S. Neumann

发表

Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.

Stefano Costanzi, Susanne Neumann, Irina G Tikhonova, 2008, Journal of medicinal chemistry.

Selective Carbon–Carbon Bond Activation of Epoxides by a Bisphosphine Pt(0) Complex

S. Neumann, A. Albinati, F. Rominger, 2019, Organometallics.

Multi-barrelled ion-selective microelectrodes as tools for the investigation of volume regulation mechanisms in invertebrate nerve cells under hyperosmotic conditions

S. Neumann, P. Dierkes, W. Schlue, 2003 .

Adiponectin gene expression is inhibited by β‐adrenergic stimulation via protein kinase A in 3T3‐L1 adipocytes

R. Paschke, J. Klein, M. Fasshauer, 2001, FEBS letters.

Isoproterenol inhibits resistin gene expression through a GS‐protein‐coupled pathway in 3T3‐L1 adipocytes

R. Paschke, J. Klein, M. Fasshauer, 2001, FEBS letters.

β-Arrestin 1 in Thyrotropin Receptor Signaling in Bone: Studies in Osteoblast-Like Cells

M. Gershengorn, S. Neumann, A. Boutin, 2020, Frontiers in Endocrinology.

Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor

R. Paschke, B. Raaka, G. Krause, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Quantitative High-Throughput Screening Using a Live-Cell cAMP Assay Identifies Small-Molecule Agonists of the TSH Receptor

Noel Southall, Adam Yasgar, P. Shinn, 2008, Journal of biomolecular screening.

Update in TSH receptor agonists and antagonists.

M. Gershengorn, S. Neumann, 2012, The Journal of clinical endocrinology and metabolism.

Small molecule TSHR agonists and antagonists.

M. Gershengorn, S. Neumann, 2011, Annales d'endocrinologie.

The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.

Noel Southall, C. Austin, Wei Zheng, 2011, MedChemComm.

β‐Arrestin‐1 mediates thyrotropin‐enhanced osteoblast differentiation

M. Gershengorn, S. Neumann, E. Eliseeva, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Defining Structural and Functional Dimensions of the Extracellular Thyrotropin Receptor Region*

R. Paschke, A. Diehl, G. Krause, 2011, The Journal of Biological Chemistry.

Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes.

R. Paschke, J. Klein, M. Fasshauer, 2002, Biochemical and biophysical research communications.

Tumor Necrosis Factor α Is a Negative Regulator of Resistin Gene Expression and Secretion in 3T3-L1 Adipocytes

R. Paschke, J. Klein, M. Fasshauer, 2001 .

Thyrotropin Stimulates Differentiation Not Proliferation of Normal Human Thyrocytes in Culture

B. Marcus-Samuels, M. Gershengorn, S. Neumann, 2016, Front. Endocrinol..

A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice.

J. Marugan, M. Gershengorn, S. Neumann, 2014, Endocrinology.

De novo triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone

Terry J. Smith, P. Arvan, J. Banga, 2017, The Journal of Biological Chemistry.

Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes.

R. Paschke, J. Klein, M. Fasshauer, 2001, Biochemical and biophysical research communications.

Identification of a Novel Epitope in the Thyroid-stimulating Hormone Receptor Ectodomain Acting as Intramolecular Signaling Interface*[boxs]

R. Paschke, G. Krause, S. Neumann, 2004, Journal of Biological Chemistry.

An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function.

R. Paschke, G. Krause, S. Mueller, 2006, Endocrinology.

A novel activating mutation in transmembrane helix 6 of the thyrotropin receptor as cause of hereditary nonautoimmune hyperthyroidism.

M. Gershengorn, S. Neumann, L. Gourgiotis, 2006, Thyroid : official journal of the American Thyroid Association.

Thyroglobulin mRNA quantification in the peripheral blood is not a reliable marker for the follow-up of patients with differentiated thyroid cancer.

