S. Costanzi

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Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.

Stefano Costanzi, Susanne Neumann, Irina G Tikhonova, 2008, Journal of medicinal chemistry.

New Insights for Drug Design from the X-Ray Crystallographic Structures of G-Protein-Coupled Receptors

K. Jacobson, S. Costanzi, 2012, Molecular Pharmacology.

Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

K. Jacobson, Zhang-Guo Gao, S. Costanzi, 2004, Journal of medicinal chemistry.

Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.

K. Jacobson, T. K. Harden, M. González-Moa, 2005, Journal of medicinal chemistry.

Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors.

K. Jacobson, Zhang-Guo Gao, T. K. Harden, 2006, Biochemical pharmacology.

P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring.

K. Jacobson, T. K. Harden, I. Tikhonova, 2007, Journal of medicinal chemistry.

Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.

Jacobson, K. Jacobson, T. K. Harden, 2011, Journal of medicinal chemistry.

Virtual screening leads to the discovery of novel non-nucleotide P2Y₁ receptor antagonists.

K. Jacobson, S. Costanzi, T. S. Santhosh Kumar, 2012, Bioorganic & medicinal chemistry.

Molecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes.

K. Jacobson, S. Costanzi, M. P. S. Jayasekara, 2012, Wiley interdisciplinary reviews. Membrane transport and signaling.

Renal resistive index and long-term outcome in chronic nephropathies.

S. Costanzi, C. Parolini, A. Noce, 2009, Radiology.

Resistive index in chronic nephropathies: predictive value of renal outcome.

S. Costanzi, C. Parolini, G. Splendiani, 2002, Clinical nephrology.

Computing Highly Correlated Positions Using Mutual Information and Graph Theory for G Protein-Coupled Receptors

Stefano Costanzi, Carson C. Chow, C. Chow, 2009, PloS one.

A Missense Mutation in the Seven-transmembrane Domain of the Human Ca2+ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator*

K. Jacobson, S. Costanzi, J. Feyen, 2006, Journal of Biological Chemistry.

Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors.

Stefano Costanzi, Irina G Tikhonova, Kenneth A Jacobson, 2009, Current pharmaceutical design.

Purine receptors: GPCR structure and agonist design.

K. Jacobson, Zhang-Guo Gao, S. Costanzi, 2004, Molecular interventions.

Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines.

J. Wess, S. Vilar, F. Deflorian, 2009, Bioorganic & medicinal chemistry.

Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling

Stefano Costanzi, Kenneth A. Jacobson, Andrei A. Ivanov, 2006, J. Comput. Aided Mol. Des..

Probing GPCR structure: adenosine and P2Y nucleotide receptors.

K. Jacobson, F. Deflorian, S. Costanzi, 2013, Methods in enzymology.

Pharmacochemistry of the platelet purinergic receptors

K. Jacobson, F. Deflorian, S. Costanzi, 2011, Purinergic Signalling.

Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.

T Kendall Harden, Stefano Costanzi, Piet Herdewijn, 2004, Bioorganic & medicinal chemistry.

Agonists and antagonists for P2 receptors.

K. Jacobson, S. Costanzi, A. Ivanov, 2006, Novartis Foundation symposium.

Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracy.

S. Costanzi, M. Skorski, Keyun Wang, 2016, Journal of molecular graphics & modelling.

Contrast-enhanced ultrasonography in chronic glomerulonephritides: correlation with histological parameters of disease activity

G. Gambaro, G. Rapaccini, N. de Matthaeis, 2018, Journal of Ultrasound.

Computational Drug Target Screening through Protein Interaction Profiles

George Hripcsak, Fernanda Borges, Santiago Vilar, 2016, Scientific Reports.

Hepatocyte growth factor and transforming growth factor beta1 ratio at baseline can predict early response to cyclophosphamide in systemic lupus erythematosus nephritis.

C. Beltrami, S. Costanzi, G. Ferraccioli, 2006, Arthritis and rheumatism.

Combined treatment with renin-angiotensin system blockers and polyunsaturated fatty acids in proteinuric IgA nephropathy: a randomized controlled trial.

G. Gambaro, S. Costanzi, G. Ferraccioli, 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Rituximab Followed by Belimumab Controls Severe Lupus Nephritis and Bullous Pemphigoid in Systemic Lupus Erythematosus Refractory to Several Combination Therapies

G. Grandaliano, S. Costanzi, G. Ferraccioli, 2020, Frontiers in Medicine.

Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue.

