B. Simoneau

发表

Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

P. Bonneau, C. Yoakim, S. LaPlante, 2007, Bioorganic & medicinal chemistry letters.

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

Steven R. LaPlante, P. Bonneau, D. Lamarre, 2003, Nature.

Novel small renin inhibitors containing 4,5- or 3,5-dihydroxy-2-substituted-6-phenylhexanamide replacements at the P2-P3 sites.

P. Anderson, B. Thavonekham, B. Simoneau, 1998, Bioorganic & medicinal chemistry.

Crystallographic Studies on the Binding Modes of P2-P3 Butanediamide Renin Inhibitors (*)

L. Tong, S. Pav, D. Lamarre, 1995, The Journal of Biological Chemistry.

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

J. Duan, M. Garneau, P. Bonneau, 2014, Antimicrobial Agents and Chemotherapy.

Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.

J. Duan, O. Hucke, M. Garneau, 2012, Bioorganic & medicinal chemistry letters.

Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.

Edward M. Tyndall, J. Duan, C. Morton, 2014, ACS medicinal chemistry letters.

Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.

Edward M. Tyndall, J. Duan, C. Morton, 2014, Bioorganic & medicinal chemistry letters.

Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.

J. Duan, M. Garneau, P. Bonneau, 2007, Bioorganic & medicinal chemistry letters.

Discovery of non-peptidic P2-P3 butanediamide renin inhibitors with high oral efficacy.

P. Anderson, C. Chabot, B. Thavonekham, 1999, Bioorganic & medicinal chemistry.

Isolation and characterization of herpes simplex virus type 1 resistant to aminothiazolylphenyl-based inhibitors of the viral helicase-primase.

M. Garneau, M. Cordingley, A. Faucher, 2004, Antiviral research.

Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives.

J. Duan, P. Bonneau, C. Yoakim, 2004, Bioorganic & medicinal chemistry letters.

The human renin infused rat: use as an in vivo model for the biological evaluation of human renin inhibitors.

D. Lamarre, P. Anderson, L. Pilote, 1999, Canadian Journal of Physiology and Pharmacology.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.

O. Hucke, P. Bonneau, S. Morin, 2013, Bioorganic & medicinal chemistry letters.

Synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid vinyl-ACCA) derivatives: key intermediates for the preparation of inhibitors of the hepatitis C virus NS3 protease.

J. Gillard, P. Beaulieu, B. Simoneau, 2005, The Journal of organic chemistry.

Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.

J. Duan, M. Garneau, C. Yoakim, 2014, ACS medicinal chemistry letters.

Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.

J. Duan, M. Garneau, S. Morin, 2013, Bioorganic & medicinal chemistry letters.

Potent inhibitors of the hepatitis C virus NS3 protease: design and synthesis of macrocyclic substrate-based beta-strand mimics.

C. Brochu, M. Poirier, Y. Tsantrizos, 2004, The Journal of organic chemistry.

An NS 3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

P. Bonneau, D. Lamarre, P. Anderson, 2003 .

Practical Synthesis of A Benzophenone-Based NNRT Inhibitor of HIV-1

C. Yoakim, Jeff O'meara, S. Landry, 2012 .

An NS 3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

P. Bonneau, D. Lamarre, P. Anderson, 2003 .

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.

O. Hucke, P. Bonneau, C. Yoakim, 2011, Bioorganic & medicinal chemistry letters.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.

J. Duan, O. Hucke, M. Garneau, 2013, Bioorganic & medicinal chemistry letters.

Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using 19F Ligand‐and 15N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series

Jean-François Mercier, Yves Bousquet, J. Mercier, 2013, ChemMedChem.

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

Wesley I. Sundquist, Stephen W. Mason, W. Sundquist, 2012, Journal of Virology.

Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.

P. Bonneau, C. Yoakim, R. Coulombe, 2009, Bioorganic & medicinal chemistry letters.

HIV and AIDS Therapeutics

P. Bonneau, B. Simoneau, 2007 .

A new regiospecific synthesis of 1,4-dihydroxyxanthones

B. Simoneau, P. Brassard, 1984 .

Stereoselective rardical-mediated reduction and alkylation of α-halo esters

C. Yoakim, C. Chabot, B. Simoneau, 1991 .

Synthetic studies in the mevinoid field. The total synthesis of ML236A

B. Simoneau, S. Danishefsky, 1988 .

Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans.

Martin Poirier, C. Brochu, M. Poirier, 2004, Organic letters.

A convenient synthesis of naturally occurring quinizarins

B. Simoneau, P. Brassard, 1988 .

Total syntheses of ML-236A and compactin by combining the lactonic (silyl) enolate rearrangement and aldehyde-diene cyclocondensation technologies

B. Simoneau, S. Danishefsky, 1989 .

Multi-gram synthesis of a nucleotide-competing reverse transcriptase inhibitor

S. Morin, B. Thavonekham, Y. Bousquet, 2013 .

Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease

M. Cordingley, A. Faucher, B. Simoneau, 2002, Nature Medicine.

Oral Bioavailability and In Vivo Efficacy of the Helicase-Primase Inhibitor BILS 45 BS against Acyclovir-Resistant Herpes Simplex Virus Type 1

J. Duan, M. Cordingley, A. Faucher, 2003, Antimicrobial Agents and Chemotherapy.

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.

Araz Jakalian, Sébastien Morin, Yves Bousquet, 2014, ACS medicinal chemistry letters.

Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor.

B. Simoneau, S. Mason, M. Liuzzi, 2004, Nucleic acids research.

Inhibitors of Respiratory Syncytial Virus Replication Target Cotranscriptional mRNA Guanylylation by Viral RNA-Dependent RNA Polymerase

J. Rancourt, M. Massariol, S. Landry, 2005, Journal of Virology.

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.

J. Duan, M. Garneau, P. Bonneau, 2016, ACS medicinal chemistry letters.

Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.

J. Duan, M. Garneau, P. Bonneau, 2005, Journal of Medicinal Chemistry.

Reactions of ketene acetals 16. The regiospecific synthesis of partially methylated purpurins

B. Simoneau, B. Paul, 1986 .