T. Tuccinardi

发表

Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship analysis, and virtual screening studies.

F. Da Settimo, C. La Motta, S. Sartini, 2009, Journal of medicinal chemistry.

Protein kinase homology models: recent developments and results.

T. Tuccinardi, A. Martinelli, 2011, Current medicinal chemistry.

An overview of recent developments in GPCR modelling: methods and validation

T. Tuccinardi, A. Martinelli, 2006, Expert opinion on drug discovery.

Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.

Armando Rossello, Tiziano Tuccinardi, Elisa Nuti, 2016, European journal of medicinal chemistry.

N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2015, Journal of medicinal chemistry.

Docking-based virtual screening: recent developments.

T. Tuccinardi, 2009, Combinatorial chemistry & high throughput screening.

Matrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors.

T. Tuccinardi, E. Nuti, A. Rossello, 2007, Current pharmaceutical design.

N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.

E. Novellino, Valeria La Pietra, L. Marinelli, 2009, Journal of medicinal chemistry.

Proposal of a new binding orientation for non-peptide AT1 antagonists: homology modeling, docking and three-dimensional quantitative structure-activity relationship analysis.

Tiziano Tuccinardi, Adriano Martinelli, Vincenzo Calderone, 2006, Journal of medicinal chemistry.

Molecular modeling of adenosine receptors: new results and trends

T. Tuccinardi, A. Martinelli, 2008, Medicinal research reviews.

Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

L. Peruzzi, M. De Leo, T. Tuccinardi, 2017, Journal of natural products.

A Virtual Screening Study of the 18 kDa Translocator Protein using Pharmacophore Models Combined with 3D‐QSAR Studies

S. Taliani, C. Martini, T. Tuccinardi, 2009, ChemMedChem.

The influence of Echinacea purpurea leaf microbiota on chicoric acid level

R. Fani, E. Gallo, F. Firenzuoli, 2019, Scientific Reports.

Receptor-based virtual screening evaluation for the identification of estrogen receptor β ligands

T. Tuccinardi, A. Martinelli, F. Minutolo, 2015, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2009, Journal of medicinal chemistry.

Study of the binding interaction between fluorinated matrix metalloproteinase inhibitors and Human Serum Albumin.

C. Geraldes, A. Maiocchi, T. Tuccinardi, 2014, European journal of medicinal chemistry.

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

T. Langer, T. Tuccinardi, F. Rizzolio, 2018, Journal of enzyme inhibition and medicinal chemistry.

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2017, Journal of enzyme inhibition and medicinal chemistry.

The Dichotomous Role of the Glycolytic Metabolism Pathway in Cancer Metastasis: Interplay with the Complex Tumor Microenvironment and Novel Therapeutic Strategies.

E. Giovannetti, N. Funel, G. Peters, 2020, Seminars in cancer biology.

Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1

T. Tuccinardi, G. Pieraccini, G. Moneti, 2014, Nature Communications.

Carrier Free Delivery System of Monoacylglycerol Lipase Hydrophobic Inhibitor for Cancer Therapy

V. Canzonieri, I. Moro, S. Parisi, 2021 .

Substituted Pyrazolo[3,4‐b]pyridines as Potent A1 Adenosine Antagonists: Synthesis, Biological Evaluation, and Development of an A1 Bovine Receptor Model

M. Trincavelli, C. Martini, C. Tintori, 2008, ChemMedChem.

Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: developments in understanding the receptor stereoselectivity.

M. Trincavelli, C. Martini, F. Musumeci, 2011, Organic & biomolecular chemistry.

Design, Synthesis, and Evaluation of GLUT Inhibitors.

T. Tuccinardi, F. Minutolo, C. Granchi, 2018, Methods in molecular biology.

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.

P. Hergenrother, T. Tuccinardi, H. Lee, 2017, Journal of agricultural and food chemistry.

Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct

A. Scaloni, C. Pomelli, G. Renzone, 2019, Antioxidants.

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

Computational studies on translocator protein (TSPO) and its ligands.