G. Cristalli, S. Costanzi, A. Vita, 2006, Journal of molecular graphics & modelling.

2-ClATP exerts anti-tumoural actions not mediated by P2 receptors in neuronal and glial cell lines.

G. Sancesario, G. Cristalli, S. Costanzi, 2004, Biochemical pharmacology.

A2B Adenosine Receptor Agonists: Synthesis and Biological Evaluation of 2‐Phenylhydroxypropynyl Adenosine and NECA Derivatives

K. Klotz, G. Cristalli, S. Costanzi, 2004, Nucleosides, nucleotides & nucleic acids.

A2B adenosine receptor blockade inhibits growth of prostate cancer cells

K. Jacobson, Zhang-Guo Gao, S. Costanzi, 2013, Purinergic Signalling.

Diet macronutrient composition reported before treatment predicts BMI change in obese children: the role of lipids

C. Maffeis, S. Costanzi, A. Morandi, 2012, European Journal of Clinical Nutrition.

Computational studies to predict or explain GPCR polypharmacology

K. Jacobson, S. Costanzi, S. Paoletta, 2015 .

New substituted 9-alkylpurines as adenosine receptor ligands.

K. Klotz, G. Cristalli, S. Costanzi, 1998, Bioorganic & medicinal chemistry.

Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura

G. Gambaro, A. Milillo, S. Costanzi, 2018, Journal of Nephrology.

Structure-Activity Relationships of Adenosine Deaminase Inhibitors

G. Cristalli, S. Costanzi, S. Vittori, 1999 .

Adenosine receptor agonists: synthesis and binding affinity of 2- (aryl)alkylthioadenosine derivatives

K. Klotz, G. Cristalli, S. Costanzi, 2004 .

Enyzmes | Glutamate Carboxypeptidase II (EC 3.4.17.21)

J. Neale, S. Costanzi, 2020 .

Plasmaperfusion on Triptophan Columns Can Improve the Clinical Outcome of Patients Affected with Myasthenia Gravis

C. Casciani, S. Costanzi, E. Staffolani, 2003, Artificial cells, blood substitutes, and immobilization biotechnology.

Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.

K. Jacobson, T. K. Harden, S. Costanzi, 2007, Journal of medicinal chemistry.

Human cytidine deaminase: a biochemical characterization of its naturally occurring variants.

S. Vilar, P. Polidori, S. Costanzi, 2014, International journal of biological macromolecules.

Corrigendum to “Human cytidine deaminase: A biochemical characterization of its naturally occurring variants” [Int. J. Biol. Macromol. 63 (2014) 64–74]

S. Vilar, P. Polidori, S. Costanzi, 2014 .

Molecular recognition at adenine nucleotide (P2) receptors in platelets.

K. Jacobson, S. Costanzi, L. Mamedova, 2005, Seminars in thrombosis and hemostasis.

Facilitating adverse drug event detection in pharmacovigilance databases using molecular structure similarity: application to rhabdomyolysis

Carol Friedman, Herbert S. Chase, Raul Rabadan, 2011, J. Am. Medical Informatics Assoc..

Role of tyrosine 33 residue for the stabilization of the tetrameric structure of human cytidine deaminase.

S. Costanzi, V. Polzonetti, P. Natalini, 2010, International journal of biological macromolecules.

Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.

K. Jacobson, T. K. Harden, S. Costanzi, 2008, Combinatorial chemistry & high throughput screening.

Chemical Warfare Agents

S. Costanzi, 2020, Kirk‐Othmer Encyclopedia of Chemical Technology.

Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells.

K. Jacobson, Zhang-Guo Gao, S. Costanzi, 2011, Biochemical pharmacology.

Molecular recognition at purine and pyrimidine nucleotide (P2) receptors.

K. Jacobson, S. Costanzi, B. Joshi, 2004, Current topics in medicinal chemistry.

Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors.

G. Cristalli, S. Costanzi, S. Vittori, 2005, Journal of medicinal chemistry.

4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor.

Kyle A. Brown, K. Jacobson, S. Costanzi, 2013, MedChemComm.

Deterioration in Clinical Status Is Not Enough to Suspend Eculizumab: A Genetic Complement-Mediated Atypical Hemolytic Uremic Syndrome Case Report

S. Costanzi, P. M. Ferraro, G. Vischini, 2019, Case reports in nephrology.

Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.

