P. Falson

发表

Multidrug resistance ABC transporter structure predictions by homology modeling approaches.

A. di Pietro, C. Dumontet, Myléne Honorat, 2011, Current drug metabolism.

A new method for the reconstitution of membrane proteins into giant unilamellar vesicles.

Patricia Bassereau, P. Bassereau, P. Falson, 2004, Biophysical journal.

Conformational changes in sarcoplasmic reticulum Ca(2+)-ATPase mutants: effect of mutations either at Ca(2+)-binding site II or at tryptophan 552 in the cytosolic domain.

C. Jaxel, M. Picard, M. le Maire, 2006, Biochemistry.

Involvement of the L6–7 Loop in SERCA1a Ca2+-ATPase Activation by Ca2+ (or Sr2+) and ATP*

M. Picard, J. Møller, M. le Maire, 2004, Journal of Biological Chemistry.

Overproduction in yeast and rapid and efficient purification of the rabbit SERCA1a Ca(2+)-ATPase.

P. A. Pedersen, M. le Maire, P. Falson, 2002, Biochimica et Biophysica Acta.

Involvement of the Cytoplasmic Loop L6‐7 in the Entry Mechanism for Transport of Ca2+ through the Sarcoplasmic Reticulum Ca2+‐ATPase

C. Jaxel, M. Maire, P. Falson, 2003, The Journal of biological chemistry.

Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model

J. Guitton, Myléne Honorat, P. Falson, 2014, Fundamental & clinical pharmacology.

A template model for studying anticancer drug efflux transporter inhibitors in vitro

J. Guitton, Myléne Honorat, P. Falson, 2013, Fundamental & clinical pharmacology.

Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion

F. Penin, L. Riva, B. Bartosch, 2015, Journal of Virology.

Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2.

A. di Pietro, B. Sarkadi, P. Falson, 2020, European journal of medicinal chemistry.

Optimizing the flavanone core toward new selective nitrogen-containing modulators of ABC transporters.

Ricardo J. Ferreira, Maria-José U. Ferreira, P. Falson, 2018, Future medicinal chemistry.

2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.

L. Chow, P. Falson, A. Boumendjel, 2016, European journal of medicinal chemistry.

The acridone derivative MBLI-87 sensitizes breast cancer resistance protein-expressing xenografts to irinotecan.

S. Bates, A. di Pietro, E. Matera, 2011, European journal of cancer.

Targeting the multidrug ABCG2 transporter with flavonoidic inhibitors: in vitro optimization and in vivo validation.

P. Carrupt, A. di Pietro, P. Falson, 2011, Current medicinal chemistry.

Methoxy stilbenes as potent, specific, untransported, and noncytotoxic inhibitors of breast cancer resistance protein.

A. di Pietro, Luciana Pereira Rangel, J. Guitton, 2012, ACS chemical biology.

Make azoles active again: chalcones as potent reversal agents of transporters-mediated resistance in Candida albicans.

R. Prasad, P. Falson, A. Pietro, 2018, Future medicinal chemistry.

Nanodisc, amphipol or detergent belts in cryoEM reconstructions of membrane proteins are similar and correspond to a common ordered solvent layer

V. Chaptal, P. Falson, V. Zampieri, 2020, bioRxiv.

Spontaneous Suppressors against Debilitating Transmembrane Mutants of CaMdr1 Disclose Novel Interdomain Communication via Signature Motifs of the Major Facilitator Superfamily

R. V. Prasad, P. Falson, A. Banerjee, 2022, bioRxiv.

Chromones bearing amino acid residues: Easily accessible and potent inhibitors of the breast cancer resistance protein ABCG2.

C. Philouze, O. Renaudet, Aline Thomas, 2020, European journal of medicinal chemistry.

Modulators of the human ABCC2: hope from natural sources?

P. Falson, F. Loghin, G. Crișan, 2015, Future medicinal chemistry.

Methyl-cyclopentadienyl Ruthenium Compounds with 2,2'-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential.

P. Falson, J. P. P. Ramalho, F. Marques, 2018, Inorganic chemistry.

Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis

C. Bréchot, D. Gozuacik, T. Capiod, 2000, Oncogene.

pHluorin enables insights into the transport mechanism of antiporter Mdr1: R215 is critical for drug/H+ antiport.

