler, 1989, European journal of biochemistry.

Oxidation-reduction of general acyl-CoA dehydrogenase by the butyryl-CoA/crotonyl-CoA couple. A new investigation of the rapid reaction kinetics.

L. Schopfer, S. Ghisla, C. Thorpe, 1988, Biochemistry.

Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS‐activator peroxynitrite

A. Daiber, R. Cohen, S. Ghisla, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Molecular cloning, expression and purification of L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma.

S. Ghisla, P. Macheroux, Phaneeswara-Rao Kommoju, 2001, Protein expression and purification.

The structure of L‐amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site

R. Coulombe, S. Ghisla, P. Macheroux, 2000, The EMBO journal.

Mechanism of bacterial bioluminescence: 4a,5-dihydroflavin analogs as models for luciferase hydroperoxide intermediates and the effect of substituents at the 8-position of flavin on luciferase kinetics.

J. W. Hastings, S. Ghisla, J. Eckstein, 1993, Biochemistry.

Synthesis of the flavocoenzyme of monoamine oxidase

S. Ghisla, P. Hemmerich, 1971, FEBS letters.

The Mechanism of Action of Flavoprotein - Catalyzed Reactions

S. Ghisla, V. Massey, 1983 .

Mechanisms of cell death induction by L-amino acid oxidase, a major component of ophidian venom

M. Murkovic, E. Ferrando-May, S. Ghisla, 2006, Apoptosis.

Mechanism of activation of acyl-CoA substrates by medium chain acyl-CoA dehydrogenase: interaction of the thioester carbonyl with the flavin adenine dinucleotide ribityl side chain.

S. Ghisla, M. Wang, J. J. Kim, 1999, Biochemistry.

Studies with Lysine N6-Hydroxylase. Effect of a Mutation in the Assumed FAD Binding Site on Coenzyme Affinities and on Lysine Hydroxylating Activity

S. Ghisla, P. Macheroux, M. Singh, 1999, Biological chemistry.

Mechanisms of enzyme inhibition by hypoglycin, methylenecyclopropylglycine and their metabolites.

S. Ghisla, K. Melde, W. Boschert, 1990, Progress in clinical and biological research.

The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation.

K. Diederichs, L. Pollegioni, W. Welte, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Molecular complex of lumiflavin and 2-aminobenzoic acid: crystal structure, crystal spectra, and solution properties.

L. K. Hanson, S. Ghisla, M. Ludwig, 1981, Biochemistry.

On the reaction of d‐amino acid oxidase with dioxygen: O2 diffusion pathways and enhancement of reactivity

L. Pollegioni, E. Rosini, G. Molla, 2011, The FEBS journal.

Studies on the reaction mechanism of general acyl-CoA dehydrogenase. Determination of selective isotope effects in the dehydrogenation of butyryl-CoA.

S. Ghisla, B. Pohl, T. Raichle, 1986, European journal of biochemistry.

Mechanism of elementary catalytic steps of pyruvate oxidase from Lactobacillus plantarum.

R. Golbik, K. Tittmann, S. Ghisla, 2000, Biochemistry.

Induction of apoptosis in yeast by L‐amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma

M. Murkovic, S. Ghisla, P. Macheroux, 2008, Yeast.

Structurally different rat liver medium-chain acyl CoA dehydrogenases directed by complementary DNAs differing in their 5'-region.

K. Yagi, N. Ohishi, S. Ghisla, 1991, Biochimica et biophysica acta.

Structural and kinetic analyses of the H121A mutant of cholesterol oxidase.

L. Lim, L. Pollegioni, G. Molla, 2006, The Biochemical journal.

FAD analogues as prosthetic groups of human glutathione reductase. Properties of the modified enzyme species and comparisons with the active site structure.

R. Schirmer, R. Krauth-Siegel, S. Ghisla, 1985, European journal of biochemistry.

Evaluating the microbicidal, antiparasitic and antitumor effects of CR-LAAO from Calloselasma rhodostoma venom.

S. Ghisla, Danilo L Menaldo, S. Sampaio, 2015, International journal of biological macromolecules.

On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335.

L. Pollegioni, S. Sacchi, G. Molla, 2004, Biochimica et biophysica acta.

Structure and characterization of the glycan moiety of L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma.

S. Ghisla, P. Macheroux, A. Vrielink, 2001, European journal of biochemistry.

Evidence for a concerted mechanism in substrate dehydrogenation via hydride transfer

L. Pollegioni, S. Ghisla, C. Harris, 2001 .

L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma. Comparative sequence analysis and characterization of active and inactive forms of the enzyme.