T. Tuccinardi, A. Martinelli, G. Ortore, 2012, Current topics in medicinal chemistry.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

C. Hulme, A. Mangoni, M. Gütschow, 2017, Molecules.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–4

F. J. Luque, C. Hulme, A. Mangoni, 2018, Molecules.

Novel Potent and Selective Agonists of the GPR55 Receptor Based on the 3-Benzylquinolin-2(1H)-One Scaffold

T. Tuccinardi, S. Bertini, R. Laprairie, 2022, Pharmaceuticals.

α/β-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases

T. Tuccinardi, F. Rizzolio, C. Granchi, 2021, Journal of medicinal chemistry.

Interaction of anticancer reduced Schiff base coumarin derivatives with human serum albumin investigated by fluorescence quenching and molecular modeling.

T. Tuccinardi, B. Creaven, M. Walsh, 2014, Bioorganic chemistry.

Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief.

C. Ghelardini, T. Tuccinardi, E. Lucarini, 2018, Journal of medicinal chemistry.

Virtual screening and crystallographic studies reveal an unexpected γ-lactone derivative active against MptpB as a potential antitubercular agent.

L. Chiarelli, M. Mori, F. Meneghetti, 2022, European journal of medicinal chemistry.

The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.

M. Marcoli, C. Ghelardini, J. Gertsch, 2020, European journal of medicinal chemistry.

Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system.

J. Gertsch, T. Tuccinardi, F. Gado, 2019, Bioorganic chemistry.

New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy

A. Giordano, V. Canzonieri, T. Tuccinardi, 2021, Journal of enzyme inhibition and medicinal chemistry.

α-Glucosidase and α-Amylase Inhibitors from Arcytophyllum thymifolium.

L. Milella, M. De Leo, T. Tuccinardi, 2016, Journal of natural products.

Development of a fluorogenic ADAMTS-7 substrate

A. Snijders, Steven A. Howell, T. Tuccinardi, 2021, Journal of enzyme inhibition and medicinal chemistry.

miRNA-203b-3p induces acute and chronic pruritus via 5-HTR2B and TRPV4.

J. Calixto, T. Tuccinardi, M. Otuki, 2022, The Journal of investigative dermatology.

Dissecting the Activity of Catechins as Incomplete Aldose Reductase Differential Inhibitors through Kinetic and Computational Approaches

G. Signore, T. Tuccinardi, A. Del Corso, 2022, Biology.

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety

P. Circosta, B. Rolando, S. Al-Karadaghi, 2022, Journal of medicinal chemistry.

Three-Dimensional Interactions Analysis of the Anticancer Target c-Src Kinase with Its Inhibitors

T. Tuccinardi, M. Macchia, G. Poli, 2020, Cancers.

Human carbonyl reductase 1 as efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation.

A. Scaloni, G. Renzone, T. Tuccinardi, 2016, Free radical biology & medicine.

Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.

M. Botta, T. Tuccinardi, A. Martinelli, 2006, Journal of medicinal chemistry.

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

T. Tuccinardi, L. Ciccone, E. Nuti, 2021, Scientific reports.

Exosite inhibition of A Disintegrin And Metalloproteinase with Thrombospondin motif (ADAMTS)-5 by a glycoconjugated arylsulfonamide

T. Tuccinardi, L. Ciccone, E. Nuti, 2020, bioRxiv.

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study

D. Boschi, T. Tuccinardi, M. Giorgis, 2022, Molecules.

Targeting GLUT1 in acute myeloid leukemia to overcome cytarabine resistance

Peng Huang, J. Hansen, R. Venskutonytė, 2020, Haematologica.

1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15 exerts immune-modulatory effects with good intestinal and blood brain barrier permeability

T. Tuccinardi, D. Marasco, A. Malfitano, 2019 .

Immunomodulatory properties of 1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15.

T. Tuccinardi, D. Marasco, A. Malfitano, 2017, Biochimie.

Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives

M. Vitale, T. Tuccinardi, A. Martinelli, 2013, Journal of Neuroimmune Pharmacology.

Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis

C. Procaccini, G. Matarese, T. Tuccinardi, 2013, PloS one.

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

T. Tuccinardi, L. Ciccone, F. Rizzolio, 2020, Journal of biomolecular structure & dynamics.

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.

J. Gertsch, T. Tuccinardi, F. Rizzolio, 2019, Journal of medicinal chemistry.

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists

J. Katzenellenbogen, K. Carlson, T. Tuccinardi, 2016, ChemMedChem.

Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.

