T. Schirmeister

发表

Non-peptidic inhibitors of cysteine proteases.

T. Schirmeister, U. Kaeppler, 2003, Mini reviews in medicinal chemistry.

Cysteine Proteases and Their Inhibitors.

T. Schirmeister, H. Otto, 1997, Chemical reviews.

Fluorine Scan of Inhibitors of the Cysteine Protease Human Cathepsin L: Dipolar and Quadrupolar Effects in the π‐Stacking of Fluorinated Phenyl Rings on Peptide Amide Bonds

F. Diederich, B. Kuhn, W. Haap, 2016, ChemMedChem.

Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide⋅⋅⋅Heteroarene π‐Stacking Interactions and Chalcogen Bonding in the S3 Pocket

F. Diederich, B. Kuhn, W. Haap, 2017, ChemMedChem.

Electrostatic complementarity in pseudoreceptor modeling based on drug molecule crystal structures: the case of loxistatin acid (E64c)

M. J. Turner, C. Bond, B. Engels, 2015 .

Challenging Problems in Charge Density Determination: Polar Bonds and Influence of the Environment

B. Engels, T. Schirmeister, R. F. Fink, 2011 .

Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening.

A. Bitto, D. Altavilla, E. Novellino, 2016, European journal of medicinal chemistry.

Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies.

Hongmei Wu, T. Schirmeister, J. Fernandes, 2015, Bioorganic & medicinal chemistry.

Biochemistry and medicinal chemistry of the dengue virus protease.

Christoph Nitsche, Steven Holloway, Tanja Schirmeister, 2014, Chemical reviews.

Novel Dengue Virus NS2B/NS3 Protease Inhibitors

Ralf Bartenschlager, Hongmei Wu, Thomas Weidner, 2014, Antimicrobial Agents and Chemotherapy.

Recent Advances in Inhibitors of Flavivirus NS 2 BNS 3 Protease from Dengue , Zika , and West Nile Viruses

T. Schirmeister, J. Araújo-Júnior, E. Silva-Júnior, 2018 .

Cis autocatalytic cleavage of glycine‐linked Zika virus NS2B‐NS3 protease constructs

U. Hellmich, T. Schirmeister, F. Hammerstein, 2019, FEBS letters.

Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors.

Jérôme Hert, Robert Abel, Lingle Wang, 2017, Journal of medicinal chemistry.

Mechanistic Study of the Reaction of Thiol‐Containing Enzymes with α,β‐Unsaturated Carbonyl Substrates by Computation and Chemoassays

B. Engels, T. Schirmeister, A. Paasche, 2010, ChemMedChem.

Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila's Taspase1

G. Schneider, R. Stauber, S. Knauer, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Peptidyl Vinyl Ketones Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment.

U. Hellmich, T. Schirmeister, S. Cosconati, 2020, ChemMedChem.

Development of Novel Benzodiazepine‐Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense

T. Schirmeister, S. Cosconati, M. Zappalà, 2020, ChemMedChem.

Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates.

T. Schirmeister, Sascha Jung, M. Kaiser, 2018, Bioorganic & medicinal chemistry.

Aziridine-2,3-Dicarboxylates, Peptidomimetic Cysteine Protease Inhibitors with Antileishmanial Activity

T. Schirmeister, A. Ponte-Sucre, H. Moll, 2006, Antimicrobial Agents and Chemotherapy.

Can Experimental Electron-Density Studies be Used as a Tool to Predict Biologically Relevant Properties of Low-Molecular Weight Enzyme Ligands?

B. Engels, Simon Grabowsky, T. Schirmeister, 2013 .

Anticancer study of heterobimetallic platinum(II)-ruthenium(II) and platinum(II)-rhodium(III) complexes with bridging dithiooxamide ligand

H. A. Rudbari, T. Schirmeister, M. Navarra, 2019, Journal of Organometallic Chemistry.

A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods.

N. Stiefl, K. Baumann, J. Ziebuhr, 2005, Journal of medicinal chemistry.

Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands.

Simon Grabowsky, T. Schirmeister, K. Schwickert, 2021, The Journal of organic chemistry.

Identification of the protease inhibitor miraziridine A in the Red sea sponge Theonella swinhoei

P. Tabares, U. Hentschel, T. Schirmeister, 2012, Pharmacognosy research.

Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors.