S. Ghisla, P. Macheroux, L. Au, 2001, European journal of biochemistry.

Studies on the glycosylation of L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma

S. Ghisla, P. Macheroux, Michael Vetsch, 1999 .

Very high resolution crystal structure of D-Amino acid oxidase : insights into the reaction mechanisms and mode of ligand binding

K. Diederichs, L. Pollegioni, W. Welte, 1999 .

Location of the active site and proposed catalytic mechanism of pterin-4a-carbinolamine dehydratase.

D. Suck, G. Stier, R. Ficner, 1996, European journal of biochemistry.

Spectroscopic characterization of human liver pterin 4a-carbinolamine dehydratase.

S. Ghisla, I. Rebrin, F. Herrmann, 1993, Advances in experimental medicine and biology.

7-substituted pterins in humans with suspected pterin-4a-carbinolamine dehydratase deficiency. Mechanism of formation via non-enzymatic transformation from 6-substituted pterins.

C. Heizmann, J. Haavik, N. Blau, 1992, European journal of biochemistry.

Oxygen Access to the Active Site of Cholesterol Oxidase through a Narrow Channel Is Gated by an Arg-Glu Pair*

R. Coulombe, S. Ghisla, A. Vrielink, 2001, The Journal of Biological Chemistry.

Purification of the yellow fluorescent protein from Vibrio fischeri and identity of the flavin chromophore.

J. W. Hastings, S. Ghisla, P. Macheroux, 1987, Biochemical and biophysical research communications.

Two Similar Gene Clusters Coding for Enzymes of a New Type of Aerobic 2-Aminobenzoate (Anthranilate) Metabolism in the BacteriumAzoarcus evansii

S. Ghisla, G. Fuchs, M. Jahn, 2001, Journal of bacteriology.

2-Aminobenzoyl-CoA monooxygenase/reductase. Evidence for two distinct loci catalyzing substrate monooxygenation and hydrogenation.

S. Ghisla, G. Fuchs, V. Massey, 1995, European journal of biochemistry.

Kinetic and mechanistic studies on the reactions of 2-aminobenzoyl-CoA monooxygenase/reductase.

S. Ghisla, B. Langkau, 1995, European journal of biochemistry.

Biosynthesis of riboflavin. 6,7-Dimethyl-8-ribityllumazine 5'-phosphate is not a substrate for riboflavin synthase.

A. Bacher, S. Ghisla, H. Rokos, 1978, Biochimica et biophysica acta.

Time‐Resolved Fluorescence Study of the Dissociation of FMN from the Yellow Fluorescence Protein from Vibrio fischeri

A. Visser, S. Ghisla, A. Hoek, 1997 .

Formation of 3‐hydroxyglutaric acid in glutaric aciduria type I: in vitro participation of medium chain acyl‐CoA dehydrogenase

J. Vockley, S. Ghisla, M. Mack, 2019, JIMD reports.

L-Lactate oxidase

S. Ghisla, V. Massey, 1991 .

A time-dependent bacterial bioluminescence emission spectrum in an in vitro single turnover system: energy transfer alone cannot account for the yellow emission of Vibrio fischeri Y-1.

J. W. Hastings, S. Ghisla, P. Colepicolo, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Bacterial luciferase : bioluminescence emission using lumanzines as substrates

J. W. Hastings, S. Ghisla, P. Macheroux, 1994 .

Phytoene Desaturase from Oryza sativa: Oligomeric Assembly, Membrane Association and Preliminary 3D-Analysis

P. Beyer, F. Drepper, B. Warscheid, 2015, PloS one.

Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans.

S. Cederbaum, B. Andresen, J. Vockley, 2002, Molecular genetics and metabolism.

Isolation and characterization of the transient, luciferase-bound flavin-4a-hydroxide in the bacterial luciferase reaction

J. W. Hastings, S. Ghisla, P. Macheroux, 1987 .

Thermal unfolding of medium-chain acyl-CoA dehydrogenase and iso(3)valeryl-CoA dehydrogenase: study of the effect of genetic defects on enzyme stability.

J. Vockley, I. Jelesarov, I. Nasser, 2004, Biochimica et biophysica acta.

Substrate activation by acyl-CoA dehydrogenases: transition-state stabilization and pKs of involved functional groups.

S. Ghisla, P. Vock, S. Engst, 1998, Biochemistry.

Covalent adducts of lactate oxidase. Photochemical formation and structure identification.

