Yi-Yu Ke

发表

Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.

E. Novellino, F. Da Settimo, C. La Motta, 2018, European journal of medicinal chemistry.

Dual Kit/Aur Inhibitors as Chemosensitizing Agents for the Treatment of Melanoma: Design, Synthesis, Docking Studies and Functional Investigation

C. La Motta, H. Hsieh, Kai Liu, 2019, Scientific Reports.

Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity

Mohane Selvaraj Coumar, Yi-Yu Ke, Sailu Sarvagalla, 2014, Journal of Computer-Aided Molecular Design.

Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification

Yung Chang Hsu, H. Hsieh, J. Hsu, 2015, Scientific Reports.

Ligand efficiency based approach for efficient virtual screening of compound libraries.

H. Hsieh, J. Hsu, Szu-Huei Wu, 2014, European journal of medicinal chemistry.

Latifolicinin A from a Fermented Soymilk Product and the Structure-Activity Relationship of Synthetic Analogues as Inhibitors of Breast Cancer Cell Growth.

Chi‐Huey Wong, Jim-Min Fang, C. Tsai, 2015, Journal of agricultural and food chemistry.

Repurposing old drugs as antiviral agents for coronaviruses

C. Chen, Szu-Huei Wu, Shiow-Ju Lee, 2020, Biomedical Journal.

A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment

Jen‐Shin Song, Yunching Chen, Yi-Yu Ke, 2021, Proceedings of the National Academy of Sciences.

Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors.

H. Hsieh, Jen‐Shin Song, Yu-Wei Liu, 2015, Journal of medicinal chemistry.

Bromomethylthioindole Inspired Carbazole Hybrids as Promising Class of Anti-MRSA Agents.

Jen‐Shin Song, Jinq-chyi Lee, Yu-Wei Liu, 2016, ACS medicinal chemistry letters.

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.

C. Chen, Y. Chao, H. Loh, 2019, European journal of medicinal chemistry.

The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling.

Chi‐Huey Wong, Shui-Tein Chen, Ying-Ta Wu, 2015, The Journal of Biological Chemistry.

The Immunologically Active Oligosaccharides Isolated from Wheatgrass Modulate Monocytes via Toll-like Receptor-2 Signaling*

Chi‐Huey Wong, Shui-Tein Chen, Chung-Yi Wu, 2013, The Journal of Biological Chemistry.

Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition.

H. Hsieh, Jen‐Shin Song, C. Shih, 2018, European journal of medicinal chemistry.

Structure of the virus capsid protein VP1 of enterovirus 71 predicted by some homology modeling and molecular docking studies

Thy-Hou Lin, Yi-Yu Ke, Yun-Chu Chen, 2006, J. Comput. Chem..

Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.

H. Hsieh, C. Chen, Y. Chao, 2013, Journal of medicinal chemistry.

Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation.

C. Chen, H. Loh, C. Shih, 2022, European journal of medicinal chemistry.

A theoretical study on the activation of Ser70 in the acylation mechanism of cephalosporin antibiotics.

T. Lin, Yi-Yu Ke, 2005, Biophysical chemistry.

Artificial intelligence approach fighting COVID-19 with repurposing drugs

Huey-Kang Sytwu, Wen-Hsing Lin, Szu-Huei Wu, 2020, Biomedical Journal.

Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins

C. Chen, Jen‐Shin Song, C. Shih, 2021, Journal of medicinal chemistry.

Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design.

Wen-Chieh Wang, Wen-Hsing Lin, Hsing-Pang Hsieh, 2016, European journal of medicinal chemistry.

Facile Identification of Dual FLT3–Aurora A Inhibitors: A Computer‐Guided Drug Design Approach

H. Hsieh, J. Hsu, Yi-Yu Ke, 2014, ChemMedChem.

Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.

Yi-Hui Peng, H. Hsieh, C. Chen, 2019, Journal of medicinal chemistry.

Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology

Jen‐Shin Song, Yi-Yu Ke, Kak‐Shan Shia, 2018, Medicinal research reviews.

Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway

H. Hsieh, Y. Chao, Sui‐Yuan Chang, 2011, Journal of Virology.

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

Yung Chang Hsu, C. Chen, J. Hsu, 2016, Oncotarget.

Chemoproteomic profiling reveals cellular targets of nitro-fatty acids

Mingzi M. Zhang, Yi-Yu Ke, Ming-yue Fang, 2021, bioRxiv.

Drug discovery to counteract antinociceptive tolerance with mu-opioid receptor endocytosis

H. Loh, P. Law, C. Shih, 2017, bioRxiv.

Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery

Jen-Shin Song, Lun K Tsou, Shiu-Hwa Yeh, 2020, Scientific Reports.

Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors.

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2017, Journal of medicinal chemistry.

Discovery of M Protease Inhibitors Encoded by SARS-CoV-2

C. Chen, J. Hsu, Szu-Huei Wu, 2020, Antimicrobial Agents and Chemotherapy.

Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease.

Jen‐Shin Song, Chi-Hui Tsai, Yi-Yu Ke, 2023, European journal of medicinal chemistry.

Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.

H. Loh, P. Law, C. Shih, 2017, European journal of medicinal chemistry.

Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers.

H. Loh, Yi-Yu Ke, Shiu-Hwa Yeh, 2017, Biochimica et biophysica acta. Proteins and proteomics.

3D‐QSAR‐Assisted Drug Design: Identification of a Potent Quinazoline‐Based Aurora Kinase Inhibitor

Yung Chang Hsu, H. Hsieh, Y. Chao, 2013, ChemMedChem.

Characterization of a mutated KCNJ5 gene, G387R, in unilateral primary aldosteronism.

C. Pan, Yung-Ming Chen, Yi-Yu Ke, 2021, Journal of molecular endocrinology.

Modeling the ligand-receptor interaction for a series of inhibitors of the capsid protein of enterovirus 71 using several three-dimensional quantitative structure-activity relationship techniques.

Thy-Hou Lin, Yi-Yu Ke, T. Lin, 2006, Journal of medicinal chemistry.