D. Gloriam, T. Schirmeister, P. Wellendorph, 2021, Journal of medicinal chemistry.

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

T. Schirmeister, M. D. Di Francesco, E. Nizi, 2008, Journal of medicinal chemistry.

Synthesis, solution behaviour and potential anticancer activity of new trinuclear organometallic palladium(II) complex of {S}-1-phenylethyl dithiooxamide: Comparison with the trinuclear heterobimetallic platinum(II) analogue

H. A. Rudbari, V. Mirkhani, T. Schirmeister, 2019, Polyhedron.

Development of Novel Peptidomimetics Containing a Vinyl Sulfone Moiety as Proteasome Inhibitors

T. Schirmeister, M. Zappalà, R. Ettari, 2011, ChemMedChem.

Co-Encapsulation of l-Asparaginase and Etoposide in Dextran Nanoparticles for Synergistic Effect in Chronic Myeloid Leukemia Cells.

P. Wich, T. Schirmeister, V. K. Kannaujiya, 2022, International journal of pharmaceutics.

Peptidomimetic nitriles as selective inhibitors for the malarial cysteine protease falcipain-2

F. Diederich, Jin Huang, T. Schirmeister, 2011 .

Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei

F. Diederich, W. Schweizer, T. Schirmeister, 2010, ChemMedChem.

Benchmark Study for the Cysteine-Histidine Proton Transfer Reaction in a Protein Environment: Gas Phase, COSMO, QM/MM Approaches.

B. Engels, T. Schirmeister, A. Paasche, 2013, Journal of chemical theory and computation.

Optimization strategy of novel peptide-based Michael acceptors for the treatment of Human African Trypanosomiasis.

U. Hellmich, T. Schirmeister, S. Cosconati, 2019, Journal of medicinal chemistry.

Antioxidant and Anti-Protease Activities of Diazepinomicin from the Sponge-Associated Micromonospora Strain RV115

U. Hentschel, H. Stopper, T. Schirmeister, 2012, Marine drugs.

Antioxidant and Anti-Protease Activities of Diazepinomicin from the Sponge-Associated Micromonospora Strain RV 115

U. Hentschel, H. Stopper, T. Schirmeister, 2012 .

Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor

N. Stiefl, K. Baumann, J. Ziebuhr, 2005, Bioorganic & Medicinal Chemistry Letters.

Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells

M. Leippe, T. Schirmeister, C. Gelhaus, 2005, Biological chemistry.

Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate

M. Leippe, R. Hilgenfeld, T. Schirmeister, 2004, Biological chemistry.

Antiproliferative Properties of a Few Auranofin-Related Gold(I) and Silver(I) Complexes in Leukemia Cells and their Interferences with the Ubiquitin Proteasome System

T. Efferth, T. Schirmeister, L. Massai, 2020, Molecules.

Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana.

Hongmei Wu, T. Schirmeister, J. Fernandes, 2015, Experimental parasitology.

Cathepsin B in Antigen-Presenting Cells Controls Mediators of the Th1 Immune Response during Leishmania major Infection

T. Reinheckel, M. Lutz, T. Schirmeister, 2014, PLoS neglected tropical diseases.

Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors

G. Knudsen, T. Ohlsson, T. Schirmeister, 2019 .

Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors

G. Knudsen, T. Ohlsson, T. Schirmeister, 2019, ACS omega.

New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities †

C. Ireland, G. Bringmann, U. Hentschel, 2011, Marine drugs.

Reactivity differences between α,β-unsaturated carbonyls and hydrazones investigated by experimental and theoretical electron density and electron localizability analyses.

Yu‐Sheng Chen, Simon Grabowsky, T. Schirmeister, 2011, The journal of physical chemistry. A.

Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives.

T. Schirmeister, C. Beemelmanns, F. Meyer, 2020, Organic letters.

Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment.

M. Windbergs, M. Helm, T. Schirmeister, 2022, Journal of medicinal chemistry.

Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation

U. Hentschel, T. Schirmeister, U. Abdelmohsen, 2014, Marine drugs.

Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors

T. Schirmeister, S. Cosconati, M. Zappalà, 2016, Journal of enzyme inhibition and medicinal chemistry.

Cysteine protease inhibitors containing small rings.

T. Schirmeister, A. Klockow, 2003, Mini reviews in medicinal chemistry.

Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture

K. Landfester, J. Münch, V. Mailänder, 2022, Communications Biology.

Ensemble‐based ADME–Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE

L. Maes, A. Scala, A. Rescifina, 2018, Chemical biology & drug design.

New cis‐Configured Aziridine‐2‐carboxylates as Aspartic Acid Protease Inhibitors

J. Gut, P. Rosenthal, G. Bringmann, 2011, ChemMedChem.

New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins.