R. Prasad, P. Falson, N. K. Khandelwal, 2016, The Biochemical journal.

Ovarian cancer cells cisplatin sensitization agents selected by mass cytometry target ABCC2 inhibition.

P. Falson, T. Andrieu, A. Boumendjel, 2018, Future medicinal chemistry.

Monoterpene indole alkaloid azine derivatives as MDR reversal agents.

Maria-José U. Ferreira, P. Falson, Silva Mulhovo, 2018, Bioorganic & medicinal chemistry.

Liver Kidney Intestine MRP 2 tissue expression Brain Lungs Gall bladder Placenta Reproductive system

P. Falson, F. Loghin, G. Crișan, 2022 .

Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1.

R. Prasad, V. Chaptal, P. Falson, 2016, Biochimica et biophysica acta.

Gradient reconstitution of membrane proteins for solid-state NMR studies

B. Meier, J. Jault, V. Chaptal, 2017, Journal of biomolecular NMR.

Clean Western blots of membrane proteins after yeast heterologous expression following a shortened version of the method of Perini et al.

J. Møller, M. le Maire, P. Falson, 2000, Analytical biochemistry.

Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1

L. Chow, A. di Pietro, P. Falson, 2017, Biochemical pharmacology.

Alpha subunit of mitochondrial F1-ATPase from the fission yeast. Deduced sequence of the wild type and identification of a mutation that alters apparent negative cooperativity.

K. Conrath, P. Falson, M. Boutry, 1991, The Journal of biological chemistry.

The non-Newtonian behavior of detergents during concentration is increased by macromolecules, in trans, and results in their over-concentration.

V. Chaptal, P. Falson, S. Magnard, 2022, Biochimie.

Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.

G. Klebe, A. Heine, J. Adamski, 2018 .

Ligand binding to macromolecules or micelles: use of centrifugal ultrafiltration to measure low-affinity binding.

M. le Maire, P. Champeil, P. Falson, 1998, Analytical biochemistry.

The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead.

C. Dumontet, P. Falson, A. Boumendjel, 2022, European journal of medicinal chemistry.

Stoichiometry of the MexA‐OprM binding, as investigated by blue native gel electrophoresis

Nathalie Ulryck, G. Phan, M. Picard, 2012, Electrophoresis.

Structure-function relationships of mitochondrial ATPase-ATPsynthase using Schizosaccharomyces pombe yeast mutants with altered F1 subunits.

A. di Pietro, G. Divita, J. Jault, 1989, Biochimie.

Purification from a yeast mutant of mitochondrial F1 with modified beta-subunit. High affinity for nucleotides and high negative cooperativity of ATPase activity.

A. di Pietro, J. Jault, P. Falson, 1989, Biochimica et biophysica acta.

A yeast strain with mutated beta-subunits of mitochondrial ATPase-ATPsynthase: high azide and bicarbonate sensitivity of the ATPase activity.

A. Goffeau, A. di Pietro, J. Jault, 1989, Biochemical and biophysical research communications.

Revertant of the yeast Schizosaccharomyces pombe with modified alpha subunits of mitochondrial ATPase-ATPsynthase: impaired nucleotide interactions with soluble and membrane-bound enzyme.

A. Goffeau, A. di Pietro, J. Jault, 1987, Biochemical and biophysical research communications.

Optimization of the chromone scaffold through QSAR and docking studies: Identification of potent inhibitors of ABCG2.

O. Renaudet, P. Falson, A. Boumendjel, 2019, European journal of medicinal chemistry.

Peroxisomal ATP-binding cassette transporters form mainly tetramers

G. Lucchi, P. Ducoroy, P. Falson, 2017, The Journal of Biological Chemistry.

Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport.

R. Prasad, V. Chaptal, P. Falson, 2017, Biochimica et biophysica acta. Biomembranes.

Synthesis and Anticancer Cytotoxicity of Azaaurones Overcoming Multidrug Resistance

G. Szakács, A. di Pietro, B. Sarkadi, 2020, Molecules.

Urea reduces the aggregation of membrane proteins on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

J. Møller, M. le Maire, P. Falson, 1996, Analytical biochemistry.

Alteration of apparent negative cooperativity of ATPase activity by alpha-subunit glutamine 173 mutation in yeast mitochondrial F1. Correlation with impaired nucleotide interaction at a regulatory site.

A. di Pietro, J. Jault, P. Falson, 1991, The Journal of biological chemistry.

Overexpression of SERCA1a Ca2+-ATPase in yeast.

