S. Salerno

发表

Targeting the KRAS Oncogene: Synthesis, Physicochemical and Biological Evaluation of Novel G-Quadruplex DNA Binders.

E. Novellino, G. Salgado, F. Da Settimo, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity.

E. Novellino, A. Lavecchia, F. Da Settimo, 2007, Journal of medicinal chemistry.

An update into the medicinal chemistry of translocator protein (TSPO) ligands.

F. Da Settimo, S. Taliani, C. Martini, 2020, European journal of medicinal chemistry.

Mitochondrial permeability transition induced by novel pyridothiopyranopyrimidine derivatives: potential new antimitochondrial antitumour agents.

S. Salerno, A. Marini, A. Toninello, 2006, Biochemical pharmacology.

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

E. Novellino, F. Da Settimo, S. Taliani, 2013, European journal of medicinal chemistry.

Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2.

E. Novellino, F. Da Settimo, S. Taliani, 2015, European journal of medicinal chemistry.

1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.

F. Da Settimo, S. Taliani, C. La Motta, 2016, Journal of medicinal chemistry.

New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors.

E. Novellino, F. Da Settimo, S. Taliani, 2018, European journal of medicinal chemistry.

Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors.

Y. Pommier, E. Novellino, F. Da Settimo, 2013, Journal of medicinal chemistry.

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.

E. Novellino, B. Cosimelli, G. Greco, 2010, Journal of medicinal chemistry.

Medicinal chemistry of indolylglyoxylamide TSPO high affinity ligands with anxiolytic-like effects.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Current topics in medicinal chemistry.

New antiproliferative agents derived from tricyclic 3,4‐dihydrobenzo[4,5]imidazo[1,2‐a][1,3,5]triazine scaffold: Synthesis and pharmacological effects

F. Vaglini, F. Da Settimo, S. Taliani, 2022, Archiv der Pharmazie.

Synthesis and biological activity of 1,4-dihydrobenzothiopyrano[4,3-c]pyrazole derivatives, novel pro-apoptotic mitochondrial targeted agents.

C. La Motta, L. Dalla Via, E. Agostinelli, 2009, Bioorganic & medicinal chemistry.

Synthesis, in vitro antiproliferative activity and DNA-interaction of benzimidazoquinazoline derivatives as potential anti-tumor agents.

A. Da Settimo, G. Primofiore, F. Da Settimo, 2001, Farmaco.

Synthesis, DNA binding and in vitro antiproliferative activity of purinoquinazoline, pyridopyrimidopurine and pyridopyrimidobenzimidazole derivatives as potential antitumor agents

G. Primofiore, G. Viola, S. Salerno, 1998 .

Synthesis and in vitro antiproliferative activity of new substituted benzo[3',2':5,6]thiopyrano[4,3-d]pyrimidines.

S. Taliani, O. Gia, S. Salerno, 2008 .

Synthesis and antiproliferative evaluation of new aryl substituted pyrido[3′,2′:5,6]thiopyrano[4,3-c]pyrazoles

G. Primofiore, S. Salerno, A. Marini, 2005 .

Synthesis of Novel 1,4-Dihydropyrido[3',2':5,6]thiopyrano[4,3-c]pyrazoles and 5H-Pyrido[3',2':5,6]thiopyrano[4,3-d]pyrimidines as Potential Antiproliferative Agents

G. Primofiore, S. Salerno, A. Marini, 2003 .

Enriching the Arsenal of Pharmacological Tools against MICAL2

F. Da Settimo, S. Taliani, D. Brancaccio, 2021, Molecules.

Discovery of Pyrido[3',2':5,6]thiopyrano[4,3-d]pyrimidine-Based Antiproliferative Multikinase Inhibitors.

E. Novellino, F. Da Settimo, S. Taliani, 2019, ACS medicinal chemistry letters.

Targeting TSPO Reduces Inflammation and Apoptosis in an In Vitro Photoreceptor-Like Model of Retinal Degeneration

S. Taliani, C. Martini, C. Cerri, 2022, ACS chemical neuroscience.

Synthesis of purinobenzodiazepine and purinobenzotriazocine derivatives, two new heterocyclic ring systems

G. Primofiore, S. Salerno, A. Marini, 1999 .

Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold.

E. Novellino, F. Da Settimo, S. Taliani, 2021, European journal of medicinal chemistry.

Novel positive allosteric modulators of A2B adenosine receptor acting as bone mineralisation promoters

G. Greco, F. Da Settimo, S. Taliani, 2020, Journal of enzyme inhibition and medicinal chemistry.

Facile synthesis of 3-substituted [1,2,4]triazino[3,4-f]purine-4,6,8-trione derivatives

G. Primofiore, S. Salerno, A. Marini, 2001 .

Dual Targeting Topoisomerase/G-Quadruplex Agents in Cancer Therapy—An Overview

F. Da Settimo, S. Taliani, S. Salerno, 2022, Biomedicines.

Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.

