C. Strickland

发表

Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.

Corey Strickland, A. Stamford, D. Wyss, 2012, Topics in current chemistry.

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.

A. Stamford, J. Cumming, L. Zhang, 2008, Bioorganic & medicinal chemistry letters.

Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.

Lynn A. Hyde, W. Greenlee, A. Stamford, 2012, Bioorganic & medicinal chemistry letters.

Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.

Peter S. Kutchukian, A. W. Shaw, Jing Li, 2020, ACS medicinal chemistry letters.

Structure and activity relationships of tartrate-based TACE inhibitors.

P. Orth, Zhuyan Guo, C. Strickland, 2010, Bioorganic & medicinal chemistry letters.

The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.

Patrick J. Curran, P. Orth, Zhuyan Guo, 2010, Bioorganic & medicinal chemistry letters.

Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies

G. Raghunathan, C. Strickland, D. Tomazela, 2020, Antibodies.

Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction

A. Cheng, Makiko Uchida, G. Raghunathan, 2021, Antibodies.

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

G. Scapin, C. Strickland, P. Reichert, 2015, Nature Structural &Molecular Biology.

Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story.

A. Stamford, C. Strickland, 2013, Current opinion in chemical biology.

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.

A. Stamford, J. Cumming, C. Strickland, 2008, Bioorganic & medicinal chemistry letters.

Discovery of potent iminoheterocycle BACE1 inhibitors.

Brian McKittrick, Andrew Stamford, Xia Chen, 2014, Bioorganic & medicinal chemistry letters.

Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously.

J. Newman, T. Peat, C. Strickland, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.

Qin Jiang, William J Greenlee, Xia Chen, 2016, Journal of medicinal chemistry.

Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.

C. Strickland, B. Lahue, G. Shipps, 2016, Bioorganic & medicinal chemistry letters.

Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.

Andrew Stamford, William Greenlee, Guoqing Li, 2010, Bioorganic & medicinal chemistry letters.

Pembrolizumab microgravity crystallization experimentation

T. Fischmann, G. Scapin, C. Strickland, 2019, npj Microgravity.

Structure of the Insulin Receptor-Insulin Complex by Single Particle CryoEM analysis

Bridget Carragher, Clinton S. Potter, Venkata P. Dandey, 2018, Nature.

Author Correction: Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

J. O'neil, G. Scapin, M. Bailly, 2021, Communications Biology.

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

M. Rudd, T. Mcdonald, S. Stachel, 2021, Nature Communications.

Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry.

Ali Nahvi, Corey Strickland, J. Burchard, 2018, ACS chemical biology.

Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

A. Therien, P. Orth, L. Hernandez, 2014, The Journal of Biological Chemistry.

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.

A. Peier, C. Strickland, Benjamin J Barlock, 2022, Journal of medicinal chemistry.

Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.

William Greenlee, Lynn Hyde, Xia Chen, 2012, Journal of medicinal chemistry.

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ Reduction.

Suresh Babu, William J Greenlee, Xia Chen, 2012, ACS medicinal chemistry letters.

Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.

Walter A. Korfmacher, W. Greenlee, J. Clader, 2015, Bioorganic & medicinal chemistry letters.

Structure of the Insulin Receptor in Complex with Insulin using Single Particle CryoEM Analysis

B. Carragher, C. Potter, V. Dandey, 2017, Microscopy and Microanalysis.

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates.

Lynn A. Hyde, W. Greenlee, A. Stamford, 2016, Journal of medicinal chemistry.

Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.

Michael Czarniecki, John C Hunter, William J Greenlee, 2010, Journal of medicinal chemistry.

Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.

Lingyan Wang, Andrew Stamford, Michael Czarniecki, 2010, Journal of medicinal chemistry.

A novel storage system for cryoEM samples.

Giovanna Scapin, Winifred W Prosise, Michael K Wismer, 2017, Journal of structural biology.

Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.

W. R. Bishop, D. Hicklin, G. Scapin, 2016, ACS medicinal chemistry letters.

Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.

Qi Zhang, A. Stamford, C. Strickland, 2008, Bioorganic & medicinal chemistry letters.

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.

A. Peier, C. Strickland, Benjamin J Barlock, 2021, Journal of medicinal chemistry.

Pembrolizumab microgravity crystallization experimentation

T. Fischmann, G. Scapin, C. Strickland, 2019, npj Microgravity.