Jussara Amato

发表

Targeting the KRAS Oncogene: Synthesis, Physicochemical and Biological Evaluation of Novel G-Quadruplex DNA Binders.

E. Novellino, G. Salgado, F. Da Settimo, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Noncanonical DNA Secondary Structures as Drug Targets: the Prospect of the i‐Motif

E. Novellino, B. Pagano, Jussara Amato, 2014, ChemMedChem.

Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics

E. Novellino, B. Pagano, Ferruccio Palazzesi, 2020, Scientific Reports.

Targeting multiple G-quadruplex-forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives.

E. Novellino, B. Pagano, Federica Moraca, 2019, European journal of medicinal chemistry.

Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations

Stefano Alcaro, Federica Moraca, Anna Artese, 2017, Proceedings of the National Academy of Sciences.

G-quadruplex on oligo affinity support (G4-OAS): an easy affinity chromatography-based assay for the screening of G-quadruplex ligands.

E. Novellino, B. Pagano, Jussara Amato, 2014, Analytical chemistry.

Looking for Efficient G‐Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug‐Like Molecules

E. Novellino, B. Pagano, Jussara Amato, 2015, ChemMedChem.

Synthesis and characterization of DNA quadruplexes containing T‐tetrads formed by bunch‐oligonucleotides

G. Piccialli, Jussara Amato, L. Mayol, 2006, Biopolymers.

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity.

G. Piccialli, S. Haider, J. Balzarini, 2012, Chemical communications.

The Dark Side of Isocyanides: Visible-Light Photocatalytic Activity in the Oxidative Functionalization of C(sp3)–H Bonds

Jussara Amato, G. Tron, M. Giustiniano, 2021, The Journal of organic chemistry.

Bio-Inspired Dual Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives.

E. Novellino, B. Pagano, Jussara Amato, 2020, Journal of medicinal chemistry.

Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands.

B. Pagano, A. Arciello, Jussara Amato, 2018, Analytica chimica acta.

Targeting G-quadruplex structure in the human c-Kit promoter with short PNA sequences.

G. Piccialli, E. Pauw, B. Pagano, 2011, Bioconjugate chemistry.

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

E. Novellino, B. Pagano, Jussara Amato, 2017, Biochimica et biophysica acta. General subjects.

Probing the interaction of distamycin A with S100β: the “unexpected” ability of S100β to bind to DNA‐binding ligands

B. Pagano, L. Cerofolini, M. Fragai, 2015, Journal of molecular recognition : JMR.

DNA-based nanostructures: The effect of the base sequence on octamer formation from d(XGGYGGT) tetramolecular G-quadruplexes.

G. Piccialli, Jussara Amato, L. Mayol, 2014, Biochimie.

Selective binding of a bioactive porphyrin-based photosensitizer to the G-quadruplex from the KRAS oncogene promoter.

F. D'Aria, Jussara Amato, M. Caterino, 2019, International journal of biological macromolecules.

HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

E. Novellino, B. Pagano, L. Hurley, 2018, Chemical communications.

Unveiling the interaction between DNA G-quadruplexes and RG-rich peptides

B. Pagano, F. Merlino, F. D'Aria, 2023, International Journal of Biological Macromolecules.

New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function

P. Grieco, F. Merlino, A. Filer, 2023, Annals of the Rheumatic Diseases.

G-Quadruplex Binders Induce Immunogenic Cell Death Markers in Aggressive Breast Cancer Cells

B. Pagano, Jussara Amato, A. Randazzo, 2019, Cancers.

Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.

Gennaro Piccialli, Nicola Borbone, Marco Persico, 2012, Journal of medicinal chemistry.

Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein

E. Novellino, A. Rosato, C. Luchinat, 2019, Nucleic acids research.

Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand

E. Novellino, H. Kessler, G. Quilici, 2021, Journal of medicinal chemistry.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

G. Rastelli, P. Fossa, A. Mangoni, 2020, Molecules.

G-quadruplexes in cancer-related gene promoters: from identification to therapeutic targeting

B. Pagano, Jussara Amato, A. Randazzo, 2023, Expert opinion on therapeutic patents.

Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives

B. Pagano, Jussara Amato, A. Randazzo, 2020, International journal of molecular sciences.

Tailoring a lead-like compound targeting multiple G-quadruplex structures.

E. Novellino, B. Pagano, Jussara Amato, 2019, European journal of medicinal chemistry.

Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry.

B. Pagano, Jussara Amato, A. Randazzo, 2019, The Analyst.

G-quadruplexes from human telomeric DNA: how many conformations in PEG containing solutions?

