Y. Kiso

发表

Solution structure of HIV-1 protease-allophenylnorstatine derivative inhibitor complex obtained from molecular dynamics simulation.

S. Hirono, I. Moriguchi, R. Kato, 1994, Chemical & pharmaceutical bulletin.

Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-->N intramolecular acyl migration: Design, synthesis and kinetic study.

Y. Kiso, Y. Hamada, H. Matsumoto, 2004, Bioorganic & medicinal chemistry.

Views on amyloid hypothesis and secretase inhibitors for treating Alzheimer's disease: progress and problems.

Y. Kiso, J. Nguyen, A. Yamani, 2006, Current pharmaceutical design.

Rejection properties of alkyl phthalates with nanofiltration membranes

Y. Kiso, 2001 .

Rejection properties of NF membranes for alkylphenols

Y. Kiso, Yong-Jun Jung, Han-Jung Park, 2007 .

The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design.

A. Velázquez‐Campoy, E. Freire, E. Freire, 2001, Archives of biochemistry and biophysics.

Overcoming Roadblocks in Lead Optimization: A Thermodynamic Perspective

E. Freire, Y. Kiso, A. Ruben, 2006, Chemical biology & drug design.

Oligoarginine-based prodrugs with self-cleavable spacers for caco-2 cell permeation.

S. Futaki, T. Fujita, Y. Kiso, 2008, Chemical & pharmaceutical bulletin.

Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption.

S. Futaki, T. Fujita, Y. Kiso, 2007, Bioorganic & medicinal chemistry letters.

Solution NMR evidence that the HIV-1 protease catalytic aspartyl groups have different ionization states in the complex formed with the asymmetric drug KNI-272.

T. Yamazaki, D. Torchia, P. Wingfield, 1996, Biochemistry.

Synthesis of polylactides with side chain functionality: ring-opening polymerimerization of a homobislactone prepared from lysine.

Y. Hirano, Y. Kiso, Y. Hayashi, 2009, Advances in experimental medicine and biology.

Wastewater treatment performance of a filtration bio-reactor equipped with a mesh as a filter material

Y. Kiso, Yong-Jun Jung, Takashi Ichinari, 2000 .

The effects of molecular width on permeation of organic solute through cellulose acetate reverse osmosis membranes

Y. Kiso, K. Jinno, T. Kitao, 1992 .

Pore radius estimation based on organic solute molecular shape and effects of pressure on pore radiu

Y. Kiso, T. Shintani, Kentaro Muroshige, 2011 .

Effect of molecular shape on rejection of uncharged organic compounds by nanofiltration membranes and on calculated pore radii

Toshiro Yamada, Y. Kiso, T. Shintani, 2010 .

Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both alpha- and beta-tubulin.

Y. Kiso, Y. Hayashi, H. Yasui, 2010, Bioorganic & medicinal chemistry.

Chemical cleaning of reverse osmosis membranes used for treating wastewater from a rolling mill process

Toshiro Yamada, Y. Kiso, Toshiyuki Shibata, 2006 .

The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors

Y. Kiso, Y. Hamada, 2012, Expert opinion on drug discovery.

Establishment of a biological assay system for human retroviral protease activity.

A. Sakurai, T. Uchiyama, Y. Kiso, 2005, Microbes and infection.

Surface Analysis of the Reverse Osmosis Membranes Used for Advanced Treatment of Human Excreta.

Y. Kiso, M. Fujii, T. Kitao, 1994 .

Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells.

M. Mukoyama, S. Suga, Y. Kiso, 1998, Kidney international.

beta-Secretase inhibitors: modification at the P4 position and improvement of inhibitory activity in cultured cells.

Kazuki Saito, Y. Kiso, Y. Hamada, 2006, Bioorganic & medicinal chemistry letters.

Click Peptides: Design and Applications

Y. Kiso, A. Taniguchi, Y. Sohma, 2008 .

Synthesis of novel amino acids, l-bis-tetrahydrofuranylglycines

T. Ishida, Y. Kiso, Tooru Kimura, 2002 .

An expedient synthesis of N(alpha)-protected-L-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2002, Bioorganic & medicinal chemistry letters.

Development of Novel Lipophilic Derivatives of DADLE (Leucine Enkephalin Analogue): Intestinal Permeability Characteristics of DADLE Derivatives in Rats

T. Fujita, Y. Kiso, A. Yamamoto, 2000, Pharmaceutical Research.

Determination of Bisphenol A in Water Using a Packed Needle Extraction Device

Y. Kiso, K. Jinno, M. Ogawa, 2009 .

Tubulin Photoaffinity Labeling with Biotin‐Tagged Derivatives of Potent Diketopiperazine Antimicrotubule Agents

M. Akamatsu, S. Neuteboom, Y. Kiso, 2008, Chembiochem : a European journal of chemical biology.

Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum.

E. Freire, Y. Kiso, R. F. de Freitas, 2014, Bioorganic & medicinal chemistry letters.

Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs.

S. Hirota, M. Skwarczynski, Y. Kiso, 2008, Bioorganic & medicinal chemistry.

NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent

Y. Hayashi, S. Neuteboom, M. Palladino, 2006, Anti-cancer drugs.

Negamycin analogue with readthrough-promoting activity as a potential drug candidate for duchenne muscular dystrophy.

Y. Nonomura, R. Matsuda, M. Shiozuka, 2012, ACS Medicinal Chemistry Letters.

Visual determination of nitrite and nitrate in waters by color band formation method.

Toshiro Yamada, Y. Kiso, M. Nagai, 2006, Chemosphere.

Sludge thickening performance of mesh filtration process.

Y. Kiso, T. Kitao, K. Min, 2004, Water science and technology : a journal of the International Association on Water Pollution Research.

Coupling of sequencing batch reactor and mesh filtration: operational parameters and wastewater treatment performance.

Toshiro Yamada, K. Min, Wenhui Wang, 2005, Water research.

Rigid backbone moiety of KNI-272, a highly selective HIV protease inhibitor: methanol, acetone and dimethylsulfoxide solvated forms of 3-[3-benzyl-2-hydroxy-9-(isoquinolin-5-yloxy)-6-methylsulfanylmethyl-5,8-dioxo-4,7-diazanonanoyl]-N-tert-butyl-1,3-thiazolidine-4-carboxamide.

T. Ishida, Y. Kiso, Tooru Kimura, 2004, Acta crystallographica. Section B, Structural science.

Intact-cell-based surface plasmon resonance measurements for ligand affinity evaluation of a membrane receptor.

Kazuki Saito, H. Kataoka, Y. Kiso, 2012, Analytical biochemistry.

Discovery of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease

Y. Kiso, Y. Hamada, 2017 .

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position.

Y. Kiso, Y. Hamada, S. Ishiura, 2014, Bioorganic & medicinal chemistry letters.

Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position.

Y. Kiso, Y. Hamada, S. Ishiura, 2012, Bioorganic & medicinal chemistry letters.

Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold.

Y. Kiso, Y. Hamada, S. Ishiura, 2009, Bioorganic & medicinal chemistry letters.

BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.

Kazuki Saito, Y. Kiso, Y. Hamada, 2008, Bioorganic & medicinal chemistry letters.

Advances in the identification of β-secretase inhibitors

Y. Kiso, Y. Hamada, 2013, Expert opinion on drug discovery.

Design of Potent Aspartic Protease Inhibitors to Treat Various Diseases

Y. Kiso, Y. Hamada, Tooru Kimura, 2008, Archiv der Pharmazie.

Human T-cell Leukemia Virus Type I (HTLV-I) Retropepsin

Y. Kiso, J. Nguyen, 2013 .

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study

E. Freire, A. Schön, Y. Kiso, 2013, European Journal of Medicinal Chemistry.

Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety

E. Freire, Y. Kiso, Y. Hayashi, 2012, Bioorganic & Medicinal Chemistry.

New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CLpro inhibitors

E. Freire, Y. Kiso, Y. Hayashi, 2009, Bioorganic & Medicinal Chemistry Letters.

Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors

E. Freire, Y. Kiso, Jennifer Barrila, 2006, Tetrahedron.

Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.