C. Sotriffer, U. Hellmich, T. Schirmeister, 2022, European journal of medicinal chemistry.

Targeting of the Leishmania mexicana cysteine protease CPB2.8ΔCTE by decorated fused benzo[b]thiophene scaffold

A. Scala, A. Rescifina, T. Schirmeister, 2016 .

Novel Class of Proteasome Inhibitors: In Silico and In Vitro Evaluation of Diverse Chloro(trifluoromethyl)aziridines

T. Efferth, A. Rescifina, T. Schirmeister, 2022, International journal of molecular sciences.

Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF‐CEM and Multidrug‐Resistant CEM/ADR5000 Leukemia Cells

T. Efferth, T. Schirmeister, M. Zappalà, 2021, Chemistry & biodiversity.

Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation

T. Efferth, Hongmei Wu, T. Schirmeister, 2017, Marine drugs.

Identification of novel small-molecular inhibitors of Staphylococcus aureus sortase A using hybrid virtual screening

S. Yarmoluk, T. Schirmeister, S. Hammerschmidt, 2022, The Journal of Antibiotics.

Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

H. Neuweiler, E. Jaenicke, U. Hellmich, 2020, bioRxiv.

Approaching an experimental electron density model of the biologically active trans‐epoxysuccinyl amide group—Substituent effects vs. crystal packing

Peter R. Spackman, M. Spackman, Yu‐Sheng Chen, 2017 .

Allicin and derivates are cysteine protease inhibitors with antiparasitic activity.

M. Leippe, T. Schirmeister, A. Stich, 2010, Bioorganic & medicinal chemistry letters.

Cysteine Proteases and Their Inhibitors

T. Schirmeister, H. Otto, 2010 .

An improved synthesis of aziridine-2,3-dicarboxylates via azido alcohols—epimerization studies

T. Schirmeister, R. Vičík, Alexander Breuning, 2003 .

β‐Lactam Derivatives as Enzyme Inhibitors: 1‐Peptidyl Derivatives of 4‐Phenylazetidin‐2‐one as Inhibitors of Elastase and Papain

T. Schirmeister, H. Otto, K. Achilles, 2000, Archiv der Pharmazie.

Inhibition of cysteine proteases by peptides containing aziridine-2,3-dicarboxylic acid building blocks.

T. Schirmeister, 1999, Biopolymers.

Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs

C. Alzheimer, A. Braeuning, U. Hellmich, 2022, Molecular psychiatry.

Development and validation of a separation method for the diastereomers and enantiomers of aziridine‐type protease inhibitors

U. Holzgrabe, T. Schirmeister, Björn Degel, 2005, Electrophoresis.

Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense

T. Schirmeister, Marta Bogacz, M. Zappalà, 2022, International journal of molecular sciences.

Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents

L. Maes, T. Schirmeister, L. Massai, 2017, BioMetals.

Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents.

T. Schirmeister, S. Cosconati, M. Zappalà, 2016, Bioorganic & medicinal chemistry letters.

Structural Determinants for the Mode of Action of the Imidazopyridine DS2 at d-containing g-Aminobutyric Acid Type A (GABAA) Receptors

D. Gloriam, T. Schirmeister, P. Wellendorph, 2020 .

Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.

U. Holzgrabe, J. McKerrow, C. Caffrey, 2006, Bioorganic & medicinal chemistry letters.

Aziridine‐2,3‐dicarboxylic Acid Derivatives as Inhibitors of Papain

T. Schirmeister, 1996 .

Two Tags in One Probe: Combining Fluorescence‐ and Biotin‐based Detection of the Trypanosomal Cysteine Protease Rhodesain

M. Gütschow, A. Braune, T. Schirmeister, 2022, Chemistry.

Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors

Christin Müller, J. Ziebuhr, S. Di Maro, 2022, European Journal of Medicinal Chemistry.

Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors.

T. Schirmeister, S. Giofrè, M. Zappalà, 2011, European journal of medicinal chemistry.

Cis‐Configured Aziridines Are New Pseudo‐Irreversible Dual‐Mode Inhibitors of Candida albicans Secreted Aspartic Protease 2

Sebastian G. Rohrer, J. Scheiber, K. Baumann, 2008, ChemMedChem.

The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines

Adolfo Botana, S. Gul, T. Schirmeister, 2020, European journal of medicinal chemistry.