B. Raaka, M. Gershengorn, I. Tikhonova, 2007, Journal of medicinal chemistry.

Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality.

K. Jacobson, S. Costanzi, Craig J. Thomas, 2005, Organic & biomolecular chemistry.

Modulation of apoptosis in human lymphocytes by adenosine analogues.

C. Franceschi, G. Cristalli, S. Costanzi, 1998, Bioorganic & medicinal chemistry letters.

Seven Transmembrane-spanning Receptors for Free Fatty Acids as Therapeutic Targets for Diabetes Mellitus: Pharmacological, Phylogenetic, and Drug Discovery Aspects*

M. Gershengorn, S. Neumann, S. Costanzi, 2008, Journal of Biological Chemistry.

Adenosine deaminase: Functional implications and different classes of inhibitors

G. Cristalli, S. Costanzi, S. Vittori, 2001, Medicinal research reviews.

Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands

Stefano Costanzi, Kenneth A. Jacobson, Irina G. Tikhonova, 2009, J. Comput. Aided Mol. Des..

Lists of Chemical Warfare Agents and Precursors from International Nonproliferation Frameworks: Structural Annotation and Chemical Fingerprint Analysis

Stefano Costanzi, Gregory D. Koblentz, Gregory D Koblentz, 2020, J. Chem. Inf. Model..

Delineation of the Molecular Mechanisms of Nucleoside Recognition by Cytidine Deaminase through Virtual Screening

Santiago Vilar, Giulio Ferino, Stefano Costanzi, 2011, ChemMedChem.

Dimroth-type rearrangement of 1-benzyl- and 1-glycosyl-5-aminoimidazoles to 4-(N-substituted amino)imidazoles

G. Mackenzie, S. Costanzi, D. Ewing, 2012 .

Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.

T Kendall Harden, Stefano Costanzi, Kenneth A Jacobson, 2006, Journal of Medicinal Chemistry.

Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1.

G. Cristalli, S. Costanzi, S. Vittori, 2002, Bioorganic & medicinal chemistry.

RING OPENING REACTIONS: SYNTHESIS OF AICAR ANALOGS AS POTENTIAL ANTIMETABOLITE AGENTS

G. Cristalli, S. Costanzi, S. Vittori, 2005, Nucleosides, nucleotides & nucleic acids.

Deaza- and Deoxyadenosine Derivatives: Synthesis and Inhibition of Animal Viruses as Human Infection Models

G. Cristalli, S. Costanzi, S. Vittori, 2003, Nucleosides, nucleotides & nucleic acids.

Purine and deazapurine nucleosides: synthetic approaches, molecular modelling and biological activity.

G. Cristalli, S. Costanzi, S. Vittori, 2003, Farmaco.

3′-DEOXYRIBOFURANOSE DERIVATIVES OF 1-DEAZA AND 3-DEAZA-ADENOSINE AND THEIR ACTIVITY AS ADENOSINE DEAMINASE INHIBITORS

G. Cristalli, S. Costanzi, S. Vittori, 2001, Nucleosides, nucleotides & nucleic acids.

N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.

A. IJzerman, G. Cristalli, S. Costanzi, 2000, Journal of medicinal chemistry.

Synthesis and adenosine deaminase inhibitory activity of 3’-deoxy-1-deazaadenosines

G. Cristalli, S. Costanzi, S. Vittori, 1999 .

Coupling of 2,6-dichloropurine and 2,6-dichlorodeazapurines with ribose and ribose modified sugars

G. Cristalli, S. Costanzi, S. Vittori, 1999 .

Synthesis of New 3′‐Deoxyribonucleosides Employing the Acid‐Catalyzed Fusion Method

G. Cristalli, S. Costanzi, S. Vittori, 1998 .

Synthesis of di- and tri-substituted adenosine derivatives and their affinities at human adenosine receptor subtypes.

K. Klotz, G. Cristalli, S. Costanzi, 1999, Nucleosides & nucleotides.

Synthesis and receptor affinity of polysubstituted adenosines.

