E. Ellsworth

发表

Physiochemical drug properties associated with in vivo toxicological outcomes.

J. Hughes, Enoch S. Huang, David A. Price, 2008, Bioorganic & medicinal chemistry letters.

5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease.

G. Zeikus, E. Lunney, S. Gulnik, 2000, Journal of medicinal chemistry.

Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor.

G. Zeikus, C. Humblet, E. Lunney, 1999, Bioorganic & medicinal chemistry.

In Vitro and In Vivo Activities of PD 0305970 and PD 0326448, New Bacterial Gyrase/Topoisomerase Inhibitors with Potent Antibacterial Activities versus Multidrug-Resistant Gram-Positive and Fastidious Organism Groups

S. Gracheck, M. Huband, E. Ellsworth, 2007, Antimicrobial Agents and Chemotherapy.

Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones.

H. D. Showalter, M. Huband, M. Shapiro, 2008, Bioorganic & medicinal chemistry letters.

Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma

Y. Yang, E. Ellsworth, Theresa A Lansdell, 2022, Biomedicines.

Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy

Y. Yang, E. Ellsworth, Theresa A Lansdell, 2020, bioRxiv.

Stereoselective synthesis of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile.

H. D. Showalter, H. Showalter, S. Murphy, 2012, The Journal of organic chemistry.

Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis

E. Ellsworth, P. Hansen, J. Watts, 2018, Molecules.

Ligand exchange between cyanocuprates and allylic stannanes: a novel, direct route to allylic cuprates possessing remarkable reactivity and stability

Robin A. J. Smith, E. Ellsworth, J. Behling, 1990 .

Fine tuning the silicon-tin bond: transmetalations forming either trialkylstannyl or trialkylsilyl higher order cyanocuprates

E. Ellsworth, B. Lipshutz, D. Reuter, 1989 .

The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents.

W. Denny, S. Hagen, J. Smaill, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.

E. Lunney, S. Hagen, J. Domagala, 1997, Journal of medicinal chemistry.

A facile synthesis of substituted 3-amino-1H-quinazoline-2,4-diones

J. Rubin, H. D. Showalter, Rajeshwar Singh, 2005 .

3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.

J. Domagala, H. D. Showalter, J. Bronstein, 2006, Journal of medicinal chemistry.

Synthesis and structural-activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents.

J. Domagala, H. D. Showalter, S. Gracheck, 2004, Bioorganic & medicinal chemistry letters.

Transmetalation reactions of higher order cyanocuprates: direct formation of trialkyltin cuprates from tin hydrides which bypasses organolithium intermediates

E. Ellsworth, B. Lipshutz, D. Reuter, 1989 .

New methodology for conjugate additions of allylic ligands to .alpha.,.beta.-unsaturated ketones: synthetic and spectroscopic studies

Robin A. J. Smith, E. Ellsworth, B. Lipshutz, 1990 .

Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors.

J. Domagala, H. D. Showalter, S. Gracheck, 2007, Bioorganic & medicinal chemistry letters.

The Role of BF3·Et2O in Reactions of Lower Order (Gilman) Organocuprates

E. Ellsworth, T. Siahaan, B. Lipshutz, 1989 .

Higher order cyanocuprates R2Cu(CN)Li2 : discrete reagents or lower order LiCN-modified gilman cuprates ?

E. Ellsworth, Sunaina Sharma, B. Lipshutz, 1990 .

On the composition of Yamamoto's reagent: "RCu.cntdot.BF3"

E. Ellsworth, B. Lipshutz, Stuart H. Dimock, 1990 .

Hydrozirconation-transmetalation. A mild, direct route to higher order vinylic cuprates from monosubstituted acetylenes

E. Ellsworth, B. Lipshutz, 1990 .

Ligand Exchange Between Cyanocuprates and Allylic Stannanes: A Novel, Direct Route to Allylic Cuprates Possessing Remarkable Reactivity and Stability.

Robin A. J. Smith, E. Ellsworth, J. Behling, 1990 .

Bromo(o‐tolyl)bis(triethylphosphine)nickel(II)

E. Ellsworth, 2001 .

Effects of BF3•Et2O on higher order organocuprate reactions: substrate activation or cuprate modification

E. Ellsworth, T. Siahaan, B. Lipshutz, 1988 .

Effects of gengenions on organocuprate reactivity/selectivity: Higher order, mixed lithio-sodio cyanocuprates

E. Ellsworth, J. Behling, A. L. Campbell, 1988 .

Unexpected affects of Me3Si-X on reactions of higher order cyanocuprates

E. Ellsworth, T. Siahaan, B. Lipshutz, 1988 .

Nonpeptidic HIV protease inhibitors: 3-(S-benzyl substituted)-4-hydroxy-6-(phenyl substituted)-2H-pyran-2-one with an inverse mode of binding

D. Ferguson, E. Ellsworth, A. Pavlovsky, 1996 .

Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme

E. Ellsworth, Bilal A. Aleiwi, Huiqing Zheng, 2019, ACS chemical biology.

The RXR Agonist MSU42011 Is Effective for the Treatment of Preclinical HER2+ Breast Cancer and Kras-Driven Lung Cancer

E. Ellsworth, T. Krieger-Burke, K. Liby, 2021, Cancers.

Therapeutic potential of targeting mixed lineage kinases in cancer and inflammation.

K. Gallo, S. Conrad, E. Ellsworth, 2019, Pharmacology & therapeutics.

Spermine in semen of male sea lamprey acts as a sex pheromone

R. Neubig, Jianfeng Ren, E. Ellsworth, 2019, PLoS biology.

The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer

E. Ellsworth, T. Krieger-Burke, K. Liby, 2020, Scientific Reports.

Machine Learning Analysis of Cocaine Addiction Informed by DAT, SERT, and NET-Based Interactome Networks.

Dong Chen, E. Ellsworth, A. J. Robison, 2022, Journal of chemical theory and computation.

Hydrozirconation-Transmetalation. A Mild, Direct Route to Higher Order Vinylic Cuprates from Monosubstituted Acetylenes.

E. Ellsworth, B. Lipshutz, 1991 .

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.

Mostofa A Hena, B. Finzel, R. Gilbertsen, 2012, Bioorganic & medicinal chemistry letters.

4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme.

G. Zeikus, E. Lunney, S. Hagen, 1999, Bioorganic & medicinal chemistry letters.

Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance

T. Dick, E. Ellsworth, M. Jackson, 2019, Antimicrobial Agents and Chemotherapy.

Inhibition of Mycobacterium tuberculosis DosRST two-component regulatory system signaling by targeting response regulator DNA binding and sensor kinase heme

E. Ellsworth, Bilal A. Aleiwi, Huiqing Zheng, 2018, bioRxiv.

The Novel RXR Agonist MSU-42011 Differentially Regulates Gene Expression in Mammary Tumors of MMTV-Neu Mice

E. Ellsworth, K. Liby, Lyndsey A. Reich, 2023, International journal of molecular sciences.

Synthesis of the novel antibacterial 6,8-dihydroxy-7-propyl-9H-pyrrolo[1,2-b][1,3]-benzoxazin-9-one

J. Domagala, Rajeshwar Singh, R. Micetich, 2000 .

Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl,5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties.

E. Lunney, S. Hagen, J. Domagala, 1999, Bioorganic & medicinal chemistry letters.

Anti-fibrillization effects of sulfonamide derivatives on α-synuclein and hyperphosphorylated tau isoform 1N4R.

B. Borhan, S. Counts, M. Kuo, 2022, Journal of molecular structure.