Y. Kiso, Y. Hayashi, H. Yasui, 2011, Bioorganic & medicinal chemistry.

Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1.

A. Fukamizu, Y. Kiso, T. Seki, 2011, Biochemical and biophysical research communications.

‘O-Acyl isopeptide method’ for the efficient synthesis of difficult sequence-containing peptides: use of ‘O-acyl isodipeptide unit’

M. Skwarczynski, Taku Yoshiya, Y. Kiso, 2006 .

Removal of phosphite and sulfate from electroless nickel–phosphorus plating bath with hydrotalcite for the management of watershed

K. Min, Y. Kamimoto, R. Ichino, 2013 .

KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides.

B. Szabó, Y. Kiso, Tooru Kimura, 2003, Bioorganic & medicinal chemistry letters.

Click Peptide Concept: O‐Acyl Isopeptide of Islet Amyloid Polypeptide as a Nonaggregative Precursor Molecule

Taku Yoshiya, Naoko Abe, Y. Kiso, 2011, Chembiochem : a European journal of chemical biology.

Development of first photoresponsive prodrug of paclitaxel.

S. Hirota, M. Skwarczynski, Y. Kiso, 2006, Bioorganic & medicinal chemistry letters.

Occurrence of atrial natriuretic polypeptide in brain.

K. Nakao, H. Imura, Y. Yamori, 1985, Biochemical and biophysical research communications.

Analysis of pesticides in environmental water samples by solid-phase micro-extraction-high-performance liquid chromatography.

J. Pawliszyn, Y. Kiso, Y. Saito, 1996, Journal of chromatography. A.

Immunohistochemical demonstration of α-atrial natriuretic polypeptide-containing neurons in the rat brain

K. Nakao, H. Imura, Y. Kiso, 2004, Histochemistry.

Trials of lipid modification of peptide hormones for intestinal delivery

Y. Kiso, Keigo Yamada, S. Muranishi, 1992 .

Application of plug–plug technique to ACE experiments for discovery of peptides binding to a larger target protein: A model study of calmodulin‐binding fragments selected from a digested mixture of reduced BSA

Kazuki Saito, S. Yokoyama, H. Hirota, 2014, Electrophoresis.

Radioimmunoassay for α-human and rat atrial natriuretic polypeptide

K. Nakao, H. Imura, Y. Yamori, 1984 .

Significance of α‐Human Atrial Natriuretic Polypeptide as a Hormone in Humans

H. Imura, Y. Yamori, K. Kangawa, 1986 .

Isolation of a novel analgesic pentapeptide, neo-kyotorphin, from bovine brain.

H. Takagi, Y. Kiso, K. Kitagawa, 1982, Life sciences.

A spot test for nitrite and nitrate detection by color band length and number of colored zebra-bands formed in a mini-column

Toshiro Yamada, Y. Kiso, M. Nagai, 2010 .

Ammonium detection by formation of colored zebra-bands in a detecting tube.

Toshiro Yamada, Y. Kamimoto, Y. Kiso, 2010, Talanta.

A spot test for ammonium ion by the color band formation method.

Toshiro Yamada, Y. Kiso, M. Nagai, 2007, Talanta.

'Click peptide' using production of monomer Aβ from the O-acyl isopeptide: application to assay system of aggregation inhibitors and cellular cytotoxicity.

Y. Kiso, A. Taniguchi, Y. Sohma, 2011, Bioorganic & medicinal chemistry.

“Click Peptide“: pH‐Triggered in Situ Production and Aggregation of Monomer Aβ1–42

K. Matsuzaki, Y. Kiso, Tooru Kimura, 2009, Chembiochem : a European journal of chemical biology.

click peptide based on the O-acyl isopeptide method : Control of Aβ1 42 production from a photo-triggered Aβ1 42 analogue

S. Hirota, K. Matsuzaki, Y. Kiso, 2006 .

Syntheses and biological activities of atrial natriuretic polypeptide analogs

Y. Kiso, Makoto Yoshida, Y. Fujiwara, 1987 .

Specific binding activities and cyclic GMP responses by atrial natriuretic polypeptide in kidney epithelial cell line (LLC-PK1).

K. Nakao, H. Imura, Y. Kiso, 1985, Biochemical and Biophysical Research Communications - BBRC.

Effects of Water Deprivation and Sodium Load on Atrial Natriuretic Polypeptide in Rat Brain

H. Imura, Y. Yamori, Y. Kiso, 1986 .

‘Click peptide’: a novel ‘O‐acyl isopeptide method’ for peptide synthesis and chemical biology‐oriented synthesis of amyloid β peptide analogues

S. Hirota, M. Skwarczynski, Taku Yoshiya, 2006, Journal of peptide science : an official publication of the European Peptide Society.

“Click Peptides”—Chemical Biology‐Oriented Synthesis of Alzheimer's Disease‐Related Amyloid β Peptide (Aβ) Analogues Based on the “O‐Acyl Isopeptide Method”

Y. Kiso, Y. Sohma, Youhei Sohma, 2006, Chembiochem : a European journal of chemical biology.

Enzyme Inhibitors, Aspartic Proteases

Y. Kiso, Y. Hamada, 2019, Kirk‐Othmer Encyclopedia of Chemical Technology.

New directions for protease inhibitors directed drug discovery

Y. Kiso, Y. Hamada, 2016, Biopolymers.

High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor.

Jun Liu, D. Goldberg, E. Freire, 2003, Biochemistry.

Biological removal characteristics of phenol with filtration bio-reactor

K. Min, Y. Kamimoto, Y. Kiso, 2015 .

Removal properties of arsenic compounds with synthetic hydrotalcite compounds

Toshiro Yamada, K. Min, Y. Kiso, 2005 .

"O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH.

M. Skwarczynski, Taku Yoshiya, Naoko Abe, 2007, Organic & biomolecular chemistry.

O-acyl isopeptide method: efficient synthesis of isopeptide segment and application to racemization-free segment condensation.

Taku Yoshiya, Y. Kiso, Tooru Kimura, 2009, Organic & biomolecular chemistry.

Isopeptide method: development of S‐acyl isopeptide method for the synthesis of difficult sequence‐containing peptides

Taku Yoshiya, Y. Kiso, Tooru Kimura, 2008, Journal of peptide science : an official publication of the European Peptide Society.

Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles.

Y. Kiso, Tooru Kimura, J. Nguyen, 2011, Bioorganic & medicinal chemistry letters.

Effect of molecular charges on renal uptake of 111In-DTPA-conjugated peptides.

H. Saji, K. Ogawa, Y. Kiso, 2001, Nuclear medicine and biology.

The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active.

A. Wlodawer, A. Gustchina, B. C. Bryksa, 2014, Molecular and biochemical parasitology.

Accelerated natriuresis induced by synthetic atrial natriuretic polypeptide in spontaneously hypertensive rats.

K. Nakao, H. Imura, Y. Kiso, 1985, Clinical and Experimental Hypertension Part A Theory and Practice.

Renal metabolism of 111In-DTPA-D-Phe1-octreotide in vivo.

H. Saji, Y. Kiso, M. Ono, 1998, Bioconjugate chemistry.

Rational Drug Design of HTLV-I Protease Inhibitors

Y. Kiso, J. Nguyen, 2009 .

Discovery of Peptide Drugs as Enzyme Inhibitors and Activators

Y. Kiso, J. Nguyen, 2015 .

Identification and endothelin‐induced activation of multiple extracellular signal‐regulated kinases in aortic smooth muscle cells

K. Nakao, S. Suga, Y. Kiso, 1992, FEBS letters.

Solution conformations of KNI-272, a tripeptide HIV protease inhibitor designed on the basis of substrate transition state: determined by NMR spectroscopy and simulated annealing calculations.

