B. Litman

发表

Primary Alcohols Modulate the Activation of the G Protein-coupled Receptor Rhodopsin by a Lipid-mediated Mechanism*

D. C. Mitchell, J. T. Lawrence, B. Litman, 1996, The Journal of Biological Chemistry.

Quantifying the differential effects of DHA and DPA on the early events in visual signal transduction.

D. C. Mitchell, B. Litman, Shui-Lin Niu, 2012, Chemistry and physics of lipids.

RHODOPSIN: ITS MOLECULAR SUBSTRUCTURE AND PHOSPHOLIPID INTERACTIONS *

B. Litman, 1979, Photochemistry and photobiology.

Rhodopsin-phospholipid reconstitution by dialysis removal of octyl glucoside.

B. Litman, M. L. Jackson, 1982, Biochemistry.

Alkyl glucosides as effective solubilizing agents for bovine rhodopsin. A comparison with several commonly used detergents.

H. G. Smith, B. Litman, G. Stubbs, 1976, Biochimica et biophysica acta.

Photon correlation spectroscopic study of the size distribution of phospholipid vesicles.

T. E. Thompson, F. D. Carlson, Y. Barenholz, 1982, Biophysical journal.

Packing characteristics of highly unsaturated bilayer lipids: Raman spectroscopic studies of multilamellar phosphatidylcholine dispersions.

I. W. Levin, E. Lewis, B. Litman, 1991, Biochemistry.

Optimization of Receptor-G Protein Coupling by Bilayer Lipid Composition I

D. C. Mitchell, B. Litman, Shui-Lin Niu, 2001, The Journal of Biological Chemistry.

Enhancement of G protein-coupled signaling by DHA phospholipids

D. C. Mitchell, B. Litman, Shui-Lin Niu, 2003, Lipids.

Purification of rhodopsin by concanavalin A affinity chromatography.

B. Litman, 1982, Methods in enzymology.

Rhodopsin-egg phosphatidylcholine reconstitution by an octyl glucoside dilution procedure.

B. Litman, M. L. Jackson, 1985, Biochimica et biophysica acta.

Binding and activation of rod outer segment phosphodiesterase and guanosine triphosphate binding protein by disc membranes: influence of reassociation method and divalent cations.

E. Dratz, J. Miller, B. Litman, 1987, Biochimica et biophysica acta.

Modulation of metarhodopsin formation by cholesterol-induced ordering of bilayer lipids.

M. Straume, J. Miller, D. C. Mitchell, 1990, Biochemistry.

Interconversion of metarhodopsins I and II: a branched photointermediate decay model.

M. Straume, J. Miller, D. C. Mitchell, 1990, Biochemistry.

Functional equivalence of metarhodopsin II and the Gt-activating form of photolyzed bovine rhodopsin.

J. Beach, D. C. Mitchell, B. Litman, 1991, Biochemistry.

Molecular order and dynamics in bilayers consisting of highly polyunsaturated phospholipids.

D. C. Mitchell, B. Litman, 1998, Biophysical journal.

Effect of cholesterol on molecular order and dynamics in highly polyunsaturated phospholipid bilayers.

D. C. Mitchell, B. Litman, 1998, Biophysical journal.

Independent structural domains in the membrane protein bovine rhodopsin.

B. Litman, A. Albert, 1978, Biochemistry.

Preparation of osmotically intact rod outer segment disks by Ficoll flotation.

H. G. Smith, B. Litman, 1982, Methods in enzymology.

Determination of molecular asymmetry in the phosphatidylethanolamine surface distribution in mixed phospholipid vesicles.

B. Litman, 1974, Biochemistry.

Effect of head group on phospholipid mixing in small, unilamellar vesicles: mixtures of dimyristoylphosphatidylcholine and dimyristoylphosphatidylethanolamine.

B. Lentz, B. Litman, 1978, Biochemistry.

Lipid model membranes. Characterization of mixed phospholipid vesicles.

B. Litman, 1973, Biochemistry.

Effect of alterations in the amphipathic microenvironment on the conformational stability of bovine opsin. 1. Mechanism of solubilization of disk membranes by the nonionic detergent, octyl glucoside.

B. Litman, G. Stubbs, 1978, Biochemistry.

Equilibrium and dynamic structure of large, unilamellar, unsaturated acyl chain phosphatidylcholine vesicles. Higher order analysis of 1,6-diphenyl-1,3,5-hexatriene and 1-[4-(trimethylammonio)phenyl]- 6-phenyl-1,3,5-hexatriene anisotropy decay.