A. Vannacci, T. Tuccinardi, A. Martinelli, 2006, Journal of medicinal chemistry.

Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives

T. Tuccinardi, V. Calderone, F. Minutolo, 2022, Molecules.

New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds

T. Tuccinardi, V. Calderone, F. Minutolo, 2022, Pharmaceuticals.

The History of Nanoscience and Nanotechnology: From Chemical–Physical Applications to Nanomedicine

Tiziano Tuccinardi, Muhammad Adeel, Flavio Rizzolio, 2019, Molecules.

Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold.

G. Demontis, T. Tuccinardi, Ivana Barravecchia, 2021, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.

E. Giovannetti, V. Canzonieri, T. Perin, 2020, European journal of medicinal chemistry.

CDK inhibitors: from the bench to clinical trials.

A. Giordano, T. Tuccinardi, F. Rizzolio, 2010, Current drug targets.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

F. J. Luque, R. Capasso, C. Hulme, 2019, Molecules.

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives

E. Giovannetti, A. Avan, E. Dreassi, 2022, Journal of medicinal chemistry.

Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2015, Journal of medicinal chemistry.

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5.

G. Giannaccini, A. Lucacchini, T. Tuccinardi, 2011, Bioorganic & medicinal chemistry letters.

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation.

E. Giovannetti, G. Peters, G. Giannaccini, 2011, European journal of medicinal chemistry.

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

G. Giannaccini, A. Lucacchini, T. Tuccinardi, 2011 .

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

E. Giovannetti, G. Peters, P. Hergenrother, 2011, Journal of medicinal chemistry.

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds.

P. Hergenrother, T. Tuccinardi, A. Martinelli, 2013, Organic & biomolecular chemistry.

Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.

G. Giannaccini, A. Lucacchini, T. Tuccinardi, 2004, Journal of medicinal chemistry.

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.

G. Biamonti, M. Radi, C. Tintori, 2015, Journal of medicinal chemistry.

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII

C. Supuran, T. Tuccinardi, Silvia Bua, 2019, International journal of molecular sciences.

Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)‐Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

R. Danesi, S. Rapposelli, G. Giannaccini, 2006, ChemMedChem.

Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2006, Bioorganic & medicinal chemistry.

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.

A. Giordano, T. Tuccinardi, A. Martinelli, 2012, European journal of medicinal chemistry.

Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors.

T. Tuccinardi, A. Rossello, S. Marques, 2006, Bioorganic & medicinal chemistry.

Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator.

T. Tuccinardi, S. Nejad Ebrahimi, F. Dal Piaz, 2016, Journal of natural products.

Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.

T. Tuccinardi, A. Martinelli, N. de Tommasi, 2015, Phytochemistry.

Antibacterial and ATP Synthesis Modulating Compounds from Salvia tingitana

T. Bürgi, I. Panfoli, D. Calzia, 2020, Journal of natural products.

Antibacterial and Hypoglycemic Diterpenoids from Salvia chamaedryoides.

L. Milella, S. Alfei, A. Schito, 2017, Journal of natural products.

A Carrier Free Delivery System of a Monoacylglycerol Lipase Hydrophobic Inhibitor.

V. Canzonieri, I. Moro, S. Parisi, 2021, International journal of pharmaceutics.

New Chromane-Based Derivatives as Inhibitors of Mycobacterium tuberculosis Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

L. Chiarelli, M. Mori, F. Meneghetti, 2018, Molecules.

Effect of Cooking Techniques on the in vitro Protein Digestibility, Fatty Acid Profile, and Oxidative Status of Mealworms (Tenebrio molitor)

T. Tuccinardi, F. Fratini, S. Mancini, 2021, Frontiers in Veterinary Science.

Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.

T. Bisogno, M. Cascio, T. Tuccinardi, 2007, Bioorganic & medicinal chemistry.

STARD3: A Prospective Target for Cancer Therapy

L. Memeo, V. Canzonieri, S. Parisi, 2021, Cancers.

What is the current value of MM/PBSA and MM/GBSA methods in drug discovery?