Y. Kiso, Y. Kobayashi, Y. Ohno, 1996, Bioorganic & medicinal chemistry.

Molecular sieving effects of disk-shaped molecules on reverse osmosis and nanofiltration separation

Toshiro Yamada, Y. Kamimoto, K. Makino, 2017 .

Atrial natriuretic polypeptide: Topographical distribution in the rat brain by radioimmunoassay and immunohistochemistry

K. Nakao, Y. Kiso, K. Nakao, 1985, Neuroscience.

Existence of atrial natriuretic polypeptide in kidney.

K. Nakao, H. Imura, Y. Yamori, 1985, Biochemical and biophysical research communications.

Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.

Y. Kiso, Y. Hayashi, J. Katada, 2000, Bioorganic & medicinal chemistry letters.

'O-Acyl isopeptide method' : racemization-free segment condensation in solid phase peptide synthesis

Taku Yoshiya, Y. Kiso, Tooru Kimura, 2006 .

Synthesis of the heptadecapeptide corresponding to the entire amino acid sequence of salmon melanin-concentrating hormone (MCH).

H. Kawauchi, Y. Kiso, H. Yajima, 1984, Chemical & pharmaceutical bulletin.

Flexibility and Function in HIV Protease: Dynamics of the HIV-1 Protease Bound to the Asymmetric Inhibitor Kynostatin 272 (KNI-272)

Yun-Xing Wang, D. Torchia, P. Wingfield, 1998 .

Waste sludge reduction with a pilot-scale membrane bioreactor for point source pollution management

K. Min, Y. Kamimoto, R. Ichino, 2013 .

Synthesis of Palmitoyl Derivatives of Insulin and Their Biological Activities

Y. Kiso, K. Takada, S. Muranishi, 1989, Pharmaceutical Research.

Identification of peptidomimetic HTLV-I protease inhibitors containing hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2004, Bioorganic & medicinal chemistry letters.

Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine.

T. Bhat, S. Gulnik, B. Liu, 1995, Structure.

Synthesis of di- and tripeptide analogues containing alpha-ketoamide as a new core structure for inhibition of HIV-1 protease.

Y. Kiso, A. F. Youssef, N. Mahfouz, 2000, European journal of medicinal chemistry.

Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine.

R. Kato, Y. Kiso, M. Shintani, 1999, Journal of medicinal chemistry.

Atrial natriuretic peptide antagonists: biological evaluation and structural correlations.

Y. Kiso, G. Budzik, W. Holleman, 1990, Molecular pharmacology.

'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2005, Bioorganic & medicinal chemistry.

Development of [Ile40]HTLV‐I protease inhibition assay using novel fluorogenic and chromogenic substrate

Y. Kiso, Tooru Kimura, Y. Hayashi, 2011, Journal of peptide science : an official publication of the European Peptide Society.

The ‘O‐acyl isopeptide method’ for the synthesis of difficult sequence‐containing peptides: application to the synthesis of Alzheimer's disease‐related amyloid β peptide (Aβ) 1–42

Y. Kiso, Tooru Kimura, Y. Hayashi, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Lipophilic Peptides: Synthesis of Lauroyl Thyrotropin-Releasing Hormone and Its Biological Activity

Y. Kiso, K. Takada, Keigo Yamada, 1991, Pharmaceutical Research.

Macrocyclization on solid support using Heck reaction

Y. Kiso, K. Akaji, 1997 .

Delivery of Peptide Drugs

Y. Kiso, J. Nguyen, 2015 .

A SIMPLE DIASTEREOSELECTIVE SYNTHESIS OF CYCLOHEXYLNORSTATINE AND ALLOCYCLOHEXYLNORSTATINE

Y. Kiso, K. Iizuka, H. Harada, 1989 .

Rejection properties of aromatic pesticides with a hollow-fiber NF membrane

K. Min, Y. Kiso, Yong-Jun Jung, 2005 .

Rejection properties of pesticides with a hollow fiber NF membrane (HNF-1)

Y. Kiso, Yong-Jun Jung, A. Mizuno, 2002 .

Efficient Removal of Protecting Groups by a 'Push-Pull' Mechanism. II. Deprotection of O-Benzyltyrosine with a Thioanisole-Trifluoroacetic Acid System without O-to-C Rearrangements

Tadashi Akita, Y. Kiso, Yoshiaki Kiso, 1980 .

Efficient removal of N-benzyloxycarbonyl group by a ‘push–pull’ mechanism using thioanisole–trifluoroacetic acid, exemplified by a synthesis of Met-enkephalin

Y. Kiso, T. Akita, K. Ukawa, 1980 .

Efficient deprotection of NG-tosylarginine with a thioanisole–trifluoromethanesulphonic acid system

Y. Kiso, T. Akita, K. Ukawa, 1980 .

N im -p-methoxyphenylsulphonylhistidine, a new derivative for peptide synthesis

N. Fujii, Y. Kiso, H. Yajima, 1979 .

Studies on peptides. L. Acidolysis of protecting groups in peptide chemistry by fluorosulphonic acid and methanesulphonic acid.

N. Fujii, Y. Kiso, H. Irie, 1975 .

2 – Amide Formation, Deprotection, and Disulfide Formation in Peptide Synthesis

Y. Kiso, H. Yajima, 1995 .

Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors.

Y. Kiso, Y. Hamada, Tooru Kimura, 2011, Bioorganic & medicinal chemistry.

Studies on Peptides. LXXXV. A New Deprotecting Procedure for p-Toluenesulfonyl and p-Methoxybenzenesulfonyl Groups from the Nim-Function of Histidine

N. Fujii, Y. Kiso, H. Yajima, 1980 .

Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases.

R. Matsuda, M. Shiozuka, Y. Kiso, 2008, Chemical communications.

Total synthesis of anti-microtubule diketopiperazine derivatives: phenylahistin and aurantiamine.

Y. Kiso, Y. Hayashi, K. Kanoh, 2000, The Journal of organic chemistry.

Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine.

H Enomoto, Y. Kiso, Y Kiso, 1992, Chemical & pharmaceutical bulletin.

New human renin inhibitors containing an unnatural amino acid, norstatine.

Y. Kiso, H. Umeyama, K. Akahane, 1988, Journal of medicinal chemistry.

Total synthesis of thiangazole

Y. Kiso, K. Akaji, 1999 .

Convergent synthesis of (−)-mirabazole B using a chloroimidazolidium coupling reagent, CIP

Y. Kiso, K. Akaji, N. Kuriyama, 1997 .

Solvent Effects on Stereo and Regioselectivities of Ring-opening Reaction of Epoxide with Aluminum Chloride

Y. Kiso, M. Inoue, T. Sugita, 1976 .

Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.

T. Ishida, Y. Kiso, H. Umeyama, 1990, Journal of medicinal chemistry.

CONVERGENT SYNTHESIS OF DOLASTATIN 15 BY SOLID PHASE COUPLING OF AN N-METHYLAMINO ACID

Y. Kiso, K. Akaji, Y. Hayashi, 1998 .

ON intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence‐containing bioactive peptides

M. Skwarczynski, Y. Kiso, Y. Hamada, 2004, Biopolymers.

Convergent Synthesis of (−)-Mirabazole C Using a Chloroimidazolidium Coupling Reagent, CIP

Y. Kiso, K. Akaji, N. Kuriyama, 1996 .

Efficient coupling of α,α-dimethyl amino acid using a new chloro imidazolidium reagent, CIP

Y. Kiso, K. Akaji, N. Kuriyama, 1994 .

A practical synthesis of an orally potent renin inhibitor, isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidyl}aminobutyrate

T. Yamaguchi, Y. Kiso, K. Hirata, 1990 .

Medicinal Chemistry of α‐Hydroxy‐β‐Amino Acids

M. Skwarczynski, Y. Kiso, Z. Ziora, 2011 .

Design and synthesis of an orally potent human renin inhibitor containing a novel amino acid, cyclohexylnorstatine

Y. Kiso, H. Umeyama, K. Akahane, 1989 .

Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.