A comparative study on the experimentally derived electron densities of three protease inhibitor model compounds.

C. Paulmann, Simon Grabowsky, T. Schirmeister, 2008, Organic & biomolecular chemistry.

Aziridide‐Based Inhibitors of Cathepsin L: Synthesis, Inhibition Activity, and Docking Studies

J. Scheiber, N. Stiefl, K. Baumann, 2006, ChemMedChem.

Aziridinyl peptides as inhibitors of cysteine proteases: effect of a free carboxylic acid function on inhibition.

T. Schirmeister, M. Peric, 2000, Bioorganic & medicinal chemistry.

Synthesis of C3/C1-Substituted Tetrahydroisoquinolines

A. Scala, T. Schirmeister, A. Piperno, 2015, Molecules.

Ruthenium(ii) and palladium(ii) homo- and heterobimetallic complexes: synthesis, crystal structures, theoretical calculations and biological studies.

T. Efferth, T. Schirmeister, Ean-jeong Seo, 2019, Dalton transactions.

Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, C. Gelhaus, 2010, Bioorganic & medicinal chemistry.

Bistacrine derivatives as new potent antimalarials.

U. Holzgrabe, T. Schirmeister, G. Pradel, 2016, Bioorganic & medicinal chemistry.

Origin of the reactivity differences of substituted aziridines: CN vs CC bond breakages.

B. Engels, T. Schirmeister, R. F. Fink, 2009, The Journal of organic chemistry.

Electron‐Density Determination of Electrophilic Building Blocks as Model Compounds for Protease Inhibitors

Simon Grabowsky, T. Schirmeister, W. Morgenroth, 2007 .

Aziridine-2,2-dicarboxylates: Synthesis, reactions, and photochromism

T. Schirmeister, 1997 .

Enzyme-catalyzed hydrolyses of E/Z-diastereotopic and E/Z-diastereomeric esters. Effect on selectivity by reaction media

T. Schirmeister, H. Otto, 1993 .

Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors

T. Schirmeister, E. Nizi, M. Zappalà, 2008, ChemMedChem.

The Importance of the Active Site Histidine for the Activity of Epoxide‐ or Aziridine‐Based Inhibitors of Cysteine Proteases

Walter Thiel, Bernd Engels, Tanja Schirmeister, 2007, ChemMedChem.

Theoretical studies about the influence of different ring substituents on the nucleophilic ring opening of three-membered heterocycles and possible implications for the mechanisms of cysteine protease inhibitors.

Bernd Engels, Tanja Schirmeister, B. Engels, 2005, The Journal of organic chemistry.

(S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors.

T. Schirmeister, 2000, Bioorganic & medicinal chemistry letters.

Conformation and Hydrogen Bonding Properties of an Aziridinyl Peptide: X-ray Structure Analysis, Raman Spectroscopy and Theoretical Investigations

M. Schmitt, J. Popp, D. Stalke, 2004 .

Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, A. Evers, 2009, Bioorganic & medicinal chemistry.

Metabolomics analysis and biological investigation of three Malvaceae plants.

T. Schirmeister, J. Nodwell, U. Abdelmohsen, 2020, Phytochemical analysis : PCA.

Promising trypanocidal heterocyclic compounds of natural origin and their synthetic analogs

T. Schirmeister, J. Araújo-Júnior, E. Silva-Júnior, 2019, Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases.

Nostotrebin 6 Related Cyclopentenediones and δ-Lactones with Broad Activity Spectrum Isolated from the Cultivation Medium of the Cyanobacterium Nostoc sp. CBT1153.

T. Schirmeister, H. Brötz-Oesterhelt, T. Niedermeyer, 2020, Journal of natural products.

Transcriptome and Functional Analysis of the Eukaryotic-Type Serine/Threonine Kinase PknB in Staphylococcus aureus

Manuel Liebeke, M. Lalk, T. Stehle, 2009, Journal of bacteriology.

Development of Rhodesain Inhibitors with a 3‐Bromoisoxazoline Warhead

T. Schirmeister, A. Pinto, L. Tamborini, 2013, ChemMedChem.

2-Sulfonylpyrimidines as Privileged Warheads for the Development of S. aureus Sortase A Inhibitors

B. Engels, T. Schirmeister, H. Räder, 2022, Frontiers in Molecular Biosciences.

Chemical biology and medicinal chemistry of RNA methyltransferases

M. Helm, T. Schirmeister, R. Zimmermann, 2022, Nucleic acids research.

Comparison of the separation of aziridine isomers applying heptakis(2,3‐di‐O‐methyl‐6‐sulfato)β‐CD and heptakis(2,3‐di‐O‐acetyl‐6‐sulfato)β‐CD in aqueous and nonaqueous systems

U. Holzgrabe, T. Schirmeister, Björn Degel, 2005, Electrophoresis.

Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain‐2 Inhibitors

Maria Zappalà, Giovanni Grazioso, Tanja Schirmeister, 2012, ChemMedChem.

SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases.

A. Ruggieri, T. Schirmeister, S. Hammerschmidt, 2021, Bioorganic & medicinal chemistry.

Natural Product Repertoire of the Genus Amphimedon

T. Schirmeister, U. Abdelmohsen, M. Fouad, 2018, Marine drugs.

Selected cytotoxic gold compounds cause significant inhibition of 20S proteasome catalytic activities.

T. Schirmeister, L. Massai, L. Messori, 2014, Journal of inorganic biochemistry.

The Medicinal Chemistry of Zika Virus

P. Zhan, Xinyong Liu, Letícia Anderson, 2021 .

Taspase1: a 'misunderstood' protease with translational cancer relevance

O. Schilling, R. Stauber, S. Knauer, 2016, Oncogene.

Inducible APOBEC3G-Vif Double Stable Cell Line as a High-Throughput Screening Platform To Identify Antiviral Compounds

M. Kirschner, A. Rethwilm, T. Schirmeister, 2009, Antimicrobial Agents and Chemotherapy.

screening platform to identify antiviral compounds

A. Rethwilm, T. Schirmeister, G. Pradel, 2009 .

GNPS-guided discovery of xylacremolide C and D, evaluation of their putative biosynthetic origin and bioactivity studies of xylacremolide A and B

T. Schirmeister, M. Poulsen, T. Heinzel, 2021, RSC advances.

Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain

T. Schirmeister, S. Cosconati, Marta Bogacz, 2022, ACS medicinal chemistry letters.

Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents

E. Novellino, A. Lavecchia, T. Schirmeister, 2014, ChemMedChem.

An Optimized Microscale Thermophoresis Method for High-Throughput Screening of DNA Methyltransferase 2 Ligands.

M. Helm, T. Schirmeister, R. Zimmermann, 2022, ACS pharmacology & translational science.

A low-cost 3D-printable differential scanning fluorometer for protein and RNA melting experiments

M. Helm, T. Schirmeister, S. Hammerschmidt, 2022, HardwareX.

New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain

S. Tenzer, B. Engels, Ute Distler, 2020, Molecules.

E/Z Diastereoselective Enzymatic Hydrolysis of Esters and Diesters.

T. Schirmeister, H. Otto, 1993 .

BANΔIT: B’‐Factor Analysis for Drug Design and Structural Biology

Fabian Barthels, Tanja Schirmeister, Christian Kersten, 2020, Molecular informatics.

Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro.

T. Schirmeister, L. Messori, M. Cinellu, 2011, Journal of inorganic biochemistry.

Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.

E. Novellino, Valeria La Pietra, L. Marinelli, 2015, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of Papain‐Family Cathepsin L‐Like Cysteine Protease Inhibitors Containing a 1,4‐Benzodiazepine Scaffold as Antiprotozoal Agents

T. Schirmeister, N. Capodicasa, A. Pinto, 2014, ChemMedChem.

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis

U. Hellmich, T. Schirmeister, S. Cosconati, 2022, Molecules.

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

F. Diederich, B. Kuhn, D. Banner, 2018, Journal of medicinal chemistry.

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases—Studies on Inhibition Mechanism and Kinetics

S. Tenzer, B. Engels, Ute Distler, 2020, Molecules.

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.

Rainer E. Martin, F. Diederich, B. Kuhn, 2018, Journal of medicinal chemistry.

Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure–Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X‐ray Crystal Structure Analysis with Human Cathepsin L

F. Diederich, D. Banner, W. Haap, 2013, ChemMedChem.

A hyaluronic acid–pentamidine bioconjugate as a macrophage mediated drug targeting delivery system for the treatment of leishmaniasis

A. Scala, T. Schirmeister, A. Piperno, 2015 .

Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei.

Michael Gütschow, Tanja Schirmeister, M. Gütschow, 2017, Bioorganic & medicinal chemistry letters.