R. Paschke, M. Eszlinger, S. Neumann, 2002, European journal of endocrinology.

Future Prospects for the Treatment of Graves’ Hyperthyroidism and Eye Disease

R. Place, M. Gershengorn, S. Neumann, 2015, Hormone and Metabolic Research.

A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.

G. Napolitano, M. Gershengorn, S. Neumann, 2011, The Journal of clinical endocrinology and metabolism.

Pertussis toxin inhibits autophosphorylation and activation of the insulin receptor kinase.

C. Kahn, M. White, D. Müller-Wieland, 1991, Biochemical and biophysical research communications.

TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis.

R. Place, B. Marcus-Samuels, G. Kahaly, 2016, The Journal of clinical endocrinology and metabolism.

Proximity ligation assay to study TSH receptor homodimerization and crosstalk with IGF-1 receptors in human thyroid cells

M. Gershengorn, S. Neumann, C. Krieger, 2022, Frontiers in Endocrinology.

Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization

B. Marcus-Samuels, E. Geras-Raaka, M. Gershengorn, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Opposing Effects of EGF Receptor Signaling on Proliferation and Differentiation Initiated by EGF or TSH/EGF Receptor Transactivation.

B. Marcus-Samuels, M. Gershengorn, S. Neumann, 2022, Endocrinology.

Search for mitochondrial DNA mutation at position 3243 in German patients with a positive family history of maternal diabetes mellitus.

R. Paschke, M. Hanefeld, S. Neumann, 2001, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk.

J. Banga, G. Kahaly, M. Gershengorn, 2019, Endocrinology.

TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro

B. Marcus-Samuels, M. Gershengorn, S. Neumann, 2020, Frontiers in Endocrinology.

Aldosterone and d-Glucose Stimulate the Proliferation of Human Cardiac Myofibroblasts In Vitro

K. Huse, R. Semrau, A. Diegeler, 2002, Hypertension.

RET germline mutation in codon 791 in a family representing 3 generations from age 5 to age 70 years: should thyroidectomy be performed?

R. Paschke, S. Neumann, C. A. Koch, 2004, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling.

R. Paschke, G. Krause, S. Neumann, 2005, Endocrinology.

Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis?

M. Gershengorn, S. Neumann, C. Krieger, 2020, International journal of molecular sciences.

TSH/IGF1 receptor crosstalk: Mechanism and clinical implications.

M. Gershengorn, S. Neumann, C. Krieger, 2020, Pharmacology & therapeutics.

Thyroid Stimulating Hormone (TSH)/Insulin-like Growth Factor 1 (IGF1) Receptor Cross-talk in Human Cells.

M. Gershengorn, S. Neumann, S. Morgan, 2018, Current opinion in endocrine and metabolic research.

Thyrotropin and Insulin-Like Growth Factor 1 Receptor Crosstalk Upregulates Sodium-Iodide Symporter Expression in Primary Cultures of Human Thyrocytes.

B. Marcus-Samuels, M. Gershengorn, S. Neumann, 2016, Thyroid : official journal of the American Thyroid Association.

Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves' disease immunoglobins.

R. Place, B. Marcus-Samuels, M. Gershengorn, 2015, The Journal of clinical endocrinology and metabolism.

(cid:2) -Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation

M. Gershengorn, S. Neumann, E. Eliseeva, 2014 .

A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.

M. Gershengorn, S. Neumann, E. Eliseeva, 2010, Endocrinology.

Letter to the Editor: "Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy".

M. Gershengorn, S. Neumann, C. Krieger, 2019, The Journal of clinical endocrinology and metabolism.

Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists.

B. Raaka, M. Gershengorn, S. Neumann, 2010, Methods in enzymology.

Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling

M. Gershengorn, S. Neumann, Michael D. Allen, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Distinction between autoimmune and nonautoimmune hyperthyroidism by determination of thyrotropin-receptor antibodies in patients with the scintigraphic diagnosis of disseminated autonomy.