M. Straume, B. Litman, Martin Straume, 1987, Biochemistry.

Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs.

D. C. Mitchell, B. Litman, Shui-Lin Niu, 2005, Biochemistry.

Why is docosahexaenoic acid essential for nervous system function?

N. Salem, K. Gawrisch, D. C. Mitchell, 1998, Biochemical Society transactions.

The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways

D. C. Mitchell, B. Litman, A. Polozova, 2001, Journal of Molecular Neuroscience.

Determination of membrane cholesterol partition coefficient using a lipid vesicle-cyclodextrin binary system: effect of phospholipid acyl chain unsaturation and headgroup composition.

B. Litman, Shui-Lin Niu, 2002, Biophysical journal.

Effect of alterations in the amphipathic microenvironment on the conformational stability of bovine opsin. 2. Rate of loss of opsin regenerability.

B. Litman, G. Stubbs, 1978, Biochemistry.

Amplification of phosphodiesterase activation is greatly reduced by rhodopsin phosphorylation.

J. Miller, B. Litman, D. Fox, 1986, Biochemistry.

Isolation and identification of the phosphorylated species of rhodopsin.

B. Litman, M. L. Jackson, B. Aton, 1984, Biochemistry.

The isolation and purification of osmotically intact discs from retinal rod outer segments.

H. G. Smith, B. Litman, G. Stubbs, 1975, Experimental eye research.

Influence of cholesterol on equilibrium and dynamic bilayer structure of unsaturated acyl chain phosphatidylcholine vesicles as determined from higher order analysis of fluorescence anisotropy decay.

M. Straume, B. Litman, 1987, Biochemistry.

Cholesterol dependent recruitment of di22:6-PC by a G protein-coupled receptor into lateral domains.

B. Litman, A. Polozova, B J Litman, 2000, Biophysical journal.

A simple method for the preparation of homogeneous phospholipid vesicles.

R. D. Carlson, T. E. Thompson, Y. Barenholz, 1977, Biochemistry.

The n—π* Cotton Effect of the Peptide Linkage

J. Schellman, B. Litman, 1965 .

States of aggregation and phase transformations in mixtures of phosphatidylcholine and octyl glucoside.

Y. Barenholz, E. Wachtel, W. Wimley, 1990, Biochemistry.

Solubilization of phosphatidylcholine bilayers by octyl glucoside.

C. Schmidt, B. Litman, D. Lichtenberg, 1982, Biochemistry.

[91] Fluorescent probe: Diphenylhexatriene

Y. Barenholz, B. Litman, 1982 .

Fluorescent probe: diphenylhexatriene.

Y. Barenholz, B. Litman, 1982, Methods in enzymology.

Microviscosity of the hydrocarbon region of the bovine retinal rod outer segment disk membrane determined by fluorescent probe measurements.

B. Litman, G. Stubbs, 1976, Biochemistry.

Rhodopsin structure and function

Burton J. Litman, D. C. Mitchell, B. Litman, 1996 .

Methods for determining rod outer segment disk phospholipid transmembrane topology.

B. Litman, 1982, Methods in enzymology.

The effect of detergent selection on retinal outer segment A280/A500 ratios.

D. M. Eadie, B. Litman, D. McConnell, 1981, The Journal of biological chemistry.

Equilibrium and dynamic bilayer structural properties of unsaturated acyl chain phosphatidylcholine-cholesterol-rhodopsin recombinant vesicles and rod outer segment disk membranes as determined from higher order analysis of fluorescence anisotropy decay.

M. Straume, B. Litman, 1988, Biochemistry.

Rhodopsin-phospholipid interactions: dependence of rate of the meta I to meta II transition on the level of associated disk phospholipid.

B. Litman, M. Ottolenghi, O. Kalisky, 1981, Biochemistry.

Activation of rod outer segment phosphodiesterase by enzymatically altered rhodopsin: a regulatory role for the carboxyl terminus of rhodopsin.

B. Litman, B. Aton, 1984, Experimental eye research.

Light release of 45Ca trapped in sonicated bovine disk vesicles.

H. G. Smith, B. Litman, R. Fager, 1982, Methods in enzymology.

Ultraviolet circular dichroism of rhodopsin in disk membranes and detergent solution.