P. A. Pedersen, M. le Maire, P. Falson, 2003, Annals of the New York Academy of Sciences.

Overexpression of SERCA1a Ca 2+ -ATPase in Yeast

P. A. Pedersen, M. Maire, P. Falson, 2003 .

5‐Oxo‐hexahydroquinoline derivatives as modulators of P‐gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells

O. Firuzi, P. Falson, L. Saso, 2019, Toxicology and applied pharmacology.

Trianionic calix[4]arene monoalkoxy derivatives : synthesis, solid-state structures and self-assembly properties

A. Coleman, P. Falson, S. Jebors, 2008 .

Structuring Detergents for Extracting and Stabilizing Functional Membrane Proteins

A. di Pietro, D. Ficheux, R. Kahn, 2011, PloS one.

PDR-like ABC systems in pathogenic fungi.

R. Prasad, P. Falson, A. Banerjee, 2019, Research in microbiology.

Chemical modification of thiol groups of mitochondrial F1-ATPase from the yeast Schizosaccharomyces pombe. Involvement of alpha- and gamma-subunits in the enzyme activity.

A. di Pietro, P. Falson, D. Gautheron, 1986, The Journal of biological chemistry.

Complete removal and exchange of sodium dodecyl sulfate bound to soluble and membrane proteins and restoration of their activities, using ceramic hydroxyapatite chromatography.

F. Penin, M. le Maire, P. Falson, 1997, Analytical biochemistry.

Overcoming the toxicity of membrane peptide expression in bacteria by upstream insertion of Asp-Pro sequence.

F. Penin, P. Falson, C. Lethias, 2004, Biochimica et biophysica acta.

Specific Xray diffraction patterns of membrane proteins caused by secondary structure collinearity.

Juliette Martin, V. Chaptal, P. Falson, 2022, Biochimica et biophysica acta. Biomembranes.

Collinearity of alpha-helices or beta strands in membrane proteins causes a characteristic peak centred on 4.9 Å resolution in diffraction intensity profiles, inducing higher diffraction anisotropy

Juliette Martin, V. Chaptal, P. Falson, 2021, bioRxiv.

The Det.Belt Server: A Tool to Visualize and Estimate Amphipathic Solvent Belts around Membrane Proteins

Juliette Martin, G. Launay, V. Chaptal, 2021, Membranes.

Serca1 Truncated Proteins Unable to Pump Calcium Reduce the Endoplasmic Reticulum Calcium Concentration and Induce Apoptosis

P. Pinton, R. Rizzuto, C. Bréchot, 2001, The Journal of cell biology.

Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1

J. Cortay, V. Chaptal, P. Falson, 2020, Scientific Reports.

A hydrophobic filter confers the cation selectivity of Zygosaccharomyces rouxii plasma-membrane Na+/H+ antiporter.

H. Sychrová, P. Falson, O. Kinclová-Zimmermannová, 2015, Journal of molecular biology.

Characterization of a Protease-resistant Domain of the Cytosolic Portion of Sarcoplasmic Reticulum Ca2+-ATPase

J. Møller, M. le Maire, P. Champeil, 1998, The Journal of Biological Chemistry.

Inhibitors of ABCG2-mediated multidrug resistance: Lead generation through computer-aided drug design.

L. Goracci, V. Chaptal, P. Falson, 2023, European journal of medicinal chemistry.

ABCG: a new fold of ABC exporters and a whole new bag of riddles!

R. Prasad, P. Falson, A. Banerjee, 2021, Advances in protein chemistry and structural biology.

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

E. Pardon, J. Steyaert, G. Chang, 2013, Proceedings of the National Academy of Sciences.

Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter

G. Schoehn, Juliette Martin, L. Monticelli, 2022, Science advances.

Drug-bound and -free outward-facing structures of a multidrug ABC exporter point to a swing mechanism

Juliette Martin, L. Monticelli, M. Högbom, 2021, bioRxiv.

Cdr1p highlights the role of the non-hydrolytic ATP-binding site in driving drug translocation in asymmetric ABC pumps.

