G. Nixon

发表

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.

J. Gut, P. Rosenthal, R. Guedes, 2010, Journal of medicinal chemistry.

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.

G. Aljayyoussi, Peter D Gibbons, G. Nixon, 2017, Journal of medicinal chemistry.

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

J. Hemingway, R. Sinden, M. Delves, 2012, Proceedings of the National Academy of Sciences.

Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

Peter D Gibbons, G. Nixon, R. Amewu, 2012, Journal of medicinal chemistry.

Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?

A. Owen, G. Aljayyoussi, G. Nixon, 2020, ACS infectious diseases.

Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library

G. Nixon, N. Berry, S. Ward, 2017, Science Advances.

Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis

M. Wenlock, G. Nixon, N. Berry, 2021, ACS medicinal chemistry letters.

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

David M. Shackleford, Brice Campo, M. Belén, 2018, Bioorganic & medicinal chemistry.

Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.

Laura M Sanz, L. Ballell-Pages, M. Blackman, 2015, Journal of medicinal chemistry.

Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease

I. Charles, J. Bibby, D. Lalloo, 2018, Antimicrobial Agents and Chemotherapy.

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

B. K. Park, V. Barton, G. Nixon, 2010, Angewandte Chemie.

A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum

Peter D Gibbons, V. Barton, G. Nixon, 2010, Malaria Journal.

2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties

Peter D Gibbons, G. Nixon, G. Biagini, 2015 .

Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action.

G. Nixon, P. O’Neill, W. Hong, 2016, Journal of medicinal chemistry.

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.

J. Bacsa, Peter D Gibbons, G. Nixon, 2010, Organic & biomolecular chemistry.

Pharmacodynamics of Flubendazole for Cryptococcal Meningoencephalitis: Repurposing and Reformulation of an Anti-Parasitic Agent for a Neglected Fungal Disease

I. Charles, J. Bibby, D. Lalloo, 2018 .

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

David M. Shackleford, R. Price, D. Fidock, 2017, Nature Communications.

Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis

N. Fotouhi, J. Bibby, G. Aljayyoussi, 2023, ACS infectious diseases.

Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) Inhibitors with Improved Drug-like Properties.

S. Antonyuk, G. Nixon, G. Biagini, 2018, ACS medicinal chemistry letters.

Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.

G. Nixon, G. Biagini, A. Shone, 2013, Future medicinal chemistry.

Antimalarial pharmacology and therapeutics of atovaquone

D. Lalloo, G. Nixon, G. Biagini, 2013, The Journal of antimicrobial chemotherapy.

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

Peter D Gibbons, G. Nixon, R. Amewu, 2012, Journal of medicinal chemistry.

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Paul Harper, Louise Ford, John Archer, 2019, Nature Communications.

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis

J. Archer, A. Hoerauf, J. Hemingway, 2019, Proceedings of the National Academy of Sciences.

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

S. Parapini, D. Taramelli, C. Davis, 2009, Journal of medicinal chemistry.

Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials

G. Nixon, R. Amewu, S. Ward, 2016 .

Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205.

S. Parapini, D. Taramelli, G. Nixon, 2021, ACS Medicinal Chemistry Letters.

Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties.

S. Antonyuk, S. Hasnain, G. Nixon, 2018 .

Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods

Paul Stocks, Paul M. O'Neill, Neil G. Berry, 2012, Journal of medicinal chemistry.

Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells

P. Rudland, R. Barraclough, G. Nixon, 2023, Biomolecules.

Antimalarial Pharmacology and Therapeutics of Atovaquone 1 2

D. Lalloo, G. Nixon, G. Biagini, 2017 .

Inhibitors of the Plasmodium Mitochondrial Respiratory Chain

G. Nixon, G. Biagini, S. Ward, 2015 .

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.

G. Aljayyoussi, Peter D Gibbons, G. Nixon, 2017, Journal of medicinal chemistry.

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis

Edward W. Tate, J. Archer, A. Hoerauf, 2019, Proceedings of the National Academy of Sciences.

Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum

S. Parapini, D. Taramelli, G. Nixon, 2023, RSC chemical biology.