S. Neuteboom, Y. Kiso, T. Usui, 2012, Bioorganic & medicinal chemistry.

Synthesis and Structure−Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure

M. Akamatsu, S. Neuteboom, M. Palladino, 2012 .

Acid catalyzed monodehydro-2,5-diketopiperazine formation from N-α-ketoacyl amino acid amides

Y. Kiso, Y. Hayashi, Yuri Yamazaki, 2009 .

Novel non-peptidic and small-sized BACE1 inhibitors.

Kazuki Saito, Y. Kiso, Y. Hamada, 2008, Bioorganic & medicinal chemistry letters.

Efficient solid phase peptide synthesis

Y. Kiso, Tooru Kimura, K. Akaji, 2009 .

Efficient synthesis of peptaibol using a chloroimidazolidium coupling reagent, CIP

Y. Kiso, Y. Tamai, K. Akaji, 1997 .

Efficient synthesis of alamethicin f-30 using a chloro imidazolidium coupling reagent, CIP

Y. Kiso, Y. Tamai, K. Akaji, 1995 .

Studies on Peptides. XXIX. p-Methoxybenzyl Mixed Carbonates

Y. Kiso, H. Yajima, F. Tamura, 1970 .

Fluoren-9-ylmethyloxycarbonyl (Fmoc) amino acid chloride as an efficient reagent for anchoring Fmoc amino acid to 4-alkoxybenzyl alcohol resin.

Y. Kiso, Tooru Kimura, K. Akaji, 1990 .

The Plasmepsin Family as Antimalarial Drug Targets

E. Freire, Y. Kiso, A. Ruben, 2011 .

An ‘active ester’-type mixed anhydride method for peptide synthesis. Use of the new reagent, norborn-5-ene-2,3-dicarboximido diphenyl phosphate (NDPP)

Y. Kiso, T. Akita, M. Satomi, 1980 .

Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV.

Y. Kiso, Y. Hamada, Tooru Kimura, 2008, Journal of medicinal chemistry.

Paclitaxel prodrugs: toward smarter delivery of anticancer agents.

Yoshio Hayashi, Mariusz Skwarczynski, M. Skwarczynski, 2006, Journal of medicinal chemistry.

Synthesis of the sphingolipid activator protein, saposin C, using an azido-protected O-acyl isopeptide as an aggregation-disrupting element

J. Matsuda, Y. Kiso, H. Hojo, 2011 .

A deblocking method using thioether-sulfonic acid systems. Application to the synthesis of met-enkephalin.

Y. Kiso, K. Kitagawa, H. Moritoki, 1979 .

Deprotection of O-methyltyrosine by a ‘push–pull’ mechanism using the thioanisole–trifluoromethanesulphonic acid system. Application to the convenient synthesis of a potent N-methylenkephalin derivative

Y. Kiso, K. Kitagawa, Shizuo Nakamura, 1979 .

Suppressing Effect of Thioanisole on a Side Reaction during the Acidolytic Cleavage of Protecting Groups of Tyrosine

Y. Kiso, K. Kitagawa, T. Akita, 1978 .

Studies on peptides. LIX. Synthesis of the nonatriacontapeptide corresponding to the entire amino acid sequence of porcine adrenocorticotropic hormone.

Y. Kiso, A. Tanaka, H. Yajima, 1976, Chemical & pharmaceutical bulletin.

Cellulose acetate as stationary phase in microcolumn LC

Y. Kiso, K. Jinno, K. Takayama, 1989 .

Mitocryptide-2: Purification, Identification, and Characterization of a Novel Cryptide That Activates Neutrophils 1

T. Takao, Y. Shimonishi, H. Nakano, 2009, The Journal of Immunology.

Cryptide signaling: Amphiphilic peptide-induced exocytotic mechanisms in mast cells.

S. Fukuhara, Y. Kiso, E. Munekata, 2008, Biochemical and biophysical research communications.

How Much Binding Affinity Can be Gained by Filling a Cavity?

E. Freire, E. Freire, V. Lafont, 2010, Chemical biology & drug design.

Phosphate removal and recovery with a synthetic hydrotalcite as an adsorbent.

Toshiro Yamada, Yong-Jun Jung, Kazumichi Kuzawa, 2006, Chemosphere.

Solventless sample preparation procedure for organophosphorus pesticides analysis using solid phase microextraction and on-line supercritical fluid extraction/high performance liquid chromatography technique

Y. Kiso, K. Jinno, Yoshihiro Saito, 2001 .

Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.

Y. Kiso, Y. Hamada, Tooru Kimura, 2010, Bioorganic & medicinal chemistry.

Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.

Kazuki Saito, Y. Kiso, Y. Hamada, 2006, Bioorganic & medicinal chemistry letters.

Bacteria of the Candidate Phylum TM7 are Prevalent in Acidophilic Nitrifying Sequencing-Batch Reactors

A. Hiraishi, Y. Kamimoto, Y. Kiso, 2014, Microbes and environments.

Effects of hydrophobicity and molecular size on rejection of aromatic pesticides with nanofiltration membranes

Y. Kiso, 2001 .

Pesticides Separation by Nanofiltration Membranes.

Y. Kiso, T. Kitao, Hangyu Li, 1996 .

Solution syntheses of two enkephalin-containing peptides, peptide E and dynorphin(1-24), using Nin-(2,4,6-triisopropylphenylsulfonyl)tryptophan.

S. Futaki, Y. Kiso, K. Kitagawa, 1989, Chemical & pharmaceutical bulletin.

Cellulose Acetate Fiber as Stationary Phase in Capillary Electrochromatography

Y. Kiso, K. Jinno, Jingwu Wu, 1998 .

Total synthesis of (+)-negamycin and its 5-epi-derivative

Y. Kiso, Y. Hayashi, T. Régnier, 2010 .

A Fluorogenic Probe for γ‐Glutamyl Cyclotransferase: Application of an Enzyme‐Triggered O‐to‐N Acyl Migration‐Type Reaction

Taku Yoshiya, Y. Kiso, Y. Tsuda, 2013, Chembiochem : a European journal of chemical biology.

Development of O-acyl isopeptide method.

Taku Yoshiya, Y. Kiso, Tooru Kimura, 2007, Biopolymers.

Fibrous stationary phase in capillary electrochromatography.

Y. Kiso, K. Jinno, H. Watanabe, 2001, Journal of biochemical and biophysical methods.

Structure-function relationships of the melanotropins

Y. Kiso, H. Yajima, H. Yajima, 1975 .

Adsorption properties of cyclic compounds on cellulose acetate

Y. Kiso, T. Kitao, K. Nishimura, 1999 .

Miniaturized solid-phase extraction as a sample preparation technique for the determination of phthalates in water

Y. Kiso, K. Jinno, Yoshihiro Saito, 2002, Analytical and Bioanalytical Chemistry.

PROTECTION OF THE TRYPTOPHAN INDOLE RING IN PEPTIDE SYNTHESIS. USE OF A NEW DERIVATIVE, Nin-2,2,2-TRICHLOROETHOXYCARBONYLTRYPTOPHAN

Y. Kiso, K. Kitagawa, T. Akita, 1983 .

Studies on Peptides. XXX. Trichloroethyloxycarbonylhydrazine

Y. Kiso, H. Yajima, 1971 .

Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices.

Y. Kiso, H. Katsuki, Y. Hirai, 1990, European journal of pharmacology.

Fiber-in-tube solid-phase microextraction: a fibrous rigid-rod heterocyclic polymer as the extraction medium

Y. Kiso, K. Jinno, T. Takeichi, 2000, Fresenius' journal of analytical chemistry.

EFFICIENT SOLID PHASE PEPTIDE SYNTHESIS ON A PHENACYL-RESIN BY A METHANESULFONIC ACID α-AMINO DEPROTECTING PROCEDURE

Y. Kiso, Tooru Kimura, K. Akaji, 1990 .

Analgesic and other pharmacological activities of an enkephalin analogue, syndyphalin (SD)-25.

Y. Kiso, N. Yoshida, M. Shimizu, 1982, European journal of pharmacology.

A new synthesis of (+)-negamycin and its derivatives as a potential therapeutic agent for Duchenne muscular dystrophy treatment.

