S. Lim

发表

Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking

David Beer, Amedeo Caflisch, Danzhi Huang, 2009, PLoS neglected tropical diseases.

Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid.

P. Shenkin, T. Schwede, P. Sanschagrin, 2010, Journal of medicinal chemistry.

West Nile Virus Drug Discovery

P. Shi, S. Lim, 2013, Viruses.

Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors.

S. Vasudevan, Sejal J Patel, N. Ma, 2006, Journal of medicinal chemistry.

Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

S. Vasudevan, Sejal J Patel, N. Ma, 2006, Bioorganic & medicinal chemistry letters.

Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead.

David Beer, Gang Wang, Zheng Yin, 2006, Bioorganic & medicinal chemistry letters.

Cell-free transcription/translation from PCR-amplified DNA for high-throughput NMR studies.

N. Dixon, G. Otting, S. Vasudevan, 2007, Angewandte Chemie.

NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease

G. Otting, S. Vasudevan, X. Su, 2009, PLoS neglected tropical diseases.

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

Wolfgang Jahnke, Dahai Luo, Ting Xu, 2008, The EMBO journal.

Dengue protease activity: the structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target.

D. Wen, S. Vasudevan, W. Y. Phong, 2011, Bioscience reports.

2′-O Methylation of Internal Adenosine by Flavivirus NS[subscript 5] Methyltransferase

David C. Chang, S. Lok, P. Shi, 2012 .

Flavivirus RNA methylation.

K. Fink, P. Shi, S. Lim, 2014, The Journal of general virology.

Yellow fever virus NS3 protease: peptide-inhibition studies.

K. Löhr, A. Sampath, S. Vasudevan, 2007, The Journal of general virology.

Identification and Molecular Characterisation of the Complete Genome of a Singapore Isolate of Hepatitis C Virus: Sequence Comparison with other Strains and Phylogenetic Analysis

Alice Tay, W. Hong, S. Lim, 2004, Virus Genes.

A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′-C-Methylguanosine for the Treatment of Dengue Virus Infection

Yen-Liang Chen, W. Zhong, P. Shi, 2020, Antimicrobial Agents and Chemotherapy.

A Cyclic Phosphoramidate Prodrug of 2’-deoxy-2’-fluoro-2’-C-methylguanosine for the Treatment of Dengue Infection

Yen-Liang Chen, W. Zhong, P. Shi, 2020, bioRxiv.

Inducible system in human hepatoma cell lines for hepatitis C virus production.

S. Brenner, H. Horstmann, M. Ng, 2002, Virology.

NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues

P. Shi, J. Lescar, S. Lim, 2019, Journal of Virology.

Acquisition of immunogenicity by AKR leukemic cells following DNA‐mediated gene transfer is associated with the reduction of constitutive reactive superoxide radicals

K. Hui, T. Sabapathy, A. A. Oei, 1994, International journal of cancer.

CD81 engineered with endocytotic signals mediates HCV cell entry: implications for receptor usage by HCV in vivo.

Y. Tan, W. Hong, S. Lim, 2003, Virology.

An anti-HIV-1 gp120 antibody expressed as an endocytotic transmembrane protein mediates internalization of HIV-1.

Y. Tan, W. Hong, S. Lim, 2003, Virology.

Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase*

P. Shi, Zhong Li, Hongmin Li, 2010, The Journal of Biological Chemistry.

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus.

P. Shi, J. Lescar, S. Lim, 2010, Virology.

Use of an in vitro Model and Yeast Two-Hybrid System to Investigate the Pathogenesis of Hepatitis C

W. Hong, S. Lim, S. Lim, 2005, Intervirology.

Characterization of a novel IRF-1-deficient mutant cell line

K. Hui, S. Lim, 2004, Immunogenetics.

Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

P. Shi, K. Swaminathan, S. Vasudevan, 2015, Proceedings of the National Academy of Sciences.

2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase

David C. Chang, S. Lok, P. Shi, 2012, PLoS pathogens.

2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase

David C. Chang, S. Lok, P. Shi, 2012, PLoS pathogens.

The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity.

S. Vasudevan, J. Lescar, C. Kang, 2018, Advances in experimental medicine and biology.

Differential polarization of immune responses by co-administration of antigens with chemokines.

A. Garzino-Demo, R. Gallo, S. Lim, 2004, Vaccine.

A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening*

Paul W Smith, P. Shi, S. Lim, 2016, The Journal of Biological Chemistry.

Biochemical and genetic characterization of dengue virus methyltransferase.

Hongping Dong, Xuping Xie, David C. Chang, 2010, Virology.

Detection and quantification of flavivirus NS5 methyl-transferase activities.

P. Shi, C. Bodenreider, S. Lim, 2013, Methods in molecular biology.

Finding new medicines for flaviviral targets.

Yen-Liang Chen, A. Sampath, S. Vasudevan, 2006, Novartis Foundation symposium.

Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies

Yen-Liang Chen, P. Shi, J. Lescar, 2020, Journal of Virology.

Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk

K. Mansfield, W. Zhong, M. Fenaux, 2016, Antimicrobial Agents and Chemotherapy.

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.

Yen-Liang Chen, W. Zhong, P. Shi, 2018, Bioorganic & medicinal chemistry letters.

Targeting SARS-CoV-2 and host cell receptor interactions

S. Lim, 2022, Antiviral Research.

Dengue drug discovery: Progress, challenges and outlook

S. Lim, 2019, Antiviral research.

Strategies for development of Dengue virus inhibitors.

Yen-Liang Chen, P. Shi, W. Schul, 2010, Antiviral research.

