Jeff O'meara

发表

Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

P. Bonneau, C. Yoakim, S. LaPlante, 2007, Bioorganic & medicinal chemistry letters.

Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists.

P. Bonneau, S. LaPlante, R. Coulombe, 2013, Journal of medicinal chemistry.

Discovery of hepatitis C virus NS3-4A protease inhibitors with improved barrier to resistance and favorable liver distribution.

M. Garneau, P. White, Jeff O'meara, 2014, Journal of medicinal chemistry.

Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: discovery of potent succinamide inhibitors.

M. Garneau, P. White, Jeff O'meara, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-arylproline analogs.

M. Garneau, P. White, Jeff O'meara, 2013, Bioorganic & medicinal chemistry letters.

Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance

G. Kukolj, P. White, Jeff O'meara, 2012, The Journal of Biological Chemistry.

N- versus O-alkylation: utilizing NMR methods to establish reliable primary structure determinations for drug discovery.

S. LaPlante, R. Coulombe, J. Gillard, 2013, Bioorganic & medicinal chemistry letters.

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

A. Edwards, A. Bullock, R. Al-awar, 2020, Journal of medicinal chemistry.

Leveraging an Open Science Drug Discovery Model to Develop CNS Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.

A. Edwards, S. Cramp, G. Poda, 2020, Journal of medicinal chemistry.

Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo

O. Hucke, M. Garneau, J. Neyts, 2013, Antimicrobial Agents and Chemotherapy.

Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus.

O. Hucke, M. Garneau, C. Brochu, 2013, Bioorganic & medicinal chemistry letters.

Practical Synthesis of A Benzophenone-Based NNRT Inhibitor of HIV-1

C. Yoakim, Jeff O'meara, S. Landry, 2012 .

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.

O. Hucke, P. Bonneau, C. Yoakim, 2011, Bioorganic & medicinal chemistry letters.

Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex.

C. Yoakim, J. Archambault, P. White, 2003, Bioorganic & medicinal chemistry letters.

Enantioselective Synthesis of β-Dibenzylamino Alcohols via a Dynamic Kinetic Resolution of α-Halo Acids

Jeff O'meara, M. Jung, T. Durst, 1998 .

Removable Phosphine Reagents for the Mitsunobu Reaction

C. Yoakim, B. Thavonekham, Jeff O'meara, 2003 .

Multiple modes of insecticidal action of three classes of polyacetylene derivatives from Rudbeckia hirta

B. Philogéne, Jeff O'meara, J. Arnason, 1997 .

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.

G. Poda, K. Packman, G. Privé, 2023, ACS medicinal chemistry letters.

Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: a combined medicinal chemistry, NMR and computational chemistry approach.

C. Yoakim, A. Jakalian, D. Cameron, 2007, Bioorganic & medicinal chemistry.

Discovery of the First Series of Inhibitors of Human Papillomavirus Type 11: Inhibition of the Assembly of the E1—E2—Origin DNA Complex

C. Yoakim, J. Archambault, P. White, 2003 .

Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.

J. Duan, M. Garneau, P. Bonneau, 2005, Journal of Medicinal Chemistry.