A. Mondal, R. Prasad, P. Falson, 2019, Biochimica et Biophysica Acta - Biomembranes.

Understanding polyspecificity within the substrate‐binding cavity of the human multidrug resistance P‐glycoprotein

A. di Pietro, G. Chang, Qinghai Zhang, 2014, The FEBS journal.

ABCG2 Transports and Transfers Heme to Albumin through Its Large Extracellular Loop*

A. di Pietro, P. Falson, O. Arnaud, 2010, The Journal of Biological Chemistry.

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2[prime]-deoxyuridine-5[prime]-monophosphate on ABCC11 in silico models

Myléne Honorat, P. Falson, R. Terreux, 2018 .

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2′-deoxyuridine-5′-monophosphate on ABCC11 in silico models

A. di Pietro, C. Dumontet, Myléne Honorat, 2013, BMC Structural Biology.

Quantification of Detergents Complexed with Membrane Proteins

M. Picard, A. Jawhari, H. Kaback, 2017, Scientific Reports.

Polymer "ruthenium-cyclopentadienyl" conjugates - New emerging anti-cancer drugs.

V. Labas, P. Falson, P. Zinck, 2019, European journal of medicinal chemistry.

The Cytoplasmic Loop between Putative Transmembrane Segments 6 and 7 in Sarcoplasmic Reticulum Ca2+-ATPase Binds Ca2+ and Is Functionally Important*

L. Bouneau, J. Møller, M. le Maire, 1997, The Journal of Biological Chemistry.

The Binding Mechanism of the Yeast F1-ATPase Inhibitory Peptide

F. Haraux, P. Falson, D. Mueller, 2005, Journal of Biological Chemistry.

Beta subunit of mitochondrial F1-ATPase from the fission yeast. Deduced sequence of the wild type protein and identification of a mutation that increases nucleotide binding.

P. Falson, M. Boutry, S. Leterme, 1991, European journal of biochemistry.

The Cytoplasmic Loop Located between Transmembrane Segments 6 and 7 Controls Activation by Ca2+ of Sarcoplasmic Reticulum Ca2+-ATPase*

S. Deschamps, L. Bouneau, J. Møller, 1998, The Journal of Biological Chemistry.

Functional nucleotide-binding domain in the F0F1-ATPsynthase alpha subunit from the yeast Schizosaccharomyces pombe.

F. Penin, R. Goody, A. di Pietro, 1993, Biochemistry.

Structural insight into the cooperativity between catalytic and noncatalytic sites of F1-ATPase.

A. Goffeau, J. Jault, P. Falson, 2004, Biochimica et biophysica acta.

Externalized Keratin 8: A Target at the Interface of Microenvironment and Intracellular Signaling in Colorectal Cancer Cells

P. Saintigny, V. Marcel, A. Jawhari, 2018, Cancers.

Mammalian membrane protein expression in baculovirus-infected insect cells.

P. Falson, Céline Trometer, 2010, Methods in molecular biology.

Directed Mutational Strategies Reveal Drug Binding and Transport by the MDR Transporters of Candida albicans

R. Prasad, P. Falson, S. Sharma, 2021, Journal of fungi.

Probing of the Membrane Topology of Sarcoplasmic Reticulum Ca2+-ATPase with Sequence-specific Antibodies

K. Fujimoto, J. Møller, M. le Maire, 1997, The Journal of Biological Chemistry.

Au courant computation of the PDB to audit diffraction anisotropy of soluble and membrane proteins

R. Read, M. Sawaya, Juliette Martin, 2018, Data in brief.

Efficient and stable reconstitution of the ABC transporter BmrA for solid-state NMR studies

B. Meier, F. Penin, J. Jault, 2014, Front. Mol. Biosci..

Stubborn Contaminants: Influence of Detergents on the Purity of the Multidrug ABC Transporter BmrA

B. Wiseman, Jonathan Sarwan, J. Jault, 2014, PloS one.

W1038 near D-loop of NBD2 is a focal point for inter-domain communication in multidrug transporter Cdr1 of Candida albicans.

R. Prasad, P. Falson, A. H. Shah, 2018, Biochimica et biophysica acta. Biomembranes.

X-ray diffraction reveals the intrinsic difference in the physical properties of membrane and soluble proteins

R. Read, M. Sawaya, Juliette Martin, 2017, Scientific Reports.

The multidrug resistance half-transporter ABCG2 is purified as a tetramer upon selective extraction from membranes.