R. Paschke, H. Wallaschofski, D. Führer, 2001, Thyroid.

Graves' Autoantibodies Exhibit Different Stimulating Activities in Cultures of Thyrocytes and Orbital Fibroblasts Not Reflected by Clinical Assays.

G. Kahaly, M. Gershengorn, S. Neumann, 2021, Thyroid : official journal of the American Thyroid Association.

Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence.

M. Gershengorn, S. Neumann, Michael D. Allen, 2011, Thyroid : official journal of the American Thyroid Association.

Functional significance of the thyrotropin receptor germline polymorphism D727E.

R. Paschke, A. Papavassiliou, K. Markou, 2003, Biochemical and biophysical research communications.

1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors.

M. Gershengorn, K. Rice, S. Neumann, 2005, Bioorganic & medicinal chemistry letters.

Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.

B. Raaka, M. Gershengorn, I. Tikhonova, 2007, Journal of medicinal chemistry.

Seven Transmembrane-spanning Receptors for Free Fatty Acids as Therapeutic Targets for Diabetes Mellitus: Pharmacological, Phylogenetic, and Drug Discovery Aspects*

M. Gershengorn, S. Neumann, S. Costanzi, 2008, Journal of Biological Chemistry.

Novel insights on thyroid-stimulating hormone receptor signal transduction.

A. Grüters, H. Biebermann, H. Krude, 2013, Endocrine reviews.

Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action

R. Paschke, T. Gudermann, S. Neumann, 2001, Journal of Molecular Medicine.

From four-fold functionalised [3.3]cyclophanes to belt-shaped and multibridged molecules

K. Rissanen, F. Vögtle, S. Neumann, 1996 .

Molecular pathogenesis of euthyroid and toxic multinodular goiter.

R. Paschke, M. Eszlinger, K. Krohn, 2005, Endocrine reviews.

Further indications for genetic heterogeneity of euthyroid familial goiter

R. Paschke, P. Langer, M. Tajtáková, 2003, Journal of Molecular Medicine.

Lack of correlation for sodium iodide symporter mRNA and protein expression and analysis of sodium iodide symporter promoter methylation in benign cold thyroid nodules.

R. Paschke, S. Neumann, A. Reske, 2004, Thyroid : official journal of the American Thyroid Association.

A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy.

M. Gershengorn, A. Turcu, S. Neumann, 2013, The Journal of clinical endocrinology and metabolism.

Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor

R. Paschke, G. Krause, S. Neumann, 2006, Journal of Molecular Medicine.

A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.

R. Paschke, G. Krause, S. Neumann, 2001, Molecular endocrinology.

Contacts between Extracellular Loop Two and Transmembrane Helix Six Determine Basal Activity of the Thyroid-stimulating Hormone Receptor*

R. Paschke, G. Krause, S. Mueller, 2007, Journal of Biological Chemistry.

Linkage of familial euthyroid goiter to the multinodular goiter-1 locus and exclusion of the candidate genes thyroglobulin, thyroperoxidase, and Na+/I- symporter.

R. Paschke, A. Reis, S. Neumann, 1999, The Journal of clinical endocrinology and metabolism.

Adrenocorticotrope Deficiency with Clinical Evidence for Late Onset in Combined Pituitary Hormone Deficiency Caused by a Homozygous 301–302delAG Mutation of the PROP1 Gene

R. Paschke, W. Kiess, S. Neumann, 2004, Pituitary.

Significance of Ectodomain Cysteine Boxes 2 and 3 for the Activation Mechanism of the Thyroid-stimulating Hormone Receptor*

R. Paschke, G. Krause, S. Mueller, 2006, Journal of Biological Chemistry.

Stimulatory TSH-Receptor Antibodies and Oxidative Stress in Graves Disease

P. D. Olivo, G. Kahaly, A. Daiber, 2018, The Journal of clinical endocrinology and metabolism.

A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts.

