G. J. Durant

发表

Design, synthesis, and neurochemical evaluation of 2-amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.

D. A. Smith, P. Dunbar, G. J. Durant, 1994, Journal of medicinal chemistry.

Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.

R. McBurney, G. J. Durant, J. Guo, 2001, Bioorganic & medicinal chemistry letters.

Chemical differentiation of histamine H1- and H2-receptor agonists.

G. J. Durant, C. Ganellin, M. Parsons, 1975, Journal of medicinal chemistry.

CHEMICAL DIFFERENTIATION OF HISTAMINE H1- AND H2-RECEPTOR AGONISTS

G. J. Durant, C. Ganellin, M. Parsons, 1976 .

Synthesis and binding characteristics of N-(1-naphthyl)-N'-(3-[(125)I]-iodophenyl)-N'-methylguanidine ([(125)I]-CNS 1261): a potential SPECT agent for imaging NMDA receptor activation.

J. Mcculloch, G. J. Durant, A. McGregor, 2000, Nuclear medicine and biology.

Dipole moment in relation to hydrogen receptor histamine antagonist activity for cimetidine analogs

R. C. Young, J. C. Emmett, R. Mitchell, 1986 .

Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors

W. Duncan, G. J. Durant, C. Ganellin, 1978, Nature.

Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers.

G. J. Durant, J. Guo, K. Burke-Howie, 1997, Journal of medicinal chemistry.

Purines, pyrimidines, and imidazoles. Part 58. Synthesis and reactions of some imidazole-2,4-dicarboxylic acid derivatives

T. Brown, G. J. Durant, G. Shaw, 1983 .

Purines, pyrimidines, and imidazoles. Part 53. Synthesis of some 5-halogeno-analogues of metiamide and cimetidine

T. Brown, G. J. Durant, G. Shaw, 1980 .

Isocytosine H2-receptor histamine antagonists II. Synthesis and evaluation of biological activity at histamine H1- and H2-receptors of 5-(heterocyclyl)methylisocytosines

G. J. Durant, C. Ganellin, M. Parsons, 1989 .

Synthesis, biochemical activity and behavioral effects of a series of 1,4,5,6-tetrahydropyrimidines as novel ligands for M1 receptors

W. Hoss, K. Ryan, P. Dunbar, 1992 .

Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels.

R. McBurney, G. J. Durant, L. Zhang, 1998, Journal of medicinal chemistry.

Cimetidine—A Non-Thiourea H2-Receptor Antagonist

Graham J. Durant, J. C. Emmett, W. Duncan, 1975 .

Sulphur-methylene isosterism in the developent of metiamide, a new histamine H2-receptor antagonist

J. C. Emmett, J. Black, G. J. Durant, 1974, Nature.

Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.

W. Hoss, P. Dunbar, G. J. Durant, 1993, Journal of Medicinal Chemistry.

Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine.

J. C. Emmett, C R Ganellin, G. J. Durant, 1977, Journal of medicinal chemistry.

Characterization and development of cimetidine as a histamine H2-receptor antagonist

J. C. Emmett, W. Duncan, G. J. Durant, 1978 .

A Convenient One Pot Procedure for N-Methylation of Aromatic Amines Using Trimethyl Orthoformate

G. J. Durant, S. Padmanabhan, N. Reddy, 1997 .

POTENTIAL ANTIHYPERTENSIVE AGENTS. SOME GUANIDINE DERIVATIVES.

G. J. Durant, D. Vallance, P. Bavin, 1963, Journal of medicinal chemistry.

Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists.

W. Hoss, P. Dunbar, G. J. Durant, 1996, Bioorganic & medicinal chemistry.

Guanidine derivatives acting at histaminergic receptors

G. J. Durant, 1986 .

Potential histamine H2-receptor antagonists. 3. Methylhistamines.

J. C. Emmett, G. J. Durant, C. Ganellin, 1976, Journal of medicinal chemistry.

Some chemical aspects of histamine H2-receptor antagonists.

J. C. Emmett, G. J. Durant, C. Ganellin, 1976, Federation proceedings.

Potential histamine H2-receptor antagonists. 2. N-alpha-Guanylhistamine.

J. Black, G. J. Durant, M. Parsons, 1975, Journal of medicinal chemistry.

Isocytosine H2-receptor histamine antagonists. I: Oxmetidine and related compounds

J. C. Emmett, G. J. Durant, C. Ganellin, 1988 .

Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.

G. J. Durant, L. Zhang, M. Perlman, 1998, Journal of medicinal chemistry.

Dimaprit, [S-[3-(N,N-dimethylamino)propyl]isothiourea]. A highly specific histamine H2-receptor agonist. Part 2. Structure-activity considerations

G. J. Durant, C. Ganellin, M. Parsons, 1977, Agents and Actions.

The chemistry of guanidines and their actions at adrenergic nerve endings.

G. J. Durant, A. M. Roe, A. Green, 1970, Progress in medicinal chemistry.

Theoretical studies on hydration of pyrrole, imidazole, and protonated imidazole in the gas phase and aqueous solution

G. J. Durant, Douglas A. Smith, P. Nagy, 1993 .

Theoretical Analyses of the Tautomeric and Conformational Equilibria of Histamine and (.alpha.R,.beta.S)-.alpha.,.beta.-Dimethylhistamine in the Gas Phase and Aqueous Solution

Graham J. Durant, W. Hoss, G. J. Durant, 1994 .