T. Tuccinardi, 2021, Expert opinion on drug discovery.

Co-Inhibition of P-gp and Hsp90 by an Isatin-Derived Compound Contributes to the Increase of the Chemosensitivity of MCF7/ADR-Resistant Cells to Doxorubicin

T. Tuccinardi, H. Alkahtani, R. Ahmad, 2021, Molecules.

Investigating the Binding Mode of an Inhibitor of the MBNL1⋅RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA‐Selective Binder

A. Baranger, S. Zimmerman, Chun-Ho Wong, 2012, Chembiochem : a European journal of chemical biology.

Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.

C. Supuran, V. Sharoyko, T. Tennikova, 2019, European journal of medicinal chemistry.

The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation

R. de Caterina, M. Wabitsch, F. Santorelli, 2019, Nutrients.

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent.

V. Canzonieri, T. Tuccinardi, F. Rizzolio, 2019, ACS medicinal chemistry letters.

Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools

L. Memeo, V. Canzonieri, T. Perin, 2020, Cancers.

Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?

S. Carradori, C. Supuran, Mariangela Agamennone, 2022, Molecules.

1,3-Dipolar cycloaddition, HPLC enantioseparation and docking studies of saccharin/isoxazole and saccharin/isoxazoline derivatives as selective carbonic anhydrase IX and XII inhibitors.

S. Carradori, C. Supuran, T. Tuccinardi, 2020, Journal of medicinal chemistry.

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties.

C. Supuran, J. Winum, C. Ghelardini, 2019, Bioorganic chemistry.

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.

P. Hergenrother, T. Tuccinardi, A. Martinelli, 2015, RSC advances.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

G. Rastelli, P. Fossa, A. Mangoni, 2020, Molecules.

Predicting Isoform-Selective Carbonic Anhydrase Inhibitors via Machine Learning and Rationalizing Structural Features Important for Selectivity

J. Bajorath, Martin Vogt, T. Tuccinardi, 2021, ACS omega.

Probing the 'bipolar' nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms.

C. Supuran, T. Tuccinardi, M. Krasavin, 2015, European journal of medicinal chemistry.

Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.

C. Supuran, T. Tuccinardi, A. Martinelli, 2008, Journal of medicinal chemistry.

Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment.

C. Supuran, V. Sharoyko, T. Tennikova, 2019, European journal of medicinal chemistry.

Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic hCA II and membrane-bound hCA IX isoforms.

C. Supuran, T. Tuccinardi, A. Angeli, 2018, Bioorganic chemistry.

Primary mono- and bis-sulfonamides obtained via regiospecific sulfochlorination of N-arylpyrazoles: inhibition profile against a panel of human carbonic anhydrases

C. Supuran, T. Tuccinardi, M. Tanc, 2017, Journal of enzyme inhibition and medicinal chemistry.

Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.

Tiziano Tuccinardi, Adriano Martinelli, Marco Macchia, 2013, Bioorganic & medicinal chemistry.

New Therapeutic Strategy for Overcoming Multidrug Resistance in Cancer Cells with Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors

S. Schenone, M. Pešić, L. Botta, 2021, Cancers.

Consensus Docking in Drug Discovery

Giulio Poli and Tiziano Tuccinardi, T. Tuccinardi, G. Poli, 2020 .

CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration

Z. Zuo, K. Kwan, Z. Chen, 2021, Proceedings of the National Academy of Sciences.

Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer

N. Maitland, T. Tuccinardi, J. Farrés, 2022, Journal of medicinal chemistry.

The influence of Echinacea purpurea leaf microbiota on chicoric acid level

R. Fani, E. Gallo, F. Firenzuoli, 2019, Scientific Reports.

The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

T. Tuccinardi, A. Chiarugi, S. Benemei, 2015, British journal of pharmacology.

Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays

T. Tuccinardi, E. Nuti, A. Rossello, 2019, Biological chemistry.

Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties.

T. Tuccinardi, A. Martinelli, V. Calderone, 2010, Bioorganic & medicinal chemistry.

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high‐grade serous ovarian cancer

V. Canzonieri, M. Agostini, L. De Stefano, 2018, Journal of controlled release : official journal of the Controlled Release Society.

New tris(hydroxypyridinones) as iron and aluminium sequestering agents: synthesis, complexation and in vivo studies.