Ten years of dengue drug discovery: progress and prospects.

David Beer, Hongping Dong, Shahul Nilar, 2013, Antiviral research.

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase*

Gang Wang, Hongping Dong, Thomas H. Keller, 2010, The Journal of Biological Chemistry.

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus

Zheng Yin, Ulrich Hommel, A. D'arcy, 2006, Nature Structural &Molecular Biology.

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

G. Bonamy, V. Sasseville, Yen-Liang Chen, 2021, Science Translational Medicine.

The dengue virus NS5 protein as a target for drug discovery.

P. Shi, S. Lim, C. Noble, 2015, Antiviral research.

Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing.

Yen-Liang Chen, S. Vasudevan, A. Davidson, 2007, Antiviral research.

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target.

Ting Xu, A. Sampath, S. Vasudevan, 2008, Antiviral research.

Mutations That Affect Dimer Formation and Helicase Activity of the Hepatitis C Virus Helicase

S. Brenner, S. Lim, Esther Y. C. Koh, 2001, Journal of Virology.

Cellular RNA Helicase p68 Relocalization and Interaction with the Hepatitis C Virus (HCV) NS5B Protein and the Potential Role of p68 in HCV RNA Replication

F. Fuller-Pace, Y. Tan, W. Hong, 2004, Journal of Virology.

Expression of a full-length hepatitis C virus cDNA up-regulates the expression of CC chemokines MCP-1 and RANTES.

W. Hong, S. Lim, A. Garzino-Demo, 2002, Virology.

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Hongping Dong, Rishi Arora, Xuping Xie, 2016, PLoS pathogens.

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening.

P. Niyomrattanakit, P. Shi, J. Lescar, 2015, Antiviral research.

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

Dahai Luo, Subhash G. Vasudevan, Moon Y. F. Tay, 2015, PLoS pathogens.

Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

Pei-Yong Shi, Yen-Liang Chen, P. Shi, 2013, Journal of Virology.

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.

Paul W Smith, P. Shi, R. Rao, 2016, Journal of medicinal chemistry.

Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir

G. Wang, Yen-Liang Chen, Daniela Cerny, 2013, Journal of Virology.

Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design.

P. Shi, S. Lim, S. Nilar, 2018, Advances in experimental medicine and biology.

Functional Profiling of Recombinant NS3 Proteases from All Four Serotypes of Dengue Virus Using Tetrapeptide and Octapeptide Substrate Libraries*[boxs]

Jennifer L. Harris, D. Wen, S. Vasudevan, 2005, Journal of Biological Chemistry.

Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization*

Holger Hannemann, A. Davidson, S. Lim, 2013, The Journal of Biological Chemistry.

Mutagenesis of the Dengue Virus Type 2 NS5 Methyltransferase Domain*

S. Vasudevan, J. Lescar, A. Davidson, 2008, Journal of Biological Chemistry.

A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

D. Wen, S. Vasudevan, J. Lescar, 2008, Antiviral research.

Helicase p 68 Relocalization and Interaction with the Hepatitis C Virus ( HCV ) NS 5 B Protein and the Potential Role of p 68 in HCV RNA Replication

F. Fuller-Pace, Y. Tan, W. Hong, 2004 .

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

P. Shi, J. Lescar, C. Bodenreider, 2010, PloS one.

A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.

A. Caflisch, G. Otting, D. Wen, 2009, Analytical biochemistry.

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities*

Ramyavardhanee Chandrasekaran, P. Shi, J. Lescar, 2013, The Journal of Biological Chemistry.

The Human Immunodeficiency Virus Type 1 Tat Protein Up-Regulates the Promoter Activity of the Beta-Chemokine Monocyte Chemoattractant Protein 1 in the Human Astrocytoma Cell Line U-87 MG: Role of SP-1, AP-1, and NF-κB Consensus Sites

A. Garzino-Demo, S. Lim, 2000, Journal of Virology.

Title Flexibility of NS 5 Methyltransferase-Polymerase LinkerRegion Is Essential for Dengue Virus Replication

T. Huber, P. Shi, K. Swaminathan, 2017 .

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

T. Huber, P. Shi, K. Swaminathan, 2015, Journal of Virology.

Identifying Initiation and Elongation Inhibitors of Dengue Virus RNA Polymerase in a High-Throughput Lead-Finding Campaign

Scott A. Busby, P. Niyomrattanakit, P. Shi, 2015, Journal of biomolecular screening.

Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development.

Stéphane Bressanelli, Pei-Yong Shi, P. Shi, 2014, Antiviral research.

Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics.

Amedeo Caflisch, Danzhi Huang, Gottfried Otting, 2009, Journal of medicinal chemistry.

1 Identification of lead-like and non-lead-like inhibitors for dengue virus NS 2 B / NS 3 protease by tryptophan fluorescence

A. Caflisch, G. Otting, D. Wen, 2009 .

Purification and crystallization of dengue and West Nile virus NS2B-NS3 complexes.

A. D'arcy, S. Lim, F. Villard, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

The β7 integrin gene (Itgb-7) promoter is responsive to TGF-β1: defining control regions

E. Leung, G. Krissansen, S. Lim, 1998, Immunogenetics.

The hepatitis C virus core protein interacts with NS5A and activates its caspase-mediated proteolytic cleavage.

W. Hong, S. Lim, Y. H. Tan, 2001, Virology.

Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics.

A. Caflisch, G. Otting, Dariusz Ekonomiuk, 2009, Journal of medicinal chemistry.

Ten years of dengue drug discovery: progress and prospects.

Paul W Smith, Yen-Liang Chen, P. Shi, 2013, Antiviral research.