B. Raaka, E. Geras-Raaka, M. Gershengorn, 2012, Thyroid : official journal of the American Thyroid Association.

Genome-wide linkage analysis reveals evidence for four new susceptibility loci for familial euthyroid goiter.

R. Paschke, L. Hegedüs, F. Rüschendorf, 2004, The Journal of clinical endocrinology and metabolism.

Human TSH receptor ligands as pharmacological probes with potential clinical application

B. Raaka, M. Gershengorn, S. Neumann, 2009, Expert review of endocrinology & metabolism.

Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor.

R. Paschke, G. Krause, S. Neumann, 2005, Endocrinology.

Thyrotropin Receptor Stimulates Internalization-Independent Persistent Phosphoinositide Signaling

E. Geras-Raaka, M. Gershengorn, S. Neumann, 2011, Molecular Pharmacology.

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

B. Raaka, Noel Southall, C. Austin, 2009, Proceedings of the National Academy of Sciences.

A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.

B. Raaka, G. Krause, M. Gershengorn, 2008, Endocrinology.

Targeting TSH and IGF-1 Receptors to Treat Thyroid Eye Disease

M. Gershengorn, S. Neumann, C. Krieger, 2020, European Thyroid Journal.

Low Affinity Analogs of Thyrotropin-releasing Hormone Are Super-agonists*

N. Kaur, M. Gershengorn, S. Neumann, 2006, Journal of Biological Chemistry.

Reiter's syndrome as a manifestation of an immune reconstitution syndrome in an HIV-infected patient: successful treatment with doxycycline.

K. Caca, S. Neumann, F. Kreth, 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.

Gerd Krause, Stefano Costanzi, Susanne Neumann, 2006, Journal of medicinal chemistry.

Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by Gs and Gi/o Proteins

B. Marcus-Samuels, M. Gershengorn, S. Neumann, 2019, Molecular Pharmacology.

An Enantiomer of an Oral Small-Molecule TSH Receptor Agonist Exhibits Improved Pharmacologic Properties

R. Place, M. Gershengorn, S. Neumann, 2016, Front. Endocrinol..

Table 7, Summary of data in PubChem

Steve Titus, Wenwei Huang, Juan J. Marugan, 2010 .

A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists.

Stefano Costanzi, Susanne Neumann, J. Deschamps, 2008, Journal of the American Chemical Society.

Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.

R. Paschke, S. Neumann, M. Claus, 2005, European journal of endocrinology.

Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor

G. Krause, M. Gershengorn, S. Neumann, 2010, Cellular and Molecular Life Sciences.

Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro

M. Ferrer, Noel Southall, Xin Hu, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of a Positive Allosteric Modulator of the TSH Receptor : Potentiation of TSH-mediated Preosteoblast Differentiation In Vitro

M. Ferrer, Noel Southall, J. Marugan, 2017 .

Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells

M. Gershengorn, S. Neumann, Alisa Boutin, 2016, Endocrinology.

Evidence That Graves' Ophthalmopathy Immunoglobulins Do Not Directly Activate IGF-1 Receptors.

B. Marcus-Samuels, G. Kahaly, M. Gershengorn, 2018, Thyroid : official journal of the American Thyroid Association.

Rebuttal to Smith and Janssen (Thyroid 2017;27:746-747. DOI: 10.1089/thy.2017.0281).

M. Gershengorn, S. Neumann, 2017, Thyroid : official journal of the American Thyroid Association.

TSHR/IGF-1R Cross-Talk, Not IGF-1R Stimulating Antibodies, Mediates Graves' Ophthalmopathy Pathogenesis.

