J. Voigt

发表

Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.

Corey Strickland, A. Stamford, D. Wyss, 2012, Topics in current chemistry.

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.

A. Stamford, J. Cumming, L. Zhang, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.

Claudio N. Cavasotto, R. Abagyan, F. Monsma, 2008, Journal of medicinal chemistry.

Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.

Lynn A. Hyde, W. Greenlee, A. Stamford, 2012, Bioorganic & medicinal chemistry letters.

Significant compensatory role of position Y-2 conferring high affinity to non-phosphorylated inhibitors of Grb2-SH2 domain.

P. Roller, J. Voigt, F. Lung, 1999, Bioorganic & medicinal chemistry letters.

Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor.

T. Burke, J. Voigt, D. Yang, 2001, Bioorganic & medicinal chemistry letters.

2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

W. Greenlee, H. Guzik, J. Clader, 2007 .

Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.

J. Clader, G. Scapin, J. Voigt, 2016, Bioorganic & medicinal chemistry.

Structural requirements for Tyr in the consensus sequence Y-E-N of a novel nonphosphorylated inhibitor to the Grb2-SH2 domain.

P. Roller, T. Burke, Z. Yao, 1999, Biochemical and biophysical research communications.

Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic.

T. Burke, Z. Yao, J. Voigt, 2000, Journal of medicinal chemistry.

Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands.

G. Milne, T. Burke, Z. Yao, 1999, Journal of medicinal chemistry.

PROSIT: Pseudo-Rotational Online Service and Interactive Tool, Applied to a Conformational Survey of Nucleosides and Nucleotides

Igor V. Filippov, Guangyu Sun, Johannes H. Voigt, 2004, J. Chem. Inf. Model..

An Efficient Synthesis of Conformationally Restricted Peptides Containing β-Aminocyclopropanecarboxylic Acids

J. Voigt, M. Noltemeyer, O. Reiser, 1997 .

Iminoheterocycles as gamma-secretase modulators.

Lynn A. Hyde, J. Voigt, Zhaoning Zhu, 2010, Bioorganic & medicinal chemistry letters.

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.

A. Stamford, J. Cumming, C. Strickland, 2008, Bioorganic & medicinal chemistry letters.

Discovery of potent iminoheterocycle BACE1 inhibitors.

Brian McKittrick, Andrew Stamford, Xia Chen, 2014, Bioorganic & medicinal chemistry letters.

Synthesis of Fmoc-protected 4-carboxydifluoromethyl-L-phenylalanine: A phosphotyrosyl mimetic of potential use for signal transduction studies

Z. Yao, J. Voigt, T. Burke, 1999 .

Monocarboxylic-based phosphotyrosyl mimetics in the design of GRB2 SH2 domain inhibitors.

G. Milne, T. Burke, H. Zhao, 1999, Bioorganic & medicinal chemistry letters.

Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif.

L. Wu, T. Burke, Z. Zhang, 2001, Journal of medicinal chemistry.

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.

Qin Jiang, William J Greenlee, Xia Chen, 2016, Journal of medicinal chemistry.

Metal-dependent inhibition of HIV-1 integrase.

Dirk Strumberg, Marc C Nicklaus, Yves Pommier, 2002, Journal of medicinal chemistry.

Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

Patrick J. Curran, A. Basso, A. Mandal, 2010, Bioorganic & medicinal chemistry letters.

Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors.

T. Burke, Z. Yao, J. Voigt, 2001, Biopolymers.

Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.

Andrew Stamford, William Greenlee, Guoqing Li, 2010, Bioorganic & medicinal chemistry letters.

Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins.

E. Androphy, J. Baleja, Zhiguo Liu, 2006, Antiviral research.

Comparison of the NCI Open Database with Seven Large Chemical Structural Databases

Johannes H. Voigt, Marc C. Nicklaus, Shaomeng Wang, 2001, J. Chem. Inf. Comput. Sci..

A New Approach to β- and γ-Amino Esters and Amino Aldehydes by Regioselective Ozonolysis of 2,3-Dihydropyrroles and 1,2,3,4-Tetrahydropyridines

J. Voigt, C. Bubert, O. Reiser, 1994 .

Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.

William Greenlee, Lynn Hyde, Xia Chen, 2012, Journal of medicinal chemistry.

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ Reduction.

Suresh Babu, William J Greenlee, Xia Chen, 2012, ACS medicinal chemistry letters.

Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.

Walter A. Korfmacher, W. Greenlee, J. Clader, 2015, Bioorganic & medicinal chemistry letters.

PROSIT, AN ONLINE SERVICE TO CALCULATE PSEUDOROTATIONAL PARAMETERS OF NUCLEOSIDES AND NUCLEOTIDES

Marc C Nicklaus, M. Nicklaus, J. Voigt, 2005, Nucleosides, nucleotides & nucleic acids.

Enhanced CACTVS Browser of the Open NCI Database

Frank Oellien, Wolf-Dietrich Ihlenfeldt, Johannes H. Voigt, 2002, J. Chem. Inf. Comput. Sci..

High affinity nonphosphorylated cyclic peptide inhibitors of Grb2-SH2/growth factor receptor interactions

Dajun Yang, P. Roller, T. Burke, 2002 .

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.

Lynn A. Hyde, W. Greenlee, Xiaohong Zhu, 2012, Journal of medicinal chemistry.

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates.

Lynn A. Hyde, W. Greenlee, A. Stamford, 2016, Journal of medicinal chemistry.

Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.

Michael Czarniecki, John C Hunter, William J Greenlee, 2010, Journal of medicinal chemistry.

Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.

Lingyan Wang, Andrew Stamford, Michael Czarniecki, 2010, Journal of medicinal chemistry.

Comparison of Random Forest and Pipeline Pilot Naïve Bayes in Prospective QSAR Predictions

Bin Chen, Robert P. Sheridan, Johannes H. Voigt, 2012, J. Chem. Inf. Model..

Enantioselective Synthesis of Nonphosphorus-Containing Phosphotyrosyl Mimetics and Their Use in the Preparation of Tyrosine Phosphatase Inhibitory Peptides

G. Milne, Z. Yao, J. Voigt, 1998 .

Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.

T. Burke, M. Nicklaus, J. Voigt, 2003, Bioorganic & medicinal chemistry letters.

Local Conformational Constraint in the Design of a Grb2 SH2 Domain Inhibitor

Dajun Yang, T. Burke, Jane Wu, 2001 .

Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.

Qi Zhang, A. Stamford, C. Strickland, 2008, Bioorganic & medicinal chemistry letters.

Comparison of Random Forest and Pipeline Pilot Naïve Bayes in Prospective QSAR Predictions

Bin Chen, R. Sheridan, V. Hornak, 2012, J. Chem. Inf. Model..

Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.

J. Voigt, A. Hruza, Matthew P. Rainka, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.

Patrick J. Curran, Ming Liu, R. Doll, 2010, ACS medicinal chemistry letters.