Chemical Space Virtual Screening against Hard-to-Drug RNA Methyltransferases DNMT2 and NSUN6

T. Schirmeister, R. Zimmermann, C. Kersten, 2023, International journal of molecular sciences.

Anti-trypanosomal activities and structural chemical properties of selected compound classes

Christoph A. Sotriffer, Georg Krohne, Markus Engstler, 2015, Parasitology Research.

Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery

D. Schuppan, T. Schirmeister, L. Nuhn, 2020, Cells.

Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors.

F. Diederich, J. E. Quinsaat, T. Schirmeister, 2012, Organic & biomolecular chemistry.

Anti-protease and Immunomodulatory Activities of Bacteria Associated with Caribbean Sponges

P. Tabares, U. Hentschel, T. Schirmeister, 2011, Marine Biotechnology.

Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design

R. Brenk, T. Schirmeister, J. Seibel, 2019, PloS one.

Asymmetric Disulfanylbenzamides as Irreversible and Selective Inhibitors of Staphylococcus aureus Sortase A

S. Tenzer, D. Schwarzer, Ute Distler, 2020, ChemMedChem.

Eliciting callus culture for production of hepatoprotective flavonoids and phenolics from Sequoia sempervirens (D. Don Endl)

T. Schirmeister, U. Abdelmohsen, G. A. Abdel Jaleel, 2019, Natural Product Research.

The significance of ionic bonding in sulfur dioxide: bond orders from X-ray diffraction data.

T. Schirmeister, D. Jayatilaka, A. Sobolev, 2012, Angewandte Chemie.

Development of a New Antileishmanial Aziridine-2,3-Dicarboxylate-Based Inhibitor with High Selectivity for Parasite Cysteine Proteases

T. Schirmeister, A. Ponte-Sucre, H. Moll, 2015, Antimicrobial Agents and Chemotherapy.

Novel bioreactor internals for the cultivation of spore‐forming fungi in pellet form

A. Schüffler, T. Schirmeister, L. Wommer, 2022, Engineering in life sciences.

Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles

T. Schirmeister, H. Moll, N. Schaschke, 2010, Antimicrobial Agents and Chemotherapy.

New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8.

J. Mottram, T. Schirmeister, W. Kiefer, 2018, European journal of medicinal chemistry.

Discovery of benzimidazole‐based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis

L. Maes, S. Ferro, A. Rescifina, 2018, Chemical biology & drug design.

Screening of Protease Inhibitors as Antiplasmodial Agents. Part I: Aziridines and Epoxides

J. Gut, M. Leippe, T. Schirmeister, 2007, ChemMedChem.

Rational Design of Aziridine‐Containing Cysteine Protease Inhibitors with Improved Potency: Studies on Inhibition Mechanism

B. Engels, T. Schirmeister, Holger Helten, 2006, ChemMedChem.

Inhibitors of cysteine proteases.

K. Baumann, T. Schirmeister, R. Vičík, 2006, Current topics in medicinal chemistry.

New peptidic cysteine protease inhibitors derived from the electrophilic alpha-amino acid aziridine-2,3-dicarboxylic acid.

T. Schirmeister, 1999, Journal of medicinal chemistry.

Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.

S. Tenzer, B. Engels, Ute Distler, 2021, Journal of medicinal chemistry.

Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain.

C. Sotriffer, H. Neuweiler, U. Hellmich, 2021, ACS chemical biology.

Impact of the Recognition Part of Dipeptidyl Nitroalkene Compounds on the Inhibition Mechanism of Cysteine Proteases Cruzain and Cathepsin L

V. Moliner, T. Schirmeister, S. Royo, 2023, ACS catalysis.

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.

E. Novellino, A. Lavecchia, T. Schirmeister, 2014, European journal of medicinal chemistry.

Identification of a new series of amides as non-covalent proteasome inhibitors.

E. Novellino, A. Lavecchia, T. Schirmeister, 2014, European journal of medicinal chemistry.

Development of peptidomimetic boronates as proteasome inhibitors.

E. Novellino, A. Lavecchia, T. Schirmeister, 2013, European journal of medicinal chemistry.

Interfering with Host Proteases in SARS-CoV-2 Entry as a Promising Therapeutic Strategy.

