P. Stocks

发表

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.

J. Gut, P. Rosenthal, R. Guedes, 2010, Journal of medicinal chemistry.

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.

G. Aljayyoussi, Peter D Gibbons, G. Nixon, 2017, Journal of medicinal chemistry.

Novel inhibitors of the Plasmodium falciparum electron transport chain

V. Barton, P. Stocks, G. Biagini, 2014, Parasitology.

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

J. Hemingway, R. Sinden, M. Delves, 2012, Proceedings of the National Academy of Sciences.

Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

Peter D Gibbons, G. Nixon, R. Amewu, 2012, Journal of medicinal chemistry.

Diamidine compounds: selective uptake and targeting in Plasmodium falciparum.

A. Stead, P. Stocks, S. Ward, 2001, Molecular pharmacology.

Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.

B. K. Park, P. Stocks, S. Ward, 2002, Journal of medicinal chemistry.

The Molecular Basis of Folate Salvage in Plasmodium falciparum

A. Nzila, S. Krishna, P. Stocks, 2011, The Journal of Biological Chemistry.

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

David M. Shackleford, Brice Campo, M. Belén, 2018, Bioorganic & medicinal chemistry.

Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.

Nuna C. P. Araújo, V. Barton, P. Stocks, 2009, Bioorganic & medicinal chemistry letters.

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Peter D Gibbons, R. Amewu, P. Stocks, 2008, Journal of medicinal chemistry.

Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action

S. Parapini, D. Taramelli, R. Amewu, 2011, ChemMedChem.

New procedures for the synthesis and analysis of 5,10,15,20-tetrakis(sulphophenyl)porphyrins and derivatives through chlorosulphonation

A. J. Sobral, A. Gonsalves, A. Serra, 1996 .

Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.

P. Stocks, S. Ward, P. O’Neill, 2004, Organic letters.

Porphyrins in aqueous amphiphilic polymers as peroxidase mimics

R. Johnstone, P. Stocks, A. G. Simpson, 1997 .

A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum

Peter D Gibbons, V. Barton, G. Nixon, 2010, Malaria Journal.

Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.

C. Davis, B. K. Park, Peter D Gibbons, 2009, Journal of medicinal chemistry.

Novel Quinoline Antimalarials

P. Stocks, S. Ward, K. Raynes, 2001 .

Artemisinin–Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation

Amy E. Chadwick, Nuna C. P. Araújo, P. Stocks, 2013, ChemMedChem.

New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain.

B. K. Park, P. Stocks, S. Ward, 1999, Journal of medicinal chemistry.

Antitumour and antimalarial activity of artemisinin-acridine hybrids.

J. Baird, I. Piantanida, B. K. Park, 2009, Bioorganic & medicinal chemistry letters.

Sulfur Oxidation Mediated by Imine Derivatives

D. M. Andrews, P. Stocks, J. Heer, 2000 .

Ruth H. Hughes, B. K. Park, P. Stocks, 2003, Journal of medicinal chemistry.

Co(thd)2: a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes

B. K. Park, P. Stocks, S. Ward, 2003 .

Design and synthesis of endoperoxide antimalarial prodrug models.

Erica Pasini, E. Pasini, E. Verissimo, 2004, Angewandte Chemie.

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.

B. K. Park, James Chadwick, P. Stocks, 2010, Bioorganic & medicinal chemistry.

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.

J. Bacsa, Peter D Gibbons, G. Nixon, 2010, Organic & biomolecular chemistry.

Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex

Andrew Owen, Paul M. O'Neill, Nicholas Fisher, 2008, Molecular Pharmacology.

PARASITE MITOCHONDRIAL bc1 COMPLEX

Dominic P. Williams, A. Owen, P. Stocks, 2008 .

HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc1 Complex

P. Stocks, G. Biagini, N. Berry, 2012, Antimicrobial Agents and Chemotherapy.

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

Peter D Gibbons, G. Nixon, R. Amewu, 2012, Journal of medicinal chemistry.

Glutathione transport: a new role for PfCRT in chloroquine resistance.

S. Müller, J. Murray, S. Krishna, 2013, Antioxidants & redox signaling.

PfCRT and the trans‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX

Ruth H. Hughes, D. Fidock, P. Stocks, 2006, Molecular microbiology.

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

S. Parapini, D. Taramelli, C. Davis, 2009, Journal of medicinal chemistry.

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

Ruth H. Hughes, Peter D Gibbons, V. Barton, 2007, Angewandte Chemie.

Piperidine dispiro-1,2,4-trioxane analogues.

P. Stocks, S. Ward, P. O’Neill, 2008, Bioorganic & medicinal chemistry letters.

Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore.

E. Verissimo, P. Stocks, M. L. Cristiano, 2006, Bioorganic & medicinal chemistry letters.

Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods

Paul Stocks, Paul M. O'Neill, Neil G. Berry, 2012, Journal of medicinal chemistry.

Complex 1 bcReduction Site of the Cytochrome falciparum Proliferation, Binds to the HDQ, a Potent Inhibitor of Plasmodium

S. Lawrenson, P. Stocks, N. Berry, 2013 .