B. Litman, 1982, Methods in enzymology.

Functional domains of rhodopsin

B. Litman, B. Aton, Jonathan B. Hartley, 1982, Vision Research.

Mechanisms of action of docosahexaenoic acid in the nervous system

Hee-Yong Kim, K. Gawrisch, B. Litman, 2001, Lipids.

Modulation of Receptor Signaling by Phospholipid Acyl Chain Composition

D. C. Mitchell, B. Litman, 2001 .

Manipulation of cholesterol levels in rod disk membranes by methyl-beta-cyclodextrin: effects on receptor activation.

D. C. Mitchell, B. Litman, Shui-Lin Niu, 2002, The Journal of biological chemistry.

A role for phospholipid polyunsaturation in modulating membrane protein function

Burton J. Litman, D. C. Mitchell, B. Litman, 2007, Lipids.

Structure and orientation of a G protein fragment in the receptor bound state from residual dipolar couplings.

A. Bax, J. Louis, G. Kontaxis, 2002, Journal of molecular biology.

DHA-rich phospholipids optimize G-Protein-coupled signaling.

D. C. Mitchell, B. Litman, Shui-Lin Niu, 2003, The Journal of pediatrics.

Reduced G Protein-coupled Signaling Efficiency in Retinal Rod Outer Segments in Response to n-3 Fatty Acid Deficiency*

Hee-Yong Kim, D. C. Mitchell, B. Litman, 2004, Journal of Biological Chemistry.

Role of sn-1-saturated,sn-2-polyunsaturated phospholipids in control of membrane receptor conformational equilibrium: effects of cholesterol and acyl chain unsaturation on the metarhodopsin I in equilibrium with metarhodopsin II equilibrium.

M. Straume, D. C. Mitchell, B. Litman, 1992, Biochemistry.

Optimization of Receptor-G Protein Coupling by Bilayer Lipid Composition II

D. C. Mitchell, B. Litman, Shui-Lin Niu, 2001, The Journal of Biological Chemistry.

Transbilayer exchange of phosphatidylethanolamine for phosphatidylcholine and N-acetimidoylphosphatidylethanolamine in single-walled bilayer vesicles.

T. E. Thompson, B. Litman, M. Roseman, 1975, Biochemistry.

Optimization of Receptor-G Protein Coupling by Bilayer Lipid Composition I

Burton J. Litman, D. C. Mitchell, B. Litman, 2001, The Journal of Biological Chemistry.

Estrogen receptors are present in human granulosa cells.

K. Leslie, B. Hurst, M. Zilberstein, 1995, The Journal of clinical endocrinology and metabolism.

Inhibition of transducin activation and guanosine triphosphatase activity by aluminum ion.

J. Miller, T. Macdonald, B. Litman, 1989, The Journal of biological chemistry.

Effect of protein hydration on receptor conformation: decreased levels of bound water promote metarhodopsin II formation.

D. C. Mitchell, B. Litman, 1999, Biochemistry.

Measurement of dipolar couplings in a transducin peptide fragment weakly bound to oriented photo-activated rhodopsin

S. Grzesiek, A. Bax, D. C. Mitchell, 2000, Journal of biomolecular NMR.

Effect of Ethanol and Osmotic Stress on Receptor Conformation

D. C. Mitchell, B. Litman, Burton J. Litman, 2000, The Journal of Biological Chemistry.

Effect of ethanol on metarhodopsin II formation is potentiated by phospholipid polyunsaturation.

D. C. Mitchell, B. Litman, 1994, Biochemistry.

The optical activity of D-erythro-sphingomyelin and its contribution to the circular dichroism of sphingomyelin-containing systems.

Y. Barenholz, B. Litman, 1975, Biochimica et biophysica acta.

Effect of light scattering on the circular dichroism of biological membranes.

B. Litman, 1972, Biochemistry.

Light-activated calcium release from sonicated bovine retinal rod outer segment disks.

H. G. Smith, B. Litman, R. Fager, 1977, Biochemistry.

Effect of phosphorylation on receptor conformation: the metarhodopsin I in equilibrium with metarhodopsin II equilibrium in multiply phosphorylated rhodopsin.

D. C. Mitchell, B. Litman, J. Kibelbek, 1992, Biochemistry.

A large-scale purification of phosphatidylethanolamine, lysophosphatidylethanolamine, and phosphatidylethanolamine, and phosphatidylcholine by high performance liquid chromatography: a partial resolution of molecular species.

B. Litman, R. Fager, S. Shapiro, 1977, Journal of lipid research.