V. Mailänder, T. Schirmeister, S. Hammerschmidt, 2021, Current medicinal chemistry.

A structure-based virtual high-throughput screening, molecular docking, molecular dynamics and MM/PBSA study identified novel putative drug-like dual inhibitors of trypanosomal cruzain and rhodesain cysteine proteases

T. Schirmeister, S. Ruchirawat, Chatchakorn Eurtivong, 2023, Molecular diversity.

A competition smFRET assay to study ligand‐induced conformational changes of the dengue virus protease

T. Schirmeister, T. Basché, G. Hinze, 2022, Protein science : a publication of the Protein Society.

Conformational Dynamics of the Dengue Virus Protease Revealed by Fluorescence Correlation and Single-Molecule FRET Studies.

U. Hellmich, T. Schirmeister, T. Basché, 2021, Journal of Physical Chemistry B.

Proline-based allosteric inhibitors of Zika and Dengue virus NS2B/NS3 proteases.

M. Windbergs, E. Hildt, U. Hellmich, 2019, Journal of medicinal chemistry.

Structure-Function Evaluation of Imidazopyridine Derivatives Selective for δ-Subunit-Containing γ-Aminobutyric Acid Type A (GABAA) Receptors.

Judith Weber, M. Piel, F. Rösch, 2018, Journal of medicinal chemistry.

Quantum Chemical-Based Protocol for the Rational Design of Covalent Inhibitors.

Stefan Tenzer, Bernd Engels, Ute Distler, 2016, Journal of the American Chemical Society.

Evidence for substrate binding-induced zwitterion formation in the catalytic Cys-His dyad of the SARS-CoV main protease.

J. Ziebuhr, B. Engels, T. Schirmeister, 2014, Biochemistry.

Graphical Workflow System for Modification Calling by Machine Learning of Reverse Transcription Signatures

Bertil Schmidt, Andreas Hildebrandt, Mark Helm, 2019, Front. Genet..

FINDUS: An Open-Source 3D Printable Liquid-Handling Workstation for Laboratory Automation in Life Sciences

Fabian Barthels, Tanja Schirmeister, Ulrich Barthels, 2020, SLAS technology.

Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.

H. Schindelin, N. Morgner, U. Hellmich, 2019, Structure.

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, M. D. Di Francesco, 2009, Journal of medicinal chemistry.

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

J. Gut, P. Rosenthal, U. Hellmich, 2017, Journal of medicinal chemistry.

Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis.

T. Schirmeister, J. Legac, Marta Bogacz, 2023, Bioorganic chemistry (Print).

Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening

T. Schirmeister, S. Cosconati, A. Messere, 2021, J. Chem. Inf. Model..

Development of Antitrypanosomal and Antiplasmodial Nonpeptidic Cysteine Protease Inhibitors based on N‐Protected‐Guanidino‐Furan and ‐Pyrrole Building Blocks

C. Schmuck, T. Schirmeister, P. Rosenthal, 2011, ChemMedChem.

Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain.

M. Leippe, T. Schirmeister, A. Evers, 2010, European journal of medicinal chemistry.

Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense.

U. Hellmich, T. Schirmeister, S. Cosconati, 2022, European journal of medicinal chemistry.

On the origin of the stabilization of the zwitterionic resting state of cysteine proteases: a theoretical study.

B. Engels, W. Thiel, T. Schirmeister, 2008, Journal of the American Chemical Society.

Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid

J. Gut, P. Rosenthal, M. Leippe, 2008, Molecules.

Bistacrines as potential antitrypanosomal agents.

U. Holzgrabe, R. Krauth-Siegel, T. Schirmeister, 2017, Bioorganic & medicinal chemistry.

Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action

T. Schirmeister, M. Kaiser, S. Royo, 2015, ChemMedChem.

Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors—A Comprehensive Reactivity and Selectivity Study

B. Engels, T. Schirmeister, S. Hammerschmidt, 2023, International journal of molecular sciences.

Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy.

Jürgen Popp, Gero Bergner, Benjamin Dietzek, 2011, The Analyst.

New non-peptidic inhibitors of papain derived from etacrynic acid.

T. Schirmeister, U. Kaeppler, 2005, Medicinal chemistry (Shariqah (United Arab Emirates)).

Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues.

A. Vilcinskas, M. Kurz, T. Schirmeister, 2022, ACS chemical biology.

Identification, Characterization and Synthesis of Natural Parasitic Cysteine Protease Inhibitors – More Potent Falcitidin Analogs

A. Vilcinskas, M. Kurz, T. Schirmeister, 2021 .

Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain.

B. Engels, U. Hellmich, R. Krauth-Siegel, 2016, ACS medicinal chemistry letters.

Tetracycline-Inducible Expression of Individual Secreted Aspartic Proteases in Candida albicans Allows Isoenzyme-Specific Inhibitor Screening

T. Schirmeister, P. Staib, M. Monod, 2007, Antimicrobial Agents and Chemotherapy.

Protocol for rational design of covalently interacting inhibitors.