Y. Kiso, Y. Hayashi, T. Régnier, 2009, Advances in Experimental Medicine and Biology.

O-N intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids.

M. Skwarczynski, Y. Kiso, Tooru Kimura, 2006, The Journal of organic chemistry.

Targets of a protease inhibitor, KNI‐272, in HIV‐1‐infected cells

T. Nakano, K. Sano, Y. Kiso, 2001, Journal of medical virology.

Studies on Peptides, XXXIX. N-Isobutoxycarbonyl-2-alkoxy-1, 2-dihydroquinoline Derivatives, as Coupling Reagents in Peptide Synthesis

Y. Kiso, H. Yajima, Y. Kai, 1973 .

2-Isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline as a coupling reagent in peptide synthesis

Y. Kiso, H. Yajima, 1972 .

Synthesis and biological evaluation of prodrug-type anti-HIV agents: ester conjugates of carboxylic acid-containing dipeptide HIV protease inhibitors and a reverse transcriptase inhibitor.

Y. Kiso, H. Matsumoto, Y. Hayashi, 2001, Bioorganic & medicinal chemistry.

A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor.

Y. Kiso, H. Matsumoto, T. Kimura, 1999, Bioorganic & medicinal chemistry letters.

Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability.

Y. Kiso, Y. Hamada, Tooru Kimura, 2005, Bioorganic & medicinal chemistry letters.

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.

S. Kitazume, T. Saido, Y. Kiso, 2004, Bioorganic & medicinal chemistry letters.

Application of intramolecular migration reaction in peptide chemistry to chemical biology, chemical pharmaceutics and medicinal chemistry.

S. Neuteboom, M. Skwarczynski, Y. Kiso, 2009, Advances in experimental medicine and biology.

O—N Intramolecular Alkoxycarbonyl Migration of Typical Protective Groups in Hydroxyamino Acids.

M. Skwarczynski, Y. Kiso, Tooru Kimura, 2006 .

Conformational study of a potent human renin inhibitor: X-ray crystal structure of isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidylamino}butyrate (KRI-1314), a pentapeptide analogue with amino acid sequence corresponding to the cleava

T. Ishida, Y. Kiso, H. Umeyama, 1991 .

Tripeptides acting on opioid receptors in rat colon.

Y. Kiso, M. Takei, Y. Ishida, 1984, European journal of pharmacology.

Syndyphalin SD‐25: a higly selective ligand for μ opiate receptors

R. Quirion, Y. Kiso, C.B. Pert, 1982, FEBS letters.

Morphine‐like activities of synthetic enkephalin analogues

Y. Kiso, K. Matsumoto, H. Moritoki, 1981, The Journal of pharmacy and pharmacology.

Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2007, Bioorganic & medicinal chemistry letters.

A Simple Diastereoselective Synthesis of Cyclohexylnorstatine and Allocyclohexylnorstatine.

Y. Kiso, K. Iizuka, H. Harada, 1990 .

Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum.

A. Wlodawer, A. Gustchina, R. Yada, 2011, Biochemistry.

Synthesis of O-acyl isopeptides.

Y. Kiso, Y. Sohma, 2013, Chemical record.

Search for substrate‐based inhibitors fitting the S2′ space of malarial aspartic protease plasmepsin II

E. Freire, Y. Kiso, Tooru Kimura, 2004, Journal of peptide science : an official publication of the European Peptide Society.

Controlled drug release: new water-soluble prodrugs of an HIV protease inhibitor.

Y. Kiso, H. Matsumoto, Tooru Kimura, 2001, Bioorganic & medicinal chemistry letters.

Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases

E. Freire, Y. Kiso, Tooru Kimura, 2004, Biological chemistry.

Chipping at large, potent human T-cell leukemia virus type 1 protease inhibitors to uncover smaller, equipotent inhibitors.

K. Nishiyama, Y. Kiso, Tooru Kimura, 2007, Bioorganic & medicinal chemistry letters.

Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.

A. Wlodawer, A. Gustchina, R. Yada, 2011, Journal of structural biology.

Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors.

Y. Kiso, Tooru Kimura, J. Nguyen, 2011, Bioorganic & medicinal chemistry letters.

Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum.

A. Wlodawer, A. Gustchina, R. Yada, 2009, Journal of molecular biology.

Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2008, Bioorganic & medicinal chemistry.

Synthesis and activity of tetrapeptidic HTLV-I protease inhibitors possessing different P3-cap moieties.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2008, Bioorganic & medicinal chemistry.

Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors.

K. Nishiyama, Y. Kiso, Tooru Kimura, 2008, Bioorganic & medicinal chemistry letters.

Crystal structures of inhibitor complexes of human T-cell leukemia virus (HTLV-1) protease.

A. Wlodawer, A. Gustchina, Mi Li, 2010, Journal of molecular biology.

Analysis of Amide Bond Formation with an α-Hydroxy-β-amino Acid Derivative, 3-Amino-2-hydroxy-4-phenylbutanoic Acid, as an Acyl Component: Byproduction of Homobislactone

Y. Kiso, Tooru Kimura, Y. Hayashi, 2001 .

Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.

E. Freire, Y. Kiso, Tooru Kimura, 2007, Bioorganic & medicinal chemistry letters.

A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV‐1 protease

A. Velázquez‐Campoy, L. Amzel, E. Freire, 2004, Proteins.

Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target.

E. Freire, I. Luque, Y. Kiso, 2002, Biochemistry.

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model

Kazuyuki Takata, Shun Shimohama, Takashi Yanagida, 2006, Neurobiology of Disease.

Inhibition by KMI‐574 leads to dislocalization of BACE1 from lipid rafts

E. Futai, Y. Kiso, S. Ishiura, 2009, Journal of neuroscience research.

Mitochondrial protein‐derived cryptides: Are endogenous N‐formylated peptides including mitocryptide‐2 components of mitochondrial damage‐associated molecular patterns?

Y. Kiso, T. Hattori, Yusuke Koike, 2016, Biopolymers.

Discovery of Mitocryptide-1, a Neutrophil-activating Cryptide from Healthy Porcine Heart*

Masahiko Kato, M. Kubota, T. Takao, 2008, Journal of Biological Chemistry.

Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2003, Bioorganic & medicinal chemistry letters.

New water-soluble prodrugs of HIV protease inhibitors based on O-->N intramolecular acyl migration.

Y. Kiso, Y. Hamada, Tooru Kimura, 2002, Bioorganic & medicinal chemistry.

Absorption of new HIV‐1 protease inhibitor, KNI‐272, after intraduodenal and intragastric administrations to rats: Effect of solvent

A. Kiriyama, Y. Kiso, K. Takada, 1995, Biopharmaceutics & drug disposition.

Plasma pharmacokinetics and urinary and biliary excretion of a new potent tripeptide HIV‐1 protease inhibitor, KNI‐272, in rats after intravenous administration

A. Kiriyama, Y. Kiso, K. Takada, 1994, Biopharmaceutics & drug disposition.

Comparison of a new orally potent tripeptide HIV‐1 protease inhibitor (anti‐aids drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations

A. Kiriyama, Y. Kiso, K. Takada, 1993, Biopharmaceutics & drug disposition.

Pharmacokinetic study of a tripeptide HIV‐1 protease inhibitor, KNI‐174, in rats after intravenous and intraduodenal administrations

A. Kiriyama, Y. Kiso, K. Takada, 1993, Biopharmaceutics & drug disposition.

Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.

A. Molla, D. Kempf, R. Kuroki, 2009, Journal of medicinal chemistry.

Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins

H. Mitsuya, B. D. Anderson, Y. Kiso, 1994, Antimicrobial Agents and Chemotherapy.

Compensating Enthalpic and Entropic Changes Hinder Binding Affinity Optimization

L. Amzel, E. Freire, V. Lafont, 2007, Chemical biology & drug design.

Alpha-human atrial natriuretic polypeptide is released from the heart and circulates in the body.