K. Klotz, G. Cristalli, S. Costanzi, 1999, Nucleosides & nucleotides.

SYNTHETIC PROCEDURE FOR THE PREPARATION OF NOVEL POTENT AND SELECTIVE A3 ADENOSINE RECEPTOR RADIOLIGANDS

G. Cristalli, S. Costanzi, S. Vittori, 2001, Nucleosides, nucleotides & nucleic acids.

Human Cytidine Deaminase: Understanding the Catalytic Mechanism

G. Cristalli, S. Costanzi, S. Vittori, 2003, Nucleosides, nucleotides & nucleic acids.

Intersubunit Interactions in Human Cytidine Deaminase

G. Cristalli, S. Costanzi, A. Vita, 2003, Nucleosides, nucleotides & nucleic acids.

COUPLING OF 2,6-DISUBSTITUTED PURINES TO RIBOSE-MODIFIED SUGARS

G. Cristalli, S. Costanzi, S. Vittori, 2001, Nucleosides, nucleotides & nucleic acids.

Purine nucleosides bearing 1-alkynyl chains as adenosine receptor agonists.

G. Cristalli, S. Costanzi, S. Vittori, 2002, Current pharmaceutical design.

Low level exposure to cadmium increases the risk of chronic kidney disease: analysis of the NHANES 1999-2006

G. Gambaro, S. Costanzi, A. Sturniolo, 2010, BMC public health.

Molecular Evolution of the Transmembrane Domains of G Protein-Coupled Receptors

C. Chow, S. Fatakia, S. Costanzi, 2011, PloS one.

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.

J. Lupski, J. Wess, P. Chanson, 2014, The New England journal of medicine.

Understanding the structural and functional differences between mouse thyrotropin‐releasing hormone receptors 1 and 2

B. Raaka, F. Deflorian, M. Gershengorn, 2008, Proteins.

Prediction of passive blood-brain partitioning: straightforward and effective classification models based on in silico derived physicochemical descriptors.

Santiago Vilar, Stefano Costanzi, S. Vilar, 2010, Journal of molecular graphics & modelling.

Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library

Ryan T. Strachan, J. Lamerdin, R. Lefkowitz, 2017, Proceedings of the National Academy of Sciences.

Functional properties of subunit interactions in human cytidine deaminase.

G. Mei, G. Cristalli, S. Costanzi, 2003, Protein engineering.

A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.

B. Raaka, G. Krause, M. Gershengorn, 2008, Endocrinology.

Novel Structural and Functional Insights into M3 Muscarinic Receptor Dimer/Oligomer Formation*

J. Wess, R. Challiss, R. Mistry, 2013, The Journal of Biological Chemistry.

Docking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models.

Claudio N. Cavasotto, Sharangdhar S. Phatak, Claudio N Cavasotto, 2011, Journal of molecular graphics & modelling.

Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.

Gerd Krause, Stefano Costanzi, Susanne Neumann, 2006, Journal of medicinal chemistry.

Comparative Genomic Analysis Using Information Theory

C. Chow, S. Fatakia, S. Costanzi, 2011 .

Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).

Dac-Trung Nguyen, F. Deflorian, J. O’Shea, 2008, Journal of medicinal chemistry.

Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.

K. Jacobson, C. Gachet, S. M. Kilbey, 2010, Bioconjugate chemistry.

A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy

L. Larocca, A. Milillo, A. Amoroso, 2015, European Journal of Human Genetics.

Nerve Agents: What They Are, How They Work, How to Counter Them.

Stefano Costanzi, John-Hanson Machado, Moriah Mitchell, 2018, ACS chemical neuroscience.

Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial

Eddie B. S. Tan, Nishit P. Parikh, Rajan K. Patel, 2023, The Lancet.

Structural basis of G protein-coupled receptor-G protein interactions.

J. Wess, S. Costanzi, Joel Karpiak, 2010, Nature chemical biology.

A2B adenosine receptor blockade inhibits growth of prostate cancer cells

K. Jacobson, Zhang-Guo Gao, S. Costanzi, 2013, Purinergic Signalling.

Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.

K. Klotz, G. Cristalli, S. Costanzi, 2001, Bioorganic & medicinal chemistry letters.

Ligand and structure‐based models for the prediction of ligand‐receptor affinities and virtual screenings: Development and application to the β2‐adrenergic receptor

Santiago Vilar, Stefano Costanzi, Joel Karpiak, 2009, J. Comput. Chem..

Chiral analogues of (+)-cyclazosin as potent α1B-adrenoceptor selective antagonist.