Studies on the structure of heparin

G. J. Durant, R. Montgomery, H. Hendrickson, 1962 .

The histamine H2 receptor agonist impromidine: synthesis and structure-activity considerations.

G. J. Durant, C. Ganellin, M. Parsons, 1985, Journal of medicinal chemistry.

Periodate oxidation of biopolymers.

G. J. Durant, A. Chatterjee, R. Montgomery, 1961, Biochemical and biophysical research communications.

The reaction of benzoyl isothiocyanate with hydrazine derivatives. Part I. Reaction with some alkyl hydrazines

G. J. Durant, 1967 .

Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.

R. McBurney, G. J. Durant, L. Zhang, 2001, Bioorganic & medicinal chemistry letters.

A GENERAL PROCEDURE FOR THE SYNTHESIS OF ACYLGUANIDINES DERIVED FROM ALIPHATIC AND AROMATIC AMINES

G. J. Durant, S. Padmanabhan, R. C. Lavin, 2001 .

Structure-activity studies of pyridinylalkyl-isocytosine H1-receptor antihistamines and identification of an active conformation.

G. J. Durant, C. Ganellin, R. Ife, 1991, Farmaco.

N-(3-azidophenyl)-N-methyl-N'-([4-1H]- and [4-3H]-1-naphthyl)guanidine. A potent and selective ligand designed as a photoaffinity label for the phencyclidine site of the N-methyl-D-aspartate receptor.

K. Gee, G. J. Durant, S. Wong, 1993, Bioconjugate chemistry.

Proceedings: The pharmacology of cimetidine, a new histamine H2-receptor antagonist.

Graham J. Durant, J. W. Black, J. Black, 1975 .

The pharmacology of cimetidine, a new histamine H2-receptor antagonist.

J W Black, C R Ganellin, J. Black, 1975, British journal of pharmacology.

Dimaprit-[S-[3-(N,N-dimethylamino)propyl]isothiourea] —A highly specific histamine H2-receptor agonist. Part 1. Pharmacology

G. J. Durant, C. Ganellin, M. Parsons, 1977, Agents and Actions.

CYANOGUANIDINE‐THIOUREA EQUIVALENCE IN THE DEVELOPMENT OF THE HISTAMINE H2‐RECEPTOR ANTAGONIST, CIMETIDINE

J. C. Emmett, G. J. Durant, H. D. Prain, 1977 .

SULPHUR-METHYLENE ISOSTERISM IN THE DEVELOPMENT OF METIAMIDE, A NEW HISTAMINE H2-RECEPTOR ANTAGONIST

Graham J. Durant, J. C. Emmett, J. W. Black, 1974 .

Neuroprotective Use‐Dependent Blockers of Na+ and Ca2+ Channels Controlling Presynaptic Release of Glutamatea

S. M. Goldin, Jun Chen, G. J. Durant, 1995, Annals of the New York Academy of Sciences.

Dipole moment in relation to H2 receptor histamine antagonist activity for cimetidine analogues.

R. C. Young, J. C. Emmett, C R Ganellin, 1986, Journal of medicinal chemistry.

Dimaprit—[S-[3-(N,N-dimethylamino)propyl]isothiourea]—A highly specific histamine H2-receptor agonist. Part 1, pharmacology

G. J. Durant, C. Ganellin, M. Parsons, 2005, Agents and Actions.

Nonsteroidal Antiinflammatory Agents. Some Arylacetic Acids

G. M. Smith, G. J. Durant, E. Szarvasi, 1965 .

Non-basic histamine H1-antagonists. I: Synthesis and biological evaluation of some substituted 2-(2-pyridylaminoalkylamino) pyrimidones and related compounds

G. J. Durant, C. Ganellin, M. Parsons, 1989 .

Characterization and development of cimetidine as a histamine H2-receptor antagonist.

J. C. Emmett, W. Duncan, G. J. Durant, 1978, Gastroenterology.

Asymmetric synthesis of a neuroprotective and orally active N-methyl-d-aspartate receptor ion-channel blocker, CNS 5788☆

G. J. Durant, S. Padmanabhan, R. C. Lavin, 2000 .

Potential histamine H2-receptor antagonists. 3. Methylhistamines.

J. C. Emmett, G. J. Durant, C. Ganellin, 1976, Journal of medicinal chemistry.

Structures of nine histamine H2 antagonists related to N-cyano-N'-methyl-N-[4-(2-pyridyl)butyl]guanidine

G. J. Durant, C. Ganellin, D. Watkin, 1993 .

Theoretical Analyses of the Tautomeric and Conformational Equilibria of Histamine and (.alpha.R,.beta.S)-.alpha.,.beta.-Dimethylhistamine in the Gas Phase and Aqueous Solution. [Erratum to document cited in CA121:9018]

W. Hoss, G. J. Durant, Douglas A. Smith, 1994 .

Monte Carlo simulations of the counter ion effect on the conformational equilibrium of the N, N'-diphenyl-guanidinium ion in aqueous solution

G. J. Durant, P. Nagy, 1996 .