M Sakamoto, K. Nakao, Y. Yamori, 1985, Biochemical and biophysical research communications.

Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2–Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages

Y. Kiso, H. Mukai, K. Nishino, 2021, International journal of molecular sciences.

Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution.

E. Freire, Y. Kiso, Tooru Kimura, 2010, Bioorganic & medicinal chemistry letters.

Avidin-biotin affinity columns. General methods for attaching biotin to peptides and proteins

Y. Kiso, K. Hofmann, F. Finn, 1978 .

Neo‐kyotorphin (Thr—Ser—Lys—Tyr—Arg), a new analgesic peptide

H. Takagi, Y. Kiso, K. Kitagawa, 1983, FEBS letters.

A membrane extraction method for trace level phosphate analysis

H. Okamura, Y. Kiso, M. Nagai, 2015 .

The effect of co-existing solutes on arsenate removal with hydrotalcite compound.

K. Ahn, Y. Kiso, T. Yamada, 2010, Water science and technology : a journal of the International Association on Water Pollution Research.

Rejection properties of non-phenylic pesticides with nanofiltration membranes

Takane Kitao, Kazuyuki Nishimura, Y. Kiso, 2000 .

Regioselective double disulfide formation using silylchloride-sulfoxide system

Y. Kiso, K. Akaji, K. Fujino, 1992 .

Recent progress in the drug discovery of non-peptidic BACE1 inhibitors

Y. Kiso, Y. Hamada, 2009, Expert opinion on drug discovery.

Novel Dextranase Catalyzing Cycloisomaltooligosaccharide Formation and Identification of Catalytic Amino Acids and Their Functions Using Chemical Rescue Approach*

N. Suzuki, R. Suzuki, M. Okuyama, 2012, The Journal of Biological Chemistry.

Application of the O-N intramolecular acyl migration reaction in medicinal chemistry.

M. Skwarczynski, Y. Kiso, 2007, Current medicinal chemistry.

Thermodynamic dissection of the binding energetics of KNI‐272, a potent HIV‐1 protease inhibitor

A. Velázquez‐Campoy, I. Luque, E. Freire, 2000, Protein science : a publication of the Protein Society.

Conventional and high-yield synthesis of DTPA-conjugated peptides: application of a monoreactive DTPA to DTPA-D-Phe1-octreotide synthesis.

H. Saji, Y. Kiso, M. Ono, 1997, Bioconjugate chemistry.

Significance of (111)In-DTPA chelate in renal radioactivity levels of (111)In-DTPA-conjugated peptides.

H. Saji, K. Ogawa, Y. Kiso, 2001, Nuclear medicine and biology.

Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins – biochemical and structural insights

A. Wlodawer, S. Sen, A. Gustchina, 2018, The FEBS journal.

A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: design and synthesis of isotaxel.

M. Skwarczynski, Y. Kiso, Y. Hamada, 2003, Journal of medicinal chemistry.

O-N intramolecular acyl migration strategy in water-soluble prodrugs of taxoids.

M. Skwarczynski, Y. Kiso, Tooru Kimura, 2003, Bioorganic & medicinal chemistry letters.

Design and synthesis of a novel water-soluble Aβ1-42 isopeptide: an efficient strategy for the preparation of Alzheimer's disease-related peptide, Aβ1-42, via O–N intramolecular acyl migration reaction

Y. Kiso, Tooru Kimura, Y. Hayashi, 2004 .

O—N Intramolecular Acyl Migration Strategy in Water-Soluble Prodrugs of Taxoids.

M. Skwarczynski, Y. Kiso, Tooru Kimura, 2004 .

Effect of the acyl groups on O-->N acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor.

Y. Kiso, Y. Hamada, H. Matsumoto, 2003, Bioorganic & medicinal chemistry letters.

O‐Acyl isopeptide method: development of an O‐acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1‐42 isopeptide

T. Maruno, Yuji Kobayashi, Taku Yoshiya, 2014, Journal of peptide science : an official publication of the European Peptide Society.

Non-pretreated O-acyl isopeptide of amyloid β peptide 1-42 is monomeric with a random coil structure but starts to aggregate in a concentration-dependent manner.

T. Maruno, Yuji Kobayashi, Taku Yoshiya, 2014, Bioorganic & medicinal chemistry letters.

A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide.

Y. Kiso, M. Yamashita, K. Akaji, 2013, Bioorganic & medicinal chemistry.

Comparative properties of Aβ1-42, Aβ11-42, and [Pyr¹¹]Aβ11-42 generated from O-acyl isopeptides.

Y. Kiso, M. Yamashita, K. Akaji, 2013, Bioorganic & medicinal chemistry letters.

Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide

Y. Kiso, M. Yamashita, H. Hojo, 2011 .

Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors.

Y. Kiso, Taeko Kakizawa, A. Taniguchi, 2011, Bioorganic & medicinal chemistry.

S‐acyl isopeptide method: Use of allyl‐type protective group for improved preparation of thioester‐containing S‐acyl isopeptides by Fmoc‐based SPPS

Taku Yoshiya, Y. Kiso, Tooru Kimura, 2011, Biopolymers.

Synthesis and conformation of an analog of the helix‐loop‐helix domain of the Id1 protein containing the O‐acyl iso‐prolyl‐seryl switch motif

Taku Yoshiya, Y. Kiso, C. Cabrele, 2010, Journal of peptide science : an official publication of the European Peptide Society.

Synthesis of amyloid beta peptide 1-42 (E22Delta) click peptide: pH-triggered in situ production of its native form.

Y. Kiso, Tooru Kimura, Taeko Kakizawa, 2009, Bioorganic & medicinal chemistry.

Controlled Production of Amyloid β Peptide from a Photo‐Triggered, Water‐Soluble Precursor “Click Peptide“

S. Hirota, M. Skwarczynski, K. Matsuzaki, 2008, Chembiochem : a European journal of chemical biology.

‘O‐Acyl isopeptide method’ for peptide synthesis: Solvent effects in the synthesis of Aβ1–42 isopeptide using ‘O‐acyl isodipeptide unit’

Taku Yoshiya, Naoko Abe, Y. Kiso, 2007, Journal of peptide science : an official publication of the European Peptide Society.

The “ O -Acyl Isopeptide Method” for the Synthesis of Alzheimer’s Disease-Related Amyloid β Peptide (Aβ) 1–42

Y. Kiso, Tooru Kimura, Y. Hayashi, 2006 .

Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2004, Chemical communications.

Epimerization‐free synthesis of cyclic peptide by use of the O‐acyl isopeptide method

Taku Yoshiya, Y. Kiso, Tooru Kimura, 2010, Journal of peptide science : an official publication of the European Peptide Society.

Switching from the unfolded to the folded state of the helix‐loop‐helix domain of the Id proteins based on the O‐acyl isopeptide method

Y. Kiso, C. Cabrele, Taeko Kakizawa, 2008, Journal of peptide science : an official publication of the European Peptide Society.

Fmoc‐based solid phase chemical synthesis of 71‐meric neuregulin 1‐β1, an epidermal growth factor‐like domain

Y. Kiso, Tooru Kimura, Y. Hayashi, 2008, Journal of peptide science : an official publication of the European Peptide Society.

[An approach to the targeted attachment of peptides and proteins to solid supports].

Y. Kiso, Y. Hayashi, Y. Yuri, 1976, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates.

Y. Kiso, Y. Hayashi, S. Rajesh, 2001, Bioorganic & medicinal chemistry letters.

No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids: scope and limitation of O-N intramolecular acyl and acyloxy migration reactions.

M. Skwarczynski, Y. Kiso, Y. Hamada, 2005, Journal of medicinal chemistry.

The novel β‐secretase inhibitor KMI‐429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild‐type mice

B. Szabó, T. Saido, Y. Kiso, 2006 .

The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.

B. Szabó, T. Saido, Y. Kiso, 2006, Journal of neurochemistry.

An approach to the targeted attachment of peptides and proteins to solid supports.