E. Novellino, B. Cosimelli, G. Greco, 2009, Journal of medicinal chemistry.

The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities

S. Taliani, S. Salerno, E. Barresi, 2021, Journal of medicinal chemistry.

Medicinal chemistry of indolylglyoxylamide GABAA/BzR high affinity ligands: identification of novel anxiolytic/non sedative agents.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Current topics in medicinal chemistry.

Synthesis of pyrimido[1,2-a]benzimidazol-4(10H)-one derivatives and evaluation of their interactions with DNA

G. Primofiore, S. Taliani, S. Salerno, 2003 .

Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs.

F. Da Settimo, S. Taliani, S. Salerno, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.

E. Novellino, B. Cosimelli, G. Greco, 2008, Journal of medicinal chemistry.

Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.

E. Novellino, F. Da Settimo, S. Taliani, 2019, European journal of medicinal chemistry.

Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.

Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors.

E. Novellino, G. Greco, A. Lavecchia, 2005, Bioorganic & medicinal chemistry.

Synthesis of novel pyrido[3′,2′:5,6]thiopyrano[3,2‐b]indol‐5(6H)‐ones and 6H‐pyrido[3′,2′:5,6]thiopyrano[4,3‐b]quinolines, two new heterocyclic ring systems

G. Primofiore, S. Salerno, A. Marini, 2002 .

Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.

Ettore Novellino, Sabrina Taliani, Federico Da Settimo, 2009, Journal of medicinal chemistry.

Carbonic Anhydrase Activators for Neurodegeneration: An Overview

F. Da Settimo, S. Taliani, S. Salerno, 2022, Molecules.

Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.

E. Novellino, F. Da Settimo, S. Taliani, 2012, Journal of medicinal chemistry.

Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model.

E. Novellino, F. Da Settimo, S. Taliani, 2008, Journal of medicinal chemistry.

Carbonic anhydrase activation profile of indole-based derivatives

F. Da Settimo, S. Taliani, C. Martini, 2021, Journal of enzyme inhibition and medicinal chemistry.

Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.

E. Novellino, B. Cosimelli, G. Greco, 2010, Journal of medicinal chemistry.

Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.

F. Da Settimo, S. Taliani, C. La Motta, 2016, Bioorganic & medicinal chemistry.

Synthesis of novel 5H, 11H‐pyrido[2′,3′:2,3]thiopyrano[4,3‐b]‐indoles by fischer‐indole cyclization

G. Primofiore, S. Salerno, A. Marini, 2000 .

Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents

F. Da Settimo, S. Taliani, S. Salerno, 2023, Molecules.

Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs.

F. Da Settimo, S. Taliani, C. La Motta, 2010, Current medicinal chemistry.

Benzothiopyranoindole-based antiproliferative agents: synthesis, cytotoxicity, nucleic acids interaction, and topoisomerases inhibition properties.

V. Barone, E. Novellino, A. Lavecchia, 2009, Journal of medicinal chemistry.

Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides.

E. Novellino, B. Cosimelli, G. Greco, 2015, Journal of medicinal chemistry.

Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes.

B. Cosimelli, G. Greco, F. Da Settimo, 2018, Bioorganic & medicinal chemistry.

3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2012, Journal of medicinal chemistry.

A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells.

L. Poliseno, F. Da Settimo, S. Taliani, 2023, European journal of medicinal chemistry.

Template for the Design of Highly Selective A 2 B Adenosine Receptor Antagonists

E. Novellino, B. Cosimelli, G. Greco, 2012 .

Indol-3-ylglyoxylamide as Privileged Scaffold in Medicinal Chemistry

F. Da Settimo, S. Taliani, S. Salerno, 2023, Pharmaceuticals.

Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies.

E. Novellino, F. Da Settimo, S. Taliani, 2014, Journal of medicinal chemistry.

Targeting the Translocator Protein (18 kDa) in Cardiac Diseases: State of the Art and Future Opportunities

F. Da Settimo, S. Taliani, S. Salerno, 2023, Journal of medicinal chemistry.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.

Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents

F. Da Settimo, S. Taliani, S. Salerno, 2024, Molecules.

Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.

E. Novellino, B. Cosimelli, G. Greco, 2010, Journal of medicinal chemistry.

Pursuing Polypharmacology: Benzothiopyranoindoles as G-Quadruplex Stabilizers and Topoisomerase I Inhibitors for Effective Anticancer Strategies.

F. Da Settimo, S. Taliani, Jussara Amato, 2024, ACS medicinal chemistry letters.

TSPO Radioligands for Neuroinflammation: An Overview

F. Da Settimo, S. Taliani, S. Salerno, 2024, Molecules.

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.

E. Novellino, B. Cosimelli, G. Greco, 2008, Journal of medicinal chemistry.