G. Marucci, M. Buccioni, S. Costanzi, 2018, Bioorganic & medicinal chemistry.

A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists.

Stefano Costanzi, Susanne Neumann, J. Deschamps, 2008, Journal of the American Chemical Society.

Sodium and Fluid Modulation in Dialysis: New Approach

S. Costanzi, G. Splendiani, A. Sturniolo, 2001, Nephron.

Computerised monitoring of sodium and fluid during haemodialysis.

S. Costanzi, G. Splendiani, A. Sturniolo, 1990, Nephrology, Dialysis and Transplantation.

Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor Activation*

M. Gershengorn, I. Tikhonova, C. Sum, 2009, Journal of Biological Chemistry.

Hypokalemic nephropathy in an adult patient with partial empty sella: a classic Bartter's syndrome, a Gitelman's syndrome or both?

M. Montalto, G. Gasbarrini, G. Addolorato, 2006, Panminerva medica.

Predicting the biological activities through QSAR analysis and docking-based scoring.

Santiago Vilar, Stefano Costanzi, S. Vilar, 2012, Methods in molecular biology.

2- and 8-alkynyl-9-ethyladenines: Synthesis and biological activity at human and rat adenosine receptors

K. Klotz, M. Trincavelli, C. Martini, 2005, Purinergic Signalling.

2-Phenylhydroxypropynyladenosine Derivatives as High Potent Agonists at A2B Adenosine Receptor Subtype

G. Cristalli, S. Costanzi, S. Vittori, 2003, Nucleosides, nucleotides & nucleic acids.

Characterization of potent ligands at human recombinant adenosine receptors

K. Klotz, G. Cristalli, S. Costanzi, 1998 .

Medicinal chemistry and pharmacology of A2B adenosine receptors.

K. Klotz, G. Cristalli, S. Costanzi, 2003, Current topics in medicinal chemistry.

N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.

K. Klotz, G. Cristalli, S. Costanzi, 2002, Journal of medicinal chemistry.

A Low Molecular Weight Agonist Signals by Binding to the Transmembrane Domain of Thyroid-stimulating Hormone Receptor (TSHR) and Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR)*

R. Paschke, B. Raaka, G. Krause, 2006, Journal of Biological Chemistry.

In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor.

Santiago Vilar, Stefano Costanzi, Joel Karpiak, 2011, Journal of molecular graphics & modelling.

Influence of the Structural Accuracy of Homology Models on Their Applicability to Docking-Based Virtual Screening: The β2 Adrenergic Receptor as a Case Study

Stefano Costanzi, Austin Cohen, Abigail Danfora, 2019, J. Chem. Inf. Model..

On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.

Stefano Costanzi, S. Costanzi, 2008, Journal of medicinal chemistry.

Homology modeling of class a G protein-coupled receptors.

Stefano Costanzi, S. Costanzi, 2012, Methods in molecular biology.

Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.

I. Tikhonova, S. Costanzi, 2009, Current pharmaceutical design.

SYNTHESIS AND ADENOSINE RECEPTOR AFFINITY AND POTENCY OF 8-ALKYNYL DERIVATIVES OF ADENOSINE

G. Cristalli, S. Costanzi, S. Vittori, 2001, Nucleosides, nucleotides & nucleic acids.

The GPCR crystallography boom: providing an invaluable source of structural information and expanding the scope of homology modeling.

Stefano Costanzi, Keyun Wang, S. Costanzi, 2014, Advances in experimental medicine and biology.

Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.

G. Spalluto, K. Jacobson, B. Cacciari, 1998, Journal of medicinal chemistry.

Action of Nucleosides and Nucleotides at 7 Transmembrane-Spanning Receptors

K. Jacobson, Zhang-Guo Gao, S. Costanzi, 2006, Nucleosides, nucleotides & nucleic acids.

2- and 8-alkynyladenosines: conformational studies and docking to human adenosine A3 receptor can explain their different biological behavior.

Stefano Costanzi, Sauro Vittori, Gloria Cristalli, 2003, Journal of molecular graphics & modelling.

Modeling G protein-coupled receptors in complex with biased agonists.

Stefano Costanzi, S. Costanzi, 2014, Trends in pharmacological sciences.

G protein-coupled receptors: computer-aided ligand discovery and computational structural analyses in the 2010s

S. Costanzi, 2013, In Silico Pharmacology.

Graph analysis of β2 adrenergic receptor structures: a “social network” of GPCR residues

S. Costanzi, K. E. Muratore, Samuel Sheftel, 2013, In Silico Pharmacology.

Modeling G protein-coupled receptors and their interactions with ligands.