Y. Kiso, K. Hofmann, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Development of Broad‐Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

E. Freire, S. Gabelli, Y. Kiso, 2008, Chemical biology & drug design.

Syntheses of Natriuretic Peptides Using a New S -Protecting Group, S -Trimethylacetamidomethyl (Tacm) Group

Y. Kiso, Makoto Yoshida, Tooru Kimura, 1994 .

A new thiol protecting trimethylacetamidomethyl group. Synthesis of a new porcine brain natriuretic peptide using the S-trimethylacetamidomethyl-cysteine

Y. Kiso, Makoto Yoshida, Tooru Kimura, 1989 .

Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor.

Y. Kiso, K. Akaji, Takaaki Mizuguchi, 2012, Bioorganic & medicinal chemistry.

Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic.

Y. Kiso, H. Matsumoto, T. Kimura, 1999, Biopolymers.

Inverse HPLC approach for the evaluation of repulsive interaction between ionic solutes and a membrane polymer

Y. Kamimoto, Y. Kiso, Yong-Jun Jung, 2015 .

Evaluation of interaction between organic solutes and a membrane polymer by an inverse HPLC method

Y. Kamimoto, Y. Kiso, Yong-Jun Jung, 2014 .

Factors affecting adsorption of organic solutes on cellulose acetate in an aqueous solution system

Y. Kiso, 1986 .

Novel β-amyloid aggregation inhibitors possessing a turn mimic.

Y. Kiso, Y. Hamada, Naoko Miyamoto, 2015, Bioorganic & medicinal chemistry letters.

[Anti-HIV compounds].

Y. Kiso, S. Kisanuki, 1993, Nihon rinsho. Japanese journal of clinical medicine.

A new stepwise deprotection method using reductive acidolysis followed by fluoride ion in solid phase peptide synthesis

Y. Kiso, Tooru Kimura, K. Akaji, 1993 .

A New Stepwise Deprotection Method using Reductive Acidolysis Followed by Fluoride Ion in Solid Phase Peptide Synthesis.

Y. Kiso, Tooru Kimura, K. Akaji, 1994 .

A new reductive acidolysis final deprotection strategy in solid phase peptide synthesis. Use of a new safety-catch linker

Y. Kiso, Tooru Kimura, T. Fukui, 1994 .

New hydroxyl protecting groups of a safety-catch type removable by reductive acidolysis.

Y. Kiso, T. Kimura, K. Akaji, 1991, Chemical & pharmaceutical bulletin.

A fluoride ion deprotection strategy in peptide synthesis. Combination with selective deprotection using the dilute methanesulfonic acid of alpha-amino protecting groups.

Y. Kiso, T. Kimura, Y. Fujiwara, 1988, Chemical & pharmaceutical bulletin.

Fmoc-based solid-phase peptide synthesis using a new t-alcohol type 4-(1′,1′-dimethyl-1′-hydroxypropyl)phenoxyacetyl handle (DHPP)–resin (Fmoc = fluoren-9-ylmethoxycarbonyl)

Y. Kiso, L. A. Carpino, K. Akaji, 1990 .

Deprotecting Reagents : SiCl4-CF3COOH-Scavenger

Y. Kiso, Tooru Kimura, 1990 .

Anchoring of Fmoc amino acid to 4-alkoxybenzyl alcohol resin using a new esterification reagent

Y. Kiso, Tooru Kimura, K. Akaji, 1992 .

Fmoc-Based Solid-Phase Peptide Synthesis Using a New t-Alcohol Type 4-(1′,1′-Dimethyl-1′-hydroxypropyl)phenoxyacetyl Handle (DHPP)-Resin (Fmoc = Fluoren-9-ylmethoxycarbonyl).

Y. Kiso, L. A. Carpino, K. Akaji, 1990 .

A new deprotecting procedure in peptide synthesis

Y. Kiso, Makoto Yoshida, Tooru Kimura, 1991 .

Tetrafluoroboric acid, a useful deprotecting reagent in peptide synthesis.

Y. Kiso, M. Yoshida, T. Kimura, 1989, Chemical & pharmaceutical bulletin.

Tetrafluoroboric acid as a useful deprotecting reagent in Fmoc-based solid-phase peptide syntheses (Fmoc = fluoren-9-ylmethoxycarbonyl)

Y. Kiso, Makoto Yoshida, Tooru Kimura, 1990 .

Studies on Peptides. XXVIII. Synthesis of the Docosapeptide which Embodies the Entire Amino Acid Sequence of β-Melanocyte-stimulating Hormone from Human Pituitary Gland

Y. Kiso, K. Kawasaki, H. Yajima, 1970 .

A reductive acidolysis final deprotection strategy in solid phase peptide synthesis based on safety-catch protection.

Y. Kiso, T. Fukui, T. Kimura, 1997, Chemical & pharmaceutical bulletin.

A new class of amino protecting group removable by reductive acidolysis: the 4-methylsulphinylbenzyloxycarbonyl (Msz) group

Y. Kiso, Makoto Yoshida, Tooru Kimura, 1989 .

Racemization-free synthesis of C-terminal cysteine-peptide using 2-chlorotrityl resin.

Y. Kiso, K. Akaji, Y. Fujiwara, 1994, Chemical & pharmaceutical bulletin.

Synthesis and biological evaluation of a 13N-labeled opioid peptide.

Y. Magata, J. Konishi, H. Saji, 1992, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere.

R. Kato, Y. Kiso, M. Shintani, 2000, Chemical & pharmaceutical bulletin.

Inhibitory effect of a dimerization-arm-mimetic peptide on EGF receptor activation.

S. Yokoyama, Y. Kiso, Tooru Kimura, 2009, Bioorganic & medicinal chemistry letters.

Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.

D. Kempf, R. Kuroki, Y. Kiso, 2018, Journal of medicinal chemistry.

Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions

Y. Kiso, Tooru Kimura, Y. Hayashi, 2005 .

A new polymer-supported Evans-type chiral auxiliary derived from α-hydroxy-β-amino acid, phenylnorstatine: synthesis and application in solid-phase asymmetric alkylation reactions

Y. Kiso, Tooru Kimura, Y. Hayashi, 2004 .

Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage.

Tomoko Ito, Y. Kiso, H. Matsumoto, 2003, Journal of medicinal chemistry.

Synthesis of a newly isolated opioid tridecapeptide, rimorphin, from pituitary using a trifluoroacetic acid-thioanisole deprotection system.

Y. Kiso, K. Kitagawa, H. Moritoki, 1983, Chemical & pharmaceutical bulletin.

Tyrosine in position 4 is the key amino acid for the binding of angiotensin II to human arteriolar receptor.

Y. Kiso, N. Sakura, M. Khosla, 1987, Endocrinologia japonica.

Synthesis of porcine brain natriuretic peptide-32 using silver tetrafluoroborate as a new deprotecting reagent of the S-trimethylacetamidomethyl group.

Y. Kiso, M. Yoshida, T. Kimura, 1990, Chemical & pharmaceutical bulletin.

Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography

Yusuke Mori, Hiroaki Adachi, Kazuo Kurihara, 2009, Proceedings of the National Academy of Sciences.

Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere.

Y. Kiso, Y Kiso, 1996, Biopolymers.

Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.

Tooru Kimura, Yoshio Hayashi, Robert McKenna, 2006, Acta crystallographica. Section D, Biological crystallography.

Different susceptibility of human immunodeficiency virus type 1 to Env gp41-derived synthetic peptides corresponding to the C-terminal heptad repeat region.

K. Ikuta, D. Yamamoto, Y. Kiso, 2005, Microbes and infection.

The Analgesic Activity of Neo-Kyotorphin: A Newly Identified Pentapeptide from Bovine Brain.

H. Takagi, Y. Kiso, K. Kitagawa, 2004, Pharmaceutical Research.

HIV protease inhibitors: peptidomimetic drugs and future perspectives.