T. Tuccinardi, A. Martinelli, S. Marques, 2010, Chemistry.

Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells

S. Fogli, F. Frontini, T. Tuccinardi, 2018, Marine drugs.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

F. J. Luque, R. Capasso, C. Hulme, 2019, Molecules.

Aldose Reductase Differential Inhibitors in Green Tea

T. Tuccinardi, A. Del Corso, M. Cappiello, 2020, Biomolecules.

Dual Targeting of the Warburg Effect with a Glucose‐Conjugated Lactate Dehydrogenase Inhibitor

P. Hergenrother, T. Tuccinardi, A. Martinelli, 2013, Chembiochem : a European journal of chemical biology.

Carbonic Anhydrase Inhibitors: Identifying Therapeutic Cancer Agents Through Virtual Screening

C. Supuran, T. Tuccinardi, G. Poli, 2021, Progress in Drug Research.

Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII.

C. Supuran, T. Tuccinardi, A. Angeli, 2017, ACS medicinal chemistry letters.

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents.

L. Chiarelli, M. Mori, F. Meneghetti, 2018, European journal of medicinal chemistry.

N-aryl-N'-ureido-O-sulfamates as potent and selective inhibitors of hCA VB over hCA VA: Deciphering the binding mode of new potential agents in mitochondrial dysfunctions.

C. Supuran, T. Tuccinardi, A. Angeli, 2020, Bioorganic chemistry.

Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones.

M. Botta, F. Zunino, C. Lanzi, 2008, Journal of medicinal chemistry.

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

T. Tuccinardi, F. Rizzolio, F. Minutolo, 2020, Expert opinion on therapeutic patents.

A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017)

T. Tuccinardi, F. Rizzolio, F. Minutolo, 2017, Expert opinion on therapeutic patents.

Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation.

S. Krupenko, T. Tuccinardi, A. Martinelli, 2011, Medicinal chemistry (Shariqah (United Arab Emirates)).

Historical perspective of tumor glycolysis: a century with Otto Warburg.

T. Tuccinardi, F. Minutolo, C. Granchi, 2022, Seminars in cancer biology.

Application of MM-PBSA Methods in Virtual Screening

Tiziano Tuccinardi, Giulio Poli, Flavio Rizzolio, 2020, Molecules.

Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies

Tiziano Tuccinardi, Antonio Giordano, Margherita Lapillo, 2019, International journal of molecular sciences.

Former Foodstuff Products in Tenebrio Molitor Rearing: Effects on Growth, Chemical Composition, Microbiological Load, and Antioxidant Status

T. Tuccinardi, F. Fratini, S. Mancini, 2019, Animals : an open access journal from MDPI.

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

T. Tuccinardi, F. Minutolo, M. Macchia, 2020, Molecules.

Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists.

Cristina Tintori, Tiziano Tuccinardi, Pier Andrea Borea, 2013, Journal of medicinal chemistry.

New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo.

Federico Corelli, Tiziano Tuccinardi, Adriano Martinelli, 2009, Journal of medicinal chemistry.

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2016, Journal of medicinal chemistry.

Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies

Tiziano Tuccinardi, Adriano Martinelli, Giulio Poli, 2016, Journal of enzyme inhibition and medicinal chemistry.

Extensive Consensus Docking Evaluation for Ligand Pose Prediction and Virtual Screening Studies

Tiziano Tuccinardi, Antonio Giordano, Adriano Martinelli, 2014, J. Chem. Inf. Model..

Identification and characterization of a new reversible MAGL inhibitor.

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2014, Bioorganic & medicinal chemistry.

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

T. Tuccinardi, F. Rizzolio, F. Minutolo, 2019, Journal of enzyme inhibition and medicinal chemistry.

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

C. Ghelardini, J. Gertsch, L. De Stefano, 2018, Journal of medicinal chemistry.

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

A. Giordano, T. Tuccinardi, A. Martinelli, 2016, Journal of enzyme inhibition and medicinal chemistry.

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.

J. Gertsch, T. Tuccinardi, F. Gado, 2018, European journal of medicinal chemistry.

Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists.

K. Varani, T. Tuccinardi, F. Vincenzi, 2016, European journal of medicinal chemistry.

Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives

M. Vitale, T. Tuccinardi, A. Martinelli, 2013, Journal of Neuroimmune Pharmacology.

New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.