S. Ghisla, V. Massey, Y. Choong, 1979, The Journal of biological chemistry.

Biosynthesis of tetrahydrobiopterin in man

S. Ghisla, T. Kuster, H. Curtius, 1985, Journal of Inherited Metabolic Disease.

Biosynthesis of tetrahydrobiopterin: possible involvement of tetrahydropterin intermediates

R. Levine, S. Ghisla, H. Curtius, 1984, Neurochemistry International.

Suicide inactivation of the flavoenzyme D-lactate dehydrogenase by alpha-hydroxybutynoate.

S. Olson, S. Ghisla, V. Massey, 1979, Biochemistry.

Oxidation of 2-thioflavins by peroxides. Formation of flavin 2-S-oxides.

S. Ghisla, P. Hemmerich, V. Massey, 1983, The Journal of biological chemistry.

Characterization of wild-type and an active site mutant of human medium chain acyl-CoA dehydrogenase after expression in Escherichia coli.

P. Bross, D. Kelly, I. Rasched, 1990, The Journal of biological chemistry.

Studies on the reaction mechanism of lactate oxidase. Formation of two covalent flavin-substrate adducts on reaction with glycollate.

S. Ghisla, V. Massey, K. Kieschke, 1980, The Journal of biological chemistry.

Ionisation Properties of Reduced, 1,5-Dihydroflavin, Rates of N(5)-H Exchange with Solvent

H. Rüterjans, S. Ghisla, P. Macheroux, 1991 .

Solvent isotope effects in reactions of human medium-chain acyl-CoA dehydrogenase active site mutants.

R. Schowen, S. Ghisla, R. Gradinaru, 2007, Biochemistry.

On The Mechanism of D-Amino Acid Oxidase

L. Pollegioni, S. Ghisla, W. Blodig, 1997, The Journal of Biological Chemistry.

Model Studies on Flavin-Dependent Carbonyl-Activation: Reduction of Carbonyl Compounds by Flavohydroquinone

S. Ghisla, P. Hemmerich, G. Blankenhorn, 1972, Zeitschrift fur Naturforschung. Teil B. Anorganische Chemie, organische Chemie, Biochemie, Biophysik, Biologie.

Dehydrogenation Mechanism in Flavoprotein Catalysis

S. Ghisla, 1982 .

Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.

S. Ghisla, M. Wang, R. Paschke, 1996, Biochemistry.

Characterization of wild-type human medium-chain acyl-CoA dehydrogenase (MCAD) and mutant enzymes present in MCAD-deficient patients by two-dimensional gel electrophoresis: evidence for post-translational modification of the enzyme.

L. Bolund, P. Bross, T. Jensen, 1994, Biochemical medicine and metabolic biology.

The crystal and molecular structure of two models of catalytic flavo(co)enzyme intermediates

M. Bolognesi, L. Incoccia, S. Ghisla, 1978 .

STRUCTURE/LINEAR FREE ENERGY CORRELATIONS AND DEUTERIUM KINETIC ISOTOPE EFFECTS USING SUBSTITUTED PHENYLGLYCINES*

L. Pollegioni, S. Ghisla, W. Blodig, 1997 .

[12] Bacterial luciferase intermediates: The neutral flavin semiquinone, its reaction with superoxide, and the flavin 4a-hydroxide

J. W. Hastings, S. Ghisla, M. Kurfürst, 1986 .

Alpha, beta-dehydrogenation by acyl-CoA dehydrogenases: role of functional groups at the active center.

P. Bross, S. Ghisla, A. Strauss, 1992, Progress in clinical and biological research.

Medium-Chain Acyl CoA Dehydrogenase: Evidence for Phosphorylation

H. Rüterjans, S. Ghisla, P. Macheroux, 1997, Biological chemistry.

Anti-pterins as Tools to Characterize the Function of Tetrahydrobiopterin in NO Synthase*

G. Prestwich, H. Schmidt, A. Reif, 1998, The Journal of Biological Chemistry.

In vitro synthesis of pig kidney general acyl CoA dehydrogenase.

K. Yagi, N. Ohishi, S. Ghisla, 1986, Biochemical and biophysical research communications.

Bioluminescence emission of bacterial luciferase with 1-deaza-FMN. Evidence for the noninvolvement of N(1)-protonated flavin species as emitters.

J. W. Hastings, S. Ghisla, P. Macheroux, 1989, European journal of biochemistry.

Cholesterol oxidase from Brevibacterium sterolicum and Streptomyces hygroscopicus : a covalent FAD binding vs. a non-covalent one

L. Pollegioni, S. Ghisla, L. Motteran, 1999 .