V. Chudasama

L. Lovat, S. Caddick, R. Hamoudi, 2016, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Dioxygen mediated hydroacylation of vinyl sulfonates and sulfones on water.

Richard J. Fitzmaurice, S. Caddick, V. Chudasama, 2010, Chemical communications.

Hydroacylation of α,β-unsaturated esters via aerobic C–H activation

Richard J. Fitzmaurice, S. Caddick, V. Chudasama, 2010, Nature Chemistry.

Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.

Pedro M. P. Gois, S. Caddick, C. Cordeiro, 2014, Chemical communications.

Fine-tuning thio-pyridazinediones as SMDC scaffolds (with intracellular thiol release via a novel self-immolative linker).

V. Chudasama, Marcos Fernández, André Shamsabadi, 2020, Chemical communications.

Recent advances in the synthesis of antibody-drug conjugates

S. Caddick, V. Chudasama, A. Maruani, 2016 .

Cysteine specific bioconjugation with benzyl isothiocyanates

Ádám A. Kelemen, G. Keserű, P. Ábrányi‐Balogh, 2020, RSC advances.

A rapid, site-selective and efficient route to the dual modification of DARPins† †Electronic supplementary information (ESI) available: LC-MS spectra for all reactions with proteins described herein. See DOI: 10.1039/c4cc00053f Click here for additional data file.

Mark E. B. Smith, S. Caddick, Stephen R. Martin, 2014, Chemical communications.

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

Mark E. B. Smith, S. Caddick, V. Chudasama, 2015, Organic & biomolecular chemistry.

Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides

V. Chudasama, André Shamsabadi, Nehaal Ahmed, 2019, ACS omega.

Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7ob03138f

Daniel A. Richards, S. Caddick, V. Chudasama, 2018, Organic & biomolecular chemistry.

Intramolecular thiomaleimide [2 + 2] photocycloadditions: stereoselective control for disulfide stapling and observation of excited state intermediates by transient absorption spectroscopy

H. Fielding, V. Stavros, M. Parkes, 2022, Chemical science.

The renaissance of chemically generated bispecific antibodies

V. Chudasama, Peter A. Szijj, 2021, Nature Reviews Chemistry.

One-pot thiol–amine bioconjugation to maleimides: simultaneous stabilisation and dual functionalisation†

Alfie G. Wills, V. Chudasama, Calise Bahou, 2020, Chemical science.

Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation.

A. Aliev, V. Chudasama, A. Maruani, 2019, Chemical communications.

Application of Next-Generation Maleimides (NGMs) to Site-Selective Antibody Conjugation.

V. Chudasama, M. Morais, Nafsika Forte, 2019, Methods in molecular biology.

Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers.

K. Howard, V. Chudasama, K. Karu, 2019, Organic & biomolecular chemistry.

Use of a next generation maleimide in combination with THIOMAB™ antibody technology delivers a highly stable, potent and near homogeneous THIOMAB™ antibody-drug conjugate (TDC)

Mark E. B. Smith, S. Caddick, V. Chudasama, 2017 .

Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody

Mark E. B. Smith, S. Caddick, V. Chudasama, 2017 .

Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines.

V. Chudasama, A. Tinker, L. Tedaldi, 2016, Organic & biomolecular chemistry.

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine† †Electronic supplementary information (ESI) available: LC-MS, ES-MS and deconvoluted spectra for all reactions with proteins described herein, and 1H and 13C NMR spectra for all small molecule construc

Mark E. B. Smith, S. Caddick, J. Baker, 2015, Organic & biomolecular chemistry.

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.

S. Caddick, R. Boyle, V. Chudasama, 2015, Chemical communications.

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC).

Mark E. B. Smith, S. Caddick, V. Chudasama, 2015, Chemical communications.

Cysteine-to-lysine transfer antibody fragment conjugation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc03825f

V. Chudasama, K. Karu, Nafsika Forte, 2019, Chemical science.

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis.

Kersti Karu, Vijay Chudasama, James R Baker, 2017, Organic & biomolecular chemistry.