Jussara Amato, C. Giancola, L. Petraccone, 2012, The journal of physical chemistry. B.

A solid-phase approach to the synthesis of N-1-alkyl analogues of cyclic inosine-diphosphate-ribose (cIDPR)

G. Piccialli, Jussara Amato, L. Mayol, 2010 .

Synthesis of A New Ribose Modified Analogue of Cyclic Inosine Diphosphate Ribose

G. Piccialli, Jussara Amato, L. Mayol, 2007, Nucleosides, nucleotides & nucleic acids.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

Stephan A. Ohnmacht, E. Novellino, B. Pagano, 2016, Journal of medicinal chemistry.

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

E. Novellino, B. Pagano, Jussara Amato, 2014, Front. Chem..

A novel β-hairpin peptide derived from the ARC repressor selectively interacts with the major groove of B-DNA.

E. Novellino, A. Mollica, B. Pagano, 2021, Bioorganic chemistry.

Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

B. Pagano, G. Capranico, Jussara Amato, 2022, Journal of medicinal chemistry.

Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound

B. Pagano, Jussara Amato, S. De Tito, 2021, International journal of molecular sciences.

Targeting G-quadruplex structure in the human c-Kit promoter with short PNA sequences.

G. Piccialli, E. Pauw, Jussara Amato, 2011, Bioconjugate chemistry.

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system.

G. Piccialli, A. Hemminki, V. Cerullo, 2012, Chemical communications.

Synthesis and characterization of monomolecular DNA G-quadruplexes formed by tetra-end-linked oligonucleotides.

G. Piccialli, Jussara Amato, L. Mayol, 2006, Bioconjugate chemistry.

Aminosilane functionalizations of mesoporous oxidized silicon for oligonucleotide synthesis and detection

Luca De Stefano, Ivo Rendina, Gennaro Piccialli, 2013, Journal of The Royal Society Interface.

Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds

B. Pagano, D. Brancaccio, A. Carotenuto, 2021, International journal of molecular sciences.

On the thermodynamics of folding of an i-motif DNA in solution under favorable conditions.

Jussara Amato, C. Giancola, A. Randazzo, 2021, Physical chemistry chemical physics : PCCP.

On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model.

G. Colombo, B. Pagano, Jussara Amato, 2020, International journal of biological macromolecules.

Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones.

E. Novellino, Jussara Amato, G. Tron, 2015, Organic letters.

Hit identification of novel small molecules interfering with MALAT1 triplex by a structure‐based virtual screening

P. Tassone, B. Pagano, Jussara Amato, 2023, Archiv der Pharmazie.

Screening of 20 species from Lamiaceae family based on phytochemical analysis, antioxidant activity and HPLC profiling

A. Alirezalu, Jussara Amato, Atefeh Moshari-Nasirkandi, 2023, Scientific reports.

Unlocking the potential of protein-derived peptides to target G-quadruplex DNA: from recognition to anticancer activity

F. Merlino, Jussara Amato, P. Zizza, 2024, Nucleic acids research.

Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study

E. Novellino, R. Budriesi, B. Pagano, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of quadruplex‐forming tetra‐end‐linked oligonucleotides: Effects of the linker size on quadruplex topology and stability

G. Piccialli, Jussara Amato, L. Mayol, 2009, Biopolymers.

Synthesis and structural characterization of new oligonucleotide and nucleoside analogues as pharmacological tools

Jussara Amato, J. Amato, 2007 .

Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition

C. Supuran, Jussara Amato, Nunzia Iaccarino, 2024, Journal of enzyme inhibition and medicinal chemistry.

Native Ion Mobility Mass Spectrometry: When Gas-Phase Ion Structures Depend on the Electrospray Charging Process

B. Pagano, Jussara Amato, A. Randazzo, 2018, Journal of The American Society for Mass Spectrometry.

Printed Electrochemical Strip for the Detection of miRNA-29a: A Possible Biomarker Related to Alzheimer’s Disease

B. Pagano, A. Fuso, M. Lucarelli, 2022, Analytical chemistry.

Label-free probing of G-quadruplex formation by surface-enhanced Raman scattering.

Gennaro Piccialli, Vincenzo Piccialli, Nicola Borbone, 2011, Analytical chemistry.

G-triplex structure and formation propensity

M. Parrinello, E. Novellino, C. Luchinat, 2014, Nucleic acids research.

Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals

E. Novellino, V. Summa, Jussara Amato, 2020, The Journal of organic chemistry.