M. Cascio, C. Ghelardini, T. Tuccinardi, 2007, Bioorganic & medicinal chemistry letters.

Former foodstuff in mealworm farming: Effects on fatty acids profile, lipid metabolism and antioxidant molecules

T. Tuccinardi, F. Fratini, S. Mancini, 2021, LWT.

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies.

B. Keppler, T. Tuccinardi, T. Kiss, 2011, Bioorganic & medicinal chemistry.

Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds.

C. Supuran, T. Tuccinardi, M. Tanc, 2017, Bioorganic & medicinal chemistry.

Rutin as promising drug for the treatment of Parkinson’s disease: an assessment of MAO-B inhibitory potential by docking, molecular dynamics and DFT studies

Hamed I. Ali, T. Tuccinardi, F. Azam, 2019, Molecular Simulation.

Bottom‐up synthesis of carbon nanoparticles with higher doxorubicin efficacy

V. Canzonieri, M. Agostini, T. Tuccinardi, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Recent Advances in In Silico Target Fishing

T. Tuccinardi, E. Martinelli, G. Poli, 2021, Molecules.

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors

T. Tuccinardi, F. Minutolo, C. Granchi, 2017, Molecules.

Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins

B. Keppler, Krisztina Bali, T. Tuccinardi, 2014, JBIC Journal of Biological Inorganic Chemistry.

VenomPred: A Machine Learning Based Platform for Molecular Toxicity Predictions

T. Tuccinardi, A. Martinelli, M. Macchia, 2022, International journal of molecular sciences.

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects

Flavio Rizzolio, Tiziano Tuccinardi, Giulio Poli, 2019, Journal of cellular physiology.

A Guide to PIN1 Function and Mutations Across Cancers

A. Giordano, V. Canzonieri, L. De Stefano, 2019, Front. Pharmacol..

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

J. Katzenellenbogen, K. Carlson, T. Tuccinardi, 2011, European journal of medicinal chemistry.

Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes.

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2006, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).

N. Ito, Y. Itoh, T. Tuccinardi, 2019, Bioorganic & medicinal chemistry.

Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design

L. Chiarelli, M. Mori, F. Meneghetti, 2020, Journal of medicinal chemistry.

Protein Kinases: Docking and Homology Modeling Reliability

Maurizio Botta, Tiziano Tuccinardi, Antonio Giordano, 2010, J. Chem. Inf. Model..

Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors

C. Supuran, T. Tuccinardi, A. Martinelli, 2018, International journal of molecular sciences.

Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor

A. Baranger, W. Chan, H. Tsoi, 2014, Journal of the American Chemical Society.

Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII.

C. Supuran, T. Tuccinardi, P. Sharma, 2016, Bioorganic & medicinal chemistry.

Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors.

T. Tuccinardi, A. Martinelli, E. Nuti, 2008, Bioorganic & medicinal chemistry.

Analysis of Human Carbonic Anhydrase II: Docking Reliability and Receptor-Based 3D-QSAR Study

Claudiu T. Supuran, Armando Rossello, Tiziano Tuccinardi, 2007, J. Chem. Inf. Model..

Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis.

Tiziano Tuccinardi, Adriano Martinelli, Gabriella Ortore, 2006, Journal of medicinal chemistry.

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.

J. Katzenellenbogen, K. Carlson, Sung Hoon Kim, 2018, European journal of medicinal chemistry.

Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.

E. Novellino, B. Cosimelli, Marina Ehlardo, 2008, Journal of medicinal chemistry.

Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2011, Journal of medicinal chemistry.

Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.

E. Masini, M. Cascio, T. Tuccinardi, 2009, Journal of medicinal chemistry.

Tenebrio molitor reared on different substrates: is it gluten free?

T. Tuccinardi, F. Fratini, S. Mancini, 2020 .

The acyl‐glucuronide metabolite of ibuprofen has analgesic and anti‐inflammatory effects via the TRPA1 channel

T. Tuccinardi, P. Geppetti, D. Preti, 2019, Pharmacological research.

Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors

Gianluca Del Frate, T. Tuccinardi, A. Martinelli, 2015, Molecules.