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones☆

Richard J. Fitzmaurice, Mark E. B. Smith, S. Caddick, 2013, Tetrahedron letters.

Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation.

T. Weil, Marco Raabe, V. Chudasama, 2020, Organic & biomolecular chemistry.

The Use of 3,6-Pyridazinediones in Organic Synthesis and Chemical Biology

V. Chudasama, A. Maruani, M. Lee, 2016 .

Bromopyridazinedione-mediated protein and peptide bioconjugation† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc12807h Click here for additional data file.

Mark E. B. Smith, G. Waksman, S. Caddick, 2011, Chemical communications.

A plug-and-play approach for the de novo generation of dually functionalised bispecifics.

S. Caddick, V. Chudasama, A. Maruani, 2019, Bioconjugate chemistry.

Chemically Generated Bispecific Antibodies – A New Dawn

V. Chudasama, Peter A. Szijj, 2021 .

Aerobically-initiated C(sp3)-H bond amination through the use of activated azodicarboxylates.

V. Chudasama, A. Maruani, André Shamsabadi, 2020, Organic & biomolecular chemistry.

Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones.

Richard J. Fitzmaurice, S. Caddick, V. Chudasama, 2014, Chemical communications.

Analysis of cotton fiber maturity. II. Glycerol retention value of cotton

N. E. Dweltz, V. Chudasama, A. Kulshreshtha, 1976 .

Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation

J. Irving, V. Chudasama, A. Chrzastek, 2022, Chemical science.

Photoimmunotherapy Using Cationic and Anionic Photosensitizer-Antibody Conjugates against HIV Env-Expressing Cells

R. Boyle, V. Chudasama, L. Janini, 2020, International journal of molecular sciences.

Metal-free, hydroacylation of C=C and N=N bonds via aerobic C-H activation of aldehydes, and reaction of the products thereof.

Richard J. Fitzmaurice, S. Caddick, V. Chudasama, 2013, Organic & biomolecular chemistry.

Functionalised thermally induced phase separation (TIPS) microparticles enabled for “click” chemistry† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0ob00106f

F. Di Maggio, V. Chudasama, Ketevan Paliashvili, 2020, Organic & biomolecular chemistry.

Synthesis of γ-ketophosphonates via aerobic hydroacylation of vinyl phosphonates

Richard J. Fitzmaurice, S. Caddick, V. Chudasama, 2011 .

Functionalisation of aldehydes via aerobic hydroacylation of azodicarboxylates 'on' water.

Richard J. Fitzmaurice, S. Caddick, V. Chudasama, 2011, Chemical communications.

Enabling the facile conversion of acyl hydrazides into N-acyl carbamates via metal-free ionic-based rupture of the N–N linkage

V. Chudasama, Jack Ren, André Shamsabadi, 2017 .

Cysteine protecting groups: applications in peptide and protein science.

V. Chudasama, R. J. Spears, Clíona McMahon, 2021, Chemical Society reviews.

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

James R. Baker, Antoine Maruani, Kerry A. Chester, 2014, Organic & biomolecular chemistry.

A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement.

V. Chudasama, André Shamsabadi, 2018, Chemical communications.

A facile, one-pot procedure for the conversion of aromatic aldehydes to esters, as well as thioesters and amides, via acyl hydrazide intermediates

Daniel A. Richards, V. Chudasama, A. Maruani, 2016 .

Pentafluorophenyl vinyl sulfonate enables efficient, metal-free, radical-based alkene hydroacylation with an aldehyde as a limiting reagent

V. Chudasama, 2015 .

Recent advances in metal-free aerobic C-H activation.

V. Chudasama, André Shamsabadi, 2019, Organic & biomolecular chemistry.

Advances in targeting the folate receptor in the treatment/imaging of cancers

V. Chudasama, F. Javaid, Marcos Fernández, 2017, Chemical science.

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

Antoine Maruani, Vijay Chudasama, Daniel A. Richards, 2016, Chemical science.