Y. Kiso, A. F. Youssef, H. Abdel-Rahman, 2002, Current medicinal chemistry.

Studies on peptides. XLIV. Synthesis of the basic trypsin inhibitor from bovine pancreas (Kunitz and Northrop) by the fragment condensation procedure on polymer support.

Y. Kiso, H. Yajima, 1974, Chemical and pharmaceutical bulletin.

STUDIES ON PEPTIDES PART 44, SYNTHESIS OF THE BASIC TRYPSIN INHIBITOR FROM BOVINE PANCREAS (KUNITZ AND NORTHROP) BY THE FRAGMENT CONDENSATION PROCEDURE ON POLYMER SUPPORT

Y. Kiso, H. Yajima, 1974 .

Toxic Amyloid Tape: A Novel Mixed Antiparallel/Parallel β-Sheet Structure Formed by Amyloid β-Protein on GM1 Clusters.

A. Naito, K. Matsuzaki, Y. Kiso, 2018, ACS chemical neuroscience.

Design, synthesis, and biophysical properties of a helical Abeta1-42 analog: Inhibition of fibrillogenesis and cytotoxicity.

K. Matsuzaki, Y. Kiso, Y. Hayashi, 2008, Biochemical and biophysical research communications.

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.

E. Freire, Y. Kiso, Tooru Kimura, 2008, Bioorganic & medicinal chemistry.

Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties.

Y. Kiso, Y. Hamada, Tooru Kimura, 2007, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of anti-HIV double-drugs. conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor through spontaneously cleavable linkers.

K. Sano, Y. Kiso, H. Matsumoto, 2001, Bioorganic & medicinal chemistry.

KNI‐577, a Potent Small‐Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition‐State Mimic

R. Kato, Y. Kiso, H. Matsumoto, 1998, Archiv der Pharmazie.

Bound Water Molecules at the Interface between the HIV-1 Protease and a Potent Inhibitor, KNI-272, Determined by NMR

T. Bhat, Yun-Xing Wang, D. Torchia, 1996 .

KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic.

Y. Kiso, K. Akaji, J. Imai, 1991, Chemical & pharmaceutical bulletin.

Small-sized BACE1 inhibitors

Y. Kiso, Tooru Kimura, Z. Ziora, 2006 .

The ‘O‐acyl isopeptide method’ for the synthesis of difficult sequence‐containing peptides: application to the synthesis of Alzheimer's disease‐related amyloid β peptide (Aβ) 1–42

Y. Kiso, Tooru Kimura, Y. Hayashi, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Generation of monoclonal antibodies against mitocryptide‐2: toward a new strategy to investigate the biological roles of cryptides

Y. Kiso, Toshihiro Shimizu, Y. Nishi, 2017, Journal of peptide science : an official publication of the European Peptide Society.

Nutrient Loss from a Tea Plantation Area in Japan

Toshiro Yamada, Takanobu Inoue, Y. Kiso, 2009 .

Bestatin potentiates the antinociception but not the motor dysfunction induced by intracerebrally administered dynorphin-B in mice

Y. Kiso, T. Nakazawa, K. Yamatsu, 1989, Neuropeptides.

Synthesis of rat brain natriuretic peptide 45 using tetrafluoroboric acid deprotection and silyl chloride disulfide formation.

Y. Kiso, Y. Nakagawa, K. Akaji, 1993, Chemical and pharmaceutical bulletin.

Total synthesis of human insulin by regioselective disulfide formation using the silyl chloride-sulfoxide method

Y. Kiso, K. Akaji, K. Fujino, 1993 .

Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic.

O. Takahashi, Y. Kiso, M. Shintani, 1991, Chemical & pharmaceutical bulletin.

Detection tube method for trace level arsenic

Y. Kamimoto, Y. Kiso, S. Asaoka, 2015 .

Synthesis and activity of a newly isolated analgesic pentapeptide, neo-kyotorphin.

H. Takagi, Y. Kiso, K. Kitagawa, 1983, Chemical & pharmaceutical bulletin.

Synthesis of HIV-1 protease analog by ligation of bromoacetyl and mercaptoethylamide peptide prepared using disulfide linkage to solid-support

Y. Kiso, H. Matsumoto, Tooru Kimura, 2002 .

Potent dipeptide HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimetic

R. Kato, Y. Kiso, H. Matsumoto, 2002 .

Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum.

A. Wlodawer, A. Gustchina, R. Yada, 2009, Journal of molecular biology.

Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position.

Y. Kiso, Y. Hamada, J. Nguyen, 2013, Bioorganic & Medicinal Chemistry.

Allophenylnorstatine containing HIV-1 protease inhibitors: design, synthesis and structure-activity relationships for selected P2 ligands

Y. Kiso, H. Matsumoto, Tooru Kimura, 2005 .

Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2008, Bioorganic & medicinal chemistry.

Acidogenic fermentation of blended food‐waste in combination with primary sludge for the production of volatile fatty acids

Yong-Jun Jung, K. Min, Z. Yun, 2005 .

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.

E. Freire, Y. Kiso, Tooru Kimura, 2008, Bioorganic & medicinal chemistry.

A Novel Dipeptide‐based HIV Protease Inhibitor Containing Allophenylnorstatine

Y. Kiso, A. F. Youssef, H. Abdel-Rahman, 2004, Archiv der Pharmazie.

Pesticide analysis by high-performance liquid chromatography using the direct injection method

Y. Kiso, K. Jinno, K. Shigetoh, 1996 .

Adsorption properties of aromatic compounds on polyethylene as a membrane material

Y. Kiso, T. Kitao, K. Nishimura, 1999 .

SYNTHESIS OF HUMAN ENDOTHELIN-1 BY REGIOSELECTIVE DISULFIDE FORMATION USING THE SILYL CHLORIDE-SULFOXIDE SYSTEM

Y. Kiso, K. Akaji, H. Nishiuchi, 1995 .

O-acyl isopeptide method: efficient synthesis of isopeptide segment and application to racemization-free segment condensation.

Taku Yoshiya, Y. Kiso, Tooru Kimura, 2009, Organic & biomolecular chemistry.

Effect of α-rat Atrial Natriuretic Polypeptide on Blood Pressure in Rats Bilateral Renal Vessels Ligated

K. Nakao, H. Imura, Y. Yamori, 1985 .

Effect of α-human Atrial Natriuretic Polypeptide (α-hANP) on Canine Renal Na+-K+ ATPase Activity

K. Nakao, H. Imura, Y. Yamori, 1985 .

Inhibitory effect of a dimerization-arm-mimetic peptide on EGF receptor activation.

S. Yokoyama, Y. Kiso, Tooru Kimura, 2009, Bioorganic & medicinal chemistry letters.

Evaluation of Malarial Protease Plasmepsin Inhibitors Containing Hydroxymethylcarbonyl Isostere

E. Freire, Y. Kiso, Tooru Kimura, 2006 .

Recent progress in the drug discovery of non-peptidic BACE1 inhibitors

Y. Kiso, Y. Hamada, 2009, Expert opinion on drug discovery.

Discovery of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease

Y. Kiso, Y. Hamada, 2017 .

BACE1 Inhibitor Peptides: Can an Infinitely Small k cat Value Turn the Substrate of an Enzyme into Its Inhibitor?

Y. Kiso, Y. Hamada, S. Ishiura, 2012, ACS medicinal chemistry letters.

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design.

Y. Kiso, Y. Hamada, S. Ishiura, 2012, Bioorganic & medicinal chemistry letters.

Tetrapeptides, as small‐sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1

Y. Kiso, Y. Hamada, Tooru Kimura, 2010, Journal of peptide science : an official publication of the European Peptide Society.

Quantitative evaluation of refolding conditions for a disulfide‐bond‐containing protein using a concise 18O‐labeling technique

Y. Kiso, Takaaki Mizuguchi, Hiromasa Uchimura, 2011, Protein Science.

Verification of protein disulfide bond arrangement by in‐gel tryptic digestion under entirely neutral pH conditions

Kazuki Saito, Y. Kiso, Takaaki Mizuguchi, 2010, Proteomics.