T. Warne

发表

The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

Gebhard F. X. Schertler, Christopher G. Tate, Andrew G. W. Leslie, 2014, PloS one.

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

A. Leslie, C. Langmead, C. Tate, 2011, Nature.

Structure of the adenosine A2A receptor bound to an engineered G protein

A. Leslie, C. Tate, Rony Nehmé, 2016, Nature.

Pi sampling: a methodical and flexible approach to initial macromolecular crystallization screening

G. Lebon, T. Warne, F. Gorrec, 2011, Acta crystallographica. Section D, Biological crystallography.

Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor

C. Tate, D. Nietlispach, T. Warne, 2017, Nature Communications.

Complete Reversible Refolding of a G-Protein Coupled Receptor on a Solid Support

P. Booth, C. Tate, G. Schertler, 2016, PloS one.

Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor

A. Leslie, J. García-Nafría, C. Tate, 2020, Nature.

PIP2 stabilises active states of GPCRs and enhances the selectivity of G-protein coupling

C. Robinson, A. Plückthun, C. Tate, 2018, Nature.

Development and crystallization of a minimal thermostabilised G protein-coupled receptor.

Christopher G Tate, C. Tate, G. Schertler, 2009, Protein expression and purification.

Biophysical Fragment Screening of the β1-Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design

Christopher G. Tate, David G. Myszka, Miles Congreve, 2013, Journal of medicinal chemistry.

Erratum: Structure of the adenosine A2A receptor bound to an engineered G protein

A. Leslie, C. Tate, Rony Nehmé, 2016, Nature.

The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

Christopher G. Tate, A. Leslie, C. Tate, 2010, Nature.

Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor

C. Tate, D. Nietlispach, T. Warne, 2017, Nature Communications.

Molecular architecture of a retinal cGMP‐gated channel: the arrangement of the cytoplasmic domains

G. Schertler, M. Higgins, T. Warne, 2002, The EMBO journal.

PIP2 stabilises active states of GPCRs and enhances the selectivity of G-protein coupling

Andreas Plückthun, Mark S. P. Sansom, Christopher G. Tate, 2018, Nature.

Structure of a β1-adrenergic G-protein-coupled receptor

Gebhard F. X. Schertler, Christopher G. Tate, Andrew G. W. Leslie, 2008, Nature.

Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

Christopher G. Tate, A. Leslie, C. Tate, 2012, Structure.

Structure of the adenosine A(2A) receptor bound to an engineered G protein (vol 536, pg 104, 2016)

Christopher G. Tate, C. Tate, Rony Nehmé, 2016 .

Molecular basis for high-affinity agonist binding in GPCRs

Andrew S Doré, Christopher G Tate, A. Leslie, 2018, Science.

Molecular determinants of β-arrestin coupling to formoterol-bound β1-adrenoceptor

A. Leslie, J. García-Nafría, C. Tate, 2020, bioRxiv.

Two distinct conformations of helix 6 observed in antagonist-bound structures of a β1-adrenergic receptor

Gebhard F. X. Schertler, Christopher G. Tate, Andrew G. W. Leslie, 2011, Proceedings of the National Academy of Sciences.

Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol–Bound β1-Adrenergic Receptor

Jillian Baker, Christopher G Tate, Miles Congreve, 2015, Molecular Pharmacology.

Expression and purification of truncated, non-glycosylated turkey beta-adrenergic receptors for crystallization.

G. Schertler, T. Warne, J. Chirnside, 2003, Biochimica et biophysica acta.

Agonist-bound structures of G protein-coupled receptors.

C. Tate, G. Lebon, T. Warne, 2012, Current opinion in structural biology.

A colorimetric determination for glycosidic and bile salt-based detergents: applications in membrane protein research.

Andrea Urbani, A. Urbani, T. Warne, 2005, Analytical biochemistry.

The importance of interactions with helix 5 in determining the efficacy of β-adrenoceptor ligands.

Christopher G Tate, C. Tate, T. Warne, 2013, Biochemical Society transactions.

The Escherichia coli multidrug transporter EmrE is a dimer in the detergent-solubilised state.

C. Tate, P. Butler, I. Ubarretxena-Belandia, 2004, Journal of molecular biology.

Complete Reversible Refolding of a G-Protein Coupled Receptor on a Solid Support

B. Hille, P. Booth, C. Tate, 2016, PloS one.

Ligand occupancy in crystal structure of β1-adrenergic G protein–coupled receptor

A. Leslie, C. Tate, T. Warne, 2015, Nature Structural &Molecular Biology.

Agonist-bound structures of G protein-coupled receptors.

C. Tate, G. Lebon, T. Warne, 2012, Current opinion in structural biology.