Post-translational site-selective protein backbone α-deuteration

Elisabete Pires, Vijay Chudasama, Benjamin G. Davis, 2018, Nature Chemical Biology.

Post-Translational Site-selective Protein α-Deuteration : Protein Backbone Modification and Use as a Tool for Protein Mechanism

S. Caddick, Jitka Daďová, V. Chudasama, 2017 .

An overview of the synthesis of acyl hydrazides from aldehydes and reactions of the products thereof.

V. Chudasama, André Shamsabadi, 2016, Organic & biomolecular chemistry.

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

Enrique Miranda, Antoine Maruani, Mark E.B. Smith, 2015, Nature Communications.

A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates.

Antoine Maruani, Vijay Chudasama, S. Caddick, 2015, Chemical communications.

Next-generation disulfide stapling: reduction and functional re-bridging all in one

S. Caddick, V. Chudasama, A. Maruani, 2015, Chemical science.

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9cc02655j

Daniel A. Richards, V. Chudasama, C. Barelle, 2019, Chemical communications.

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

Edward W. Tate, V. Chudasama, E. Tate, 2020, ACS chemical biology.

Reversible protein affinity-labelling using bromomaleimide-based reagents† †Electronic supplementary information (ESI) available: 1H and 13C spectra for all new and known compounds, and ES-MS spectra for all reactions with proteins described herein. See DOI: 10.1039/c3ob40239h Click here for additio

Richard J. Fitzmaurice, S. Caddick, J. Baker, 2013, Organic & biomolecular chemistry.

Effect of Treatment with Methylolated Acid Amides on Various Fibre Properties of Cotton

N. E. Dweltz, V. Chudasama, A. Kulshreshtha, 1976 .

Synthesis of novel and potent vorapaxar analogues.

R. Chambers, S. Caddick, A. Aliev, 2016, Organic & biomolecular chemistry.

Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc02747h

Katrina Campbell, Vijay Chudasama, Peter Smyth, 2017, Chemical science.

Employing defined bioconjugates to generate chemically functionalised gold nanoparticles for in vitro diagnostic applications†

Daniel A. Richards, Michael R. Thomas, M. Stevens, 2021, Nanoscale.

Optical control of trimeric P2X receptors and acid-sensing ion channels

S. Caddick, V. Chudasama, Laricia Bragg, 2013, Proceedings of the National Academy of Sciences.

Dual modification of biomolecules.

Daniel A. Richards, V. Chudasama, A. Maruani, 2016, Organic & biomolecular chemistry.

Modular Chemical Construction of IgG-like Mono- and Bispecific Synthetic Antibodies (SynAbs)

J. Blayney, V. Chudasama, A. Maruani, 2023, ACS central science.

Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer

J. F. Burrows, D. Longley, S. Caddick, 2020, British Journal of Cancer.

Corrigendum: Recent advances in the construction of antibody-drug conjugates.

Antoine Maruani, Vijay Chudasama, S. Caddick, 2016, Nature chemistry.

Bromomaleimide-Linked Bioconjugates Are Cleavable in Mammalian Cells

S. Caddick, J. Molloy, V. Chudasama, 2011, Chembiochem : a European journal of chemical biology.

E- and Z-stereoselectivity in the preparation of enamides from glycidyl sulfonamides and carbamates.

V. Chudasama, Rachel Munday, W. Kerr, 2012, Organic & biomolecular chemistry.

Synthesis of a novel HER2 targeted aza-BODIPY-antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation.

R. Boyle, V. Chudasama, A. Maruani, 2018, Organic & biomolecular chemistry.

A Humanized Antibody against LRG1 that Inhibits Angiogenesis and Reduces Retinal Vascular Leakage

J. Greenwood, M. Gourlaouen, S. Liyanage, 2020, bioRxiv.

Synthesis of an Amphiphilic Miktoarm Star Terpolymer for Self-Assembly into Patchy Polymersomes.

