R. Amewu

发表

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.

J. Gut, P. Rosenthal, R. Guedes, 2010, Journal of medicinal chemistry.

The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

S. Kwofie, R. Amewu, Whelton A. Miller, 2021, Natural Products and Bioprospecting.

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.

G. Aljayyoussi, Peter D Gibbons, G. Nixon, 2017, Journal of medicinal chemistry.

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

J. Hemingway, R. Sinden, M. Delves, 2012, Proceedings of the National Academy of Sciences.

Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

Peter D Gibbons, G. Nixon, R. Amewu, 2012, Journal of medicinal chemistry.

Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.

J. Gut, P. Rosenthal, M. Mota, 2014, ACS medicinal chemistry letters.

Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets

R. Amewu, D. Osei-Safo, P. Sakyi, 2021, Molecules.

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

David M. Shackleford, Brice Campo, M. Belén, 2018, Bioorganic & medicinal chemistry.

Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.

R. Amewu, James Chadwick, S. Ward, 2011, Journal of medicinal chemistry.

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Peter D Gibbons, R. Amewu, P. Stocks, 2008, Journal of medicinal chemistry.

Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin.

R. Amewu, N. Berry, S. Ward, 2006, Organic & biomolecular chemistry.

Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

A. Srivastava, R. Amewu, James Chadwick, 2011 .

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

B. K. Park, V. Barton, G. Nixon, 2010, Angewandte Chemie.

Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action

S. Parapini, D. Taramelli, R. Amewu, 2011, ChemMedChem.

A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum

Peter D Gibbons, V. Barton, G. Nixon, 2010, Malaria Journal.

Evaluation of the fluorescent-thin layer chromatography (f-TLC) for the diagnosis of Buruli ulcer disease in Ghana

R. Amewu, A. Ablordey, K. Asiedu, 2022, PloS one.

Homology Modeling, de Novo Design of Ligands, and Molecular Docking Identify Potential Inhibitors of Leishmania donovani 24-Sterol Methyltransferase

Michael D. Wilson, S. Kwofie, R. Amewu, 2022, Frontiers in Cellular and Infection Microbiology.

Differential constituents in roots, stems and leaves of Newbouldia laevis Thunb. screened by LC/ESI-Q-TOF-MS

P. Caboni, R. Amewu, D. Osei-Safo, 2020, Results in Chemistry.

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.

J. Bacsa, Peter D Gibbons, G. Nixon, 2010, Organic & biomolecular chemistry.

Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents

J. Keiser, R. Amewu, F. Cho-Ngwa, 2020, PLoS neglected tropical diseases.

Targeting Leishmania donovani sterol methyltransferase for leads using pharmacophore modeling and computational molecular mechanics studies

S. Kwofie, R. Amewu, Whelton A. Miller, 2023, Informatics in Medicine Unlocked.

Detection of Mycolactone by Thin Layer Chromatography.

R. Amewu, T. Spangenberg, 2022, Methods in molecular biology.

Unravelling the myth surrounding sterol biosynthesis as plausible target for drug design against leishmaniasis

Alfred K. Bienibuor, S. Kwofie, R. Amewu, 2021, Journal of Parasitic Diseases.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

David M. Shackleford, R. Price, D. Fidock, 2017, Nature Communications.

Inhibiting Leishmania donovani Sterol Methyltransferase to Identify Lead Compounds Using Molecular Modelling

S. Kwofie, R. Amewu, Whelton A. Miller, 2023, Pharmaceuticals.

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

Peter D Gibbons, G. Nixon, R. Amewu, 2012, Journal of medicinal chemistry.

Targeting the Ubiquinol-Reduction (Qi) Site of the Mitochondrial Cytochrome bc1 Complex for the Development of Next Generation Quinolone Antimalarials

S. Antonyuk, R. Amewu, G. Biagini, 2022, Biology.

Setting Our Sights on Infectious Diseases

John P. Overington, P. Herrling, J. McCarthy, 2019, ACS infectious diseases.

An Endoperoxide‐Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites

Ana S. Newton, J. Gut, P. Rosenthal, 2013, ChemMedChem.

An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity.

R. Amewu, S. Ward, P. O’Neill, 2008, Bioorganic & medicinal chemistry letters.

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential

R. Amewu, G. Biagini, S. Ward, 2013, The Journal of antimicrobial chemotherapy.

Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity

I. Tuffour, R. Amewu, G. Dziwornu, 2017, Molecules.

Synthesis and Initial Testing of Novel Antimalarial and Antitubercular Isonicotinohydrazides

R. Amewu, D. Yeboah-Manu, I. Darko Otchere, 2022, Results in Chemistry.

Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials

G. Nixon, R. Amewu, S. Ward, 2016 .

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

Ruth H. Hughes, Peter D Gibbons, V. Barton, 2007, Angewandte Chemie.

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.

R. Amewu, James Chadwick, S. Ward, 2013, Bioorganic & medicinal chemistry.

Synthesis of 1,2,4-trioxepanes via application of thiol-olefin co-oxygenation methodology.

R. Amewu, N. Berry, S. Ward, 2006, Bioorganic & medicinal chemistry letters.

Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods

Paul Stocks, Paul M. O'Neill, Neil G. Berry, 2012, Journal of medicinal chemistry.

Drug discovery research in Ghana, challenges, current efforts, and the way forward

K. Chibale, Patrick Amoateng, R. Amewu, 2022, PLoS Neglected Tropical Diseases.

Enhancement Of Solubility, Dissolution And Stability Properties Of Griseofulvin

R. Amewu, G. Bonney, Gifty Bonney, 2017 .

Setting Our Sights on Infectious Diseases

John P. Overington, P. Herrling, J. McCarthy, 2019, ACS infectious diseases.

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.

G. Aljayyoussi, Peter D Gibbons, G. Nixon, 2017, Journal of medicinal chemistry.

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

Ruth H. Hughes, R. Amewu, G. Biagini, 2007, Angewandte Chemie.