Predicting potentially pathogenic effects of hRPE65 missense mutations: a computational strategy based on molecular dynamics simulations

G. Demontis, A. Saba, T. Tuccinardi, 2022, Journal of enzyme inhibition and medicinal chemistry.

An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of hRPE65

G. Demontis, A. Saba, T. Tuccinardi, 2023, Journal of enzyme inhibition and medicinal chemistry.

Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors

T. Tuccinardi, F. Rizzolio, S. Bertini, 2022, International journal of molecular sciences.

Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).

T. Tuccinardi, A. Martinelli, P. Baraldi, 2015, European journal of medicinal chemistry.

Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.

M. Botta, K. Varani, T. Tuccinardi, 2008, Bioorganic & medicinal chemistry.

Binding-interaction prediction of RNA-binding ligands.

Tiziano Tuccinardi, T. Tuccinardi, 2011, Future medicinal chemistry.

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

L. Chiarelli, M. Mori, F. Meneghetti, 2019, Journal of enzyme inhibition and medicinal chemistry.

Rational Development of MAGL Inhibitors.

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2018, Methods in molecular biology.

Development of a cheminformatics platform for selectivity analyses of carbonic anhydrase inhibitors

C. Supuran, T. Tuccinardi, A. Martinelli, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents †

T. Tuccinardi, F. Minutolo, L. Guazzelli, 2019, Molecules.

A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs.

S. Rapposelli, T. Tuccinardi, E. Orlandini, 2005, Bioorganic & medicinal chemistry letters.

1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.

G. Giannaccini, T. Tuccinardi, A. Martinelli, 2005, Bioorganic & medicinal chemistry letters.

Construction and Validation of a RET TK Catalytic Domain by Homology Modeling

Fabrizio Manetti, Maurizio Botta, Tiziano Tuccinardi, 2007, J. Chem. Inf. Model..

T. Tuccinardi, A. Martinelli, C. Manera, 2008, Mini reviews in medicinal chemistry.

Inhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds

C. Supuran, T. Tuccinardi, A. Geronikaki, 2016, Journal of enzyme inhibition and medicinal chemistry.

Identification of New Fyn Kinase Inhibitors Using a FLAP-Based Approach

Flavio Rizzolio, Tiziano Tuccinardi, Adriano Martinelli, 2013, J. Chem. Inf. Model..

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

J. Katzenellenbogen, K. Carlson, Xiaozhuo Chen, 2015, ChemMedChem.

Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization.

C. Martini, E. Stura, L. Vera, 2017, ACS medicinal chemistry letters.

Adenosine receptor modelling. A1/A2a selectivity.

T. Tuccinardi, A. Martinelli, C. Manera, 2006, European journal of medicinal chemistry.

Enhanced activity of a pluronic F127 formulated Pin1 inhibitor for ovarian cancer therapy

V. Canzonieri, T. Perin, T. Tuccinardi, 2023, Journal of Drug Delivery Science and Technology.

Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies

T. Tuccinardi, F. Rizzolio, 2019, Front. Pharmacol..

Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach

A. Asai, A. Gelain, T. Tuccinardi, 2016, Journal of enzyme inhibition and medicinal chemistry.

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore‐based Approach

T. Tuccinardi, A. Martinelli, F. Minutolo, 2016, Molecular informatics.

Application of a FLAP-Consensus Docking Mixed Strategy for the Identification of New Fatty Acid Amide Hydrolase Inhibitors

Tiziano Tuccinardi, Adriano Martinelli, Giulio Poli, 2015, J. Chem. Inf. Model..

Abstract LB-080: Reactivating RBL2/p130 oncosuppressive function as a new, possible antitumoral strategy

Francesca Pentimalli, Luca Esposito, Iris Maria Forte, 2015 .

MolBook UNIPI—Create, Manage, Analyze, and Share Your Chemical Data for Free

T. Tuccinardi, M. Macchia, G. Poli, 2023, J. Chem. Inf. Model..

VenomPred 2.0: A Novel In Silico Platform for an Extended and Human Interpretable Toxicological Profiling of Small Molecules.

T. Tuccinardi, C. Granchi, G. Poli, 2023, Journal of chemical information and modeling.

Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.

Xiaozhuo Chen, T. Tuccinardi, A. Martinelli, 2013, Bioorganic & medicinal chemistry letters.