G. Battaglia, V. Chudasama, J. Gaitzsch, 2016, ACS macro letters.

Recent advances in N- and C-terminus cysteine protein bioconjugation.

V. Chudasama, R. J. Spears, 2023, Current opinion in chemical biology.

Leucine-rich alpha-2-glycoprotein 1 (LRG1) as a novel ADC target

J. Greenwood, S. Moss, V. Chudasama, 2021, RSC chemical biology.

A Light‐Induced Decarboxylative‐Elimination of Substituted Maleimides as a Strategy Towards Triggered Photorelease

Daniel A. Richards, V. Chudasama, K. Karu, 2023, European Journal of Organic Chemistry.

Assembly of High-Potency Photosensitizer-Antibody Conjugates through Application of Dendron Multiplier Technology.

Antoine Maruani, Vijay Chudasama, Andrew Beeby, 2017, Bioconjugate chemistry.

Photoinduced Photosensitizer–Antibody Conjugates Kill HIV Env-Expressing Cells, Also Inactivating HIV

R. Boyle, V. Chudasama, R. Diaz, 2021, ACS omega.

Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly.

K. Gothelf, J. Wengel, K. Howard, 2022, Bioconjugate chemistry.

A versatile synthesis of 2,4-substituted oxazoles.

Jonathan D. Wilden, V. Chudasama, 2008, Chemical communications.

Intramolecular thiomaleimide [2 + 2] photocycloadditions: stereoselective control for disul ﬁ de stapling and observation of excited state intermediates by transient absorption spectroscopy † ChemicalScience EDGE ARTICLE

H. Fielding, V. Stavros, M. Parkes, 2022 .

Daniel A. Richards, V. Chudasama, C. Scott, 2017, Chemical science.

Optical control of trimeric P2X receptors and acid-sensing ion channels

S. Caddick, V. Chudasama, Laricia Bragg, 2013, Proceedings of the National Academy of Sciences.

Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability.

R. Chambers, S. Caddick, V. Chudasama, 2016, Organic & biomolecular chemistry.

Dual modification of biomolecules.

Daniel A. Richards, V. Chudasama, A. Maruani, 2016, Organic & biomolecular chemistry.

Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines.

Daniel A. Richards, V. Chudasama, A. Tinker, 2016, Organic & biomolecular chemistry.

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones☆

Richard J. Fitzmaurice, S. Caddick, V. Chudasama, 2013, Tetrahedron letters.

Trifunctional Dibromomaleimide Reagents Built Around A Lysine Scaffold Deliver Site‐selective Dual‐modality Antibody Conjugation

V. Chudasama, J. R. Baker, Yanbo Zhao, 2023, Chembiochem : a European journal of chemical biology.

Rapid Access to Potent Bispecific T Cell Engagers Using Biogenic Tyrosine Click Chemistry.

F. V. van Delft, V. Chudasama, S. Tracey, 2023, Bioconjugate chemistry.

Assembly of High-Potency Photosensitizer-Antibody Conjugates through Application of Dendron Multiplier Technology.

R. Boyle, V. Chudasama, A. Beeby, 2017, Bioconjugate chemistry.

Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment.

S. Caddick, R. Boyle, V. Chudasama, 2014, Bioconjugate chemistry.

Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer

C. Bertozzi, V. Chudasama, M. Gray, 2023, Nature Chemistry.

Chemical generation of checkpoint inhibitory T cell engagers (CiTEs) for the treatment of cancer

V. Chudasama, M. Gray, Peter A. Szijj, 2022 .

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC).

S. Caddick, V. Chudasama, V. Rajkumar, 2015, Chemical communications.

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

Daniel A. Richards, V. Chudasama, A. Maruani, 2016, Chemical Science.

Modular Synthesis of Semiconducting Graft Co-polymers to Achieve "clickable" Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting.

Daniel A. Richards, A. Najer, M. Dallman, 2023, Advanced materials.

The use of bromopyridazinedione derivatives in chemical biology.

V. Chudasama, Calise Bahou, 2022, Organic & biomolecular chemistry.