A. di Pietro, S. Marco, P. Falson, 2010, Biochimica et biophysica acta.

Gradient reconstitution of membrane proteins for solid-state NMR studies

B. Meier, J. Jault, V. Chaptal, 2017, Journal of Biomolecular NMR.

Role of the yeast ABC transporter Yor1p in cadmium detoxification.

A. Goffeau, Z. Nagy, P. Falson, 2006, Biochimie.

Multidrug resistance ATP-binding cassette membrane transporters as targets for improving oropharyngeal candidiasis treatment

P. Falson, Lorena Martínez, 2014 .

Functional cell surface expression of the anion transport domain of human red cell band 3 (AE1) in the yeast Saccharomyces cerevisiae.

M. Tanner, M. le Maire, P. Falson, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Functional Properties of Sarcoplasmic Reticulum Ca2+-ATPase after Proteolytic Cleavage at Leu119-Lys120, Close to the A-domain

M. Picard, Carole Gauron, J. Møller, 2004, Journal of Biological Chemistry.

Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.

A. di Pietro, C. Dumontet, P. Falson, 2010, Journal of medicinal chemistry.

Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties

J. Coll, A. Hurbin, P. Falson, 2017, Scientific Reports.

Glycosyl-Substituted Dicarboxylates as Detergents for the Extraction, Overstabilization, and Crystallization of Membrane Proteins.

A. Jawhari, V. Chaptal, P. Falson, 2018, Angewandte Chemie.

Involvement of the Cytoplasmic Loop L6–7 in the Entry Mechanism for Transport of Ca2+ through the Sarcoplasmic Reticulum Ca2+-ATPase* 210

L. Bouneau, J. Møller, M. le Maire, 2002, The Journal of Biological Chemistry.

Expression of the sarcoplasmic reticulum Ca2+‐ATPase in yeast

S. Deschamps, M. Palmgren, J. Møller, 1994, FEBS letters.

Modular construction of quaternary hemiaminal-based inhibitor candidates and their in cellulo assessment with HIV-1 protease.

R. Wolkowicz, J. Hasserodt, P. Falson, 2013, Bioorganic & medicinal chemistry.

Structure, function, and inhibition of catalytically asymmetric ABC transporters: Lessons from the PDR subfamily.

R. V. Prasad, V. Chaptal, P. Falson, 2023, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Drug candidates targeting multidrug resistance in cancer and infections

P. Falson, A. Boumendjel, M. Le Borgne, 2023, European Journal of Medicinal Chemistry.

Modulators of the Efflux Pump Cdr1p of Candida albicans: Mechanisms of Action and Chemical Features.

R. Prasad, P. Falson, A. Boumendjel, 2017, Current medicinal chemistry.

Expression of sarcoplasmic reticulum CA2+‐ATPase in yeast

S. Deschamps, M. le Maire, P. Falson, 1995 .

Heterologous expression of the red-cell anion exchanger (band 3; AE1).

M. Tanner, M. le Maire, P. Falson, 1999, Biochemical Society Transactions.

Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand.

B. Buckley, P. Falson, F. Marques, 2019, European journal of medicinal chemistry.

Nucleotide-Free Crystal Structure of Nucleotide-Binding Domain 1 from Human Abcc1 Supports a 'General-Base Catalysis' Mechanism for ATP Hydrolysis.

P. Falson, A. Pietro, S. Magnard, 2014 .

Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H+ Antiporter.

P. Falson, A. H. Shah, Manpreet Kaur Rawal, 2018, Journal of molecular biology.

Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion

F. Penin, L. Riva, B. Bartosch, 2015, Journal of Virology.

Glycosyl-Substituted Dicarboxylates as Detergents for the Extraction, Overstabilization, and Crystallization of Membrane Proteins.

A. Jawhari, V. Chaptal, P. Falson, 2018, Angewandte Chemie.

The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains

G. Gerbaud, J. Jault, V. Chaptal, 2023, The Journal of biological chemistry.

Purification and characterization of Cdr1, the drug-efflux pump conferring azole resistance in Candida species.

V. Chaptal, P. Falson, A. Boumendjel, 2023, Biochimie.

Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1

J. Cortay, V. Chaptal, P. Falson, 2020, Scientific Reports.

Leishmania tarentolae as a Promising Tool for Expressing Polytopic and Multi-Transmembrane Spans Eukaryotic Membrane Proteins: The Case of the ABC Pump ABCG6.

J. Molle, V. Chaptal, P. Falson, 2016, Methods in molecular biology.