Christoph A Sotriffer, Bernd Engels, Tanja Schirmeister, 2014, Chemphyschem : a European journal of chemical physics and physical chemistry.

Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of Trypanosoma brucei rhodesiense.

A. Allegra, T. Schirmeister, M. Zappalà, 2020, ACS medicinal chemistry letters.

Rational design of improved aziridine-based inhibitors of cysteine proteases.

B. Engels, T. Schirmeister, V. Buback, 2009, The journal of physical chemistry. B.

Atomistic insights into the inhibition of cysteine proteases: first QM/MM calculations clarifying the stereoselectivity of epoxide-based inhibitors.

B. Engels, W. Thiel, T. Schirmeister, 2008, The journal of physical chemistry. B.

Atomistic insights into the inhibition of cysteine proteases: first QM/MM calculations clarifying the regiospecificity and the inhibition potency of epoxide- and aziridine-based inhibitors.

Walter Thiel, Bernd Engels, Tanja Schirmeister, 2008, The journal of physical chemistry. B.

Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense

A. Allegra, T. Schirmeister, M. Zappalà, 2023, International journal of molecular sciences.

Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor

N. Stiefl, K. Baumann, J. Ziebuhr, 2005, Bioorganic & Medicinal Chemistry Letters.

Next Generation of Fluorometric Protease Assays: 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-amides (NBD-Amides) as Class-Spanning Protease Substrates.

T. Schirmeister, S. Hammerschmidt, R. Zimmermann, 2023, Chemistry.

Inhibitory effects of 190 compounds against SARS‐CoV‐2 Mpro protein: Molecular docking interactions

T. Schirmeister, M. Scotti, M. Biavatti, 2023, Archiv der Pharmazie.

Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.

J. Gut, P. Rosenthal, M. Leippe, 2010, Journal of medicinal chemistry.

Selective noncovalent proteasome inhibiting activity of trifluoromethyl‐containing gem‐quaternary aziridines

A. Rescifina, T. Schirmeister, Laura Ielo, 2023, Archiv der Pharmazie.

Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors

T. Schirmeister, E. Nizi, M. Zappalà, 2008, ChemMedChem.

Development of a New Antileishmanial Aziridine-2,3-Dicarboxylate-Based Inhibitor with High Selectivity for Parasite Cysteine Proteases

T. Schirmeister, A. Ponte-Sucre, H. Moll, 2015, Antimicrobial Agents and Chemotherapy.

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

J. Gut, P. Rosenthal, U. Hellmich, 2017, Journal of medicinal chemistry.

Vinyl sulfone building blocks in covalently reversible reactions with thiols

Alexandre N. Sobolev, Bernd Engels, Tanja Schirmeister, 2015 .

Bis-Acridines as Lead Antiparasitic Agents: Structure-Activity Analysis of a Discrete Compound Library In Vitro

F. Cohen, A. Fairlamb, B. C. May, 2007, Antimicrobial Agents and Chemotherapy.

Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2

C. Sotriffer, Christin Müller, J. Ziebuhr, 2020, ChemMedChem.

Enzyme kinetics and hit validation in fluorimetric protease assays.

Knut Baumann, Markus Schiller, Tanja Schirmeister, 2010, Current topics in medicinal chemistry.

Effect of protease inhibitors on exflagellation in Plasmodium falciparum.

T. Schirmeister, G. Pradel, Ingrid Rupp, 2008, Molecular and biochemical parasitology.

Covalent S-Adenosylhomocysteine-Based DNA Methyltransferase 2 Inhibitors with a New Type of Aryl Warhead.

M. Helm, T. Schirmeister, Frederik Lermyte, 2023, ACS medicinal chemistry letters.

Synthesis of SARS-CoV-2 Mpro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronaviruses.

S. Pieraccini, G. Gribaudo, D. Passarella, 2023, Organic & biomolecular chemistry.

Book Review: Medicinal Chemistry. An Introduction. Von Gareth Thomas

T. Schirmeister, 2001 .

Two palladium (II) complexes derived from halogen-substituted Schiff bases and 2-picolylamine induce parthanatos-type cell death in sensitive and multi-drug resistant CCRF-CEM leukemia cells.

T. Efferth, T. Schirmeister, J. Boulos, 2023, European journal of pharmacology.