B. Marcus-Samuels, M. Gershengorn, S. Neumann, 2017, Thyroid : official journal of the American Thyroid Association.

Rebuttal to Smith and Janssen

M. Gershengorn, S. Neumann, 2017 .

A Low Molecular Weight Agonist Signals by Binding to the Transmembrane Domain of Thyroid-stimulating Hormone Receptor (TSHR) and Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR)*

R. Paschke, B. Raaka, G. Krause, 2006, Journal of Biological Chemistry.

The intramolecular agonist is obligate for activation of glycoprotein hormone receptors

T. Schöneberg, P. Scheerer, S. Neumann, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Small molecule agonists and antagonists as potential new therapeutics targeting the TSH receptor

S. Neumann, 2017 .

Signaling‐sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor

Gerd Krause, Susanne Neumann, Gunnar Kleinau, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Thyrotropin regulation of differentiated gene transcription in adult human thyrocytes in primary culture

B. Marcus-Samuels, M. Gershengorn, S. Neumann, 2020, Molecular and Cellular Endocrinology.

TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization

M. Gershengorn, S. Neumann, E. Eliseeva, 2021, Cellular Signalling.

Inhibiting thyrotropin/insulin‐like growth factor 1 receptor crosstalk to treat Graves' ophthalmopathy: studies in orbital fibroblasts in vitro

R. Place, M. Gershengorn, S. Neumann, 2017, British journal of pharmacology.

Quantitative High-Throughput Screening Using a Live-Cell cAMP Assay Identifies Small-Molecule Agonists of the TSH Receptor

Noel Southall, Adam Yasgar, P. Shinn, 2008, Journal of biomolecular screening.

Sodium/iodide symporter mRNA expression in cold thyroid nodules

R. Paschke, S. Neumann, 2001, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Identification of Residues Important for Agonist Recognition and Activation in GPR40*

Stefano Costanzi, Susanne Neumann, Irina G Tikhonova, 2007, Journal of Biological Chemistry.

Mutation detection in mosaic situations: RNA mismatch assay and denaturing gradient gel electrophoresis are more sensitive than conventional cycle sequencing.

R. Paschke, R. Kinne, S. Neumann, 2001, Analytical biochemistry.

Persistent signaling by thyrotropin‐releasing hormone receptors correlates with G‐protein and receptor levels

M. Gershengorn, S. Neumann, Michael D. Allen, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Persistent cAMP signaling by TSH receptors revealed by phosphodiesterase inhibition.

E. Geras-Raaka, M. Gershengorn, S. Neumann, 2013, Thyroid : official journal of the American Thyroid Association.

Inhibition of TSH/IGF-1 receptor crosstalk by Teprotumumab as a treatment modality of Thyroid Eye Disease.

G. Kahaly, M. Gershengorn, S. Neumann, 2021, The Journal of clinical endocrinology and metabolism.

Orientation of μ-Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding

E. Nisenbaum, I. Lindberg, D. Tieleman, 2011, Molecular Pharmacology.

Potentiometric measurement of cell volume changes and intracellular ion concentrations in leech Retzius neurones

S. Neumann, P. Dierkes, W. Schlue, 2001 .

TSH, But Not Thyroid-Stimulating Antibodies, Induces Biphasic Regulation of Gene Expression in Human Thyrocytes.

S. Neumann, J. Klubo-Gwiezdzinska, Daesong Jang, 2019, Thyroid : official journal of the American Thyroid Association.

Thyrotropin, but Not Thyroid-Stimulating Antibodies, Induces Biphasic Regulation of Gene Expression in Human Thyrocytes

J. Banga, M. Gershengorn, S. Neumann, 2020 .

TSH Elicits Cell-Autonomous, Biphasic Responses: A Mechanism Inhibiting Hyperstimulation.

M. Gershengorn, S. Neumann, Alisa Boutin, 2020, Endocrinology.

Normal Human Thyrocytes in Culture.

M. Gershengorn, S. Neumann, S. Morgan, 2018, Methods in molecular biology.

Combined Immunosuppressive Therapy for Severe Graves Dermopathy

M. Gershengorn, M. Skarulis, S. Neumann, 2021, Annals of Internal Medicine.

Agonists of the TSH Receptor Quantitative High-Throughput Screening Using a Live-Cell cAMP Assay Identifies Small-Molecule

Noel Southall, Adam Yasgar, P. Shinn, 2008 .