S. Costanzi, 2013, Current opinion in structural biology.

Modeling G Protein-Coupled Receptors: a Concrete Possibility.

Stefano Costanzi, S. Costanzi, 2010, Chimica oggi.

Dimer / Oligomer Formation Muscarinic Receptor 3 into M Novel Structural and Functional Insights Signal Transduction :

J. Wess, R. Challiss, R. Mistry, 2013 .

Identification of four amino acid residues essential for catalysis in human cytidine deaminase by site-directed mutagenesis and chemical modifications.

A. Cambi, S. Costanzi, P. Natalini, 1998, Protein engineering.

Structure and Function of G Protein-Coupled Receptors Studied Using Sequence Analysis, Molecular Modeling and Receptor Engineeri

K. Jacobson, I. Tikhonova, S. Costanzi, 2007 .

Application of Monte Carlo-based receptor ensemble docking to virtual screening for GPCR ligands.

Santiago Vilar, Stefano Costanzi, S. Vilar, 2013, Methods in enzymology.

Identification of Residues Important for Agonist Recognition and Activation in GPR40*

Stefano Costanzi, Susanne Neumann, Irina G Tikhonova, 2007, Journal of Biological Chemistry.

Structural Basis of M3 Muscarinic Receptor Dimer/Oligomer Formation*

Tong Liu, Moritz Heusel, Stefano Costanzi, 2011, The Journal of Biological Chemistry.

Computational studies to predict or explain G protein coupled receptor polypharmacology.

Stefano Costanzi, Silvia Paoletta, Kenneth A Jacobson, 2014, Trends in pharmacological sciences.

In Silico screening for agonists and blockers of the β2 adrenergic receptor: Implications of inactive and activated state structures

Santiago Vilar, Stefano Costanzi, S. Vilar, 2012, J. Comput. Chem..

Chapter 18:Structure-based Virtual Screening for Ligands of G Protein-coupled Receptors

Stefano Costanzi, S. Costanzi, 2011 .

Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.

K. Jacobson, S. Costanzi, H. Maruoka, 2010, Journal of medicinal chemistry.

Plasma perfusion in myasthenia gravis.

C. Casciani, S. Costanzi, G. Splendiani, 1988, ASAIO transactions.

Myasthenia gravis (MG) treatment with immunoadsorbent columns.

C. Casciani, S. Costanzi, G. Splendiani, 1991, Biomaterials Artificial Cells and Immobilization Biotechnology.

Semi-selective immunoadsorption treatment in myasthenia gravis.

C. Casciani, S. Costanzi, G. Sturniolo, 1992, Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology.

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

Charles L. Brooks, Adrian W. R. Serohijos, John Moult, 2009, Nature Reviews Drug Discovery.

Structure and function of G protein-coupled receptors studied using sequence analysis, molecular modeling and receptor engineering: adenosine receptor.

K. Jacobson, I. Tikhonova, S. Costanzi, 2007 .

Supporting the fight against the proliferation of chemical weapons through cheminformatics

Gregory D. Koblentz, S. Costanzi, Richard T. Cupitt, 2022, Pure and Applied Chemistry.

Expanding the Australia Group’s chemical weapons precursors control list with a family-based approach

Gregory D. Koblentz, S. Costanzi, Richard T. Cupitt, 2023, Pure and Applied Chemistry.

Atomistic insights into rhodopsin activation from a dynamic model.

Gerhard Hummer, Robert B Best, Stefano Costanzi, 2008, Journal of the American Chemical Society.

Structural aspects of M3 muscarinic acetylcholine receptor dimer formation and activation

J. Wess, R. Mistry, Yaru Zhou, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Modeling G protein-coupled receptors and their interactions with ligands.

S. Costanzi, 2013, Current opinion in structural biology.

In Silico screening for agonists and blockers of the β2 adrenergic receptor: Implications of inactive and activated state structures

S. Vilar, S. Costanzi, 2012, J. Comput. Chem..

Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.

I. Tikhonova, S. Costanzi, 2009, Current pharmaceutical design.

In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor.

S. Vilar, S. Costanzi, Joel Karpiak, 2011, Journal of molecular graphics & modelling.